Tetratricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPS2_LEIBR

TriTrypDb:

LbrM.35.4280 , LBRM2903_350053400

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPS2

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006335	DNA replication-dependent chromatin assembly	5	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031055	chromatin remodeling at centromere	6	1
GO:0034080	CENP-A containing chromatin assembly	7	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	404	406	PF00675	0.602
CLV_PCSK_KEX2_1	409	411	PF00082	0.627
CLV_PCSK_KEX2_1	424	426	PF00082	0.629
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.691
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.629
CLV_PCSK_PC7_1	405	411	PF00082	0.691
CLV_PCSK_SKI1_1	130	134	PF00082	0.456
CLV_PCSK_SKI1_1	197	201	PF00082	0.356
CLV_PCSK_SKI1_1	312	316	PF00082	0.453
DEG_APCC_DBOX_1	171	179	PF00400	0.251
DEG_APCC_DBOX_1	196	204	PF00400	0.236
DEG_APCC_DBOX_1	269	277	PF00400	0.440
DEG_SPOP_SBC_1	52	56	PF00917	0.763
DOC_CKS1_1	325	330	PF01111	0.635
DOC_CYCLIN_yCln2_LP_2	360	366	PF00134	0.647
DOC_PP2B_LxvP_1	360	363	PF13499	0.562
DOC_PP2B_LxvP_1	384	387	PF13499	0.603
DOC_USP7_MATH_1	387	391	PF00917	0.668
DOC_USP7_MATH_2	328	334	PF00917	0.592
DOC_WW_Pin1_4	13	18	PF00397	0.521
DOC_WW_Pin1_4	324	329	PF00397	0.640
DOC_WW_Pin1_4	391	396	PF00397	0.704
LIG_14-3-3_CanoR_1	145	150	PF00244	0.459
LIG_14-3-3_CanoR_1	268	274	PF00244	0.460
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BIR_III_2	229	233	PF00653	0.481
LIG_FHA_1	161	167	PF00498	0.412
LIG_FHA_1	217	223	PF00498	0.259
LIG_FHA_2	145	151	PF00498	0.614
LIG_FHA_2	270	276	PF00498	0.477
LIG_FHA_2	325	331	PF00498	0.505
LIG_FHA_2	409	415	PF00498	0.700
LIG_FHA_2	53	59	PF00498	0.817
LIG_FHA_2	81	87	PF00498	0.499
LIG_GBD_Chelix_1	284	292	PF00786	0.510
LIG_LIR_Gen_1	163	173	PF02991	0.332
LIG_LIR_Gen_1	356	366	PF02991	0.605
LIG_LIR_Nem_3	108	114	PF02991	0.361
LIG_LIR_Nem_3	163	168	PF02991	0.342
LIG_LIR_Nem_3	330	334	PF02991	0.598
LIG_NRBOX	291	297	PF00104	0.440
LIG_PCNA_PIPBox_1	110	119	PF02747	0.357
LIG_PCNA_yPIPBox_3	141	153	PF02747	0.577
LIG_SH2_CRK	111	115	PF00017	0.364
LIG_SH2_CRK	224	228	PF00017	0.388
LIG_SH2_GRB2like	165	168	PF00017	0.478
LIG_SH2_PTP2	165	168	PF00017	0.478
LIG_SH2_SRC	103	106	PF00017	0.414
LIG_SH2_STAP1	103	107	PF00017	0.431
LIG_SH2_STAP1	210	214	PF00017	0.369
LIG_SH2_STAP1	217	221	PF00017	0.307
LIG_SH2_STAT5	131	134	PF00017	0.344
LIG_SH2_STAT5	165	168	PF00017	0.478
LIG_SH2_STAT5	359	362	PF00017	0.664
LIG_SH3_3	149	155	PF00018	0.625
LIG_SH3_3	392	398	PF00018	0.708
LIG_SUMO_SIM_anti_2	233	241	PF11976	0.592
LIG_TRAF2_1	231	234	PF00917	0.626
LIG_TRAF2_1	27	30	PF00917	0.594
LIG_TRAF2_1	327	330	PF00917	0.514
LIG_TRAF2_1	38	41	PF00917	0.694
LIG_TRAF2_1	56	59	PF00917	0.653
LIG_TRAF2_1	83	86	PF00917	0.495
LIG_TYR_ITIM	109	114	PF00017	0.354
