Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPR9_LEIBR

TriTrypDb:

LbrM.35.4250 , LBRM2903_350053000

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.674
CLV_NRD_NRD_1	146	148	PF00675	0.534
CLV_NRD_NRD_1	171	173	PF00675	0.743
CLV_NRD_NRD_1	308	310	PF00675	0.605
CLV_NRD_NRD_1	421	423	PF00675	0.553
CLV_PCSK_KEX2_1	146	148	PF00082	0.532
CLV_PCSK_KEX2_1	171	173	PF00082	0.756
CLV_PCSK_KEX2_1	308	310	PF00082	0.626
CLV_PCSK_KEX2_1	421	423	PF00082	0.553
CLV_PCSK_SKI1_1	224	228	PF00082	0.688
CLV_PCSK_SKI1_1	254	258	PF00082	0.594
CLV_PCSK_SKI1_1	296	300	PF00082	0.430
CLV_PCSK_SKI1_1	406	410	PF00082	0.700
CLV_PCSK_SKI1_1	77	81	PF00082	0.326
CLV_PCSK_SKI1_1	99	103	PF00082	0.333
DEG_APCC_DBOX_1	110	118	PF00400	0.531
DEG_APCC_DBOX_1	171	179	PF00400	0.431
DEG_APCC_DBOX_1	295	303	PF00400	0.222
DEG_APCC_DBOX_1	76	84	PF00400	0.540
DEG_Nend_UBRbox_2	1	3	PF02207	0.713
DOC_CYCLIN_RxL_1	134	145	PF00134	0.379
DOC_CYCLIN_RxL_1	74	84	PF00134	0.538
DOC_MAPK_gen_1	108	117	PF00069	0.542
DOC_MAPK_HePTP_8	131	143	PF00069	0.456
DOC_MAPK_MEF2A_6	134	143	PF00069	0.279
DOC_MAPK_MEF2A_6	254	261	PF00069	0.367
DOC_MAPK_RevD_3	131	147	PF00069	0.401
DOC_PP1_RVXF_1	136	143	PF00149	0.378
DOC_PP1_RVXF_1	25	32	PF00149	0.519
DOC_PP2B_LxvP_1	215	218	PF13499	0.463
DOC_USP7_MATH_1	271	275	PF00917	0.322
DOC_USP7_MATH_1	319	323	PF00917	0.482
DOC_USP7_MATH_1	333	337	PF00917	0.539
DOC_USP7_MATH_1	368	372	PF00917	0.463
DOC_USP7_MATH_1	378	382	PF00917	0.401
DOC_USP7_MATH_1	486	490	PF00917	0.355
DOC_WW_Pin1_4	193	198	PF00397	0.438
DOC_WW_Pin1_4	337	342	PF00397	0.522
LIG_14-3-3_CanoR_1	111	115	PF00244	0.524
LIG_14-3-3_CanoR_1	318	324	PF00244	0.441
LIG_14-3-3_CanoR_1	330	338	PF00244	0.596
LIG_APCC_ABBA_1	505	510	PF00400	0.313
LIG_APCC_ABBAyCdc20_2	236	242	PF00400	0.339
LIG_BRCT_BRCA1_1	439	443	PF00533	0.326
LIG_EH1_1	283	291	PF00400	0.346
LIG_EVH1_1	215	219	PF00568	0.508
LIG_FHA_1	121	127	PF00498	0.307
LIG_FHA_1	207	213	PF00498	0.520
LIG_FHA_1	66	72	PF00498	0.576
LIG_FHA_2	352	358	PF00498	0.402
LIG_FHA_2	367	373	PF00498	0.491
LIG_FHA_2	407	413	PF00498	0.459
LIG_FHA_2	67	73	PF00498	0.603
LIG_LIR_Nem_3	440	446	PF02991	0.329
LIG_NRBOX	139	145	PF00104	0.349
LIG_NRBOX	294	300	PF00104	0.332
LIG_Pex14_1	106	110	PF04695	0.570
LIG_SH2_NCK_1	471	475	PF00017	0.425
LIG_SH2_STAP1	122	126	PF00017	0.335
LIG_SH2_STAP1	450	454	PF00017	0.304
LIG_SH2_STAP1	62	66	PF00017	0.457
LIG_SH2_STAT5	122	125	PF00017	0.328
LIG_SH2_STAT5	37	40	PF00017	0.592
LIG_SH2_STAT5	504	507	PF00017	0.236
LIG_SH3_1	213	219	PF00018	0.466
LIG_SH3_2	344	349	PF14604	0.397
LIG_SH3_3	213	219	PF00018	0.515
LIG_SH3_3	256	262	PF00018	0.381
LIG_SH3_3	313	319	PF00018	0.373
LIG_SH3_3	338	344	PF00018	0.549
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.358
LIG_SUMO_SIM_par_1	125	132	PF11976	0.469
LIG_TRAF2_1	409	412	PF00917	0.419
LIG_TRAF2_1	414	417	PF00917	0.421
LIG_TRAF2_1	494	497	PF00917	0.378
LIG_UBA3_1	130	134	PF00899	0.418
LIG_UBA3_1	179	186	PF00899	0.545
