Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPQ4_LEIBR

TriTrypDb:

LbrM.35.4100 , LBRM2903_350051300

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HPQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	534	538	PF00656	0.678
CLV_C14_Caspase3-7	659	663	PF00656	0.506
CLV_C14_Caspase3-7	78	82	PF00656	0.738
CLV_C14_Caspase3-7	791	795	PF00656	0.529
CLV_NRD_NRD_1	183	185	PF00675	0.538
CLV_NRD_NRD_1	674	676	PF00675	0.651
CLV_NRD_NRD_1	725	727	PF00675	0.533
CLV_PCSK_KEX2_1	183	185	PF00082	0.538
CLV_PCSK_KEX2_1	311	313	PF00082	0.374
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.507
CLV_PCSK_SKI1_1	308	312	PF00082	0.586
CLV_PCSK_SKI1_1	47	51	PF00082	0.372
CLV_PCSK_SKI1_1	675	679	PF00082	0.641
CLV_PCSK_SKI1_1	790	794	PF00082	0.527
DEG_APCC_DBOX_1	674	682	PF00400	0.630
DEG_APCC_DBOX_1	714	722	PF00400	0.532
DEG_SPOP_SBC_1	127	131	PF00917	0.516
DEG_SPOP_SBC_1	342	346	PF00917	0.437
DEG_SPOP_SBC_1	619	623	PF00917	0.569
DOC_CKS1_1	601	606	PF01111	0.801
DOC_MAPK_DCC_7	541	550	PF00069	0.776
DOC_MAPK_gen_1	675	681	PF00069	0.566
DOC_MAPK_MEF2A_6	30	38	PF00069	0.493
DOC_MAPK_MEF2A_6	541	550	PF00069	0.776
DOC_PP1_RVXF_1	103	109	PF00149	0.489
DOC_PP4_FxxP_1	560	563	PF00568	0.582
DOC_PP4_FxxP_1	568	571	PF00568	0.603
DOC_USP7_MATH_1	127	131	PF00917	0.602
DOC_USP7_MATH_1	229	233	PF00917	0.663
DOC_USP7_MATH_1	295	299	PF00917	0.620
DOC_USP7_MATH_1	393	397	PF00917	0.598
DOC_USP7_MATH_1	440	444	PF00917	0.630
DOC_USP7_MATH_1	523	527	PF00917	0.711
DOC_USP7_MATH_1	531	535	PF00917	0.705
DOC_USP7_MATH_1	599	603	PF00917	0.640
DOC_USP7_MATH_1	620	624	PF00917	0.733
DOC_USP7_MATH_1	643	647	PF00917	0.643
DOC_USP7_MATH_1	658	662	PF00917	0.660
DOC_USP7_MATH_1	687	691	PF00917	0.604
DOC_USP7_MATH_1	70	74	PF00917	0.757
DOC_USP7_MATH_1	83	87	PF00917	0.770
DOC_WW_Pin1_4	122	127	PF00397	0.709
DOC_WW_Pin1_4	16	21	PF00397	0.594
DOC_WW_Pin1_4	222	227	PF00397	0.610
DOC_WW_Pin1_4	332	337	PF00397	0.562
DOC_WW_Pin1_4	354	359	PF00397	0.332
DOC_WW_Pin1_4	417	422	PF00397	0.710
DOC_WW_Pin1_4	429	434	PF00397	0.570
DOC_WW_Pin1_4	447	452	PF00397	0.590
DOC_WW_Pin1_4	499	504	PF00397	0.712
DOC_WW_Pin1_4	571	576	PF00397	0.675
DOC_WW_Pin1_4	578	583	PF00397	0.770
DOC_WW_Pin1_4	597	602	PF00397	0.743
DOC_WW_Pin1_4	608	613	PF00397	0.539
DOC_WW_Pin1_4	798	803	PF00397	0.717
LIG_14-3-3_CanoR_1	202	207	PF00244	0.444
LIG_14-3-3_CanoR_1	249	258	PF00244	0.348
LIG_14-3-3_CanoR_1	265	271	PF00244	0.436
