Cytospin-A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cytospin-A

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPT4_LEIBR

TriTrypDb:

LbrM.35.4400 , LBRM2903_350054600

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	4
GO:0031514	motile cilium	5	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

A4HPT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPT4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.624
CLV_C14_Caspase3-7	606	610	PF00656	0.434
CLV_C14_Caspase3-7	624	628	PF00656	0.602
CLV_NRD_NRD_1	212	214	PF00675	0.490
CLV_NRD_NRD_1	487	489	PF00675	0.550
CLV_NRD_NRD_1	620	622	PF00675	0.605
CLV_PCSK_KEX2_1	212	214	PF00082	0.490
CLV_PCSK_KEX2_1	332	334	PF00082	0.658
CLV_PCSK_KEX2_1	619	621	PF00082	0.629
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.481
CLV_PCSK_PC7_1	208	214	PF00082	0.548
CLV_PCSK_SKI1_1	297	301	PF00082	0.462
CLV_PCSK_SKI1_1	308	312	PF00082	0.409
CLV_PCSK_SKI1_1	34	38	PF00082	0.646
CLV_PCSK_SKI1_1	466	470	PF00082	0.519
CLV_PCSK_SKI1_1	488	492	PF00082	0.504
CLV_PCSK_SKI1_1	524	528	PF00082	0.434
CLV_PCSK_SKI1_1	568	572	PF00082	0.472
CLV_PCSK_SKI1_1	646	650	PF00082	0.497
DEG_APCC_DBOX_1	111	119	PF00400	0.492
DEG_APCC_DBOX_1	288	296	PF00400	0.455
DEG_APCC_DBOX_1	645	653	PF00400	0.488
DEG_SCF_FBW7_2	124	129	PF00400	0.721
DEG_SPOP_SBC_1	419	423	PF00917	0.688
DOC_CYCLIN_RxL_1	249	258	PF00134	0.576
DOC_MAPK_RevD_3	198	213	PF00069	0.552
DOC_USP7_MATH_1	102	106	PF00917	0.595
DOC_USP7_MATH_1	124	128	PF00917	0.675
DOC_USP7_MATH_1	146	150	PF00917	0.702
DOC_USP7_MATH_1	157	161	PF00917	0.715
DOC_USP7_MATH_1	2	6	PF00917	0.669
DOC_USP7_MATH_1	223	227	PF00917	0.511
DOC_USP7_MATH_1	255	259	PF00917	0.499
DOC_USP7_MATH_1	36	40	PF00917	0.663
DOC_USP7_MATH_1	419	423	PF00917	0.509
DOC_USP7_MATH_1	47	51	PF00917	0.539
DOC_USP7_MATH_1	580	584	PF00917	0.622
DOC_USP7_MATH_1	59	63	PF00917	0.527
DOC_USP7_MATH_1	631	635	PF00917	0.612
DOC_USP7_UBL2_3	573	577	PF12436	0.582
DOC_USP7_UBL2_3	654	658	PF12436	0.638
DOC_WW_Pin1_4	122	127	PF00397	0.652
DOC_WW_Pin1_4	23	28	PF00397	0.652
DOC_WW_Pin1_4	333	338	PF00397	0.640
DOC_WW_Pin1_4	390	395	PF00397	0.505
LIG_14-3-3_CanoR_1	101	107	PF00244	0.462
LIG_14-3-3_CanoR_1	11	19	PF00244	0.737
LIG_14-3-3_CanoR_1	197	201	PF00244	0.531
LIG_14-3-3_CanoR_1	266	276	PF00244	0.575
LIG_14-3-3_CanoR_1	333	337	PF00244	0.684
LIG_14-3-3_CanoR_1	34	41	PF00244	0.714
LIG_14-3-3_CanoR_1	374	383	PF00244	0.694
LIG_14-3-3_CanoR_1	407	416	PF00244	0.650
LIG_14-3-3_CanoR_1	417	427	PF00244	0.603
LIG_14-3-3_CanoR_1	524	533	PF00244	0.373
LIG_Actin_WH2_2	247	264	PF00022	0.521
