Putative oxidoreductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase, putative

Species:

Leishmania braziliensis

UniProt:

A4HPT6_LEIBR

TriTrypDb:

LbrM.35.4420 , LBRM2903_350054800

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPT6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003960	NADPH:quinone reductase activity	5	6
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0016491	oxidoreductase activity	2	10
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	6
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	6
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.409
CLV_C14_Caspase3-7	201	205	PF00656	0.329
CLV_C14_Caspase3-7	318	322	PF00656	0.348
CLV_NRD_NRD_1	19	21	PF00675	0.380
CLV_PCSK_KEX2_1	167	169	PF00082	0.434
CLV_PCSK_KEX2_1	188	190	PF00082	0.362
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.434
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.362
CLV_PCSK_SKI1_1	112	116	PF00082	0.441
CLV_PCSK_SKI1_1	310	314	PF00082	0.451
DEG_SPOP_SBC_1	12	16	PF00917	0.312
DOC_MAPK_gen_1	142	150	PF00069	0.390
DOC_MAPK_MEF2A_6	120	128	PF00069	0.400
DOC_MAPK_MEF2A_6	300	308	PF00069	0.380
DOC_MIT_MIM_1	201	210	PF04212	0.382
DOC_PP2B_LxvP_1	106	109	PF13499	0.411
DOC_PP4_FxxP_1	279	282	PF00568	0.339
DOC_USP7_MATH_1	254	258	PF00917	0.391
DOC_USP7_UBL2_3	17	21	PF12436	0.368
DOC_WW_Pin1_4	63	68	PF00397	0.226
LIG_14-3-3_CanoR_1	20	26	PF00244	0.486
LIG_14-3-3_CanoR_1	40	44	PF00244	0.194
LIG_APCC_ABBA_1	304	309	PF00400	0.411
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_BRCT_BRCA1_1	15	19	PF00533	0.456
LIG_BRCT_BRCA1_2	15	21	PF00533	0.317
LIG_FHA_1	130	136	PF00498	0.352
LIG_FHA_1	156	162	PF00498	0.322
LIG_FHA_1	182	188	PF00498	0.515
LIG_FHA_1	21	27	PF00498	0.469
LIG_FHA_1	264	270	PF00498	0.370
LIG_FHA_2	13	19	PF00498	0.391
LIG_FHA_2	64	70	PF00498	0.226
LIG_HCF-1_HBM_1	324	327	PF13415	0.429
LIG_LIR_Gen_1	122	131	PF02991	0.350
LIG_LIR_Gen_1	216	227	PF02991	0.352
LIG_LIR_Gen_1	69	79	PF02991	0.236
LIG_LIR_Nem_3	122	126	PF02991	0.339
LIG_LIR_Nem_3	216	222	PF02991	0.352
LIG_LIR_Nem_3	247	252	PF02991	0.266
LIG_LIR_Nem_3	330	335	PF02991	0.364
LIG_LIR_Nem_3	42	48	PF02991	0.341
LIG_LIR_Nem_3	5	10	PF02991	0.517
LIG_LIR_Nem_3	69	75	PF02991	0.243
LIG_MYND_1	117	121	PF01753	0.451
LIG_NRBOX	264	270	PF00104	0.266
LIG_Pex14_2	280	284	PF04695	0.374
LIG_Pex14_2	68	72	PF04695	0.432
LIG_PTB_Apo_2	54	61	PF02174	0.382
LIG_PTB_Phospho_1	54	60	PF10480	0.382
LIG_SH2_CRK	332	336	PF00017	0.363
LIG_SH2_CRK	45	49	PF00017	0.322
LIG_SH2_GRB2like	60	63	PF00017	0.226
LIG_SH2_NCK_1	219	223	PF00017	0.349
LIG_SH2_PTP2	123	126	PF00017	0.384
LIG_SH2_STAT5	123	126	PF00017	0.381
LIG_SH2_STAT5	298	301	PF00017	0.425
LIG_SH2_STAT5	60	63	PF00017	0.398
LIG_SH3_3	253	259	PF00018	0.304
LIG_SUMO_SIM_anti_2	147	152	PF11976	0.352
LIG_SUMO_SIM_anti_2	266	273	PF11976	0.300
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.382
LIG_SUMO_SIM_par_1	266	273	PF11976	0.290
LIG_TRAF2_1	179	182	PF00917	0.329
LIG_TYR_ITIM	217	222	PF00017	0.374
LIG_TYR_ITIM	43	48	PF00017	0.382
LIG_TYR_ITSM	328	335	PF00017	0.373
LIG_UBA3_1	242	250	PF00899	0.524
MOD_CK1_1	129	135	PF00069	0.376
MOD_CK1_1	2	8	PF00069	0.517
MOD_CK1_1	202	208	PF00069	0.348
MOD_CK1_1	245	251	PF00069	0.370
MOD_CK1_1	261	267	PF00069	0.240
MOD_CK1_1	328	334	PF00069	0.363
MOD_CK2_1	176	182	PF00069	0.402
MOD_CK2_1	21	27	PF00069	0.531
