Transcription factor S-II-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase I subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HPT3_LEIBR

TriTrypDb:

LbrM.35.4390 , LBRM2903_350054500

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	6
GO:0005736	RNA polymerase I complex	4	1
GO:0030880	RNA polymerase complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	6
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	6
GO:1902494	catalytic complex	2	6
GO:1990234	transferase complex	3	6
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPT3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006351	DNA-templated transcription	7	10
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:0097659	nucleic acid-templated transcription	6	10
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006353	DNA-templated transcription termination	6	1
GO:0006363	termination of RNA polymerase I transcription	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003677	DNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.595
DOC_CKS1_1	10	15	PF01111	0.644
DOC_USP7_MATH_1	121	125	PF00917	0.528
DOC_USP7_MATH_1	3	7	PF00917	0.573
DOC_WW_Pin1_4	9	14	PF00397	0.656
LIG_14-3-3_CanoR_1	112	116	PF00244	0.598
LIG_14-3-3_CanoR_1	139	149	PF00244	0.480
LIG_14-3-3_CanoR_1	162	168	PF00244	0.355
LIG_BIR_II_1	1	5	PF00653	0.707
LIG_BRCT_BRCA1_1	123	127	PF00533	0.461
LIG_FHA_1	132	138	PF00498	0.508
LIG_FHA_1	155	161	PF00498	0.319
LIG_FHA_2	10	16	PF00498	0.550
LIG_FHA_2	112	118	PF00498	0.511
LIG_FHA_2	141	147	PF00498	0.607
LIG_FHA_2	56	62	PF00498	0.525
LIG_FHA_2	98	104	PF00498	0.464
LIG_LIR_Gen_1	64	72	PF02991	0.420
LIG_LIR_Nem_3	64	68	PF02991	0.421
LIG_MLH1_MIPbox_1	123	127	PF16413	0.461
LIG_REV1ctd_RIR_1	96	106	PF16727	0.494
LIG_RPA_C_Fungi	71	83	PF08784	0.445
LIG_SH2_STAT5	21	24	PF00017	0.527
LIG_SH2_STAT5	27	30	PF00017	0.474
LIG_SH3_3	7	13	PF00018	0.454
MOD_CK1_1	163	169	PF00069	0.199
MOD_CK1_1	2	8	PF00069	0.759
MOD_CK1_1	75	81	PF00069	0.674
MOD_CK1_1	90	96	PF00069	0.501
MOD_CK2_1	150	156	PF00069	0.386
MOD_CK2_1	170	176	PF00069	0.271
MOD_CK2_1	55	61	PF00069	0.567
MOD_CK2_1	9	15	PF00069	0.550
MOD_CK2_1	97	103	PF00069	0.445
MOD_GlcNHglycan	1	4	PF01048	0.745
MOD_GlcNHglycan	172	175	PF01048	0.277
MOD_GlcNHglycan	65	68	PF01048	0.561
MOD_GlcNHglycan	78	81	PF01048	0.598
MOD_GlcNHglycan	92	96	PF01048	0.567
MOD_GSK3_1	111	118	PF00069	0.556
MOD_GSK3_1	131	138	PF00069	0.396
MOD_GSK3_1	150	157	PF00069	0.418
MOD_GSK3_1	182	189	PF00069	0.302
MOD_GSK3_1	71	78	PF00069	0.688
MOD_GSK3_1	87	94	PF00069	0.495
MOD_NEK2_1	115	120	PF00069	0.706
MOD_NEK2_1	154	159	PF00069	0.323
MOD_NEK2_1	72	77	PF00069	0.626
MOD_NEK2_1	91	96	PF00069	0.531
MOD_NEK2_2	122	127	PF00069	0.636
MOD_NEK2_2	55	60	PF00069	0.463
MOD_OFUCOSY	158	164	PF10250	0.199
MOD_PIKK_1	3	9	PF00454	0.471
MOD_PKA_2	111	117	PF00069	0.533
MOD_PKA_2	168	174	PF00069	0.320
MOD_PKA_2	49	55	PF00069	0.503
MOD_PKA_2	72	78	PF00069	0.568
MOD_Plk_1	150	156	PF00069	0.364
MOD_Plk_4	122	128	PF00069	0.659
MOD_Plk_4	176	182	PF00069	0.277
MOD_ProDKin_1	9	15	PF00069	0.657
TRG_ENDOCYTIC_2	65	68	PF00928	0.518
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H9	Leptomonas seymouri	66%	100%
A0A0S4JEQ7	Bodo saltans	37%	100%
A0A1X0P371	Trypanosomatidae	43%	100%
A0A3Q8IHM6	Leishmania donovani	77%	77%
A0A3S5IRT0	Trypanosoma rangeli	35%	100%
A4IE59	Leishmania infantum	77%	77%
D0A8P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ATJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q100	Leishmania major	76%	100%