Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HPR2_LEIBR

TriTrypDb:

LbrM.35.4180 , LBRM2903_350052000

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	588	592	PF00656	0.730
CLV_C14_Caspase3-7	728	732	PF00656	0.588
CLV_NRD_NRD_1	125	127	PF00675	0.820
CLV_NRD_NRD_1	421	423	PF00675	0.776
CLV_NRD_NRD_1	531	533	PF00675	0.738
CLV_NRD_NRD_1	567	569	PF00675	0.779
CLV_NRD_NRD_1	677	679	PF00675	0.811
CLV_NRD_NRD_1	701	703	PF00675	0.552
CLV_PCSK_KEX2_1	125	127	PF00082	0.820
CLV_PCSK_KEX2_1	360	362	PF00082	0.590
CLV_PCSK_KEX2_1	421	423	PF00082	0.776
CLV_PCSK_KEX2_1	561	563	PF00082	0.868
CLV_PCSK_KEX2_1	677	679	PF00082	0.811
CLV_PCSK_KEX2_1	701	703	PF00082	0.552
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.559
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.615
CLV_PCSK_SKI1_1	125	129	PF00082	0.671
CLV_PCSK_SKI1_1	151	155	PF00082	0.819
CLV_PCSK_SKI1_1	438	442	PF00082	0.571
CLV_PCSK_SKI1_1	476	480	PF00082	0.571
CLV_PCSK_SKI1_1	678	682	PF00082	0.807
CLV_PCSK_SKI1_1	787	791	PF00082	0.457
CLV_PCSK_SKI1_1	844	848	PF00082	0.719
DEG_APCC_DBOX_1	150	158	PF00400	0.662
DEG_APCC_DBOX_1	786	794	PF00400	0.713
DEG_SPOP_SBC_1	486	490	PF00917	0.569
DEG_SPOP_SBC_1	56	60	PF00917	0.550
DEG_SPOP_SBC_1	816	820	PF00917	0.602
DOC_CYCLIN_RxL_1	148	156	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	396	402	PF00134	0.557
DOC_MAPK_gen_1	125	131	PF00069	0.818
DOC_MAPK_gen_1	360	368	PF00069	0.566
DOC_MAPK_MEF2A_6	360	368	PF00069	0.566
DOC_MAPK_MEF2A_6	787	794	PF00069	0.462
DOC_MAPK_NFAT4_5	361	369	PF00069	0.566
DOC_MAPK_NFAT4_5	787	795	PF00069	0.465
DOC_PP2B_LxvP_1	152	155	PF13499	0.701
DOC_PP2B_LxvP_1	761	764	PF13499	0.677
DOC_PP2B_LxvP_1	846	849	PF13499	0.717
DOC_PP4_FxxP_1	31	34	PF00568	0.564
DOC_PP4_FxxP_1	794	797	PF00568	0.725
DOC_USP7_MATH_1	143	147	PF00917	0.833
DOC_USP7_MATH_1	22	26	PF00917	0.813
DOC_USP7_MATH_1	247	251	PF00917	0.765
DOC_USP7_MATH_1	323	327	PF00917	0.769
DOC_USP7_MATH_1	44	48	PF00917	0.599
DOC_USP7_MATH_1	458	462	PF00917	0.529
DOC_USP7_MATH_1	486	490	PF00917	0.810
DOC_USP7_MATH_1	560	564	PF00917	0.748
DOC_USP7_MATH_1	567	571	PF00917	0.680
DOC_USP7_MATH_1	583	587	PF00917	0.774
DOC_USP7_UBL2_3	438	442	PF12436	0.571
DOC_USP7_UBL2_3	557	561	PF12436	0.597
DOC_WW_Pin1_4	197	202	PF00397	0.573
DOC_WW_Pin1_4	245	250	PF00397	0.632
DOC_WW_Pin1_4	337	342	PF00397	0.722
DOC_WW_Pin1_4	345	350	PF00397	0.775
DOC_WW_Pin1_4	366	371	PF00397	0.817
DOC_WW_Pin1_4	379	384	PF00397	0.622
DOC_WW_Pin1_4	385	390	PF00397	0.532
