Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HPR4_LEIBR

TriTrypDb:

LbrM.35.4200 , LBRM2903_350052200

Length:

1016

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.596
CLV_C14_Caspase3-7	461	465	PF00656	0.582
CLV_C14_Caspase3-7	611	615	PF00656	0.535
CLV_MEL_PAP_1	931	937	PF00089	0.592
CLV_NRD_NRD_1	1003	1005	PF00675	0.825
CLV_NRD_NRD_1	190	192	PF00675	0.602
CLV_NRD_NRD_1	357	359	PF00675	0.846
CLV_NRD_NRD_1	407	409	PF00675	0.575
CLV_NRD_NRD_1	538	540	PF00675	0.815
CLV_NRD_NRD_1	769	771	PF00675	0.575
CLV_NRD_NRD_1	873	875	PF00675	0.604
CLV_NRD_NRD_1	933	935	PF00675	0.739
CLV_PCSK_FUR_1	229	233	PF00082	0.708
CLV_PCSK_FUR_1	536	540	PF00082	0.800
CLV_PCSK_KEX2_1	1003	1005	PF00082	0.825
CLV_PCSK_KEX2_1	190	192	PF00082	0.602
CLV_PCSK_KEX2_1	231	233	PF00082	0.714
CLV_PCSK_KEX2_1	357	359	PF00082	0.846
CLV_PCSK_KEX2_1	361	363	PF00082	0.786
CLV_PCSK_KEX2_1	508	510	PF00082	0.737
CLV_PCSK_KEX2_1	538	540	PF00082	0.791
CLV_PCSK_KEX2_1	769	771	PF00082	0.575
CLV_PCSK_KEX2_1	873	875	PF00082	0.629
CLV_PCSK_KEX2_1	891	893	PF00082	0.704
CLV_PCSK_KEX2_1	932	934	PF00082	0.742
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.714
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.852
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.675
CLV_PCSK_PC1ET2_1	891	893	PF00082	0.774
CLV_PCSK_PC7_1	357	363	PF00082	0.848
CLV_PCSK_PC7_1	999	1005	PF00082	0.813
CLV_PCSK_SKI1_1	154	158	PF00082	0.565
CLV_PCSK_SKI1_1	191	195	PF00082	0.595
CLV_PCSK_SKI1_1	796	800	PF00082	0.754
CLV_PCSK_SKI1_1	874	878	PF00082	0.591
DEG_SCF_FBW7_1	162	169	PF00400	0.572
DEG_SCF_FBW7_2	345	351	PF00400	0.590
DEG_SPOP_SBC_1	335	339	PF00917	0.584
DOC_CKS1_1	345	350	PF01111	0.576
DOC_CKS1_1	430	435	PF01111	0.597
DOC_CYCLIN_RxL_1	793	802	PF00134	0.749
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.694
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	788	794	PF00134	0.528
DOC_MAPK_FxFP_2	530	533	PF00069	0.582
DOC_MAPK_HePTP_8	245	257	PF00069	0.710
DOC_MAPK_MEF2A_6	248	257	PF00069	0.720
DOC_MAPK_MEF2A_6	749	757	PF00069	0.557
DOC_PP2B_LxvP_1	139	142	PF13499	0.779
DOC_PP4_FxxP_1	503	506	PF00568	0.590
DOC_PP4_FxxP_1	530	533	PF00568	0.835
DOC_PP4_FxxP_1	580	583	PF00568	0.762
DOC_PP4_MxPP_1	858	861	PF00568	0.578
DOC_USP7_MATH_1	131	135	PF00917	0.805