LIG_BIR_III_4	120	124	PF00653	0.652
LIG_BIR_III_4	579	583	PF00653	0.620
LIG_BRCT_BRCA1_1	235	239	PF00533	0.463
LIG_FHA_1	149	155	PF00498	0.642
LIG_FHA_1	222	228	PF00498	0.667
LIG_FHA_1	262	268	PF00498	0.557
LIG_FHA_1	298	304	PF00498	0.521
LIG_FHA_1	480	486	PF00498	0.600
LIG_FHA_1	507	513	PF00498	0.600
LIG_FHA_1	74	80	PF00498	0.692
LIG_FHA_2	537	543	PF00498	0.609
LIG_FHA_2	564	570	PF00498	0.554
LIG_FHA_2	90	96	PF00498	0.629
LIG_LIR_Gen_1	280	288	PF02991	0.489
LIG_LIR_Gen_1	421	432	PF02991	0.519
LIG_LIR_Gen_1	95	104	PF02991	0.626
LIG_LIR_Nem_3	211	217	PF02991	0.449
LIG_LIR_Nem_3	24	28	PF02991	0.491
LIG_LIR_Nem_3	280	285	PF02991	0.501
LIG_LIR_Nem_3	354	358	PF02991	0.575
LIG_LIR_Nem_3	421	427	PF02991	0.547
LIG_LIR_Nem_3	542	547	PF02991	0.566
LIG_LIR_Nem_3	95	99	PF02991	0.645
LIG_NRBOX	114	120	PF00104	0.503
LIG_NRBOX	291	297	PF00104	0.454
LIG_Pex14_2	395	399	PF04695	0.763
LIG_SH2_NCK_1	630	634	PF00017	0.515
LIG_SH2_STAT5	547	550	PF00017	0.622
LIG_SH3_2	29	34	PF14604	0.494
LIG_SH3_3	226	232	PF00018	0.597
LIG_SH3_3	24	30	PF00018	0.544
LIG_SH3_3	413	419	PF00018	0.687
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.510
LIG_SUMO_SIM_anti_2	253	258	PF11976	0.568
LIG_SUMO_SIM_anti_2	291	298	PF11976	0.463
LIG_SUMO_SIM_par_1	114	120	PF11976	0.571
LIG_SUMO_SIM_par_1	531	537	PF11976	0.481
MOD_CDK_SPxxK_3	390	397	PF00069	0.505
MOD_CK1_1	142	148	PF00069	0.741
MOD_CK1_1	149	155	PF00069	0.732
MOD_CK1_1	175	181	PF00069	0.543
MOD_CK1_1	347	353	PF00069	0.488
MOD_CK1_1	360	366	PF00069	0.661
MOD_CK1_1	373	379	PF00069	0.671
MOD_CK1_1	385	391	PF00069	0.644
MOD_CK1_1	409	415	PF00069	0.650
MOD_CK1_1	50	56	PF00069	0.709
MOD_CK1_1	62	68	PF00069	0.643
MOD_CK2_1	2	8	PF00069	0.513
MOD_CK2_1	557	563	PF00069	0.510
MOD_CK2_1	631	637	PF00069	0.561
MOD_DYRK1A_RPxSP_1	333	337	PF00069	0.497
MOD_GlcNHglycan	12	15	PF01048	0.704
MOD_GlcNHglycan	148	151	PF01048	0.755
MOD_GlcNHglycan	363	366	PF01048	0.682
MOD_GlcNHglycan	38	41	PF01048	0.686
MOD_GlcNHglycan	387	390	PF01048	0.699
MOD_GlcNHglycan	4	7	PF01048	0.754
MOD_GlcNHglycan	49	52	PF01048	0.673
MOD_GlcNHglycan	536	539	PF01048	0.568
MOD_GlcNHglycan	609	612	PF01048	0.563
MOD_GSK3_1	142	149	PF00069	0.670
MOD_GSK3_1	168	175	PF00069	0.735
MOD_GSK3_1	2	9	PF00069	0.558
MOD_GSK3_1	297	304	PF00069	0.422
MOD_GSK3_1	344	351	PF00069	0.692
MOD_GSK3_1	357	364	PF00069	0.587
MOD_GSK3_1	370	377	PF00069	0.662
MOD_GSK3_1	383	390	PF00069	0.592
MOD_GSK3_1	405	412	PF00069	0.638
MOD_GSK3_1	41	48	PF00069	0.695
MOD_GSK3_1	536	543	PF00069	0.561
MOD_GSK3_1	59	66	PF00069	0.579
MOD_N-GLC_1	142	147	PF02516	0.711