DOC_WW_Pin1_4	395	400	PF00397	0.744
DOC_WW_Pin1_4	440	445	PF00397	0.564
DOC_WW_Pin1_4	497	502	PF00397	0.803
DOC_WW_Pin1_4	555	560	PF00397	0.841
DOC_WW_Pin1_4	563	568	PF00397	0.725
DOC_WW_Pin1_4	641	646	PF00397	0.840
DOC_WW_Pin1_4	680	685	PF00397	0.814
DOC_WW_Pin1_4	76	81	PF00397	0.551
LIG_14-3-3_CanoR_1	125	130	PF00244	0.819
LIG_14-3-3_CanoR_1	177	185	PF00244	0.619
LIG_14-3-3_CanoR_1	26	35	PF00244	0.704
LIG_14-3-3_CanoR_1	265	269	PF00244	0.811
LIG_14-3-3_CanoR_1	539	547	PF00244	0.529
LIG_14-3-3_CanoR_1	650	655	PF00244	0.570
LIG_14-3-3_CanoR_1	677	685	PF00244	0.822
LIG_14-3-3_CanoR_1	736	742	PF00244	0.810
LIG_14-3-3_CanoR_1	760	764	PF00244	0.561
LIG_14-3-3_CanoR_1	773	781	PF00244	0.502
LIG_14-3-3_CanoR_1	83	90	PF00244	0.618
LIG_APCC_ABBA_1	431	436	PF00400	0.558
LIG_BIR_II_1	1	5	PF00653	0.787
LIG_BRCT_BRCA1_1	116	120	PF00533	0.707
LIG_BRCT_BRCA1_1	403	407	PF00533	0.699
LIG_BRCT_BRCA1_1	593	597	PF00533	0.812
LIG_CtBP_PxDLS_1	402	406	PF00389	0.554
LIG_CtBP_PxDLS_1	408	412	PF00389	0.527
LIG_DLG_GKlike_1	702	709	PF00625	0.554
LIG_EVH1_2	848	852	PF00568	0.731
LIG_FHA_1	130	136	PF00498	0.561
LIG_FHA_1	229	235	PF00498	0.589
LIG_FHA_1	281	287	PF00498	0.631
LIG_FHA_1	289	295	PF00498	0.633
LIG_FHA_1	308	314	PF00498	0.748
LIG_FHA_1	34	40	PF00498	0.811
LIG_FHA_1	388	394	PF00498	0.675
LIG_FHA_1	44	50	PF00498	0.641
LIG_FHA_1	585	591	PF00498	0.578
LIG_FHA_1	715	721	PF00498	0.703
LIG_FHA_1	776	782	PF00498	0.792
LIG_FHA_2	142	148	PF00498	0.832
LIG_FHA_2	162	168	PF00498	0.491
LIG_FHA_2	225	231	PF00498	0.814
LIG_FHA_2	57	63	PF00498	0.620
LIG_FHA_2	7	13	PF00498	0.752
LIG_FHA_2	726	732	PF00498	0.567
LIG_FHA_2	852	858	PF00498	0.675
LIG_LIR_Apic_2	29	34	PF02991	0.566
LIG_LIR_Apic_2	577	583	PF02991	0.592
LIG_LIR_Gen_1	117	127	PF02991	0.684
LIG_LIR_Gen_1	477	487	PF02991	0.566
LIG_LIR_Gen_1	531	542	PF02991	0.511
LIG_LIR_Gen_1	594	603	PF02991	0.551
LIG_LIR_Gen_1	613	623	PF02991	0.472
LIG_LIR_Gen_1	691	700	PF02991	0.550
LIG_LIR_Gen_1	755	764	PF02991	0.554
LIG_LIR_Gen_1	788	798	PF02991	0.470
LIG_LIR_Gen_1	854	862	PF02991	0.660
LIG_LIR_Nem_3	147	153	PF02991	0.564
LIG_LIR_Nem_3	477	482	PF02991	0.570
LIG_LIR_Nem_3	531	537	PF02991	0.503
LIG_LIR_Nem_3	594	600	PF02991	0.554
LIG_LIR_Nem_3	613	619	PF02991	0.470
LIG_LIR_Nem_3	653	657	PF02991	0.780
LIG_LIR_Nem_3	691	697	PF02991	0.553
LIG_LIR_Nem_3	700	706	PF02991	0.528
LIG_LIR_Nem_3	755	761	PF02991	0.552
LIG_LIR_Nem_3	788	794	PF02991	0.713
LIG_LIR_Nem_3	838	843	PF02991	0.720
LIG_LIR_Nem_3	854	858	PF02991	0.409
