Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPS7_LEIBR

TriTrypDb:

LbrM.35.4330 , LBRM2903_350053800

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.774
CLV_MEL_PAP_1	4	10	PF00089	0.506
CLV_NRD_NRD_1	133	135	PF00675	0.551
CLV_NRD_NRD_1	384	386	PF00675	0.509
CLV_NRD_NRD_1	390	392	PF00675	0.543
CLV_NRD_NRD_1	85	87	PF00675	0.495
CLV_PCSK_KEX2_1	133	135	PF00082	0.626
CLV_PCSK_KEX2_1	281	283	PF00082	0.803
CLV_PCSK_KEX2_1	384	386	PF00082	0.602
CLV_PCSK_KEX2_1	390	392	PF00082	0.670
CLV_PCSK_KEX2_1	85	87	PF00082	0.495
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.803
CLV_PCSK_SKI1_1	113	117	PF00082	0.581
CLV_PCSK_SKI1_1	29	33	PF00082	0.730
CLV_PCSK_SKI1_1	413	417	PF00082	0.581
DEG_MDM2_SWIB_1	158	165	PF02201	0.591
DEG_Nend_UBRbox_1	1	4	PF02207	0.777
DEG_SPOP_SBC_1	190	194	PF00917	0.698
DEG_SPOP_SBC_1	329	333	PF00917	0.576
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	31	34	PF00134	0.723
DOC_MAPK_gen_1	381	389	PF00069	0.426
DOC_PP2B_LxvP_1	135	138	PF13499	0.642
DOC_PP2B_LxvP_1	219	222	PF13499	0.593
DOC_PP2B_LxvP_1	266	269	PF13499	0.788
DOC_PP2B_LxvP_1	31	34	PF13499	0.723
DOC_PP2B_LxvP_1	55	58	PF13499	0.520
DOC_PP4_FxxP_1	8	11	PF00568	0.496
DOC_USP7_MATH_1	120	124	PF00917	0.636
DOC_USP7_MATH_1	126	130	PF00917	0.525
DOC_USP7_MATH_1	139	143	PF00917	0.320
DOC_USP7_MATH_1	228	232	PF00917	0.592
DOC_USP7_MATH_1	260	264	PF00917	0.542
DOC_USP7_MATH_1	342	346	PF00917	0.770
DOC_USP7_MATH_1	396	400	PF00917	0.430
DOC_USP7_MATH_1	51	55	PF00917	0.757
DOC_WW_Pin1_4	32	37	PF00397	0.690
DOC_WW_Pin1_4	330	335	PF00397	0.578
LIG_14-3-3_CanoR_1	113	122	PF00244	0.588
LIG_14-3-3_CanoR_1	2	11	PF00244	0.625
LIG_14-3-3_CanoR_1	202	209	PF00244	0.626
LIG_14-3-3_CanoR_1	229	233	PF00244	0.694
LIG_14-3-3_CanoR_1	86	92	PF00244	0.529
LIG_BRCT_BRCA1_1	154	158	PF00533	0.591
LIG_BRCT_BRCA1_1	230	234	PF00533	0.588
LIG_BRCT_BRCA1_1	4	8	PF00533	0.505
LIG_Clathr_ClatBox_1	415	419	PF01394	0.440
LIG_EVH1_2	68	72	PF00568	0.743
LIG_FHA_1	114	120	PF00498	0.626
LIG_FHA_1	263	269	PF00498	0.540
LIG_FHA_1	366	372	PF00498	0.553
LIG_FHA_2	184	190	PF00498	0.639
LIG_FHA_2	54	60	PF00498	0.771
LIG_LIR_Apic_2	5	11	PF02991	0.504
LIG_LIR_Gen_1	155	166	PF02991	0.594
LIG_LIR_Nem_3	155	161	PF02991	0.587
LIG_NRBOX	40	46	PF00104	0.668
LIG_PCNA_yPIPBox_3	402	416	PF02747	0.659
LIG_Pex14_2	127	131	PF04695	0.613
LIG_Pex14_2	154	158	PF04695	0.591
LIG_SH2_STAT3	149	152	PF00017	0.471
LIG_SH2_STAT5	160	163	PF00017	0.423
LIG_SH2_STAT5	404	407	PF00017	0.661
