Putative phosphoglycerate mutase family member 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycerate mutase family member 5, putative

Species:

Leishmania braziliensis

UniProt:

A4HPS5_LEIBR

TriTrypDb:

LbrM.35.4310 , LBRM2903_350053600

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 8
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPS5

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010821	regulation of mitochondrion organization	6	1
GO:0010822	positive regulation of mitochondrion organization	7	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0022603	regulation of anatomical structure morphogenesis	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0035970	peptidyl-threonine dephosphorylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050793	regulation of developmental process	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051094	positive regulation of developmental process	4	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090140	regulation of mitochondrial fission	5	1
GO:0090141	positive regulation of mitochondrial fission	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004722	protein serine/threonine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.395
CLV_NRD_NRD_1	147	149	PF00675	0.381
CLV_NRD_NRD_1	228	230	PF00675	0.448
CLV_NRD_NRD_1	6	8	PF00675	0.533
CLV_PCSK_KEX2_1	147	149	PF00082	0.361
CLV_PCSK_KEX2_1	228	230	PF00082	0.305
CLV_PCSK_KEX2_1	6	8	PF00082	0.566
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.458
CLV_PCSK_SKI1_1	139	143	PF00082	0.505
CLV_PCSK_SKI1_1	160	164	PF00082	0.429
CLV_PCSK_SKI1_1	180	184	PF00082	0.331
CLV_PCSK_SKI1_1	186	190	PF00082	0.568
CLV_PCSK_SKI1_1	23	27	PF00082	0.407
CLV_PCSK_SKI1_1	249	253	PF00082	0.502
CLV_PCSK_SKI1_1	290	294	PF00082	0.322
CLV_PCSK_SKI1_1	6	10	PF00082	0.511
DEG_APCC_DBOX_1	147	155	PF00400	0.416
DOC_CYCLIN_RxL_1	136	146	PF00134	0.468
DOC_CYCLIN_RxL_1	290	302	PF00134	0.235
DOC_MAPK_gen_1	129	138	PF00069	0.452
DOC_MAPK_gen_1	211	220	PF00069	0.390
DOC_MAPK_gen_1	6	14	PF00069	0.546
DOC_MAPK_MEF2A_6	7	16	PF00069	0.526
DOC_PP2B_LxvP_1	297	300	PF13499	0.235
DOC_PP4_FxxP_1	269	272	PF00568	0.250
DOC_USP7_MATH_1	247	251	PF00917	0.471
DOC_USP7_MATH_1	272	276	PF00917	0.381
DOC_USP7_MATH_1	310	314	PF00917	0.261
DOC_USP7_MATH_1	92	96	PF00917	0.551
DOC_WW_Pin1_4	16	21	PF00397	0.590
DOC_WW_Pin1_4	31	36	PF00397	0.534
LIG_14-3-3_CanoR_1	211	220	PF00244	0.296
LIG_14-3-3_CanoR_1	249	258	PF00244	0.391
LIG_14-3-3_CanoR_1	290	295	PF00244	0.295
LIG_14-3-3_CanoR_1	306	310	PF00244	0.264
LIG_14-3-3_CanoR_1	94	103	PF00244	0.397
LIG_BIR_II_1	1	5	PF00653	0.575
LIG_BRCT_BRCA1_1	1	5	PF00533	0.559
LIG_CtBP_PxDLS_1	337	341	PF00389	0.400
LIG_FHA_1	213	219	PF00498	0.321
LIG_FHA_1	24	30	PF00498	0.653
LIG_FHA_1	276	282	PF00498	0.326
LIG_FHA_1	320	326	PF00498	0.262
LIG_FHA_1	71	77	PF00498	0.414
LIG_FHA_2	275	281	PF00498	0.281
LIG_FHA_2	62	68	PF00498	0.460
LIG_LIR_Apic_2	266	272	PF02991	0.269
LIG_LIR_Apic_2	73	77	PF02991	0.417
LIG_LIR_Apic_2	80	85	PF02991	0.339
LIG_LIR_Nem_3	2	8	PF02991	0.572
