Similar to leishmania major. l411.4-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

similar to leishmania major. l411.4-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPQ3_LEIBR

TriTrypDb:

LbrM.35.4090 , LBRM2903_350051100 , LBRM2903_350051200

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	11
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HPQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPQ3

Function

Biological processes
Term	Name	Level	Count
GO:0007338	single fertilization	3	11
GO:0009566	fertilization	2	11
GO:0022414	reproductive process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.201
CLV_NRD_NRD_1	26	28	PF00675	0.465
CLV_NRD_NRD_1	515	517	PF00675	0.669
CLV_NRD_NRD_1	88	90	PF00675	0.483
CLV_PCSK_KEX2_1	515	517	PF00082	0.652
CLV_PCSK_KEX2_1	88	90	PF00082	0.501
CLV_PCSK_PC7_1	84	90	PF00082	0.465
CLV_PCSK_SKI1_1	254	258	PF00082	0.449
CLV_PCSK_SKI1_1	447	451	PF00082	0.533
CLV_PCSK_SKI1_1	516	520	PF00082	0.668
CLV_PCSK_SKI1_1	523	527	PF00082	0.623
CLV_PCSK_SKI1_1	84	88	PF00082	0.465
CLV_PCSK_SKI1_1	95	99	PF00082	0.458
DEG_APCC_DBOX_1	94	102	PF00400	0.336
DEG_SPOP_SBC_1	261	265	PF00917	0.169
DEG_SPOP_SBC_1	454	458	PF00917	0.352
DOC_CYCLIN_RxL_1	251	260	PF00134	0.222
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.336
DOC_MAPK_gen_1	27	35	PF00069	0.173
DOC_MAPK_gen_1	88	94	PF00069	0.169
DOC_MAPK_MEF2A_6	27	35	PF00069	0.247
DOC_MAPK_RevD_3	76	89	PF00069	0.316
DOC_PP1_RVXF_1	252	258	PF00149	0.336
DOC_PP1_RVXF_1	562	569	PF00149	0.590
DOC_PP2B_LxvP_1	256	259	PF13499	0.260
DOC_PP2B_LxvP_1	280	283	PF13499	0.310
DOC_PP2B_LxvP_1	506	509	PF13499	0.319
DOC_USP7_MATH_1	137	141	PF00917	0.318
DOC_USP7_MATH_1	16	20	PF00917	0.389
DOC_USP7_MATH_1	175	179	PF00917	0.245
DOC_USP7_MATH_1	227	231	PF00917	0.301
DOC_USP7_MATH_1	261	265	PF00917	0.342
DOC_USP7_MATH_1	431	435	PF00917	0.352
DOC_USP7_MATH_1	454	458	PF00917	0.338
DOC_USP7_MATH_1	72	76	PF00917	0.320
DOC_WW_Pin1_4	18	23	PF00397	0.516
DOC_WW_Pin1_4	192	197	PF00397	0.336
DOC_WW_Pin1_4	238	243	PF00397	0.308
DOC_WW_Pin1_4	297	302	PF00397	0.336
DOC_WW_Pin1_4	500	505	PF00397	0.459
LIG_14-3-3_CanoR_1	203	211	PF00244	0.271
LIG_14-3-3_CanoR_1	376	380	PF00244	0.330
LIG_14-3-3_CanoR_1	412	418	PF00244	0.348
LIG_14-3-3_CanoR_1	516	526	PF00244	0.450
LIG_14-3-3_CanoR_1	88	96	PF00244	0.257
LIG_Actin_WH2_2	73	90	PF00022	0.169
LIG_APCC_ABBAyCdc20_2	515	521	PF00400	0.290
LIG_BIR_II_1	1	5	PF00653	0.324
LIG_BRCT_BRCA1_1	456	460	PF00533	0.251
LIG_deltaCOP1_diTrp_1	531	537	PF00928	0.311
LIG_FHA_1	133	139	PF00498	0.296
LIG_FHA_1	199	205	PF00498	0.325
LIG_FHA_1	213	219	PF00498	0.323
LIG_FHA_1	246	252	PF00498	0.327
LIG_FHA_1	266	272	PF00498	0.342
