UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPT7_LEIBR

TriTrypDb:

LbrM.35.4430 , LBRM2903_350054900

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HPT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPT7

Function

Biological processes
Term	Name	Level	Count
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	11
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	11
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003975	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.176
CLV_MEL_PAP_1	181	187	PF00089	0.529
CLV_NRD_NRD_1	45	47	PF00675	0.263
CLV_NRD_NRD_1	73	75	PF00675	0.383
CLV_PCSK_KEX2_1	72	74	PF00082	0.398
CLV_PCSK_SKI1_1	155	159	PF00082	0.253
CLV_PCSK_SKI1_1	320	324	PF00082	0.409
CLV_PCSK_SKI1_1	370	374	PF00082	0.505
CLV_PCSK_SKI1_1	454	458	PF00082	0.326
CLV_PCSK_SKI1_1	46	50	PF00082	0.360
CLV_PCSK_SKI1_1	51	55	PF00082	0.351
DEG_APCC_DBOX_1	183	191	PF00400	0.356
DEG_APCC_DBOX_1	453	461	PF00400	0.368
DEG_SCF_FBW7_1	296	301	PF00400	0.204
DOC_CDC14_PxL_1	384	392	PF14671	0.363
DOC_CKS1_1	295	300	PF01111	0.273
DOC_CYCLIN_RxL_1	43	52	PF00134	0.559
DOC_MAPK_gen_1	151	158	PF00069	0.453
DOC_PP1_RVXF_1	432	438	PF00149	0.533
DOC_PP4_FxxP_1	185	188	PF00568	0.329
DOC_PP4_FxxP_1	375	378	PF00568	0.326
DOC_USP7_MATH_1	279	283	PF00917	0.379
DOC_USP7_MATH_1	360	364	PF00917	0.451
DOC_USP7_UBL2_3	151	155	PF12436	0.533
DOC_USP7_UBL2_3	43	47	PF12436	0.429
DOC_USP7_UBL2_3	81	85	PF12436	0.624
DOC_WW_Pin1_4	294	299	PF00397	0.273
DOC_WW_Pin1_4	38	43	PF00397	0.427
LIG_14-3-3_CanoR_1	212	216	PF00244	0.348
LIG_14-3-3_CanoR_1	454	460	PF00244	0.563
LIG_14-3-3_CanoR_1	74	83	PF00244	0.656
LIG_APCC_ABBA_1	424	429	PF00400	0.581
LIG_APCC_ABBA_1	459	464	PF00400	0.284
LIG_BRCT_BRCA1_1	216	220	PF00533	0.350
LIG_CaM_NSCaTE_8	196	203	PF13499	0.245
LIG_CtBP_PxDLS_1	89	93	PF00389	0.486
LIG_eIF4E_1	368	374	PF01652	0.334
LIG_eIF4E_1	455	461	PF01652	0.384
LIG_EVH1_2	207	211	PF00568	0.176
LIG_FHA_1	119	125	PF00498	0.396
LIG_FHA_1	132	138	PF00498	0.313
LIG_FHA_1	256	262	PF00498	0.324
LIG_FHA_1	369	375	PF00498	0.253
LIG_FHA_1	39	45	PF00498	0.422
LIG_FHA_1	406	412	PF00498	0.591
LIG_FHA_1	434	440	PF00498	0.467
LIG_FHA_2	59	65	PF00498	0.468
LIG_GBD_Chelix_1	103	111	PF00786	0.451
LIG_LIR_Gen_1	122	133	PF02991	0.334
LIG_LIR_Gen_1	349	359	PF02991	0.306
LIG_LIR_Gen_1	414	425	PF02991	0.495
LIG_LIR_Gen_1	436	445	PF02991	0.418
LIG_LIR_Nem_3	122	128	PF02991	0.403
LIG_LIR_Nem_3	217	222	PF02991	0.331
LIG_LIR_Nem_3	349	354	PF02991	0.306
LIG_LIR_Nem_3	414	420	PF02991	0.495
LIG_LIR_Nem_3	436	440	PF02991	0.418
LIG_LIR_Nem_3	458	462	PF02991	0.356
LIG_NRBOX	318	324	PF00104	0.451
LIG_NRBOX	456	462	PF00104	0.450
LIG_Pex14_2	109	113	PF04695	0.198
LIG_SH2_CRK	125	129	PF00017	0.329
LIG_SH2_CRK	417	421	PF00017	0.483
LIG_SH2_PTP2	229	232	PF00017	0.339
LIG_SH2_SRC	229	232	PF00017	0.176
LIG_SH2_SRC	462	465	PF00017	0.396
LIG_SH2_STAP1	351	355	PF00017	0.306
LIG_SH2_STAP1	368	372	PF00017	0.277
LIG_SH2_STAT5	100	103	PF00017	0.306
LIG_SH2_STAT5	229	232	PF00017	0.268
LIG_SH2_STAT5	241	244	PF00017	0.190
LIG_SH2_STAT5	246	249	PF00017	0.204
LIG_SH2_STAT5	34	37	PF00017	0.326
LIG_SH2_STAT5	351	354	PF00017	0.306
LIG_SH2_STAT5	40	43	PF00017	0.517
