Regulator_of_chromosome_condensation_(RCC1)_repea t

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulator of chromosome condensation 1-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPS4_LEIBR

TriTrypDb:

LbrM.35.4300 , LBRM2903_350053500

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0031010	ISWI-type complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1

Expansion

Sequence features

A4HPS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.486
CLV_NRD_NRD_1	315	317	PF00675	0.413
CLV_NRD_NRD_1	37	39	PF00675	0.617
CLV_PCSK_KEX2_1	37	39	PF00082	0.617
CLV_PCSK_KEX2_1	636	638	PF00082	0.642
CLV_PCSK_PC1ET2_1	636	638	PF00082	0.642
CLV_PCSK_SKI1_1	446	450	PF00082	0.490
CLV_PCSK_SKI1_1	509	513	PF00082	0.516
CLV_PCSK_SKI1_1	636	640	PF00082	0.649
CLV_PCSK_SKI1_1	64	68	PF00082	0.621
DEG_APCC_KENBOX_2	335	339	PF00400	0.512
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DEG_SPOP_SBC_1	154	158	PF00917	0.415
DOC_CKS1_1	252	257	PF01111	0.449
DOC_CKS1_1	599	604	PF01111	0.537
DOC_CYCLIN_yCln2_LP_2	419	425	PF00134	0.556
DOC_MAPK_gen_1	263	271	PF00069	0.354
DOC_MAPK_gen_1	477	486	PF00069	0.570
DOC_MAPK_MEF2A_6	263	271	PF00069	0.342
DOC_MAPK_MEF2A_6	552	560	PF00069	0.558
DOC_PP1_RVXF_1	308	314	PF00149	0.329
DOC_PP1_RVXF_1	637	643	PF00149	0.573
DOC_PP2B_LxvP_1	172	175	PF13499	0.523
DOC_PP4_FxxP_1	9	12	PF00568	0.578
DOC_USP7_MATH_1	369	373	PF00917	0.497
DOC_USP7_MATH_1	407	411	PF00917	0.555
DOC_USP7_MATH_1	478	482	PF00917	0.704
DOC_USP7_MATH_1	48	52	PF00917	0.735
DOC_USP7_MATH_1	533	537	PF00917	0.572
DOC_USP7_MATH_1	578	582	PF00917	0.792
DOC_USP7_MATH_1	611	615	PF00917	0.817
DOC_USP7_MATH_1	85	89	PF00917	0.472
DOC_USP7_UBL2_3	458	462	PF12436	0.786
DOC_WW_Pin1_4	251	256	PF00397	0.407
DOC_WW_Pin1_4	37	42	PF00397	0.648
DOC_WW_Pin1_4	598	603	PF00397	0.681
DOC_WW_Pin1_4	629	634	PF00397	0.718
LIG_14-3-3_CanoR_1	37	41	PF00244	0.672
LIG_14-3-3_CanoR_1	477	483	PF00244	0.497
LIG_14-3-3_CanoR_1	534	538	PF00244	0.490
LIG_14-3-3_CanoR_1	64	73	PF00244	0.503
LIG_Actin_WH2_2	344	361	PF00022	0.306
LIG_Actin_WH2_2	49	66	PF00022	0.420
LIG_APCC_ABBA_1	652	657	PF00400	0.594
LIG_BRCT_BRCA1_1	5	9	PF00533	0.577
LIG_CaM_IQ_9	56	72	PF13499	0.620
LIG_CtBP_PxDLS_1	30	34	PF00389	0.475
LIG_deltaCOP1_diTrp_1	641	647	PF00928	0.572
LIG_FHA_1	156	162	PF00498	0.437
LIG_FHA_1	245	251	PF00498	0.413
LIG_FHA_1	252	258	PF00498	0.369
LIG_FHA_1	330	336	PF00498	0.340
LIG_FHA_1	365	371	PF00498	0.482
LIG_FHA_1	431	437	PF00498	0.439
LIG_FHA_1	47	53	PF00498	0.703
LIG_FHA_1	593	599	PF00498	0.648
LIG_FHA_2	286	292	PF00498	0.323
LIG_FHA_2	307	313	PF00498	0.286
LIG_FHA_2	465	471	PF00498	0.741
LIG_FHA_2	566	572	PF00498	0.579
LIG_FHA_2	618	624	PF00498	0.650
LIG_FHA_2	658	664	PF00498	0.641
LIG_LIR_Apic_2	6	12	PF02991	0.573
LIG_LIR_Apic_2	679	685	PF02991	0.711