LIG_FHA_1	402	408	PF00498	0.294
LIG_FHA_1	454	460	PF00498	0.297
LIG_FHA_1	477	483	PF00498	0.308
LIG_FHA_1	501	507	PF00498	0.366
LIG_FHA_1	6	12	PF00498	0.486
LIG_FHA_2	245	251	PF00498	0.169
LIG_FHA_2	32	38	PF00498	0.336
LIG_FHA_2	526	532	PF00498	0.463
LIG_LIR_Gen_1	110	119	PF02991	0.274
LIG_LIR_Gen_1	130	139	PF02991	0.361
LIG_LIR_Gen_1	157	165	PF02991	0.278
LIG_LIR_Gen_1	230	237	PF02991	0.298
LIG_LIR_Gen_1	278	287	PF02991	0.251
LIG_LIR_Gen_1	531	540	PF02991	0.309
LIG_LIR_Nem_3	110	114	PF02991	0.259
LIG_LIR_Nem_3	157	163	PF02991	0.262
LIG_LIR_Nem_3	230	234	PF02991	0.251
LIG_LIR_Nem_3	278	282	PF02991	0.251
LIG_LIR_Nem_3	405	411	PF02991	0.318
LIG_LIR_Nem_3	416	420	PF02991	0.333
LIG_LIR_Nem_3	531	535	PF02991	0.392
LIG_LIR_Nem_3	543	549	PF02991	0.395
LIG_Pex14_2	348	352	PF04695	0.222
LIG_SH2_CRK	417	421	PF00017	0.315
LIG_SH2_CRK	549	553	PF00017	0.445
LIG_SH2_PTP2	111	114	PF00017	0.169
LIG_SH2_PTP2	408	411	PF00017	0.358
LIG_SH2_PTP2	422	425	PF00017	0.284
LIG_SH2_STAP1	200	204	PF00017	0.321
LIG_SH2_STAP1	549	553	PF00017	0.445
LIG_SH2_STAT5	10	13	PF00017	0.441
LIG_SH2_STAT5	100	103	PF00017	0.287
LIG_SH2_STAT5	111	114	PF00017	0.266
LIG_SH2_STAT5	131	134	PF00017	0.259
LIG_SH2_STAT5	200	203	PF00017	0.317
LIG_SH2_STAT5	303	306	PF00017	0.336
LIG_SH2_STAT5	344	347	PF00017	0.290
LIG_SH2_STAT5	408	411	PF00017	0.312
LIG_SH2_STAT5	422	425	PF00017	0.191
LIG_SH2_STAT5	565	568	PF00017	0.680
LIG_SH3_3	136	142	PF00018	0.341
LIG_SH3_3	190	196	PF00018	0.271
LIG_SH3_3	75	81	PF00018	0.310
LIG_SUMO_SIM_par_1	29	34	PF11976	0.260
LIG_SUMO_SIM_par_1	477	484	PF11976	0.345
LIG_TRAF2_1	468	471	PF00917	0.357
LIG_TYR_ITIM	197	202	PF00017	0.169
LIG_TYR_ITIM	420	425	PF00017	0.305
MOD_CK1_1	130	136	PF00069	0.300
MOD_CK1_1	18	24	PF00069	0.518
MOD_CK1_1	192	198	PF00069	0.310
MOD_CK1_1	238	244	PF00069	0.345
MOD_CK1_1	260	266	PF00069	0.325
MOD_CK1_1	285	291	PF00069	0.265
MOD_CK1_1	306	312	PF00069	0.336
MOD_CK1_1	350	356	PF00069	0.343
MOD_CK1_1	463	469	PF00069	0.337
MOD_CK1_1	474	480	PF00069	0.339
MOD_CK2_1	238	244	PF00069	0.246
MOD_CK2_1	287	293	PF00069	0.298
MOD_CK2_1	525	531	PF00069	0.448
MOD_GlcNHglycan	1	4	PF01048	0.634
MOD_GlcNHglycan	139	142	PF01048	0.530
MOD_GlcNHglycan	18	21	PF01048	0.531
MOD_GlcNHglycan	204	207	PF01048	0.503
MOD_GlcNHglycan	223	226	PF01048	0.471
MOD_GlcNHglycan	237	240	PF01048	0.477
MOD_GlcNHglycan	259	262	PF01048	0.503
MOD_GlcNHglycan	264	267	PF01048	0.494
MOD_GlcNHglycan	289	292	PF01048	0.531
MOD_GlcNHglycan	391	394	PF01048	0.397
MOD_GlcNHglycan	401	404	PF01048	0.340
MOD_GlcNHglycan	89	92	PF01048	0.552
MOD_GSK3_1	1	8	PF00069	0.501
MOD_GSK3_1	123	130	PF00069	0.280
MOD_GSK3_1	14	21	PF00069	0.458
MOD_GSK3_1	198	205	PF00069	0.217
