NmrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPQ7_LEIBR

TriTrypDb:

LbrM.35.4130 , LBRM2903_350051600

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.520
CLV_NRD_NRD_1	102	104	PF00675	0.635
CLV_PCSK_KEX2_1	63	65	PF00082	0.500
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.542
CLV_PCSK_SKI1_1	220	224	PF00082	0.656
CLV_PCSK_SKI1_1	37	41	PF00082	0.587
DEG_Nend_Nbox_1	1	3	PF02207	0.645
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.609
DOC_MAPK_gen_1	163	172	PF00069	0.606
DOC_MAPK_gen_1	34	43	PF00069	0.629
DOC_MAPK_MEF2A_6	37	45	PF00069	0.583
DOC_PP4_FxxP_1	45	48	PF00568	0.583
DOC_USP7_MATH_1	137	141	PF00917	0.711
DOC_USP7_MATH_1	146	150	PF00917	0.576
DOC_USP7_MATH_1	84	88	PF00917	0.507
DOC_USP7_MATH_2	250	256	PF00917	0.632
DOC_WW_Pin1_4	152	157	PF00397	0.534
LIG_14-3-3_CanoR_1	187	195	PF00244	0.541
LIG_14-3-3_CanoR_1	37	42	PF00244	0.599
LIG_14-3-3_CanoR_1	64	74	PF00244	0.560
LIG_CaM_NSCaTE_8	95	102	PF13499	0.730
LIG_FHA_1	156	162	PF00498	0.510
LIG_FHA_1	38	44	PF00498	0.578
LIG_GBD_Chelix_1	166	174	PF00786	0.565
LIG_LIR_Apic_2	42	48	PF02991	0.575
LIG_LIR_Gen_1	265	271	PF02991	0.587
LIG_LIR_Gen_1	46	55	PF02991	0.587
LIG_LIR_Nem_3	13	19	PF02991	0.578
LIG_LIR_Nem_3	162	167	PF02991	0.673
LIG_LIR_Nem_3	265	269	PF02991	0.564
LIG_LIR_Nem_3	46	52	PF02991	0.702
LIG_NRBOX	169	175	PF00104	0.666
LIG_PDZ_Class_2	266	271	PF00595	0.459
LIG_Pex14_2	45	49	PF04695	0.580
LIG_PTB_Apo_2	166	173	PF02174	0.488
LIG_SH2_CRK	164	168	PF00017	0.452
LIG_SH2_SRC	55	58	PF00017	0.713
LIG_SH2_STAP1	11	15	PF00017	0.594
LIG_SH2_STAP1	16	20	PF00017	0.564
LIG_SH2_STAT5	19	22	PF00017	0.577
LIG_SH2_STAT5	266	269	PF00017	0.598
LIG_SH2_STAT5	67	70	PF00017	0.518
LIG_SH3_3	107	113	PF00018	0.721
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.565
LIG_SUMO_SIM_anti_2	87	92	PF11976	0.465
LIG_TRAF2_1	54	57	PF00917	0.609
LIG_TYR_ITIM	65	70	PF00017	0.764
MOD_CK1_1	177	183	PF00069	0.593
MOD_CK1_1	186	192	PF00069	0.536
MOD_Cter_Amidation	61	64	PF01082	0.504
MOD_GlcNHglycan	124	127	PF01048	0.729
MOD_GlcNHglycan	148	151	PF01048	0.673
MOD_GlcNHglycan	52	55	PF01048	0.685
MOD_GSK3_1	155	162	PF00069	0.525
MOD_N-GLC_1	152	157	PF02516	0.689
MOD_NEK2_1	117	122	PF00069	0.728
MOD_NEK2_1	138	143	PF00069	0.695
MOD_NEK2_1	159	164	PF00069	0.602
MOD_NEK2_1	174	179	PF00069	0.612
MOD_NEK2_1	183	188	PF00069	0.649
MOD_NEK2_1	50	55	PF00069	0.601
MOD_PKA_2	186	192	PF00069	0.545
MOD_Plk_1	227	233	PF00069	0.538
MOD_Plk_2-3	191	197	PF00069	0.561
MOD_Plk_4	117	123	PF00069	0.485
MOD_Plk_4	235	241	PF00069	0.740
MOD_Plk_4	252	258	PF00069	0.605
MOD_ProDKin_1	152	158	PF00069	0.532
TRG_ENDOCYTIC_2	164	167	PF00928	0.459
TRG_ENDOCYTIC_2	266	269	PF00928	0.606
TRG_ENDOCYTIC_2	67	70	PF00928	0.771

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L2	Leptomonas seymouri	44%	99%
A0A3Q8IL86	Leishmania donovani	73%	99%
A4ID06	Leishmania infantum	73%	99%
E9ATH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q4Q125	Leishmania major	74%	100%