UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPT7_LEIBR

TriTrypDb:

LbrM.35.4430 , LBRM2903_350054900

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A4HPT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPT7

Function

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Biological processes
Term	Name	Level	Count
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	11
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	11
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003975	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.176
CLV_MEL_PAP_1	181	187	PF00089	0.529
CLV_NRD_NRD_1	45	47	PF00675	0.263
CLV_NRD_NRD_1	73	75	PF00675	0.383
CLV_PCSK_KEX2_1	72	74	PF00082	0.398
CLV_PCSK_SKI1_1	155	159	PF00082	0.253
CLV_PCSK_SKI1_1	320	324	PF00082	0.409
CLV_PCSK_SKI1_1	370	374	PF00082	0.505
CLV_PCSK_SKI1_1	454	458	PF00082	0.326
CLV_PCSK_SKI1_1	46	50	PF00082	0.360

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUV1	Leptomonas seymouri	70%	100%
A0A0S4IKK6	Bodo saltans	49%	100%
A0A3Q8IJH0	Leishmania donovani	85%	100%
A0A3R7MVB5	Trypanosoma rangeli	47%	100%
A4IE55	Leishmania infantum	86%	100%
D0A8Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ATK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P07286	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P0CD61	Dictyostelium discoideum	36%	100%
P23338	Cricetulus longicaudatus	35%	100%

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