LIG_14-3-3_CanoR_1	281	285	PF00244	0.516
LIG_14-3-3_CanoR_1	326	336	PF00244	0.573
LIG_14-3-3_CanoR_1	47	54	PF00244	0.383
LIG_14-3-3_CanoR_1	702	710	PF00244	0.560
LIG_Actin_WH2_2	401	417	PF00022	0.631
LIG_BIR_III_2	609	613	PF00653	0.575
LIG_BIR_III_4	537	541	PF00653	0.535
LIG_BRCT_BRCA1_1	376	380	PF00533	0.635
LIG_CSL_BTD_1	506	509	PF09270	0.668
LIG_CtBP_PxDLS_1	190	194	PF00389	0.488
LIG_FHA_1	192	198	PF00498	0.457
LIG_FHA_1	253	259	PF00498	0.441
LIG_FHA_1	297	303	PF00498	0.673
LIG_FHA_1	387	393	PF00498	0.409
LIG_FHA_1	429	435	PF00498	0.718
LIG_FHA_1	461	467	PF00498	0.618
LIG_FHA_1	48	54	PF00498	0.366
LIG_FHA_1	635	641	PF00498	0.810
LIG_FHA_1	702	708	PF00498	0.583
LIG_FHA_1	99	105	PF00498	0.366
LIG_FHA_2	362	368	PF00498	0.626
LIG_FHA_2	601	607	PF00498	0.570
LIG_FHA_2	647	653	PF00498	0.539
LIG_FHA_2	669	675	PF00498	0.536
LIG_FHA_2	706	712	PF00498	0.557
LIG_FHA_2	815	821	PF00498	0.618
LIG_LIR_Apic_2	283	287	PF02991	0.497
LIG_LIR_Apic_2	567	571	PF02991	0.541
LIG_LIR_Gen_1	101	110	PF02991	0.573
LIG_LIR_Gen_1	161	172	PF02991	0.339
LIG_LIR_Nem_3	101	106	PF02991	0.583
LIG_NRBOX	259	265	PF00104	0.294
LIG_OCRL_FandH_1	102	114	PF00620	0.526
LIG_SH2_GRB2like	284	287	PF00017	0.617
LIG_SH2_GRB2like	339	342	PF00017	0.543
LIG_SH2_NCK_1	284	288	PF00017	0.497
LIG_SH2_PTP2	543	546	PF00017	0.782
LIG_SH2_SRC	284	287	PF00017	0.501
LIG_SH2_SRC	339	342	PF00017	0.426
LIG_SH2_SRC	543	546	PF00017	0.782
LIG_SH2_STAP1	688	692	PF00017	0.363
LIG_SH2_STAT3	10	13	PF00017	0.475
LIG_SH2_STAT3	515	518	PF00017	0.556
LIG_SH2_STAT5	10	13	PF00017	0.445
LIG_SH2_STAT5	339	342	PF00017	0.524
LIG_SH2_STAT5	543	546	PF00017	0.782
LIG_SH3_2	333	338	PF14604	0.323
LIG_SH3_3	17	23	PF00018	0.355
LIG_SH3_3	223	229	PF00018	0.581
LIG_SH3_3	234	240	PF00018	0.617
LIG_SH3_3	330	336	PF00018	0.324
LIG_SH3_3	418	424	PF00018	0.693
LIG_SH3_3	445	451	PF00018	0.752
LIG_SH3_3	463	469	PF00018	0.771
LIG_SH3_3	541	547	PF00018	0.662
LIG_SH3_3	598	604	PF00018	0.803
LIG_SH3_3	611	617	PF00018	0.627
LIG_SH3_3	63	69	PF00018	0.637
LIG_SUMO_SIM_anti_2	703	711	PF11976	0.375
LIG_SUMO_SIM_par_1	410	418	PF11976	0.667
LIG_SxIP_EBH_1	325	338	PF03271	0.323
LIG_TRAF2_1	241	244	PF00917	0.479
LIG_TYR_ITIM	337	342	PF00017	0.434
LIG_WRC_WIRS_1	159	164	PF05994	0.472
LIG_WW_3	19	23	PF00397	0.350
MOD_CDC14_SPxK_1	335	338	PF00782	0.310
MOD_CDK_SPK_2	222	227	PF00069	0.476
MOD_CDK_SPxK_1	16	22	PF00069	0.352