MOD_GlcNHglycan	128	131	PF01048	0.357
MOD_GlcNHglycan	260	263	PF01048	0.345
MOD_GlcNHglycan	272	275	PF01048	0.310
MOD_GlcNHglycan	300	303	PF01048	0.346
MOD_GlcNHglycan	327	330	PF01048	0.363
MOD_GSK3_1	170	177	PF00069	0.374
MOD_GSK3_1	244	251	PF00069	0.339
MOD_GSK3_1	254	261	PF00069	0.299
MOD_N-GLC_1	48	53	PF02516	0.339
MOD_N-GLC_1	56	61	PF02516	0.339
MOD_NEK2_1	19	24	PF00069	0.423
MOD_NEK2_1	270	275	PF00069	0.337
MOD_NEK2_1	61	66	PF00069	0.385
MOD_OFUCOSY	172	178	PF10250	0.339
MOD_PIKK_1	61	67	PF00454	0.226
MOD_PK_1	21	27	PF00069	0.322
MOD_PKA_1	20	26	PF00069	0.315
MOD_PKA_2	19	25	PF00069	0.419
MOD_PKA_2	39	45	PF00069	0.214
MOD_Plk_4	170	176	PF00069	0.374
MOD_Plk_4	21	27	PF00069	0.537
MOD_Plk_4	264	270	PF00069	0.386
MOD_Plk_4	291	297	PF00069	0.357
MOD_Plk_4	56	62	PF00069	0.382
MOD_Plk_4	74	80	PF00069	0.382
MOD_ProDKin_1	63	69	PF00069	0.226
MOD_SUMO_for_1	119	122	PF00179	0.440
MOD_SUMO_rev_2	179	184	PF00179	0.382
MOD_SUMO_rev_2	32	39	PF00179	0.374
TRG_DiLeu_BaEn_1	111	116	PF01217	0.289
TRG_DiLeu_BaEn_3	181	187	PF01217	0.329
TRG_ENDOCYTIC_2	123	126	PF00928	0.386
TRG_ENDOCYTIC_2	219	222	PF00928	0.339
TRG_ENDOCYTIC_2	249	252	PF00928	0.269
TRG_ENDOCYTIC_2	332	335	PF00928	0.550
TRG_ENDOCYTIC_2	45	48	PF00928	0.374
TRG_ENDOCYTIC_2	99	102	PF00928	0.401
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D2YG03	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	26%	95%
A0A0N0P3I0	Leptomonas seymouri	72%	100%
A0A0N0P6Q4	Leptomonas seymouri	27%	100%
A0A0N0P7C5	Leptomonas seymouri	41%	100%
A0A0N1I4X2	Leptomonas seymouri	25%	73%
A0A0N1I913	Leptomonas seymouri	43%	98%
A0A0N1PB21	Leptomonas seymouri	27%	99%
A0A0S4ILA6	Bodo saltans	27%	100%
A0A0S4ILS9	Bodo saltans	25%	100%
A0A0S4IT20	Bodo saltans	27%	99%
A0A0S4IUY2	Bodo saltans	30%	100%
A0A0S4JMB1	Bodo saltans	45%	97%
A0A0S4KHW9	Bodo saltans	28%	100%
A0A1X0NZZ5	Trypanosomatidae	28%	100%
A0A1X0P0B2	Trypanosomatidae	41%	100%
A0A1X0P8R2	Trypanosomatidae	29%	100%
A0A3Q8ICJ5	Leishmania donovani	24%	100%
A0A3Q8IRG0	Leishmania donovani	86%	100%
A0A3R7L374	Trypanosoma rangeli	30%	100%
A0A3R7MFN7	Trypanosoma rangeli	26%	98%
A0A3S7WSH2	Leishmania donovani	42%	99%
A0A3S7X2E3	Leishmania donovani	25%	97%
A0A422NF38	Trypanosoma rangeli	30%	100%
A0A422NKE0	Trypanosoma rangeli	40%	100%
A0A451EJQ8	Leishmania donovani	30%	100%
A4H3L9	Leishmania braziliensis	30%	100%
A4H761	Leishmania braziliensis	42%	100%
A4HVK0	Leishmania infantum	42%	99%
A4I0D8	Leishmania infantum	24%	100%
A4I4G0	Leishmania infantum	25%	97%
A4IE56	Leishmania infantum	86%	100%
A4YGN2	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	26%	100%
A6QQF5	Bos taurus	33%	97%
A7RK30	Nematostella vectensis	30%	93%
B0BNC9	Rattus norvegicus	31%	97%
B8NTZ8	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	30%	92%
C9ZLK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A480	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E5AE42	Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)	27%	95%
E9ACK2	Leishmania major	30%	100%
E9ADV9	Leishmania major	25%	100%
E9AG46	Leishmania infantum	30%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AP96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	99%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AWA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B3N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
