Rieske domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPR8_LEIBR

TriTrypDb:

LbrM.35.4240 , LBRM2903_350052900

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPR8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	30	34	PF00082	0.358
DEG_Kelch_Keap1_1	84	89	PF01344	0.426
DOC_CYCLIN_yCln2_LP_2	25	31	PF00134	0.441
DOC_USP7_MATH_1	164	168	PF00917	0.433
DOC_USP7_MATH_1	40	44	PF00917	0.549
DOC_WW_Pin1_4	48	53	PF00397	0.360
LIG_14-3-3_CanoR_1	30	35	PF00244	0.360
LIG_Clathr_ClatBox_1	82	86	PF01394	0.369
LIG_Clathr_ClatBox_1	92	96	PF01394	0.481
LIG_CtBP_PxDLS_1	116	120	PF00389	0.473
LIG_eIF4E_1	31	37	PF01652	0.473
LIG_FHA_1	145	151	PF00498	0.481
LIG_FHA_1	31	37	PF00498	0.372
LIG_IRF3_LxIS_1	32	38	PF10401	0.514
LIG_LIR_Nem_3	10	14	PF02991	0.430
LIG_LIR_Nem_3	26	32	PF02991	0.332
LIG_LYPXL_SIV_4	28	36	PF13949	0.438
LIG_PDZ_Class_3	189	194	PF00595	0.629
LIG_SH2_CRK	29	33	PF00017	0.411
LIG_SH2_PTP2	31	34	PF00017	0.432
LIG_SH2_STAT5	31	34	PF00017	0.432
LIG_SH2_STAT5	81	84	PF00017	0.438
LIG_SH3_3	110	116	PF00018	0.577
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.459
LIG_SUMO_SIM_par_1	147	153	PF11976	0.413
LIG_SUMO_SIM_par_1	32	38	PF11976	0.459
LIG_SUMO_SIM_par_1	64	70	PF11976	0.469
LIG_UBA3_1	183	187	PF00899	0.568
MOD_GlcNHglycan	121	125	PF01048	0.573
MOD_GlcNHglycan	175	178	PF01048	0.390
MOD_GSK3_1	144	151	PF00069	0.453
MOD_NEK2_1	35	40	PF00069	0.513
MOD_Plk_2-3	7	13	PF00069	0.446
MOD_Plk_4	30	36	PF00069	0.379
MOD_ProDKin_1	48	54	PF00069	0.361
TRG_DiLeu_BaEn_1	67	72	PF01217	0.564
TRG_DiLeu_BaEn_3	144	150	PF01217	0.530
TRG_ENDOCYTIC_2	11	14	PF00928	0.433
TRG_ENDOCYTIC_2	29	32	PF00928	0.257
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7H7	Leptomonas seymouri	72%	100%
A0A0S4IXL7	Bodo saltans	41%	97%
A0A1X0P3Z4	Trypanosomatidae	49%	90%
A0A3Q8IJQ0	Leishmania donovani	89%	100%
A0A422NVN8	Trypanosoma rangeli	53%	100%
A4ICZ5	Leishmania infantum	89%	100%
D0A8N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	93%
E9ATI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q115	Leishmania major	88%	100%