LIG_TYR_ITIM	222	227	PF00017	0.395
MOD_CK1_1	358	364	PF00069	0.571
MOD_CK1_1	415	421	PF00069	0.731
MOD_CK1_1	53	59	PF00069	0.691
MOD_CK2_1	269	275	PF00069	0.417
MOD_CK2_1	324	330	PF00069	0.508
MOD_CK2_1	44	50	PF00069	0.676
MOD_CK2_1	52	58	PF00069	0.607
MOD_CK2_1	80	86	PF00069	0.535
MOD_DYRK1A_RPxSP_1	391	395	PF00069	0.726
MOD_GlcNHglycan	1	4	PF01048	0.597
MOD_GlcNHglycan	124	127	PF01048	0.513
MOD_GlcNHglycan	343	346	PF01048	0.571
MOD_GlcNHglycan	364	367	PF01048	0.629
MOD_GlcNHglycan	391	394	PF01048	0.701
MOD_GlcNHglycan	395	398	PF01048	0.622
MOD_GlcNHglycan	417	420	PF01048	0.751
MOD_GlcNHglycan	429	432	PF01048	0.786
MOD_GSK3_1	1	8	PF00069	0.697
MOD_GSK3_1	280	287	PF00069	0.540
MOD_GSK3_1	354	361	PF00069	0.579
MOD_GSK3_1	370	377	PF00069	0.598
MOD_GSK3_1	387	394	PF00069	0.558
MOD_GSK3_1	40	47	PF00069	0.718
MOD_GSK3_1	408	415	PF00069	0.743
MOD_GSK3_1	50	57	PF00069	0.665
MOD_GSK3_1	9	16	PF00069	0.519
MOD_NEK2_1	1	6	PF00069	0.571
MOD_NEK2_1	380	385	PF00069	0.580
MOD_PIKK_1	135	141	PF00454	0.320
MOD_PIKK_1	44	50	PF00454	0.685
MOD_PKA_2	144	150	PF00069	0.437
MOD_PKA_2	269	275	PF00069	0.463
MOD_PKA_2	90	96	PF00069	0.328
MOD_PKB_1	425	433	PF00069	0.739
MOD_Plk_1	157	163	PF00069	0.425
MOD_Plk_1	355	361	PF00069	0.600
MOD_Plk_1	412	418	PF00069	0.747
MOD_Plk_1	75	81	PF00069	0.699
MOD_Plk_4	157	163	PF00069	0.315
MOD_Plk_4	235	241	PF00069	0.466
MOD_Plk_4	284	290	PF00069	0.490
MOD_Plk_4	355	361	PF00069	0.694
MOD_Plk_4	380	386	PF00069	0.599
MOD_Plk_4	5	11	PF00069	0.535
MOD_ProDKin_1	13	19	PF00069	0.520
MOD_ProDKin_1	324	330	PF00069	0.639
MOD_ProDKin_1	391	397	PF00069	0.704
MOD_SUMO_for_1	27	30	PF00179	0.522
MOD_SUMO_rev_2	229	238	PF00179	0.489
MOD_SUMO_rev_2	274	278	PF00179	0.496
MOD_SUMO_rev_2	333	341	PF00179	0.628
MOD_SUMO_rev_2	417	426	PF00179	0.636
TRG_DiLeu_BaEn_1	291	296	PF01217	0.437
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.429
TRG_ENDOCYTIC_2	111	114	PF00928	0.384
TRG_ENDOCYTIC_2	165	168	PF00928	0.478
TRG_ENDOCYTIC_2	224	227	PF00928	0.398
TRG_ENDOCYTIC_2	359	362	PF00928	0.586
TRG_ER_diArg_1	153	156	PF00400	0.402
TRG_NLS_Bipartite_1	406	428	PF00514	0.696
TRG_NLS_MonoCore_2	423	428	PF00514	0.628
TRG_NLS_MonoExtC_3	404	409	PF00514	0.615
TRG_NLS_MonoExtC_3	423	429	PF00514	0.597
TRG_NLS_MonoExtN_4	405	410	PF00514	0.597
TRG_NLS_MonoExtN_4	421	428	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	141	146	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXN4	Leptomonas seymouri	82%	100%
A0A0S4IPT5	Bodo saltans	48%	100%
A0A1X0P488	Trypanosomatidae	49%	89%
A0A3R7NPK3	Trypanosoma rangeli	50%	95%
A0A3S7XBE8	Leishmania donovani	87%	100%
A4ICZ1	Leishmania infantum	87%	100%
D0A8N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ATI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q111	Leishmania major	84%	99%
V5BS19	Trypanosoma cruzi	54%	95%