LIG_LIR_Gen_1	166	175	PF02991	0.409
LIG_LIR_Gen_1	191	199	PF02991	0.504
LIG_LIR_Gen_1	379	384	PF02991	0.491
LIG_LIR_Gen_1	481	490	PF02991	0.568
LIG_LIR_Nem_3	114	118	PF02991	0.476
LIG_LIR_Nem_3	166	172	PF02991	0.382
LIG_LIR_Nem_3	191	195	PF02991	0.423
LIG_LIR_Nem_3	225	231	PF02991	0.344
LIG_LIR_Nem_3	291	297	PF02991	0.328
LIG_LIR_Nem_3	379	383	PF02991	0.414
LIG_LIR_Nem_3	481	485	PF02991	0.544
LIG_MYND_1	304	308	PF01753	0.449
LIG_MYND_1	447	451	PF01753	0.498
LIG_NRBOX	507	513	PF00104	0.640
LIG_PCNA_yPIPBox_3	336	345	PF02747	0.542
LIG_PTB_Apo_2	109	116	PF02174	0.533
LIG_PTB_Phospho_1	109	115	PF10480	0.563
LIG_REV1ctd_RIR_1	345	354	PF16727	0.519
LIG_SH2_CRK	115	119	PF00017	0.537
LIG_SH2_CRK	398	402	PF00017	0.550
LIG_SH2_NCK_1	398	402	PF00017	0.593
LIG_SH2_PTP2	682	685	PF00017	0.698
LIG_SH2_SRC	188	191	PF00017	0.541
LIG_SH2_SRC	28	31	PF00017	0.481
LIG_SH2_SRC	504	507	PF00017	0.644
LIG_SH2_STAP1	125	129	PF00017	0.468
LIG_SH2_STAP1	398	402	PF00017	0.524
LIG_SH2_STAT3	524	527	PF00017	0.614
LIG_SH2_STAT3	7	10	PF00017	0.613
LIG_SH2_STAT5	162	165	PF00017	0.400
LIG_SH2_STAT5	28	31	PF00017	0.481
LIG_SH2_STAT5	287	290	PF00017	0.328
LIG_SH2_STAT5	346	349	PF00017	0.444
LIG_SH2_STAT5	391	394	PF00017	0.399
LIG_SH2_STAT5	398	401	PF00017	0.517
LIG_SH2_STAT5	515	518	PF00017	0.487
LIG_SH2_STAT5	524	527	PF00017	0.486
LIG_SH2_STAT5	682	685	PF00017	0.586
LIG_SH3_1	38	44	PF00018	0.491
LIG_SH3_2	529	534	PF14604	0.661
LIG_SH3_3	15	21	PF00018	0.665
LIG_SH3_3	249	255	PF00018	0.325
LIG_SH3_3	308	314	PF00018	0.334
LIG_SH3_3	360	366	PF00018	0.528
LIG_SH3_3	38	44	PF00018	0.658
LIG_SH3_3	441	447	PF00018	0.671
LIG_SH3_3	481	487	PF00018	0.572
LIG_SH3_3	526	532	PF00018	0.565
LIG_SH3_3	596	602	PF00018	0.675
LIG_SH3_CIN85_PxpxPR_1	529	534	PF14604	0.723
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.550
LIG_SUMO_SIM_par_1	246	251	PF11976	0.478
LIG_SUMO_SIM_par_1	329	337	PF11976	0.363
LIG_SUMO_SIM_par_1	648	660	PF11976	0.649
LIG_TRAF2_1	468	471	PF00917	0.757
LIG_TRAF2_1	58	61	PF00917	0.594
LIG_TRAF2_1	620	623	PF00917	0.810
LIG_WW_3	313	317	PF00397	0.413
LIG_WW_3	531	535	PF00397	0.700
MOD_CDK_SPK_2	629	634	PF00069	0.737
MOD_CDK_SPxK_1	37	43	PF00069	0.481
MOD_CDK_SPxxK_3	629	636	PF00069	0.725
MOD_CK1_1	430	436	PF00069	0.492
MOD_CK1_1	51	57	PF00069	0.676
MOD_CK1_1	589	595	PF00069	0.738
MOD_CK1_1	629	635	PF00069	0.699
MOD_CK2_1	219	225	PF00069	0.342
MOD_CK2_1	285	291	PF00069	0.387
MOD_CK2_1	306	312	PF00069	0.253
MOD_CK2_1	464	470	PF00069	0.779
MOD_CK2_1	55	61	PF00069	0.559
MOD_CK2_1	617	623	PF00069	0.646
MOD_CK2_1	653	659	PF00069	0.597
MOD_Cter_Amidation	634	637	PF01082	0.684
MOD_GlcNHglycan	206	209	PF01048	0.489
MOD_GlcNHglycan	429	432	PF01048	0.495
MOD_GlcNHglycan	535	538	PF01048	0.593
MOD_GlcNHglycan	591	594	PF01048	0.777
MOD_GlcNHglycan	628	632	PF01048	0.659