MOD_GSK3_1	212	219	PF00069	0.333
MOD_GSK3_1	257	264	PF00069	0.307
MOD_GSK3_1	303	310	PF00069	0.334
MOD_GSK3_1	472	479	PF00069	0.326
MOD_GSK3_1	489	496	PF00069	0.172
MOD_GSK3_1	72	79	PF00069	0.279
MOD_GSK3_1	96	103	PF00069	0.327
MOD_N-GLC_1	161	166	PF02516	0.536
MOD_N-GLC_1	413	418	PF02516	0.523
MOD_N-GLC_1	454	459	PF02516	0.510
MOD_N-GLC_1	493	498	PF02516	0.497
MOD_N-GLC_2	292	294	PF02516	0.533
MOD_NEK2_1	1	6	PF00069	0.424
MOD_NEK2_1	202	207	PF00069	0.320
MOD_NEK2_1	375	380	PF00069	0.297
MOD_NEK2_1	389	394	PF00069	0.256
MOD_NEK2_1	407	412	PF00069	0.306
MOD_NEK2_1	460	465	PF00069	0.334
MOD_NEK2_1	489	494	PF00069	0.314
MOD_NEK2_1	525	530	PF00069	0.448
MOD_NEK2_1	535	540	PF00069	0.366
MOD_NEK2_1	55	60	PF00069	0.265
MOD_NEK2_1	76	81	PF00069	0.326
MOD_NEK2_1	87	92	PF00069	0.298
MOD_NEK2_2	161	166	PF00069	0.336
MOD_NEK2_2	198	203	PF00069	0.315
MOD_NEK2_2	347	352	PF00069	0.169
MOD_OFUCOSY	313	320	PF10250	0.474
MOD_PIKK_1	303	309	PF00454	0.259
MOD_PK_1	387	393	PF00069	0.169
MOD_PKA_2	202	208	PF00069	0.271
MOD_PKA_2	375	381	PF00069	0.327
MOD_PKA_2	431	437	PF00069	0.352
MOD_PKA_2	87	93	PF00069	0.213
MOD_Plk_1	161	167	PF00069	0.312
MOD_Plk_1	31	37	PF00069	0.331
MOD_Plk_1	413	419	PF00069	0.333
MOD_Plk_1	454	460	PF00069	0.336
MOD_Plk_1	47	53	PF00069	0.336
MOD_Plk_1	493	499	PF00069	0.325
MOD_Plk_4	227	233	PF00069	0.246
MOD_Plk_4	282	288	PF00069	0.265
MOD_Plk_4	347	353	PF00069	0.248
MOD_Plk_4	455	461	PF00069	0.316
MOD_Plk_4	476	482	PF00069	0.308
MOD_Plk_4	55	61	PF00069	0.331
MOD_Plk_4	96	102	PF00069	0.329
MOD_ProDKin_1	18	24	PF00069	0.514
MOD_ProDKin_1	192	198	PF00069	0.336
MOD_ProDKin_1	238	244	PF00069	0.308
MOD_ProDKin_1	297	303	PF00069	0.336
MOD_ProDKin_1	500	506	PF00069	0.463
MOD_SUMO_for_1	509	512	PF00179	0.470
TRG_DiLeu_BaEn_1	531	536	PF01217	0.438
TRG_ENDOCYTIC_2	111	114	PF00928	0.234
TRG_ENDOCYTIC_2	131	134	PF00928	0.336
TRG_ENDOCYTIC_2	199	202	PF00928	0.336
TRG_ENDOCYTIC_2	408	411	PF00928	0.338
TRG_ENDOCYTIC_2	417	420	PF00928	0.285
TRG_ENDOCYTIC_2	422	425	PF00928	0.253
TRG_ENDOCYTIC_2	549	552	PF00928	0.381
TRG_ENDOCYTIC_2	554	557	PF00928	0.609
TRG_ER_diArg_1	354	357	PF00400	0.338
TRG_ER_diArg_1	430	433	PF00400	0.169
TRG_ER_diArg_1	87	89	PF00400	0.316
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A060A682	Tetrahymena thermophila	22%	77%
A0A0N1I7I3	Leptomonas seymouri	50%	92%
A0A0S4KHY6	Bodo saltans	25%	85%
A0A1X0P0J5	Trypanosomatidae	24%	93%
A0A3Q8IW91	Leishmania donovani	75%	99%
A0A3R7NLN3	Trypanosoma rangeli	26%	97%
A4ID10	Leishmania infantum	75%	99%
A7SIM4	Nematostella vectensis	21%	67%
D0A4L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	92%
Q4Q129	Leishmania major	75%	100%
V5BFV7	Trypanosoma cruzi	27%	97%