LIG_LIR_Nem_3	860	864	PF02991	0.553
LIG_LYPXL_yS_3	7	10	PF13949	0.500
LIG_NRBOX	308	314	PF00104	0.569
LIG_NRBOX	830	836	PF00104	0.686
LIG_NRP_CendR_1	868	871	PF00754	0.741
LIG_PCNA_yPIPBox_3	520	533	PF02747	0.652
LIG_Pex14_2	515	519	PF04695	0.692
LIG_PTAP_UEV_1	482	487	PF05743	0.659
LIG_PTB_Apo_2	705	712	PF02174	0.552
LIG_SH2_CRK	534	538	PF00017	0.766
LIG_SH2_CRK	758	762	PF00017	0.556
LIG_SH2_CRK	843	847	PF00017	0.707
LIG_SH2_GRB2like	290	293	PF00017	0.561
LIG_SH2_SRC	609	612	PF00017	0.539
LIG_SH2_STAP1	290	294	PF00017	0.719
LIG_SH2_STAP1	625	629	PF00017	0.565
LIG_SH2_STAT5	219	222	PF00017	0.561
LIG_SH2_STAT5	290	293	PF00017	0.717
LIG_SH2_STAT5	336	339	PF00017	0.564
LIG_SH2_STAT5	38	41	PF00017	0.555
LIG_SH2_STAT5	609	612	PF00017	0.539
LIG_SH2_STAT5	73	76	PF00017	0.534
LIG_SH2_STAT5	791	794	PF00017	0.465
LIG_SH2_STAT5	840	843	PF00017	0.713
LIG_SH3_3	246	252	PF00018	0.633
LIG_SH3_3	322	328	PF00018	0.804
LIG_SH3_3	343	349	PF00018	0.598
LIG_SH3_3	396	402	PF00018	0.728
LIG_SH3_3	422	428	PF00018	0.557
LIG_SH3_3	480	486	PF00018	0.697
LIG_SUMO_SIM_anti_2	271	276	PF11976	0.559
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.545
LIG_SUMO_SIM_anti_2	829	836	PF11976	0.437
LIG_SUMO_SIM_anti_2	860	866	PF11976	0.653
LIG_SUMO_SIM_par_1	401	406	PF11976	0.553
LIG_SUMO_SIM_par_1	9	15	PF11976	0.625
LIG_TYR_ITIM	841	846	PF00017	0.714
LIG_WRC_WIRS_1	852	857	PF05994	0.683
MOD_CDC14_SPxK_1	558	561	PF00782	0.849
MOD_CDC14_SPxK_1	566	569	PF00782	0.722
MOD_CDK_SPK_2	197	202	PF00069	0.571
MOD_CDK_SPK_2	563	568	PF00069	0.604
MOD_CDK_SPxK_1	555	561	PF00069	0.845
MOD_CDK_SPxK_1	563	569	PF00069	0.726
MOD_CDK_SPxxK_3	555	562	PF00069	0.849
MOD_CDK_SPxxK_3	76	83	PF00069	0.544
MOD_CK1_1	104	110	PF00069	0.586
MOD_CK1_1	161	167	PF00069	0.576
MOD_CK1_1	176	182	PF00069	0.558
MOD_CK1_1	222	228	PF00069	0.552
MOD_CK1_1	245	251	PF00069	0.592
MOD_CK1_1	307	313	PF00069	0.644
MOD_CK1_1	382	388	PF00069	0.688
MOD_CK1_1	398	404	PF00069	0.619
MOD_CK1_1	410	416	PF00069	0.653
MOD_CK1_1	443	449	PF00069	0.556
MOD_CK1_1	507	513	PF00069	0.604
MOD_CK1_1	55	61	PF00069	0.776
MOD_CK1_1	563	569	PF00069	0.605
MOD_CK1_1	630	636	PF00069	0.646
MOD_CK1_1	683	689	PF00069	0.799
MOD_CK1_1	690	696	PF00069	0.682
MOD_CK1_1	712	718	PF00069	0.788
MOD_CK1_1	747	753	PF00069	0.808
MOD_CK1_1	762	768	PF00069	0.568
MOD_CK1_1	771	777	PF00069	0.674
MOD_CK1_1	79	85	PF00069	0.673
MOD_CK2_1	141	147	PF00069	0.833
MOD_CK2_1	161	167	PF00069	0.488
MOD_CK2_1	403	409	PF00069	0.556