DOC_USP7_MATH_1	184	188	PF00917	0.838
DOC_USP7_MATH_1	394	398	PF00917	0.577
DOC_USP7_MATH_1	41	45	PF00917	0.801
DOC_USP7_MATH_1	417	421	PF00917	0.824
DOC_USP7_MATH_1	485	489	PF00917	0.716
DOC_USP7_MATH_1	523	527	PF00917	0.661
DOC_USP7_MATH_1	679	683	PF00917	0.724
DOC_USP7_MATH_1	722	726	PF00917	0.709
DOC_USP7_MATH_1	91	95	PF00917	0.804
DOC_USP7_MATH_1	96	100	PF00917	0.822
DOC_USP7_MATH_1	961	965	PF00917	0.846
DOC_WW_Pin1_4	162	167	PF00397	0.638
DOC_WW_Pin1_4	20	25	PF00397	0.856
DOC_WW_Pin1_4	339	344	PF00397	0.684
DOC_WW_Pin1_4	423	428	PF00397	0.656
DOC_WW_Pin1_4	429	434	PF00397	0.652
DOC_WW_Pin1_4	452	457	PF00397	0.709
DOC_WW_Pin1_4	540	545	PF00397	0.559
DOC_WW_Pin1_4	564	569	PF00397	0.795
DOC_WW_Pin1_4	596	601	PF00397	0.633
DOC_WW_Pin1_4	85	90	PF00397	0.601
DOC_WW_Pin1_4	867	872	PF00397	0.700
DOC_WW_Pin1_4	923	928	PF00397	0.834
LIG_14-3-3_CanoR_1	190	196	PF00244	0.671
LIG_14-3-3_CanoR_1	364	370	PF00244	0.761
LIG_14-3-3_CanoR_1	524	530	PF00244	0.652
LIG_14-3-3_CanoR_1	536	542	PF00244	0.687
LIG_14-3-3_CanoR_1	57	62	PF00244	0.794
LIG_14-3-3_CanoR_1	698	702	PF00244	0.740
LIG_14-3-3_CanoR_1	708	712	PF00244	0.743
LIG_14-3-3_CanoR_1	769	775	PF00244	0.574
LIG_BIR_III_4	982	986	PF00653	0.791
LIG_BRCT_BRCA1_1	526	530	PF00533	0.841
LIG_BRCT_BRCA1_1	641	645	PF00533	0.735
LIG_FHA_1	162	168	PF00498	0.572
LIG_FHA_1	187	193	PF00498	0.652
LIG_FHA_1	247	253	PF00498	0.606
LIG_FHA_1	297	303	PF00498	0.651
LIG_FHA_1	313	319	PF00498	0.581
LIG_FHA_1	340	346	PF00498	0.587
LIG_FHA_1	373	379	PF00498	0.831
LIG_FHA_1	41	47	PF00498	0.711
LIG_FHA_1	429	435	PF00498	0.578
LIG_FHA_1	452	458	PF00498	0.710
LIG_FHA_1	465	471	PF00498	0.648
LIG_FHA_1	636	642	PF00498	0.612
LIG_FHA_1	656	662	PF00498	0.783
LIG_FHA_1	90	96	PF00498	0.663
LIG_FHA_1	905	911	PF00498	0.777
LIG_FHA_1	926	932	PF00498	0.575
LIG_FHA_2	163	169	PF00498	0.573
LIG_FHA_2	437	443	PF00498	0.588
LIG_FHA_2	597	603	PF00498	0.572
LIG_FHA_2	711	717	PF00498	0.727
LIG_FHA_2	769	775	PF00498	0.826
LIG_FHA_2	988	994	PF00498	0.636
LIG_HCF-1_HBM_1	847	850	PF13415	0.810
LIG_Integrin_RGD_1	402	404	PF01839	0.603
LIG_Integrin_RGD_1	729	731	PF01839	0.718
LIG_Integrin_RGD_1	952	954	PF01839	0.604
LIG_LIR_Apic_2	411	417	PF02991	0.670
LIG_LIR_Apic_2	527	533	PF02991	0.835
LIG_LIR_Apic_2	577	583	PF02991	0.773
LIG_LIR_Gen_1	642	653	PF02991	0.761