MOD_CDK_SPxK_1	332	338	PF00069	0.319
MOD_CDK_SPxxK_3	798	805	PF00069	0.763
MOD_CK1_1	109	115	PF00069	0.429
MOD_CK1_1	155	161	PF00069	0.548
MOD_CK1_1	225	231	PF00069	0.577
MOD_CK1_1	271	277	PF00069	0.637
MOD_CK1_1	343	349	PF00069	0.530
MOD_CK1_1	417	423	PF00069	0.727
MOD_CK1_1	57	63	PF00069	0.573
MOD_CK1_1	600	606	PF00069	0.800
MOD_CK1_1	646	652	PF00069	0.725
MOD_CK1_1	654	660	PF00069	0.699
MOD_CK1_1	90	96	PF00069	0.590
MOD_CK2_1	2	8	PF00069	0.508
MOD_CK2_1	361	367	PF00069	0.507
MOD_CK2_1	382	388	PF00069	0.567
MOD_CK2_1	620	626	PF00069	0.787
MOD_CK2_1	646	652	PF00069	0.588
MOD_CK2_1	680	686	PF00069	0.503
MOD_CK2_1	705	711	PF00069	0.547
MOD_Cter_Amidation	589	592	PF01082	0.558
MOD_GlcNHglycan	154	157	PF01048	0.517
MOD_GlcNHglycan	231	234	PF01048	0.607
MOD_GlcNHglycan	271	274	PF01048	0.605
MOD_GlcNHglycan	384	387	PF01048	0.632
MOD_GlcNHglycan	42	45	PF01048	0.505
MOD_GlcNHglycan	442	445	PF01048	0.700
MOD_GlcNHglycan	484	487	PF01048	0.690
MOD_GlcNHglycan	525	528	PF01048	0.726
MOD_GlcNHglycan	534	537	PF01048	0.700
MOD_GlcNHglycan	56	59	PF01048	0.465
MOD_GlcNHglycan	622	625	PF01048	0.765
MOD_GlcNHglycan	645	648	PF01048	0.773
MOD_GlcNHglycan	652	656	PF01048	0.775
MOD_GlcNHglycan	658	661	PF01048	0.720
MOD_GlcNHglycan	790	793	PF01048	0.680
MOD_GlcNHglycan	83	86	PF01048	0.657
MOD_GlcNHglycan	92	95	PF01048	0.574
MOD_GSK3_1	106	113	PF00069	0.578
MOD_GSK3_1	122	129	PF00069	0.612
MOD_GSK3_1	132	139	PF00069	0.532
MOD_GSK3_1	207	214	PF00069	0.513
MOD_GSK3_1	225	232	PF00069	0.616
MOD_GSK3_1	276	283	PF00069	0.571
MOD_GSK3_1	341	348	PF00069	0.458
MOD_GSK3_1	350	357	PF00069	0.409
MOD_GSK3_1	382	389	PF00069	0.583
MOD_GSK3_1	447	454	PF00069	0.585
MOD_GSK3_1	53	60	PF00069	0.534
MOD_GSK3_1	646	653	PF00069	0.684
MOD_GSK3_1	654	661	PF00069	0.771
MOD_GSK3_1	701	708	PF00069	0.561
MOD_GSK3_1	81	88	PF00069	0.655
MOD_N-GLC_1	136	141	PF02516	0.492
MOD_N-GLC_1	340	345	PF02516	0.541
MOD_N-GLC_2	87	89	PF02516	0.554
MOD_NEK2_1	106	111	PF00069	0.503
MOD_NEK2_1	132	137	PF00069	0.608
MOD_NEK2_1	252	257	PF00069	0.315
MOD_NEK2_1	280	285	PF00069	0.516
MOD_NEK2_1	302	307	PF00069	0.635
MOD_NEK2_1	313	318	PF00069	0.427
MOD_NEK2_1	340	345	PF00069	0.476
MOD_NEK2_1	361	366	PF00069	0.503
MOD_NEK2_1	371	376	PF00069	0.434
MOD_NEK2_1	392	397	PF00069	0.586
MOD_NEK2_1	414	419	PF00069	0.587
MOD_NEK2_1	427	432	PF00069	0.761
MOD_NEK2_1	489	494	PF00069	0.553
MOD_NEK2_1	510	515	PF00069	0.722
