IQ calmodulin-binding motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPS6_LEIBR

TriTrypDb:

LbrM.35.4320 , LBRM2903_350053700

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPS6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.762
CLV_NRD_NRD_1	134	136	PF00675	0.346
CLV_NRD_NRD_1	172	174	PF00675	0.406
CLV_NRD_NRD_1	187	189	PF00675	0.519
CLV_NRD_NRD_1	410	412	PF00675	0.845
CLV_NRD_NRD_1	459	461	PF00675	0.665
CLV_NRD_NRD_1	525	527	PF00675	0.731
CLV_NRD_NRD_1	74	76	PF00675	0.349
CLV_NRD_NRD_1	97	99	PF00675	0.349
CLV_PCSK_KEX2_1	178	180	PF00082	0.651
CLV_PCSK_KEX2_1	187	189	PF00082	0.422
CLV_PCSK_KEX2_1	296	298	PF00082	0.550
CLV_PCSK_KEX2_1	459	461	PF00082	0.763
CLV_PCSK_KEX2_1	464	466	PF00082	0.678
CLV_PCSK_KEX2_1	525	527	PF00082	0.671
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.665
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.507
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.761
CLV_PCSK_PC7_1	460	466	PF00082	0.757
CLV_PCSK_SKI1_1	149	153	PF00082	0.484
CLV_PCSK_SKI1_1	246	250	PF00082	0.579
CLV_PCSK_SKI1_1	354	358	PF00082	0.563
CLV_PCSK_SKI1_1	380	384	PF00082	0.679
CLV_PCSK_SKI1_1	75	79	PF00082	0.348
DEG_COP1_1	197	204	PF00400	0.718
DOC_ANK_TNKS_1	321	328	PF00023	0.565
DOC_CKS1_1	382	387	PF01111	0.675
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.514
DOC_MAPK_gen_1	284	293	PF00069	0.486
DOC_MAPK_gen_1	75	81	PF00069	0.549
DOC_MAPK_HePTP_8	12	24	PF00069	0.453
DOC_MAPK_MEF2A_6	15	24	PF00069	0.449
DOC_MAPK_MEF2A_6	380	389	PF00069	0.545
DOC_SPAK_OSR1_1	460	464	PF12202	0.754
DOC_USP7_MATH_1	153	157	PF00917	0.609
DOC_USP7_MATH_1	268	272	PF00917	0.667
DOC_USP7_MATH_1	438	442	PF00917	0.802
DOC_USP7_MATH_1	452	456	PF00917	0.762
DOC_USP7_MATH_2	368	374	PF00917	0.807
DOC_USP7_UBL2_3	174	178	PF12436	0.399
DOC_WW_Pin1_4	236	241	PF00397	0.807
DOC_WW_Pin1_4	295	300	PF00397	0.594
DOC_WW_Pin1_4	30	35	PF00397	0.685
DOC_WW_Pin1_4	361	366	PF00397	0.548
DOC_WW_Pin1_4	381	386	PF00397	0.657
DOC_WW_Pin1_4	396	401	PF00397	0.567
DOC_WW_Pin1_4	491	496	PF00397	0.498
LIG_14-3-3_CanoR_1	187	195	PF00244	0.552
LIG_14-3-3_CanoR_1	290	299	PF00244	0.712
LIG_14-3-3_CanoR_1	317	323	PF00244	0.681
LIG_14-3-3_CanoR_1	331	335	PF00244	0.502
LIG_14-3-3_CanoR_1	405	413	PF00244	0.711
LIG_14-3-3_CanoR_1	82	88	PF00244	0.507
LIG_14-3-3_CanoR_1	90	96	PF00244	0.489
LIG_Actin_WH2_2	160	175	PF00022	0.602
