Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPT2_LEIBR

TriTrypDb:

LbrM.35.4380 , LBRM2903_350054400

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HPT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	5	9	PF00082	0.407
CLV_PCSK_SKI1_1	81	85	PF00082	0.426
DEG_APCC_DBOX_1	4	12	PF00400	0.607
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DOC_CKS1_1	186	191	PF01111	0.501
DOC_MAPK_gen_1	112	119	PF00069	0.556
DOC_MAPK_HePTP_8	113	125	PF00069	0.556
DOC_MAPK_MEF2A_6	112	121	PF00069	0.556
DOC_MAPK_MEF2A_6	41	48	PF00069	0.226
DOC_MAPK_MEF2A_6	5	13	PF00069	0.522
DOC_MAPK_NFAT4_5	114	122	PF00069	0.555
DOC_WW_Pin1_4	185	190	PF00397	0.501
DOC_WW_Pin1_4	21	26	PF00397	0.249
LIG_BRCT_BRCA1_1	44	48	PF00533	0.226
LIG_BRCT_BRCA1_2	44	50	PF00533	0.226
LIG_DCNL_PONY_1	1	4	PF03556	0.645
LIG_EH1_1	180	188	PF00400	0.501
LIG_FHA_1	154	160	PF00498	0.352
LIG_FHA_1	180	186	PF00498	0.389
LIG_FHA_1	189	195	PF00498	0.593
LIG_FHA_1	21	27	PF00498	0.426
LIG_FHA_1	51	57	PF00498	0.226
LIG_LIR_Gen_1	45	56	PF02991	0.337
LIG_LIR_Nem_3	45	51	PF02991	0.317
LIG_LIR_Nem_3	78	83	PF02991	0.322
LIG_LIR_Nem_3	95	100	PF02991	0.342
LIG_Pex14_2	120	124	PF04695	0.501
LIG_Pex14_2	16	20	PF04695	0.249
LIG_Pex14_2	167	171	PF04695	0.288
LIG_Pex14_2	80	84	PF04695	0.346
LIG_SH2_CRK	100	104	PF00017	0.430
LIG_SH2_GRB2like	29	32	PF00017	0.416
LIG_SH2_STAP1	100	104	PF00017	0.501
LIG_SH2_STAP1	181	185	PF00017	0.249
LIG_SH2_STAP1	29	33	PF00017	0.356
LIG_SH2_STAT5	181	184	PF00017	0.371
LIG_SH3_3	112	118	PF00018	0.579
LIG_SUMO_SIM_par_1	52	57	PF11976	0.226
MOD_CK1_1	148	154	PF00069	0.351
MOD_CK1_1	169	175	PF00069	0.256
MOD_GlcNHglycan	168	171	PF01048	0.438
MOD_GSK3_1	27	34	PF00069	0.429
MOD_GSK3_1	50	57	PF00069	0.355
MOD_GSK3_1	59	66	PF00069	0.304
MOD_GSK3_1	79	86	PF00069	0.171
MOD_N-GLC_1	153	158	PF02516	0.555
MOD_N-GLC_1	59	64	PF02516	0.556
MOD_NEK2_1	20	25	PF00069	0.406
MOD_PIKK_1	188	194	PF00454	0.519
MOD_Plk_1	153	159	PF00069	0.355
MOD_Plk_1	42	48	PF00069	0.408
MOD_Plk_4	154	160	PF00069	0.349
MOD_Plk_4	42	48	PF00069	0.356
MOD_Plk_4	92	98	PF00069	0.390
MOD_ProDKin_1	185	191	PF00069	0.501
MOD_ProDKin_1	21	27	PF00069	0.249
TRG_ENDOCYTIC_2	100	103	PF00928	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C3	Leptomonas seymouri	58%	100%
A0A0S4J784	Bodo saltans	33%	89%
A0A3S7XBF7	Leishmania donovani	79%	100%
A4IE60	Leishmania infantum	79%	100%
E9ATJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q101	Leishmania major	80%	100%