LIG_SH2_STAT5	417	420	PF00017	0.486
LIG_SH2_STAT5	425	428	PF00017	0.524
LIG_SH2_STAT5	455	458	PF00017	0.411
LIG_SH3_3	173	179	PF00018	0.310
LIG_SH3_3	210	216	PF00018	0.329
LIG_SH3_3	391	397	PF00018	0.417
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.310
LIG_SUMO_SIM_anti_2	173	178	PF11976	0.379
LIG_SUMO_SIM_par_1	24	30	PF11976	0.418
LIG_SUMO_SIM_par_1	275	282	PF11976	0.350
LIG_SUMO_SIM_par_1	357	363	PF11976	0.379
LIG_TYR_ITIM	460	465	PF00017	0.374
LIG_UBA3_1	53	60	PF00899	0.593
LIG_WRC_WIRS_1	456	461	PF05994	0.516
MOD_CDK_SPK_2	38	43	PF00069	0.427
MOD_CK1_1	362	368	PF00069	0.379
MOD_CK2_1	58	64	PF00069	0.474
MOD_GlcNHglycan	234	237	PF01048	0.536
MOD_GlcNHglycan	7	10	PF01048	0.474
MOD_GSK3_1	156	163	PF00069	0.309
MOD_GSK3_1	166	173	PF00069	0.315
MOD_GSK3_1	186	193	PF00069	0.120
MOD_GSK3_1	211	218	PF00069	0.367
MOD_GSK3_1	294	301	PF00069	0.319
MOD_GSK3_1	34	41	PF00069	0.459
MOD_GSK3_1	362	369	PF00069	0.349
MOD_GSK3_1	405	412	PF00069	0.528
MOD_N-GLC_1	118	123	PF02516	0.511
MOD_N-GLC_1	190	195	PF02516	0.529
MOD_N-GLC_1	415	420	PF02516	0.281
MOD_N-GLC_1	58	63	PF02516	0.256
MOD_N-GLC_2	11	13	PF02516	0.438
MOD_N-GLC_2	225	227	PF02516	0.376
MOD_N-GLC_2	286	288	PF02516	0.198
MOD_NEK2_1	133	138	PF00069	0.384
MOD_NEK2_1	211	216	PF00069	0.356
MOD_NEK2_1	27	32	PF00069	0.401
MOD_NEK2_1	354	359	PF00069	0.306
MOD_NEK2_1	383	388	PF00069	0.306
MOD_NEK2_1	410	415	PF00069	0.490
MOD_NEK2_1	5	10	PF00069	0.380
MOD_PKA_2	211	217	PF00069	0.348
MOD_PKB_1	398	406	PF00069	0.590
MOD_Plk_1	415	421	PF00069	0.492
MOD_Plk_4	172	178	PF00069	0.418
MOD_Plk_4	215	221	PF00069	0.368
MOD_Plk_4	248	254	PF00069	0.370
MOD_Plk_4	27	33	PF00069	0.339
MOD_Plk_4	272	278	PF00069	0.318
MOD_Plk_4	279	285	PF00069	0.326
MOD_Plk_4	349	355	PF00069	0.313
MOD_Plk_4	368	374	PF00069	0.282
MOD_Plk_4	415	421	PF00069	0.478
MOD_Plk_4	455	461	PF00069	0.430
MOD_Plk_4	99	105	PF00069	0.418
MOD_ProDKin_1	294	300	PF00069	0.273
MOD_ProDKin_1	38	44	PF00069	0.425
MOD_SUMO_rev_2	429	436	PF00179	0.585
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.359
TRG_ENDOCYTIC_2	100	103	PF00928	0.349
TRG_ENDOCYTIC_2	125	128	PF00928	0.333
TRG_ENDOCYTIC_2	229	232	PF00928	0.327
TRG_ENDOCYTIC_2	249	252	PF00928	0.120
TRG_ENDOCYTIC_2	351	354	PF00928	0.306
TRG_ENDOCYTIC_2	417	420	PF00928	0.486
TRG_ENDOCYTIC_2	462	465	PF00928	0.379
TRG_ER_diArg_1	397	400	PF00400	0.517
TRG_ER_diArg_1	72	74	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUV1	Leptomonas seymouri	70%	100%
A0A0S4IKK6	Bodo saltans	49%	100%
A0A3Q8IJH0	Leishmania donovani	85%	100%
A0A3R7MVB5	Trypanosoma rangeli	47%	100%
A4IE55	Leishmania infantum	86%	100%
D0A8Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ATK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P07286	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P0CD61	Dictyostelium discoideum	36%	100%
P23338	Cricetulus longicaudatus	35%	100%
P24140	Cricetulus griseus	35%	100%
P42864	Leishmania amazonensis	84%	100%
P42867	Mus musculus	36%	100%
P42881	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q4Q0Z6	Leishmania major	84%	100%
Q5EA65	Bos taurus	35%	100%
Q9H3H5	Homo sapiens	35%	100%
V5B6U2	Trypanosoma cruzi	48%	100%