MOD_CK2_1	6	12	PF00069	0.754
MOD_CMANNOS	526	529	PF00535	0.653
MOD_DYRK1A_RPxSP_1	555	559	PF00069	0.587
MOD_GlcNHglycan	1	4	PF01048	0.538
MOD_GlcNHglycan	116	119	PF01048	0.624
MOD_GlcNHglycan	243	247	PF01048	0.778
MOD_GlcNHglycan	301	304	PF01048	0.626
MOD_GlcNHglycan	384	387	PF01048	0.815
MOD_GlcNHglycan	412	415	PF01048	0.548
MOD_GlcNHglycan	45	49	PF01048	0.641
MOD_GlcNHglycan	497	500	PF01048	0.661
MOD_GlcNHglycan	54	57	PF01048	0.738
MOD_GlcNHglycan	574	577	PF01048	0.856
MOD_GlcNHglycan	593	596	PF01048	0.517
MOD_GlcNHglycan	616	619	PF01048	0.542
MOD_GlcNHglycan	632	635	PF01048	0.522
MOD_GlcNHglycan	697	700	PF01048	0.796
MOD_GlcNHglycan	711	714	PF01048	0.534
MOD_GlcNHglycan	747	750	PF01048	0.688
MOD_GlcNHglycan	754	757	PF01048	0.685
MOD_GlcNHglycan	773	776	PF01048	0.508
MOD_GlcNHglycan	778	781	PF01048	0.765
MOD_GlcNHglycan	92	95	PF01048	0.596
MOD_GSK3_1	121	128	PF00069	0.819
MOD_GSK3_1	129	136	PF00069	0.695
MOD_GSK3_1	167	174	PF00069	0.775
MOD_GSK3_1	22	29	PF00069	0.816
MOD_GSK3_1	224	231	PF00069	0.611
MOD_GSK3_1	264	271	PF00069	0.657
MOD_GSK3_1	280	287	PF00069	0.697
MOD_GSK3_1	317	324	PF00069	0.627
MOD_GSK3_1	33	40	PF00069	0.630
MOD_GSK3_1	366	373	PF00069	0.601
MOD_GSK3_1	387	394	PF00069	0.784
MOD_GSK3_1	403	410	PF00069	0.586
MOD_GSK3_1	44	51	PF00069	0.625
MOD_GSK3_1	481	488	PF00069	0.719
MOD_GSK3_1	504	511	PF00069	0.618
MOD_GSK3_1	52	59	PF00069	0.482
MOD_GSK3_1	563	570	PF00069	0.805
MOD_GSK3_1	610	617	PF00069	0.726
MOD_GSK3_1	676	683	PF00069	0.664
MOD_GSK3_1	712	719	PF00069	0.786
MOD_GSK3_1	721	728	PF00069	0.642
MOD_GSK3_1	737	744	PF00069	0.560
MOD_GSK3_1	745	752	PF00069	0.778
MOD_GSK3_1	759	766	PF00069	0.582
MOD_GSK3_1	771	778	PF00069	0.619
MOD_GSK3_1	82	89	PF00069	0.578
MOD_N-GLC_1	56	61	PF02516	0.553
MOD_N-GLC_1	591	596	PF02516	0.714
MOD_N-GLC_1	621	626	PF02516	0.804
MOD_N-GLC_1	707	712	PF02516	0.746
MOD_N-GLC_1	826	831	PF02516	0.437
MOD_NEK2_1	224	229	PF00069	0.673
MOD_NEK2_1	297	302	PF00069	0.637
MOD_NEK2_1	364	369	PF00069	0.581
MOD_NEK2_1	403	408	PF00069	0.568
MOD_NEK2_1	514	519	PF00069	0.632
MOD_NEK2_1	538	543	PF00069	0.520
MOD_NEK2_1	614	619	PF00069	0.781
MOD_NEK2_1	676	681	PF00069	0.715
MOD_NEK2_1	716	721	PF00069	0.581
MOD_NEK2_1	737	742	PF00069	0.811
MOD_NEK2_1	745	750	PF00069	0.677
MOD_NEK2_1	815	820	PF00069	0.723
MOD_NEK2_2	725	730	PF00069	0.545
MOD_PIKK_1	104	110	PF00454	0.586
MOD_PIKK_1	307	313	PF00454	0.733
MOD_PIKK_1	33	39	PF00454	0.715
MOD_PIKK_1	488	494	PF00454	0.584
MOD_PIKK_1	548	554	PF00454	0.574