MOD_GSK3_1	149	156	PF00069	0.353
MOD_GSK3_1	184	191	PF00069	0.558
MOD_GSK3_1	204	211	PF00069	0.189
MOD_GSK3_1	219	226	PF00069	0.371
MOD_GSK3_1	365	372	PF00069	0.486
MOD_GSK3_1	44	51	PF00069	0.724
MOD_GSK3_1	55	62	PF00069	0.321
MOD_GSK3_1	585	592	PF00069	0.688
MOD_GSK3_1	653	660	PF00069	0.585
MOD_N-GLC_1	208	213	PF02516	0.381
MOD_N-GLC_1	402	407	PF02516	0.530
MOD_N-GLC_1	44	49	PF02516	0.774
MOD_NEK2_1	138	143	PF00069	0.569
MOD_NEK2_1	3	8	PF00069	0.536
MOD_NEK2_1	340	345	PF00069	0.511
MOD_NEK2_1	36	41	PF00069	0.611
MOD_NEK2_1	558	563	PF00069	0.648
MOD_NEK2_2	165	170	PF00069	0.433
MOD_PIKK_1	190	196	PF00454	0.538
MOD_PIKK_1	382	388	PF00454	0.532
MOD_PIKK_1	409	415	PF00454	0.629
MOD_PIKK_1	600	606	PF00454	0.771
MOD_PIKK_1	612	618	PF00454	0.769
MOD_PK_1	246	252	PF00069	0.376
MOD_PKA_2	149	155	PF00069	0.413
MOD_PKA_2	358	364	PF00069	0.514
MOD_PKA_2	36	42	PF00069	0.682
MOD_PKA_2	376	382	PF00069	0.393
MOD_PKA_2	533	539	PF00069	0.494
MOD_PKA_2	585	591	PF00069	0.543
MOD_PKB_1	182	190	PF00069	0.358
MOD_Plk_1	165	171	PF00069	0.344
MOD_Plk_1	208	214	PF00069	0.381
MOD_Plk_1	329	335	PF00069	0.328
MOD_Plk_1	657	663	PF00069	0.633
MOD_Plk_2-3	55	61	PF00069	0.656
MOD_Plk_2-3	645	651	PF00069	0.626
MOD_Plk_2-3	657	663	PF00069	0.611
MOD_Plk_4	100	106	PF00069	0.402
MOD_Plk_4	138	144	PF00069	0.513
MOD_Plk_4	149	155	PF00069	0.250
MOD_Plk_4	329	335	PF00069	0.328
MOD_Plk_4	340	346	PF00069	0.470
MOD_Plk_4	358	364	PF00069	0.526
MOD_Plk_4	430	436	PF00069	0.460
MOD_Plk_4	440	446	PF00069	0.523
MOD_Plk_4	565	571	PF00069	0.531
MOD_Plk_4	650	656	PF00069	0.659
MOD_Plk_4	85	91	PF00069	0.550
MOD_ProDKin_1	251	257	PF00069	0.407
MOD_ProDKin_1	37	43	PF00069	0.655
MOD_ProDKin_1	598	604	PF00069	0.683
MOD_ProDKin_1	629	635	PF00069	0.707
MOD_SUMO_for_1	638	641	PF00179	0.652
MOD_SUMO_rev_2	450	460	PF00179	0.754
TRG_DiLeu_BaEn_1	253	258	PF01217	0.223
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.490
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.369
TRG_ENDOCYTIC_2	115	118	PF00928	0.538
TRG_ENDOCYTIC_2	228	231	PF00928	0.344
TRG_ENDOCYTIC_2	398	401	PF00928	0.540
TRG_ER_diArg_1	181	184	PF00400	0.398
TRG_ER_diArg_1	263	266	PF00400	0.388
TRG_ER_diArg_1	36	38	PF00400	0.633
TRG_NES_CRM1_1	241	253	PF08389	0.203
TRG_NES_CRM1_1	61	72	PF08389	0.607
TRG_NLS_MonoExtC_3	635	641	PF00514	0.658
TRG_NLS_MonoExtN_4	633	640	PF00514	0.673
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4I0	Leptomonas seymouri	66%	100%
A0A0S4JSE7	Bodo saltans	32%	100%
A0A1X0P381	Trypanosomatidae	41%	100%
A0A3Q8IGE7	Leishmania donovani	83%	100%
A0A3S5IS08	Trypanosoma rangeli	44%	100%
A4ICY9	Leishmania infantum	83%	100%
D0A8N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ATI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q109	Leishmania major	83%	100%
V5DNG6	Trypanosoma cruzi	43%	100%