Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPT0_LEIBR

TriTrypDb:

LbrM.35.4360 , LBRM2903_350054200

Length:

181

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPT0

PDB structure(s): 7ane_ax

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.623
CLV_PCSK_FUR_1	121	125	PF00082	0.615
CLV_PCSK_KEX2_1	123	125	PF00082	0.566
CLV_PCSK_KEX2_1	168	170	PF00082	0.621
CLV_PCSK_KEX2_1	26	28	PF00082	0.612
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.566
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.495
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.631
CLV_PCSK_SKI1_1	124	128	PF00082	0.559
CLV_PCSK_SKI1_1	165	169	PF00082	0.630
DEG_Nend_UBRbox_1	1	4	PF02207	0.643
DOC_CKS1_1	148	153	PF01111	0.645
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.557
DOC_SPAK_OSR1_1	125	129	PF12202	0.560
DOC_USP7_UBL2_3	35	39	PF12436	0.599
DOC_WW_Pin1_4	132	137	PF00397	0.544
DOC_WW_Pin1_4	147	152	PF00397	0.603
DOC_WW_Pin1_4	153	158	PF00397	0.584
DOC_WW_Pin1_4	8	13	PF00397	0.530
LIG_14-3-3_CanoR_1	169	179	PF00244	0.519
LIG_14-3-3_CanoR_1	5	15	PF00244	0.665
LIG_14-3-3_CanoR_1	60	64	PF00244	0.577
LIG_CSL_BTD_1	140	143	PF09270	0.592
LIG_FHA_1	2	8	PF00498	0.689
LIG_LIR_Gen_1	13	23	PF02991	0.591
LIG_LIR_Gen_1	137	147	PF02991	0.670
LIG_LIR_Gen_1	62	69	PF02991	0.546
LIG_LIR_Gen_1	83	91	PF02991	0.559
LIG_LIR_Nem_3	13	18	PF02991	0.562
LIG_LIR_Nem_3	162	167	PF02991	0.691
LIG_LIR_Nem_3	62	66	PF02991	0.555
LIG_LIR_Nem_3	83	88	PF02991	0.544
LIG_Pex14_2	126	130	PF04695	0.555
LIG_Pex14_2	160	164	PF04695	0.685
LIG_SH3_3	106	112	PF00018	0.550
LIG_SH3_3	140	146	PF00018	0.606
LIG_SH3_3	96	102	PF00018	0.578
LIG_TYR_ITIM	61	66	PF00017	0.559
MOD_CDK_SPxK_1	8	14	PF00069	0.567
MOD_CDK_SPxxK_3	147	154	PF00069	0.643
MOD_CK1_1	173	179	PF00069	0.634
MOD_CK1_1	38	44	PF00069	0.597
MOD_GlcNHglycan	173	176	PF01048	0.651
MOD_GSK3_1	13	20	PF00069	0.580
MOD_GSK3_1	169	176	PF00069	0.677
MOD_N-GLC_1	169	174	PF02516	0.680
MOD_NEK2_1	1	6	PF00069	0.592
MOD_NEK2_1	152	157	PF00069	0.588
MOD_NEK2_1	18	23	PF00069	0.588
MOD_NEK2_1	74	79	PF00069	0.636
MOD_PIKK_1	155	161	PF00454	0.620
MOD_PIKK_1	93	99	PF00454	0.574
MOD_PKA_1	168	174	PF00069	0.635
MOD_PKA_2	1	7	PF00069	0.586
MOD_PKA_2	168	174	PF00069	0.726
MOD_PKA_2	59	65	PF00069	0.571
MOD_PKA_2	74	80	PF00069	0.549
MOD_ProDKin_1	132	138	PF00069	0.546
MOD_ProDKin_1	147	153	PF00069	0.602
MOD_ProDKin_1	8	14	PF00069	0.533
MOD_SUMO_rev_2	106	112	PF00179	0.599
TRG_ENDOCYTIC_2	63	66	PF00928	0.554
TRG_ER_diArg_1	124	126	PF00400	0.623
TRG_NLS_MonoExtN_4	121	127	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTA3	Leptomonas seymouri	89%	100%
A0A0S4IP42	Bodo saltans	71%	100%
A0A1X0P4J4	Trypanosomatidae	71%	100%
A0A3R7L6J8	Trypanosoma rangeli	77%	100%
A0A3S7XBI9	Leishmania donovani	92%	97%
A4IE62	Leishmania infantum	92%	97%
D0A8P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9ATJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	98%
Q4Q103	Leishmania major	92%	100%