Charged multivesicular body protein 4b

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Snf7, putative

Species:

Leishmania braziliensis

UniProt:

A4HPQ2_LEIBR

TriTrypDb:

LbrM.35.4080 , LBRM2903_350051000

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	1
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0009898	cytoplasmic side of plasma membrane	4	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0036452	ESCRT complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098552	side of membrane	2	1
GO:0098562	cytoplasmic side of membrane	3	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0007034	vacuolar transport	4	12
GO:0009987	cellular process	1	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0006900	vesicle budding from membrane	5	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0061024	membrane organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.390
CLV_NRD_NRD_1	74	76	PF00675	0.305
CLV_PCSK_KEX2_1	121	123	PF00082	0.387
CLV_PCSK_KEX2_1	41	43	PF00082	0.321
CLV_PCSK_KEX2_1	48	50	PF00082	0.321
CLV_PCSK_KEX2_1	74	76	PF00082	0.311
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.409
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.321
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.321
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.311
CLV_PCSK_SKI1_1	204	208	PF00082	0.636
CLV_Separin_Metazoa	108	112	PF03568	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DOC_PIKK_1	163	171	PF02985	0.376
DOC_USP7_MATH_1	195	199	PF00917	0.365
DOC_USP7_UBL2_3	117	121	PF12436	0.362
DOC_USP7_UBL2_3	200	204	PF12436	0.554
DOC_USP7_UBL2_3	23	27	PF12436	0.524
LIG_Actin_WH2_2	107	123	PF00022	0.422
LIG_APCC_ABBAyCdc20_2	75	81	PF00400	0.362
LIG_FHA_1	157	163	PF00498	0.200
LIG_FHA_2	208	214	PF00498	0.655
LIG_FHA_2	26	32	PF00498	0.508
LIG_PDZ_Class_3	220	225	PF00595	0.645
LIG_Pex14_2	2	6	PF04695	0.602
LIG_SH2_STAP1	79	83	PF00017	0.362
LIG_SH2_STAT3	79	82	PF00017	0.362
LIG_SH3_2	202	207	PF14604	0.674
LIG_SH3_3	188	194	PF00018	0.324
LIG_SH3_3	199	205	PF00018	0.625
LIG_TRAF2_1	116	119	PF00917	0.335
LIG_UBA3_1	1	10	PF00899	0.618
LIG_UBA3_1	139	145	PF00899	0.353
MOD_GSK3_1	92	99	PF00069	0.333
MOD_N-GLC_1	101	106	PF02516	0.368
MOD_NEK2_1	120	125	PF00069	0.416
MOD_NEK2_1	96	101	PF00069	0.329
MOD_PIKK_1	195	201	PF00454	0.445
MOD_PIKK_1	207	213	PF00454	0.656
MOD_PIKK_1	63	69	PF00454	0.362
MOD_PKA_1	63	69	PF00069	0.362
MOD_Plk_1	101	107	PF00069	0.368
MOD_SUMO_for_1	116	119	PF00179	0.340
MOD_SUMO_rev_2	118	123	PF00179	0.362
MOD_SUMO_rev_2	182	191	PF00179	0.390
TRG_NES_CRM1_1	170	182	PF08389	0.390
TRG_NLS_Bipartite_1	63	79	PF00514	0.340
TRG_NLS_MonoCore_2	73	78	PF00514	0.321
TRG_NLS_MonoExtC_3	74	80	PF00514	0.321
TRG_NLS_MonoExtN_4	74	79	PF00514	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5W8	Leptomonas seymouri	82%	100%
A0A0N1IHV1	Leptomonas seymouri	28%	100%
A0A0N1ILA5	Leptomonas seymouri	37%	100%
A0A0S4J9L8	Bodo saltans	30%	100%
A0A0S4JI05	Bodo saltans	58%	93%
A0A1X0NJR2	Trypanosomatidae	32%	100%
A0A1X0NZJ9	Trypanosomatidae	32%	100%
A0A1X0P4I7	Trypanosomatidae	62%	99%
A0A3Q8IJN8	Leishmania donovani	90%	100%
A0A3R7NQB4	Trypanosoma rangeli	57%	99%
A0A3S7WU01	Leishmania donovani	36%	100%
A0A3S7X8S3	Leishmania donovani	29%	100%
A0A422NAN8	Trypanosoma rangeli	32%	100%
A2VDY3	Bos taurus	31%	100%
A4H8L7	Leishmania braziliensis	35%	100%
A4HM91	Leishmania braziliensis	28%	100%
A4HWY8	Leishmania infantum	36%	100%
A4IAV5	Leishmania infantum	29%	100%
A4ID11	Leishmania infantum	90%	100%
C9ZW12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A2A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A8G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9AEN3	Leishmania major	30%	100%
E9AQQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ATG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B5T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O82197	Arabidopsis thaliana	33%	100%
P0CR54	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	33%	100%
P0CR55	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	33%	100%
P39929	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	94%
P59074	Homo sapiens	32%	100%
Q4Q130	Leishmania major	88%	100%
Q4QES7	Leishmania major	34%	100%
Q4QQV8	Rattus norvegicus	30%	100%
Q54JK4	Dictyostelium discoideum	26%	100%
Q569C1	Rattus norvegicus	32%	97%
Q5ABD0	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q5FW29	Xenopus tropicalis	32%	100%
Q5RBR3	Pongo abelii	30%	100%
Q5XGW6	Xenopus laevis	36%	100%
Q5ZHP5	Gallus gallus	34%	99%
Q6BSH2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	100%
Q6CJL0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	97%
Q6DD52	Xenopus laevis	32%	100%
Q6FW96	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	99%
Q6GL11	Xenopus tropicalis	36%	100%
Q6GNN8	Xenopus laevis	33%	99%
Q753W3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	95%
Q7T339	Danio rerio	31%	100%
Q7ZVC4	Danio rerio	35%	100%
Q86H98	Dictyostelium discoideum	26%	100%
Q96CF2	Homo sapiens	34%	97%
Q9BY43	Homo sapiens	32%	100%
Q9D7F7	Mus musculus	33%	97%
Q9D7S9	Mus musculus	30%	100%
Q9D8B3	Mus musculus	36%	100%
Q9FMC5	Arabidopsis thaliana	28%	96%
Q9H444	Homo sapiens	36%	100%
Q9LPN5	Arabidopsis thaliana	28%	96%
Q9NZZ3	Homo sapiens	30%	100%
Q9P7F7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q9SZE4	Arabidopsis thaliana	32%	100%
Q9VVI9	Drosophila melanogaster	27%	100%