MOD_PIKK_1	803	809	PF00454	0.447
MOD_PIKK_1	82	88	PF00454	0.575
MOD_PKA_1	125	131	PF00069	0.818
MOD_PKA_1	421	427	PF00069	0.660
MOD_PKA_1	568	574	PF00069	0.598
MOD_PKA_2	125	131	PF00069	0.804
MOD_PKA_2	176	182	PF00069	0.616
MOD_PKA_2	264	270	PF00069	0.811
MOD_PKA_2	421	427	PF00069	0.699
MOD_PKA_2	538	544	PF00069	0.773
MOD_PKA_2	567	573	PF00069	0.761
MOD_PKA_2	630	636	PF00069	0.699
MOD_PKA_2	676	682	PF00069	0.665
MOD_PKA_2	735	741	PF00069	0.812
MOD_PKA_2	759	765	PF00069	0.678
MOD_PKA_2	82	88	PF00069	0.608
MOD_Plk_1	161	167	PF00069	0.651
MOD_Plk_1	222	228	PF00069	0.552
MOD_Plk_1	317	323	PF00069	0.551
MOD_Plk_1	370	376	PF00069	0.638
MOD_Plk_1	44	50	PF00069	0.793
MOD_Plk_1	621	627	PF00069	0.711
MOD_Plk_1	690	696	PF00069	0.566
MOD_Plk_1	707	713	PF00069	0.713
MOD_Plk_2-3	599	605	PF00069	0.541
MOD_Plk_4	153	159	PF00069	0.558
MOD_Plk_4	290	296	PF00069	0.630
MOD_Plk_4	514	520	PF00069	0.608
MOD_Plk_4	6	12	PF00069	0.594
MOD_Plk_4	650	656	PF00069	0.669
MOD_Plk_4	684	690	PF00069	0.551
MOD_Plk_4	797	803	PF00069	0.601
MOD_ProDKin_1	197	203	PF00069	0.574
MOD_ProDKin_1	245	251	PF00069	0.631
MOD_ProDKin_1	337	343	PF00069	0.721
MOD_ProDKin_1	345	351	PF00069	0.777
MOD_ProDKin_1	366	372	PF00069	0.814
MOD_ProDKin_1	379	385	PF00069	0.624
MOD_ProDKin_1	395	401	PF00069	0.741
MOD_ProDKin_1	440	446	PF00069	0.563
MOD_ProDKin_1	497	503	PF00069	0.802
MOD_ProDKin_1	555	561	PF00069	0.845
MOD_ProDKin_1	563	569	PF00069	0.726
MOD_ProDKin_1	641	647	PF00069	0.837
MOD_ProDKin_1	680	686	PF00069	0.814
MOD_ProDKin_1	76	82	PF00069	0.553
MOD_SUMO_for_1	260	263	PF00179	0.572
MOD_SUMO_for_1	359	362	PF00179	0.561
MOD_SUMO_for_1	447	450	PF00179	0.604
MOD_SUMO_for_1	603	606	PF00179	0.653
MOD_SUMO_rev_2	430	440	PF00179	0.591
TRG_AP2beta_CARGO_1	691	701	PF09066	0.549
TRG_DiLeu_BaEn_1	12	17	PF01217	0.504
TRG_DiLeu_BaEn_1	451	456	PF01217	0.540
TRG_DiLeu_BaEn_1	830	835	PF01217	0.682
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.573
TRG_ENDOCYTIC_2	534	537	PF00928	0.764
TRG_ENDOCYTIC_2	7	10	PF00928	0.753
TRG_ENDOCYTIC_2	758	761	PF00928	0.558
TRG_ENDOCYTIC_2	786	789	PF00928	0.649
TRG_ENDOCYTIC_2	791	794	PF00928	0.699
TRG_ENDOCYTIC_2	812	815	PF00928	0.690
TRG_ENDOCYTIC_2	843	846	PF00928	0.717
TRG_ER_diArg_1	676	678	PF00400	0.808
TRG_ER_diArg_1	701	703	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHL5	Leishmania donovani	56%	80%
A4ID02	Leishmania infantum	56%	80%
E9ATH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	80%
Q4Q121	Leishmania major	55%	80%