LIG_BRCT_BRCA1_1	390	394	PF00533	0.538
LIG_CaM_IQ_9	122	138	PF13499	0.546
LIG_CaM_IQ_9	62	78	PF13499	0.546
LIG_CaM_IQ_9	85	101	PF13499	0.546
LIG_FHA_1	196	202	PF00498	0.562
LIG_FHA_1	242	248	PF00498	0.564
LIG_FHA_1	3	9	PF00498	0.634
LIG_FHA_1	316	322	PF00498	0.695
LIG_FHA_1	330	336	PF00498	0.537
LIG_FHA_1	382	388	PF00498	0.545
LIG_FHA_1	474	480	PF00498	0.609
LIG_FHA_1	60	66	PF00498	0.549
LIG_FHA_2	163	169	PF00498	0.535
LIG_LIR_Gen_1	366	377	PF02991	0.553
LIG_LIR_Nem_3	366	372	PF02991	0.546
LIG_LIR_Nem_3	68	72	PF02991	0.587
LIG_MLH1_MIPbox_1	390	394	PF16413	0.538
LIG_Pex14_2	457	461	PF04695	0.659
LIG_SH2_CRK	29	33	PF00017	0.584
LIG_SH2_CRK	9	13	PF00017	0.478
LIG_SH2_GRB2like	11	14	PF00017	0.472
LIG_SH2_NCK_1	29	33	PF00017	0.584
LIG_SH2_SRC	11	14	PF00017	0.472
LIG_SH2_STAP1	142	146	PF00017	0.532
LIG_SH2_STAT3	141	144	PF00017	0.545
LIG_SH2_STAT5	11	14	PF00017	0.472
LIG_SH2_STAT5	113	116	PF00017	0.446
LIG_SH2_STAT5	147	150	PF00017	0.500
LIG_SH2_STAT5	269	272	PF00017	0.498
LIG_SH3_2	492	497	PF14604	0.494
LIG_SH3_3	206	212	PF00018	0.677
LIG_SH3_3	237	243	PF00018	0.803
LIG_SH3_3	298	304	PF00018	0.525
LIG_SH3_3	362	368	PF00018	0.704
LIG_SH3_3	375	381	PF00018	0.670
LIG_SH3_3	489	495	PF00018	0.567
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.439
LIG_SUMO_SIM_par_1	305	311	PF11976	0.628
LIG_SUMO_SIM_par_1	55	60	PF11976	0.539
LIG_TRAF2_1	368	371	PF00917	0.542
LIG_TRAF2_1	496	499	PF00917	0.476
LIG_WRC_WIRS_1	454	459	PF05994	0.661
MOD_CDC14_SPxK_1	494	497	PF00782	0.478
MOD_CDK_SPxK_1	491	497	PF00069	0.495
MOD_CK1_1	134	140	PF00069	0.640
MOD_CK1_1	197	203	PF00069	0.559
MOD_CK1_1	232	238	PF00069	0.744
MOD_CK1_1	252	258	PF00069	0.494
MOD_CK1_1	30	36	PF00069	0.678
MOD_CK1_1	311	317	PF00069	0.733
MOD_CK1_1	392	398	PF00069	0.649
MOD_CK1_1	399	405	PF00069	0.666
MOD_CK1_1	441	447	PF00069	0.762
MOD_CK1_1	94	100	PF00069	0.543
MOD_CK2_1	15	21	PF00069	0.580
MOD_CK2_1	162	168	PF00069	0.534
MOD_CK2_1	252	258	PF00069	0.732
MOD_CK2_1	43	49	PF00069	0.606
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.518
MOD_GlcNHglycan	17	20	PF01048	0.593
MOD_GlcNHglycan	231	234	PF01048	0.619
MOD_GlcNHglycan	253	257	PF01048	0.592
MOD_GlcNHglycan	270	273	PF01048	0.650
MOD_GlcNHglycan	45	48	PF01048	0.550
MOD_GlcNHglycan	489	492	PF01048	0.774
MOD_GlcNHglycan	49	54	PF01048	0.522
MOD_GlcNHglycan	522	525	PF01048	0.770
MOD_GlcNHglycan	83	86	PF01048	0.238
MOD_GSK3_1	11	18	PF00069	0.490