MOD_NEK2_1	53	58	PF00069	0.457
MOD_NEK2_1	558	563	PF00069	0.532
MOD_NEK2_1	823	828	PF00069	0.669
MOD_NEK2_1	98	103	PF00069	0.650
MOD_NEK2_2	276	281	PF00069	0.644
MOD_NEK2_2	303	308	PF00069	0.443
MOD_NEK2_2	70	75	PF00069	0.551
MOD_OFUCOSY	250	256	PF10250	0.298
MOD_PIKK_1	313	319	PF00454	0.505
MOD_PIKK_1	695	701	PF00454	0.496
MOD_PIKK_1	702	708	PF00454	0.420
MOD_PIKK_1	825	831	PF00454	0.621
MOD_PIKK_1	87	93	PF00454	0.719
MOD_PIKK_1	96	102	PF00454	0.615
MOD_PK_1	207	213	PF00069	0.304
MOD_PKA_2	2	8	PF00069	0.623
MOD_PKA_2	201	207	PF00069	0.451
MOD_PKA_2	280	286	PF00069	0.581
MOD_PKA_2	414	420	PF00069	0.640
MOD_PKA_2	460	466	PF00069	0.634
MOD_PKA_2	666	672	PF00069	0.710
MOD_PKA_2	701	707	PF00069	0.514
MOD_Plk_1	136	142	PF00069	0.490
MOD_Plk_1	243	249	PF00069	0.478
MOD_Plk_1	361	367	PF00069	0.595
MOD_Plk_1	393	399	PF00069	0.549
MOD_Plk_4	128	134	PF00069	0.599
MOD_Plk_4	2	8	PF00069	0.503
MOD_Plk_4	243	249	PF00069	0.496
MOD_Plk_4	271	277	PF00069	0.571
MOD_Plk_4	296	302	PF00069	0.494
MOD_Plk_4	350	356	PF00069	0.461
MOD_Plk_4	393	399	PF00069	0.416
MOD_Plk_4	510	516	PF00069	0.604
MOD_Plk_4	705	711	PF00069	0.376
MOD_ProDKin_1	122	128	PF00069	0.707
MOD_ProDKin_1	16	22	PF00069	0.592
MOD_ProDKin_1	222	228	PF00069	0.618
MOD_ProDKin_1	332	338	PF00069	0.566
MOD_ProDKin_1	354	360	PF00069	0.328
MOD_ProDKin_1	417	423	PF00069	0.714
MOD_ProDKin_1	429	435	PF00069	0.567
MOD_ProDKin_1	447	453	PF00069	0.586
MOD_ProDKin_1	499	505	PF00069	0.710
MOD_ProDKin_1	571	577	PF00069	0.672
MOD_ProDKin_1	578	584	PF00069	0.773
MOD_ProDKin_1	597	603	PF00069	0.741
MOD_ProDKin_1	608	614	PF00069	0.538
MOD_ProDKin_1	798	804	PF00069	0.718
MOD_SUMO_rev_2	384	392	PF00179	0.550
MOD_SUMO_rev_2	669	678	PF00179	0.613
MOD_SUMO_rev_2	791	800	PF00179	0.617
TRG_DiLeu_BaEn_2	242	248	PF01217	0.470
TRG_DiLeu_BaLyEn_6	506	511	PF01217	0.488
TRG_DiLeu_BaLyEn_6	799	804	PF01217	0.685
TRG_ENDOCYTIC_2	304	307	PF00928	0.449
TRG_ENDOCYTIC_2	339	342	PF00928	0.543
TRG_ENDOCYTIC_2	543	546	PF00928	0.784
TRG_ER_diArg_1	74	77	PF00400	0.642
TRG_ER_diArg_1	804	807	PF00400	0.545
TRG_NES_CRM1_1	765	775	PF08389	0.378
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL79	Leptomonas seymouri	40%	93%
A0A3S7XBE3	Leishmania donovani	66%	99%
A4ID09	Leishmania infantum	66%	100%
D0A8G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ATG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	99%
Q4Q128	Leishmania major	67%	100%