Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPQ6_LEIBR

TriTrypDb:

LbrM.35.4120 , LBRM2903_350051500

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HPQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.589
CLV_C14_Caspase3-7	29	33	PF00656	0.506
CLV_NRD_NRD_1	25	27	PF00675	0.601
CLV_NRD_NRD_1	291	293	PF00675	0.275
CLV_NRD_NRD_1	46	48	PF00675	0.690
CLV_NRD_NRD_1	89	91	PF00675	0.505
CLV_PCSK_KEX2_1	25	27	PF00082	0.601
CLV_PCSK_KEX2_1	46	48	PF00082	0.690
CLV_PCSK_KEX2_1	89	91	PF00082	0.505
CLV_PCSK_SKI1_1	273	277	PF00082	0.301
CLV_PCSK_SKI1_1	278	282	PF00082	0.321
CLV_PCSK_SKI1_1	37	41	PF00082	0.516
CLV_PCSK_SKI1_1	371	375	PF00082	0.443
CLV_PCSK_SKI1_1	46	50	PF00082	0.489
DEG_APCC_DBOX_1	343	351	PF00400	0.585
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DOC_ANK_TNKS_1	155	162	PF00023	0.558
DOC_CYCLIN_RxL_1	368	376	PF00134	0.444
DOC_MAPK_MEF2A_6	246	253	PF00069	0.475
DOC_PP1_RVXF_1	172	178	PF00149	0.522
DOC_PP4_FxxP_1	281	284	PF00568	0.417
DOC_PP4_FxxP_1	365	368	PF00568	0.487
DOC_USP7_MATH_1	108	112	PF00917	0.798
DOC_USP7_MATH_1	129	133	PF00917	0.727
DOC_USP7_MATH_1	14	18	PF00917	0.662
DOC_USP7_MATH_1	35	39	PF00917	0.723
DOC_USP7_MATH_1	64	68	PF00917	0.546
DOC_WW_Pin1_4	140	145	PF00397	0.584
DOC_WW_Pin1_4	161	166	PF00397	0.550
DOC_WW_Pin1_4	7	12	PF00397	0.553
LIG_14-3-3_CanoR_1	15	21	PF00244	0.526
LIG_14-3-3_CanoR_1	328	334	PF00244	0.529
LIG_14-3-3_CanoR_1	37	42	PF00244	0.639
LIG_14-3-3_CanoR_1	46	55	PF00244	0.588
LIG_BRCT_BRCA1_1	331	335	PF00533	0.475
LIG_Clathr_ClatBox_1	366	370	PF01394	0.478
LIG_deltaCOP1_diTrp_1	325	333	PF00928	0.529
LIG_FHA_1	57	63	PF00498	0.452
LIG_FHA_2	143	149	PF00498	0.558
LIG_FHA_2	180	186	PF00498	0.553
LIG_FHA_2	231	237	PF00498	0.476
LIG_LIR_Apic_2	362	368	PF02991	0.495
LIG_LIR_Apic_2	91	96	PF02991	0.528
LIG_LIR_Gen_1	312	322	PF02991	0.475
LIG_LIR_Nem_3	236	240	PF02991	0.312
LIG_LIR_Nem_3	332	336	PF02991	0.475
LIG_LIR_Nem_3	338	342	PF02991	0.475
LIG_PCNA_PIPBox_1	307	316	PF02747	0.417
LIG_PTB_Apo_2	308	315	PF02174	0.475
LIG_PTB_Phospho_1	308	314	PF10480	0.475
LIG_Rb_pABgroove_1	308	316	PF01858	0.529
LIG_SH2_CRK	297	301	PF00017	0.475
LIG_SH2_CRK	93	97	PF00017	0.523
LIG_SH2_GRB2like	339	342	PF00017	0.434
LIG_SH2_NCK_1	93	97	PF00017	0.514
LIG_SH2_STAT5	336	339	PF00017	0.475
LIG_SH2_STAT5	342	345	PF00017	0.475
LIG_SH2_STAT5	93	96	PF00017	0.567
LIG_SH3_1	93	99	PF00018	0.515
LIG_SH3_3	266	272	PF00018	0.475
LIG_SH3_3	355	361	PF00018	0.347
LIG_SH3_3	5	11	PF00018	0.670
LIG_SH3_3	93	99	PF00018	0.551
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.667
LIG_UBA3_1	76	82	PF00899	0.420
LIG_WRC_WIRS_1	231	236	PF05994	0.486
LIG_WW_2	11	14	PF00397	0.505
LIG_WW_3	224	228	PF00397	0.586
MOD_CK1_1	151	157	PF00069	0.688
MOD_CK1_1	254	260	PF00069	0.456
MOD_CK2_1	142	148	PF00069	0.702
MOD_CK2_1	151	157	PF00069	0.759
MOD_CK2_1	271	277	PF00069	0.475
MOD_CMANNOS	326	329	PF00535	0.275
MOD_Cter_Amidation	44	47	PF01082	0.684
MOD_GlcNHglycan	125	128	PF01048	0.643
MOD_GlcNHglycan	132	135	PF01048	0.560
MOD_GlcNHglycan	16	19	PF01048	0.749
MOD_GlcNHglycan	273	276	PF01048	0.350
MOD_GlcNHglycan	32	36	PF01048	0.627
MOD_GlcNHglycan	382	385	PF01048	0.521
MOD_GSK3_1	102	109	PF00069	0.703
MOD_GSK3_1	118	125	PF00069	0.648
MOD_GSK3_1	138	145	PF00069	0.783
MOD_GSK3_1	3	10	PF00069	0.584
MOD_GSK3_1	31	38	PF00069	0.630
MOD_N-GLC_1	106	111	PF02516	0.541
MOD_NEK2_1	251	256	PF00069	0.482
MOD_PIKK_1	40	46	PF00454	0.514
MOD_PIKK_1	56	62	PF00454	0.481
MOD_PK_1	26	32	PF00069	0.509
MOD_PKA_2	103	109	PF00069	0.613
MOD_PKA_2	121	127	PF00069	0.626
MOD_PKA_2	14	20	PF00069	0.636
MOD_Plk_1	179	185	PF00069	0.591
MOD_Plk_1	31	37	PF00069	0.644
MOD_Plk_4	16	22	PF00069	0.545
MOD_Plk_4	329	335	PF00069	0.475
MOD_Plk_4	37	43	PF00069	0.577
MOD_ProDKin_1	140	146	PF00069	0.584
MOD_ProDKin_1	161	167	PF00069	0.547
MOD_ProDKin_1	7	13	PF00069	0.555
TRG_DiLeu_BaEn_1	362	367	PF01217	0.489
TRG_DiLeu_BaEn_2	276	282	PF01217	0.417
TRG_DiLeu_BaEn_4	362	368	PF01217	0.495
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.526
TRG_ENDOCYTIC_2	314	317	PF00928	0.475
TRG_ENDOCYTIC_2	74	77	PF00928	0.457
TRG_ENDOCYTIC_2	81	84	PF00928	0.397
TRG_ER_diArg_1	24	26	PF00400	0.604
TRG_ER_diArg_1	88	90	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBQ8	Leptomonas seymouri	59%	99%
A0A3Q8IGD8	Leishmania donovani	79%	98%
A4ID07	Leishmania infantum	79%	98%
E9ATH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q4Q126	Leishmania major	80%	100%