MOD_N-GLC_1	158	163	PF02516	0.721
MOD_N-GLC_1	360	365	PF02516	0.664
MOD_N-GLC_1	370	375	PF02516	0.635
MOD_NEK2_1	119	124	PF00069	0.478
MOD_NEK2_1	186	191	PF00069	0.635
MOD_NEK2_1	261	266	PF00069	0.455
MOD_NEK2_1	267	272	PF00069	0.504
MOD_NEK2_1	331	336	PF00069	0.760
MOD_NEK2_1	399	404	PF00069	0.619
MOD_NEK2_1	41	46	PF00069	0.731
MOD_NEK2_1	420	425	PF00069	0.656
MOD_NEK2_1	490	495	PF00069	0.357
MOD_NEK2_1	534	539	PF00069	0.576
MOD_NEK2_2	223	228	PF00069	0.562
MOD_PIKK_1	186	192	PF00454	0.574
MOD_PIKK_1	216	222	PF00454	0.573
MOD_PIKK_1	267	273	PF00454	0.545
MOD_PIKK_1	409	415	PF00454	0.543
MOD_PIKK_1	434	440	PF00454	0.620
MOD_PIKK_1	524	530	PF00454	0.478
MOD_PIKK_1	89	95	PF00454	0.646
MOD_PKA_1	332	338	PF00069	0.684
MOD_PKA_1	619	625	PF00069	0.560
MOD_PKA_2	10	16	PF00069	0.527
MOD_PKA_2	196	202	PF00069	0.464
MOD_PKA_2	261	267	PF00069	0.524
MOD_PKA_2	332	338	PF00069	0.663
MOD_PKA_2	344	350	PF00069	0.650
MOD_PKA_2	373	379	PF00069	0.772
MOD_PKA_2	406	412	PF00069	0.595
MOD_PKA_2	589	595	PF00069	0.611
MOD_PKA_2	607	613	PF00069	0.442
MOD_PKA_2	619	625	PF00069	0.566
MOD_Plk_1	142	148	PF00069	0.512
MOD_Plk_1	172	178	PF00069	0.640
MOD_Plk_1	301	307	PF00069	0.487
MOD_Plk_2-3	114	120	PF00069	0.560
MOD_Plk_2-3	563	569	PF00069	0.611
MOD_Plk_4	114	120	PF00069	0.571
MOD_Plk_4	196	202	PF00069	0.594
MOD_Plk_4	223	229	PF00069	0.685
MOD_Plk_4	543	549	PF00069	0.357
MOD_Plk_4	631	637	PF00069	0.575
MOD_ProDKin_1	122	128	PF00069	0.661
MOD_ProDKin_1	23	29	PF00069	0.648
MOD_ProDKin_1	333	339	PF00069	0.639
MOD_ProDKin_1	390	396	PF00069	0.506
MOD_SUMO_for_1	483	486	PF00179	0.597
MOD_SUMO_rev_2	560	567	PF00179	0.474
TRG_DiLeu_BaEn_1	111	116	PF01217	0.483
TRG_DiLeu_BaEn_1	263	268	PF01217	0.346
TRG_DiLeu_BaEn_1	288	293	PF01217	0.455
TRG_DiLeu_LyEn_5	263	268	PF01217	0.346
TRG_ENDOCYTIC_2	214	217	PF00928	0.441
TRG_ENDOCYTIC_2	424	427	PF00928	0.622
TRG_ER_diArg_1	212	214	PF00400	0.527
TRG_ER_diArg_1	619	621	PF00400	0.613
TRG_ER_diLys_1	659	664	PF00400	0.700
TRG_NES_CRM1_1	475	486	PF08389	0.528
TRG_NLS_MonoCore_2	656	661	PF00514	0.660
TRG_NLS_MonoExtC_3	656	661	PF00514	0.673
TRG_NLS_MonoExtN_4	654	661	PF00514	0.662
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	449	453	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM9	Leptomonas seymouri	57%	99%
A0A3R7NMF4	Trypanosoma rangeli	36%	100%
A0A3S7XBE2	Leishmania donovani	78%	100%
A4IE58	Leishmania infantum	78%	100%
D0A8P9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ATJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q0Z9	Leishmania major	78%	100%
V5BS07	Trypanosoma cruzi	38%	100%