LIG_LIR_Nem_3	262	268	PF02991	0.255
LIG_LIR_Nem_3	332	336	PF02991	0.388
LIG_PCNA_yPIPBox_3	44	57	PF02747	0.351
LIG_Pex14_2	265	269	PF04695	0.250
LIG_Pex14_2	5	9	PF04695	0.529
LIG_PTB_Apo_2	51	58	PF02174	0.485
LIG_Rb_pABgroove_1	51	59	PF01858	0.418
LIG_SH2_STAT5	137	140	PF00017	0.394
LIG_SH2_STAT5	268	271	PF00017	0.235
LIG_SH2_STAT5	291	294	PF00017	0.282
LIG_SH2_STAT5	70	73	PF00017	0.440
LIG_SH3_3	32	38	PF00018	0.657
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.257
LIG_SUMO_SIM_par_1	339	344	PF11976	0.483
LIG_TRAF2_1	170	173	PF00917	0.439
LIG_TRAF2_1	63	66	PF00917	0.405
MOD_CDK_SPxxK_3	16	23	PF00069	0.525
MOD_CK1_1	207	213	PF00069	0.323
MOD_CK1_1	275	281	PF00069	0.278
MOD_CK2_1	274	280	PF00069	0.240
MOD_CK2_1	61	67	PF00069	0.469
MOD_GlcNHglycan	189	192	PF01048	0.396
MOD_GlcNHglycan	253	256	PF01048	0.469
MOD_GlcNHglycan	274	277	PF01048	0.300
MOD_GlcNHglycan	47	50	PF01048	0.579
MOD_GlcNHglycan	93	97	PF01048	0.487
MOD_GSK3_1	247	254	PF00069	0.425
MOD_GSK3_1	270	277	PF00069	0.201
MOD_GSK3_1	315	322	PF00069	0.347
MOD_N-GLC_1	111	116	PF02516	0.325
MOD_NEK2_1	1	6	PF00069	0.561
MOD_NEK2_1	29	34	PF00069	0.617
MOD_NEK2_1	305	310	PF00069	0.235
MOD_NEK2_1	8	13	PF00069	0.495
MOD_NEK2_2	111	116	PF00069	0.526
MOD_PKA_1	180	186	PF00069	0.275
MOD_PKA_2	121	127	PF00069	0.383
MOD_PKA_2	131	137	PF00069	0.330
MOD_PKA_2	270	276	PF00069	0.184
MOD_PKA_2	305	311	PF00069	0.249
MOD_PKA_2	319	325	PF00069	0.249
MOD_Plk_1	111	117	PF00069	0.529
MOD_Plk_2-3	168	174	PF00069	0.444
MOD_Plk_4	323	329	PF00069	0.410
MOD_Plk_4	8	14	PF00069	0.577
MOD_ProDKin_1	16	22	PF00069	0.590
MOD_ProDKin_1	31	37	PF00069	0.530
MOD_SUMO_rev_2	113	120	PF00179	0.391
MOD_SUMO_rev_2	173	183	PF00179	0.543
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.520
TRG_ENDOCYTIC_2	291	294	PF00928	0.329
TRG_ENDOCYTIC_2	333	336	PF00928	0.390
TRG_ER_diArg_1	227	229	PF00400	0.396
TRG_ER_diArg_1	5	7	PF00400	0.565
TRG_NLS_Bipartite_1	147	167	PF00514	0.432
TRG_NLS_MonoExtC_3	162	168	PF00514	0.420
TRG_NLS_MonoExtN_4	147	152	PF00514	0.419
TRG_NLS_MonoExtN_4	160	167	PF00514	0.307
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P665	Leptomonas seymouri	65%	100%
A0A0N0P6K6	Leptomonas seymouri	61%	100%
A0A0S4J0R9	Bodo saltans	34%	98%
A0A1X0P349	Trypanosomatidae	50%	100%
A0A3S7XBE7	Leishmania donovani	86%	100%
A4ICY8	Leishmania infantum	85%	100%
B3MR30	Drosophila ananassae	32%	100%
B3P9N0	Drosophila erecta	32%	100%
B4GXS1	Drosophila persimilis	32%	100%
B4I9J6	Drosophila sechellia	31%	100%
B4JMM7	Drosophila grimshawi	34%	100%
B4L6S9	Drosophila mojavensis	31%	100%
B4M7S0	Drosophila virilis	33%	100%
B4NE96	Drosophila willistoni	33%	100%
B4PY69	Drosophila yakuba	32%	100%
B4R313	Drosophila simulans	31%	100%
D0A8P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ATJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O46084	Drosophila melanogaster	31%	100%
Q29HG0	Drosophila pseudoobscura pseudoobscura	33%	100%
Q4Q108	Leishmania major	84%	100%
Q562B5	Rattus norvegicus	32%	100%
Q8BX10	Mus musculus	31%	100%
Q96HS1	Homo sapiens	31%	100%
V5B6V2	Trypanosoma cruzi	53%	100%