MOD_CDC14_SPxK_1	340	343	PF00782	0.492
MOD_CDK_SPxK_1	337	343	PF00069	0.500
MOD_CK1_1	129	135	PF00069	0.475
MOD_CK1_1	322	328	PF00069	0.572
MOD_CK1_1	331	337	PF00069	0.686
MOD_CK1_1	367	373	PF00069	0.582
MOD_CK1_1	65	71	PF00069	0.509
MOD_CK2_1	142	148	PF00069	0.512
MOD_CK2_1	242	248	PF00069	0.501
MOD_CK2_1	366	372	PF00069	0.650
MOD_CK2_1	406	412	PF00069	0.513
MOD_CK2_1	439	445	PF00069	0.373
MOD_CK2_1	66	72	PF00069	0.508
MOD_Cter_Amidation	169	172	PF01082	0.555
MOD_GlcNHglycan	148	151	PF01048	0.564
MOD_GlcNHglycan	156	159	PF01048	0.532
MOD_GlcNHglycan	160	163	PF01048	0.457
MOD_GlcNHglycan	273	276	PF01048	0.423
MOD_GlcNHglycan	286	289	PF01048	0.388
MOD_GlcNHglycan	330	333	PF01048	0.670
MOD_GlcNHglycan	365	369	PF01048	0.651
MOD_GlcNHglycan	380	383	PF01048	0.530
MOD_GlcNHglycan	439	442	PF01048	0.453
MOD_GlcNHglycan	63	67	PF01048	0.306
MOD_GSK3_1	113	120	PF00069	0.308
MOD_GSK3_1	122	129	PF00069	0.249
MOD_GSK3_1	142	149	PF00069	0.265
MOD_GSK3_1	150	157	PF00069	0.477
MOD_GSK3_1	189	196	PF00069	0.599
MOD_GSK3_1	324	331	PF00069	0.666
MOD_GSK3_1	332	339	PF00069	0.614
MOD_GSK3_1	364	371	PF00069	0.628
MOD_GSK3_1	38	45	PF00069	0.492
MOD_GSK3_1	435	442	PF00069	0.452
MOD_GSK3_1	463	470	PF00069	0.441
MOD_GSK3_1	509	516	PF00069	0.344
MOD_GSK3_1	62	69	PF00069	0.464
MOD_NEK2_1	110	115	PF00069	0.272
MOD_NEK2_1	126	131	PF00069	0.275
MOD_NEK2_1	142	147	PF00069	0.375
MOD_NEK2_1	152	157	PF00069	0.631
MOD_NEK2_1	179	184	PF00069	0.546
MOD_NEK2_1	284	289	PF00069	0.350
MOD_NEK2_1	437	442	PF00069	0.396
MOD_NEK2_1	446	451	PF00069	0.365
MOD_NEK2_1	454	459	PF00069	0.379
MOD_NEK2_2	486	491	PF00069	0.457
MOD_NEK2_2	509	514	PF00069	0.333
MOD_PIKK_1	189	195	PF00454	0.640
MOD_PIKK_1	242	248	PF00454	0.639
MOD_PIKK_1	454	460	PF00454	0.270
MOD_PKA_1	146	152	PF00069	0.489
MOD_PKA_2	110	116	PF00069	0.368
MOD_PKA_2	146	152	PF00069	0.612
MOD_PKA_2	240	246	PF00069	0.382
MOD_PKA_2	513	519	PF00069	0.381
MOD_Plk_1	13	19	PF00069	0.545
MOD_Plk_1	463	469	PF00069	0.391
MOD_Plk_1	509	515	PF00069	0.352
MOD_Plk_1	62	68	PF00069	0.453
MOD_Plk_4	110	116	PF00069	0.307
MOD_Plk_4	179	185	PF00069	0.487
MOD_Plk_4	319	325	PF00069	0.595
MOD_Plk_4	333	339	PF00069	0.502
MOD_Plk_4	380	386	PF00069	0.699
MOD_ProDKin_1	193	199	PF00069	0.551
MOD_ProDKin_1	337	343	PF00069	0.668
MOD_SUMO_rev_2	496	503	PF00179	0.493
MOD_SUMO_rev_2	95	103	PF00179	0.441
TRG_DiLeu_BaEn_1	356	361	PF01217	0.718
TRG_DiLeu_BaEn_1	380	385	PF01217	0.483
TRG_ENDOCYTIC_2	504	507	PF00928	0.344
TRG_ER_diArg_1	420	422	PF00400	0.464
TRG_NES_CRM1_1	7	19	PF08389	0.405
TRG_Pf-PMV_PEXEL_1	296	301	PF00026	0.254
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL78	Leptomonas seymouri	68%	99%
A0A1X0P397	Trypanosomatidae	35%	100%
A0A3Q8IW98	Leishmania donovani	82%	99%
A0A3R7KTQ7	Trypanosoma rangeli	32%	100%
A4ICZ4	Leishmania infantum	83%	99%
D0A8N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ATI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q4Q114	Leishmania major	82%	100%
V5B6V7	Trypanosoma cruzi	34%	100%