Golgi SNARE protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi SNAP receptor complex member 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HPS0_LEIBR

TriTrypDb:

LbrM.35.4260 , LBRM2903_350053100

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	12
GO:0005801	cis-Golgi network	5	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0098588	bounding membrane of organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0005797	Golgi medial cisterna	5	1
GO:0031201	SNARE complex	3	1
GO:0031984	organelle subcompartment	2	1
GO:0031985	Golgi cisterna	4	1
GO:0032991	protein-containing complex	1	1
GO:0098791	Golgi apparatus subcompartment	3	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4HPS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPS0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.394
CLV_NRD_NRD_1	150	152	PF00675	0.371
CLV_NRD_NRD_1	158	160	PF00675	0.328
CLV_NRD_NRD_1	176	178	PF00675	0.284
CLV_NRD_NRD_1	253	255	PF00675	0.252
CLV_NRD_NRD_1	256	258	PF00675	0.321
CLV_NRD_NRD_1	29	31	PF00675	0.401
CLV_PCSK_FUR_1	254	258	PF00082	0.366
CLV_PCSK_KEX2_1	109	111	PF00082	0.391
CLV_PCSK_KEX2_1	149	151	PF00082	0.374
CLV_PCSK_KEX2_1	175	177	PF00082	0.478
CLV_PCSK_KEX2_1	255	257	PF00082	0.339
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.342
CLV_PCSK_SKI1_1	139	143	PF00082	0.426
CLV_PCSK_SKI1_1	150	154	PF00082	0.361
CLV_PCSK_SKI1_1	207	211	PF00082	0.314
DEG_Nend_UBRbox_2	1	3	PF02207	0.548
DEG_ODPH_VHL_1	178	191	PF01847	0.523
DEG_SPOP_SBC_1	69	73	PF00917	0.668
DOC_ANK_TNKS_1	175	182	PF00023	0.539
DOC_CYCLIN_RxL_1	201	214	PF00134	0.376
DOC_MAPK_gen_1	254	262	PF00069	0.443
DOC_MAPK_gen_1	30	37	PF00069	0.622
DOC_MAPK_RevD_3	242	257	PF00069	0.519
DOC_PP4_FxxP_1	80	83	PF00568	0.568
DOC_USP7_MATH_1	57	61	PF00917	0.716
DOC_USP7_MATH_1	74	78	PF00917	0.683
DOC_WW_Pin1_4	47	52	PF00397	0.668
DOC_WW_Pin1_4	61	66	PF00397	0.771
DOC_WW_Pin1_4	78	83	PF00397	0.701
LIG_14-3-3_CanoR_1	133	141	PF00244	0.622
LIG_14-3-3_CanoR_1	19	25	PF00244	0.622
LIG_14-3-3_CanoR_1	219	227	PF00244	0.550
LIG_14-3-3_CanoR_1	6	12	PF00244	0.662
LIG_APCC_ABBA_1	35	40	PF00400	0.623
LIG_BRCT_BRCA1_1	267	271	PF00533	0.424
LIG_BRCT_BRCA1_1	76	80	PF00533	0.711
LIG_FHA_1	19	25	PF00498	0.618
LIG_FHA_1	62	68	PF00498	0.754
LIG_FHA_2	220	226	PF00498	0.514
LIG_FHA_2	51	57	PF00498	0.720
LIG_LIR_Apic_2	77	83	PF02991	0.723
LIG_LIR_Gen_1	10	18	PF02991	0.472
LIG_LIR_Gen_1	225	235	PF02991	0.463
LIG_LIR_Gen_1	268	277	PF02991	0.394
LIG_LIR_Gen_1	87	97	PF02991	0.660
LIG_LIR_Nem_3	10	14	PF02991	0.482
LIG_LIR_Nem_3	135	141	PF02991	0.487
LIG_LIR_Nem_3	225	230	PF02991	0.493
LIG_LIR_Nem_3	268	274	PF02991	0.394
LIG_LIR_Nem_3	87	93	PF02991	0.658
LIG_PDZ_Class_2	272	277	PF00595	0.362
LIG_Pex14_2	271	275	PF04695	0.389
LIG_Rb_pABgroove_1	32	40	PF01858	0.640
LIG_SH2_NCK_1	163	167	PF00017	0.648
LIG_SH2_STAP1	163	167	PF00017	0.648
LIG_SH3_3	62	68	PF00018	0.754
LIG_SUMO_SIM_par_1	258	264	PF11976	0.451
LIG_SUMO_SIM_par_1	33	41	PF11976	0.651
LIG_UBA3_1	247	255	PF00899	0.472
MOD_CK1_1	50	56	PF00069	0.644
MOD_CK2_1	219	225	PF00069	0.467
MOD_GlcNHglycan	185	188	PF01048	0.378
MOD_GlcNHglycan	45	48	PF01048	0.433
MOD_GlcNHglycan	61	64	PF01048	0.477
MOD_GlcNHglycan	72	75	PF01048	0.570
MOD_GlcNHglycan	76	79	PF01048	0.528
MOD_GSK3_1	195	202	PF00069	0.381
MOD_GSK3_1	261	268	PF00069	0.407
MOD_GSK3_1	43	50	PF00069	0.626
MOD_GSK3_1	57	64	PF00069	0.672
MOD_GSK3_1	70	77	PF00069	0.641
MOD_NEK2_1	111	116	PF00069	0.537
MOD_NEK2_1	165	170	PF00069	0.644
MOD_NEK2_1	70	75	PF00069	0.749
MOD_PIKK_1	219	225	PF00454	0.424
MOD_PIKK_1	92	98	PF00454	0.610
MOD_PKA_1	150	156	PF00069	0.538
MOD_PKA_2	132	138	PF00069	0.621
MOD_PKA_2	150	156	PF00069	0.461
MOD_PKA_2	18	24	PF00069	0.628
MOD_PKB_1	217	225	PF00069	0.376
MOD_Plk_1	104	110	PF00069	0.571
MOD_Plk_1	111	117	PF00069	0.598
MOD_Plk_4	111	117	PF00069	0.536
MOD_Plk_4	261	267	PF00069	0.380
MOD_Plk_4	84	90	PF00069	0.667
MOD_ProDKin_1	47	53	PF00069	0.671
MOD_ProDKin_1	61	67	PF00069	0.770
MOD_ProDKin_1	78	84	PF00069	0.700
MOD_SUMO_rev_2	39	44	PF00179	0.603
TRG_DiLeu_BaEn_2	238	244	PF01217	0.512
TRG_ER_diArg_1	108	110	PF00400	0.610
TRG_ER_diArg_1	149	151	PF00400	0.597
TRG_ER_diArg_1	156	159	PF00400	0.544
TRG_ER_diArg_1	175	177	PF00400	0.686
TRG_ER_diArg_1	253	256	PF00400	0.445
TRG_NES_CRM1_1	27	41	PF08389	0.625
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH6	Leptomonas seymouri	64%	100%
A0A0S4IYJ5	Bodo saltans	31%	100%
A0A1X0P3F0	Trypanosomatidae	36%	100%
A0A3R7MXC4	Trypanosoma rangeli	33%	100%
A0A3S7XBH8	Leishmania donovani	79%	100%
A4ICZ3	Leishmania infantum	79%	100%
D0A8N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ATI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
O22151	Arabidopsis thaliana	25%	100%
P38736	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q4Q113	Leishmania major	77%	100%
V5BMF0	Trypanosoma cruzi	32%	100%