MOD_GSK3_1	149	156	PF00069	0.492
MOD_GSK3_1	214	221	PF00069	0.715
MOD_GSK3_1	232	239	PF00069	0.622
MOD_GSK3_1	291	298	PF00069	0.662
MOD_GSK3_1	308	315	PF00069	0.677
MOD_GSK3_1	325	332	PF00069	0.636
MOD_GSK3_1	388	395	PF00069	0.687
MOD_GSK3_1	399	406	PF00069	0.740
MOD_GSK3_1	421	428	PF00069	0.782
MOD_GSK3_1	441	448	PF00069	0.706
MOD_GSK3_1	483	490	PF00069	0.760
MOD_GSK3_1	77	84	PF00069	0.438
MOD_NEK2_1	120	125	PF00069	0.411
MOD_NEK2_1	195	200	PF00069	0.559
MOD_NEK2_1	222	227	PF00069	0.553
MOD_NEK2_1	344	349	PF00069	0.603
MOD_NEK2_1	372	377	PF00069	0.564
MOD_NEK2_1	388	393	PF00069	0.655
MOD_NEK2_1	394	399	PF00069	0.770
MOD_NEK2_1	403	408	PF00069	0.669
MOD_NEK2_1	425	430	PF00069	0.606
MOD_NEK2_1	473	478	PF00069	0.647
MOD_NEK2_1	520	525	PF00069	0.767
MOD_NEK2_1	81	86	PF00069	0.303
MOD_NEK2_2	214	219	PF00069	0.560
MOD_NEK2_2	453	458	PF00069	0.768
MOD_NEK2_2	77	82	PF00069	0.496
MOD_PIKK_1	162	168	PF00454	0.591
MOD_PIKK_1	344	350	PF00454	0.745
MOD_PIKK_1	404	410	PF00454	0.693
MOD_PKA_2	134	140	PF00069	0.640
MOD_PKA_2	153	159	PF00069	0.512
MOD_PKA_2	186	192	PF00069	0.489
MOD_PKA_2	316	322	PF00069	0.579
MOD_PKA_2	330	336	PF00069	0.500
MOD_PKA_2	404	410	PF00069	0.844
MOD_PKA_2	81	87	PF00069	0.261
MOD_Plk_1	181	187	PF00069	0.656
MOD_Plk_1	258	264	PF00069	0.468
MOD_Plk_1	370	376	PF00069	0.566
MOD_Plk_1	441	447	PF00069	0.531
MOD_Plk_1	59	65	PF00069	0.416
MOD_Plk_4	200	206	PF00069	0.567
MOD_Plk_4	258	264	PF00069	0.493
MOD_Plk_4	302	308	PF00069	0.559
MOD_Plk_4	330	336	PF00069	0.565
MOD_Plk_4	389	395	PF00069	0.538
MOD_Plk_4	445	451	PF00069	0.540
MOD_ProDKin_1	236	242	PF00069	0.808
MOD_ProDKin_1	295	301	PF00069	0.597
MOD_ProDKin_1	30	36	PF00069	0.685
MOD_ProDKin_1	361	367	PF00069	0.547
MOD_ProDKin_1	381	387	PF00069	0.660
MOD_ProDKin_1	396	402	PF00069	0.571
MOD_ProDKin_1	491	497	PF00069	0.495
MOD_SUMO_rev_2	505	511	PF00179	0.651
TRG_DiLeu_BaEn_1	258	263	PF01217	0.471
TRG_ENDOCYTIC_2	147	150	PF00928	0.620
TRG_ENDOCYTIC_2	29	32	PF00928	0.588
TRG_ENDOCYTIC_2	9	12	PF00928	0.554
TRG_ER_diArg_1	321	324	PF00400	0.573
TRG_ER_diArg_1	459	461	PF00400	0.763
TRG_NLS_MonoCore_2	410	415	PF00514	0.809

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I2	Leptomonas seymouri	40%	100%
A0A3S7XBK4	Leishmania donovani	68%	99%
A4IE66	Leishmania infantum	68%	99%
E9ATJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q107	Leishmania major	68%	100%