LIG_LIR_Nem_3	614	619	PF02991	0.536
LIG_LIR_Nem_3	884	890	PF02991	0.787
LIG_MYND_1	413	417	PF01753	0.569
LIG_Pex14_2	580	584	PF04695	0.517
LIG_SH2_CRK	6	10	PF00017	0.591
LIG_SH2_CRK	653	657	PF00017	0.538
LIG_SH2_CRK	890	894	PF00017	0.519
LIG_SH2_NCK_1	653	657	PF00017	0.538
LIG_SH2_STAT5	294	297	PF00017	0.544
LIG_SH2_STAT5	414	417	PF00017	0.576
LIG_SH2_STAT5	653	656	PF00017	0.536
LIG_SH2_STAT5	831	834	PF00017	0.820
LIG_SH2_STAT5	856	859	PF00017	0.832
LIG_SH2_STAT5	994	997	PF00017	0.628
LIG_SH3_1	969	975	PF00018	0.595
LIG_SH3_2	791	796	PF14604	0.756
LIG_SH3_3	139	145	PF00018	0.709
LIG_SH3_3	210	216	PF00018	0.759
LIG_SH3_3	487	493	PF00018	0.852
LIG_SH3_3	562	568	PF00018	0.606
LIG_SH3_3	658	664	PF00018	0.700
LIG_SH3_3	788	794	PF00018	0.781
LIG_SH3_3	854	860	PF00018	0.575
LIG_SH3_3	95	101	PF00018	0.600
LIG_SH3_3	969	975	PF00018	0.842
LIG_SUMO_SIM_anti_2	601	607	PF11976	0.578
LIG_SUMO_SIM_par_1	389	395	PF11976	0.558
LIG_SUMO_SIM_par_1	905	912	PF11976	0.570
LIG_TRAF2_1	319	322	PF00917	0.844
LIG_TRAF2_1	599	602	PF00917	0.824
LIG_TRAF2_1	816	819	PF00917	0.652
LIG_UBA3_1	415	419	PF00899	0.577
LIG_WW_3	793	797	PF00397	0.751
MOD_CDK_SPxK_1	867	873	PF00069	0.831
MOD_CDK_SPxxK_3	867	874	PF00069	0.581
MOD_CK1_1	14	20	PF00069	0.851
MOD_CK1_1	149	155	PF00069	0.766
MOD_CK1_1	160	166	PF00069	0.689
MOD_CK1_1	185	191	PF00069	0.688
MOD_CK1_1	271	277	PF00069	0.798
MOD_CK1_1	306	312	PF00069	0.789
MOD_CK1_1	365	371	PF00069	0.716
MOD_CK1_1	374	380	PF00069	0.755
MOD_CK1_1	386	392	PF00069	0.744
MOD_CK1_1	39	45	PF00069	0.577
MOD_CK1_1	421	427	PF00069	0.811
MOD_CK1_1	504	510	PF00069	0.705
MOD_CK1_1	555	561	PF00069	0.823
MOD_CK1_1	627	633	PF00069	0.557
MOD_CK1_1	63	69	PF00069	0.800
MOD_CK1_1	680	686	PF00069	0.694
MOD_CK1_1	710	716	PF00069	0.688
MOD_CK1_1	965	971	PF00069	0.736
MOD_CK1_1	99	105	PF00069	0.826
MOD_CK2_1	389	395	PF00069	0.810
MOD_CK2_1	447	453	PF00069	0.699
MOD_CK2_1	456	462	PF00069	0.795
MOD_CK2_1	596	602	PF00069	0.571
MOD_CK2_1	710	716	PF00069	0.727
MOD_CK2_1	740	746	PF00069	0.725
MOD_Cter_Amidation	358	361	PF01082	0.596
MOD_GlcNHglycan	110	113	PF01048	0.724
MOD_GlcNHglycan	133	136	PF01048	0.666
MOD_GlcNHglycan	16	19	PF01048	0.851
MOD_GlcNHglycan	270	273	PF01048	0.640
MOD_GlcNHglycan	275	279	PF01048	0.537
MOD_GlcNHglycan	305	308	PF01048	0.685