K4BW79	Solanum lycopersicum	28%	88%
O23939	Fragaria vesca	28%	100%
O35017	Bacillus subtilis (strain 168)	26%	100%
O35045	Bacillus subtilis (strain 168)	27%	100%
O45903	Caenorhabditis elegans	28%	99%
O58389	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	24%	98%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	98%
P0DN30	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	28%	100%
P19333	Tetronarce californica	26%	90%
P20368	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	25%	100%
P28304	Escherichia coli (strain K12)	27%	100%
P38230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	27%	100%
P42865	Leishmania amazonensis	87%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	30%	100%
P49383	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	98%
Q08257	Homo sapiens	24%	100%
Q0VC50	Bos taurus	25%	86%
Q24K16	Bos taurus	43%	90%
Q28452	Lama guanicoe	27%	100%
Q28GQ2	Xenopus tropicalis	27%	97%
Q2FJ31	Staphylococcus aureus (strain USA300)	23%	100%
Q2G0G1	Staphylococcus aureus (strain NCTC 8325 / PS 47)	23%	100%
Q2YSX0	Staphylococcus aureus (strain bovine RF122 / ET3-1)	23%	100%
Q32L99	Bos taurus	25%	97%
Q3MIE4	Rattus norvegicus	30%	84%
Q3UNZ8	Mus musculus	31%	97%
Q4Q0Z7	Leishmania major	85%	100%
Q4Q4F7	Leishmania major	26%	100%
Q4QB77	Leishmania major	24%	100%
Q4QG82	Leishmania major	43%	100%
Q53FA7	Homo sapiens	26%	100%
Q54YT4	Dictyostelium discoideum	26%	97%
Q5BK81	Rattus norvegicus	25%	97%
Q5HI63	Staphylococcus aureus (strain COL)	23%	100%
Q5HM44	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	28%	100%
Q5R4S7	Pongo abelii	26%	100%
Q5R806	Pongo abelii	24%	97%
Q62465	Mus musculus	29%	84%
Q6G7C8	Staphylococcus aureus (strain MSSA476)	27%	100%
Q6GBM4	Staphylococcus aureus (strain MSSA476)	23%	100%
Q6GEP3	Staphylococcus aureus (strain MRSA252)	28%	100%
Q6GJ63	Staphylococcus aureus (strain MRSA252)	23%	100%
Q6GQN8	Danio rerio	27%	90%
Q7A742	Staphylococcus aureus (strain N315)	23%	100%
Q7T3C7	Danio rerio	26%	88%
Q7YS70	Bos taurus	27%	91%
Q80TB8	Mus musculus	26%	82%
Q84V25	Fragaria ananassa	28%	100%
Q8BGC4	Mus musculus	42%	90%
Q8CRJ7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	28%	100%
Q8H0M1	Spinacia oleracea	28%	100%
Q8JFV8	Danio rerio	30%	70%
Q8LCU7	Arabidopsis thaliana	27%	91%
Q8N4Q0	Homo sapiens	42%	90%
Q8N8N7	Homo sapiens	24%	97%
Q8NVD1	Staphylococcus aureus (strain MW2)	27%	100%
Q8NXU1	Staphylococcus aureus (strain MW2)	23%	100%
Q8VDQ1	Mus musculus	25%	97%
Q941I0	Fragaria ananassa	28%	100%
Q96XE0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	26%	98%
Q975C8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	28%	100%
Q99536	Homo sapiens	30%	87%
Q99W07	Staphylococcus aureus (strain Mu50 / ATCC 700699)	23%	100%
Q9AYU1	Triphysaria versicolor	27%	100%
Q9BV79	Homo sapiens	25%	91%
Q9DCS3	Mus musculus	27%	91%
Q9EQZ5	Cavia porcellus	31%	100%
Q9HCJ6	Homo sapiens	27%	81%
Q9P6C8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	96%
Q9SV68	Arabidopsis thaliana	29%	100%
Q9UYX0	Pyrococcus abyssi (strain GE5 / Orsay)	24%	98%
Q9V6U9	Drosophila melanogaster	24%	95%
Q9Z311	Rattus norvegicus	26%	91%
Q9ZUC1	Arabidopsis thaliana	28%	88%
S0DRW9	Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)	22%	100%
V5B1P3	Trypanosoma cruzi	29%	100%
V5BXF0	Trypanosoma cruzi	30%	100%
W7NCN7	Gibberella moniliformis (strain M3125 / FGSC 7600)	26%	95%