LIG_SH3_3	116	122	PF00018	0.638
LIG_SH3_3	212	218	PF00018	0.723
LIG_SH3_3	254	260	PF00018	0.580
LIG_SH3_3	30	36	PF00018	0.705
LIG_SH3_3	315	321	PF00018	0.657
LIG_Sin3_3	301	308	PF02671	0.524
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.413
LIG_SUMO_SIM_par_1	367	372	PF11976	0.705
LIG_SUMO_SIM_par_1	41	48	PF11976	0.405
LIG_SUMO_SIM_par_1	414	420	PF11976	0.440
LIG_WRC_WIRS_1	405	410	PF05994	0.400
MOD_CDK_SPK_2	330	335	PF00069	0.578
MOD_CK1_1	346	352	PF00069	0.726
MOD_CK1_1	355	361	PF00069	0.618
MOD_CK1_1	6	12	PF00069	0.744
MOD_CK1_1	73	79	PF00069	0.618
MOD_CK2_1	330	336	PF00069	0.579
MOD_CK2_1	411	417	PF00069	0.563
MOD_Cter_Amidation	279	282	PF01082	0.808
MOD_GlcNHglycan	116	119	PF01048	0.376
MOD_GlcNHglycan	19	22	PF01048	0.492
MOD_GlcNHglycan	204	207	PF01048	0.811
MOD_GlcNHglycan	247	250	PF01048	0.637
MOD_GlcNHglycan	262	265	PF01048	0.604
MOD_GlcNHglycan	288	291	PF01048	0.721
MOD_GlcNHglycan	294	297	PF01048	0.793
MOD_GlcNHglycan	345	348	PF01048	0.654
MOD_GlcNHglycan	357	360	PF01048	0.567
MOD_GlcNHglycan	47	50	PF01048	0.709
MOD_GlcNHglycan	72	75	PF01048	0.715
MOD_GSK3_1	109	116	PF00069	0.592
MOD_GSK3_1	152	159	PF00069	0.590
MOD_GSK3_1	198	205	PF00069	0.638
MOD_GSK3_1	2	9	PF00069	0.690
MOD_GSK3_1	286	293	PF00069	0.625
MOD_GSK3_1	342	349	PF00069	0.599
MOD_GSK3_1	53	60	PF00069	0.616
MOD_N-GLC_1	27	32	PF02516	0.471
MOD_N-GLC_1	343	348	PF02516	0.580
MOD_NEK2_1	107	112	PF00069	0.405
MOD_NEK2_1	114	119	PF00069	0.479
MOD_NEK2_1	198	203	PF00069	0.596
MOD_NEK2_1	292	297	PF00069	0.723
MOD_NEK2_1	45	50	PF00069	0.700
MOD_NEK2_2	139	144	PF00069	0.631
MOD_NEK2_2	153	158	PF00069	0.363
MOD_PIKK_1	228	234	PF00454	0.588
MOD_PKA_2	228	234	PF00069	0.588
MOD_PKA_2	45	51	PF00069	0.476
MOD_PKA_2	6	12	PF00069	0.506
MOD_Plk_1	27	33	PF00069	0.501
MOD_Plk_1	343	349	PF00069	0.581
MOD_Plk_4	153	159	PF00069	0.553
MOD_Plk_4	262	268	PF00069	0.545
MOD_Plk_4	95	101	PF00069	0.616
MOD_ProDKin_1	32	38	PF00069	0.681
MOD_ProDKin_1	330	336	PF00069	0.579
TRG_DiLeu_BaEn_2	9	15	PF01217	0.505
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.694
TRG_ER_diArg_1	133	135	PF00400	0.626
TRG_ER_diArg_1	383	385	PF00400	0.595
TRG_ER_diArg_1	389	391	PF00400	0.674
TRG_ER_diArg_1	85	87	PF00400	0.623
TRG_Pf-PMV_PEXEL_1	381	386	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ILA1	Leishmania donovani	69%	99%
A4IE65	Leishmania infantum	70%	99%
E9ATJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4Q106	Leishmania major	68%	100%