MOD_GlcNHglycan	385	388	PF01048	0.599
MOD_GlcNHglycan	395	399	PF01048	0.631
MOD_GlcNHglycan	470	473	PF01048	0.817
MOD_GlcNHglycan	503	506	PF01048	0.670
MOD_GlcNHglycan	554	557	PF01048	0.771
MOD_GlcNHglycan	589	592	PF01048	0.797
MOD_GlcNHglycan	594	597	PF01048	0.729
MOD_GlcNHglycan	622	625	PF01048	0.762
MOD_GlcNHglycan	66	69	PF01048	0.757
MOD_GlcNHglycan	679	682	PF01048	0.746
MOD_GlcNHglycan	689	692	PF01048	0.645
MOD_GlcNHglycan	724	727	PF01048	0.571
MOD_GlcNHglycan	801	804	PF01048	0.749
MOD_GlcNHglycan	81	84	PF01048	0.701
MOD_GlcNHglycan	839	842	PF01048	0.800
MOD_GlcNHglycan	911	914	PF01048	0.706
MOD_GlcNHglycan	965	968	PF01048	0.631
MOD_GSK3_1	146	153	PF00069	0.775
MOD_GSK3_1	157	164	PF00069	0.677
MOD_GSK3_1	178	185	PF00069	0.787
MOD_GSK3_1	191	198	PF00069	0.557
MOD_GSK3_1	253	260	PF00069	0.598
MOD_GSK3_1	335	342	PF00069	0.642
MOD_GSK3_1	36	43	PF00069	0.582
MOD_GSK3_1	360	367	PF00069	0.740
MOD_GSK3_1	374	381	PF00069	0.713
MOD_GSK3_1	417	424	PF00069	0.661
MOD_GSK3_1	434	441	PF00069	0.610
MOD_GSK3_1	447	454	PF00069	0.660
MOD_GSK3_1	464	471	PF00069	0.526
MOD_GSK3_1	511	518	PF00069	0.666
MOD_GSK3_1	574	581	PF00069	0.793
MOD_GSK3_1	592	599	PF00069	0.553
MOD_GSK3_1	60	67	PF00069	0.821
MOD_GSK3_1	620	627	PF00069	0.769
MOD_GSK3_1	635	642	PF00069	0.644
MOD_GSK3_1	651	658	PF00069	0.684
MOD_GSK3_1	673	680	PF00069	0.597
MOD_GSK3_1	706	713	PF00069	0.744
MOD_GSK3_1	848	855	PF00069	0.799
MOD_GSK3_1	85	92	PF00069	0.719
MOD_GSK3_1	96	103	PF00069	0.790
MOD_GSK3_1	961	968	PF00069	0.848
MOD_N-GLC_1	14	19	PF02516	0.694
MOD_N-GLC_1	281	286	PF02516	0.657
MOD_N-GLC_1	421	426	PF02516	0.793
MOD_N-GLC_1	609	614	PF02516	0.543
MOD_N-GLC_1	63	68	PF02516	0.596
MOD_NEK2_1	150	155	PF00069	0.817
MOD_NEK2_1	161	166	PF00069	0.638
MOD_NEK2_1	286	291	PF00069	0.533
MOD_NEK2_1	303	308	PF00069	0.606
MOD_NEK2_1	418	423	PF00069	0.556
MOD_NEK2_1	451	456	PF00069	0.835
MOD_NEK2_1	511	516	PF00069	0.601
MOD_NEK2_1	594	599	PF00069	0.738
MOD_NEK2_1	635	640	PF00069	0.731
MOD_NEK2_1	687	692	PF00069	0.761
MOD_NEK2_1	715	720	PF00069	0.694
MOD_NEK2_2	525	530	PF00069	0.588
MOD_PIKK_1	286	292	PF00454	0.440
MOD_PIKK_1	408	414	PF00454	0.828
MOD_PIKK_1	464	470	PF00454	0.728
MOD_PKA_1	360	366	PF00069	0.605
MOD_PKA_1	408	414	PF00069	0.799
MOD_PKA_2	260	266	PF00069	0.692
MOD_PKA_2	365	371	PF00069	0.782
MOD_PKA_2	523	529	PF00069	0.713
MOD_PKA_2	537	543	PF00069	0.694
MOD_PKA_2	697	703	PF00069	0.742
MOD_PKA_2	707	713	PF00069	0.742
MOD_PKA_2	768	774	PF00069	0.576
MOD_PKA_2	852	858	PF00069	0.826
MOD_PKA_2	998	1004	PF00069	0.810
MOD_PKB_1	362	370	PF00069	0.743
MOD_PKB_1	55	63	PF00069	0.644
MOD_PKB_1	704	712	PF00069	0.703
MOD_Plk_1	274	280	PF00069	0.508
MOD_Plk_1	421	427	PF00069	0.827
MOD_Plk_1	628	634	PF00069	0.734
MOD_Plk_1	706	712	PF00069	0.746
MOD_Plk_1	715	721	PF00069	0.569
MOD_Plk_1	846	852	PF00069	0.809
MOD_Plk_1	904	910	PF00069	0.672
MOD_Plk_4	157	163	PF00069	0.605
MOD_Plk_4	260	266	PF00069	0.528
MOD_Plk_4	281	287	PF00069	0.579
MOD_Plk_4	374	380	PF00069	0.576
MOD_Plk_4	386	392	PF00069	0.506
MOD_Plk_4	41	47	PF00069	0.572
MOD_Plk_4	447	453	PF00069	0.825
MOD_Plk_4	525	531	PF00069	0.839
MOD_Plk_4	680	686	PF00069	0.575
MOD_Plk_4	852	858	PF00069	0.772
MOD_ProDKin_1	162	168	PF00069	0.639
MOD_ProDKin_1	20	26	PF00069	0.852
MOD_ProDKin_1	339	345	PF00069	0.684
MOD_ProDKin_1	423	429	PF00069	0.655
MOD_ProDKin_1	452	458	PF00069	0.712
MOD_ProDKin_1	540	546	PF00069	0.559
MOD_ProDKin_1	564	570	PF00069	0.794
MOD_ProDKin_1	596	602	PF00069	0.633
MOD_ProDKin_1	85	91	PF00069	0.602
MOD_ProDKin_1	867	873	PF00069	0.705
MOD_ProDKin_1	923	929	PF00069	0.834
MOD_SUMO_for_1	445	448	PF00179	0.687
MOD_SUMO_rev_2	437	445	PF00179	0.704
MOD_SUMO_rev_2	668	676	PF00179	0.594
MOD_SUMO_rev_2	954	961	PF00179	0.810
TRG_DiLeu_BaEn_1	601	606	PF01217	0.579
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.667
TRG_ENDOCYTIC_2	616	619	PF00928	0.539
TRG_ENDOCYTIC_2	750	753	PF00928	0.704
TRG_ENDOCYTIC_2	890	893	PF00928	0.779
TRG_ER_diArg_1	1002	1004	PF00400	0.743
TRG_ER_diArg_1	190	192	PF00400	0.602
TRG_ER_diArg_1	535	538	PF00400	0.815
TRG_ER_diArg_1	55	58	PF00400	0.851
TRG_ER_diArg_1	873	875	PF00400	0.604
TRG_ER_diArg_1	931	934	PF00400	0.739
TRG_NLS_MonoExtC_3	359	364	PF00514	0.756
TRG_NLS_MonoExtN_4	357	364	PF00514	0.846
TRG_Pf-PMV_PEXEL_1	804	808	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	873	878	PF00026	0.847

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIW4	Leishmania donovani	67%	100%
A4ID00	Leishmania infantum	66%	100%
E9ATH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q119	Leishmania major	67%	100%