RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4HPQ0_LEIBR

TriTrypDb:

LbrM.35.4060 , LBRM2903_350050800

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	191	193	PF00675	0.337
CLV_NRD_NRD_1	23	25	PF00675	0.644
CLV_NRD_NRD_1	292	294	PF00675	0.284
CLV_PCSK_KEX2_1	191	193	PF00082	0.337
CLV_PCSK_KEX2_1	23	25	PF00082	0.644
CLV_PCSK_KEX2_1	291	293	PF00082	0.404
CLV_PCSK_SKI1_1	226	230	PF00082	0.438
CLV_PCSK_SKI1_1	42	46	PF00082	0.381
CLV_PCSK_SKI1_1	76	80	PF00082	0.552
DEG_APCC_DBOX_1	147	155	PF00400	0.403
DEG_SIAH_1	240	248	PF03145	0.463
DOC_MAPK_gen_1	291	300	PF00069	0.315
DOC_PP2B_LxvP_1	170	173	PF13499	0.445
DOC_USP7_MATH_1	215	219	PF00917	0.616
DOC_USP7_MATH_1	256	260	PF00917	0.578
DOC_USP7_MATH_1	93	97	PF00917	0.657
DOC_USP7_UBL2_3	42	46	PF12436	0.599
DOC_WW_Pin1_4	152	157	PF00397	0.545
DOC_WW_Pin1_4	229	234	PF00397	0.668
DOC_WW_Pin1_4	236	241	PF00397	0.646
LIG_14-3-3_CanoR_1	23	29	PF00244	0.588
LIG_14-3-3_CanoR_1	291	297	PF00244	0.291
LIG_BRCT_BRCA1_1	94	98	PF00533	0.572
LIG_FHA_1	133	139	PF00498	0.378
LIG_FHA_1	293	299	PF00498	0.289
LIG_FHA_1	70	76	PF00498	0.483
LIG_FHA_2	172	178	PF00498	0.430
LIG_FHA_2	246	252	PF00498	0.595
LIG_LIR_Gen_1	270	279	PF02991	0.193
LIG_LIR_LC3C_4	272	276	PF02991	0.193
LIG_LIR_Nem_3	270	274	PF02991	0.313
LIG_SH2_CRK	120	124	PF00017	0.289
LIG_SH2_CRK	271	275	PF00017	0.404
LIG_SH2_STAP1	271	275	PF00017	0.193
LIG_SH2_STAT5	287	290	PF00017	0.335
LIG_SH2_STAT5	49	52	PF00017	0.531
LIG_SH2_STAT5	7	10	PF00017	0.405
LIG_SH3_3	235	241	PF00018	0.601
LIG_SH3_3	273	279	PF00018	0.353
MOD_CK1_1	224	230	PF00069	0.643
MOD_CK1_1	236	242	PF00069	0.512
MOD_CK1_1	69	75	PF00069	0.295
MOD_CK2_1	23	29	PF00069	0.776
MOD_CK2_1	245	251	PF00069	0.506
MOD_GlcNHglycan	216	220	PF01048	0.654
MOD_GlcNHglycan	235	238	PF01048	0.448
MOD_GSK3_1	152	159	PF00069	0.592
MOD_GSK3_1	229	236	PF00069	0.580
MOD_N-GLC_1	156	161	PF02516	0.519
MOD_N-GLC_2	262	264	PF02516	0.193
MOD_NEK2_1	11	16	PF00069	0.547
MOD_NEK2_1	285	290	PF00069	0.404
MOD_NMyristoyl	1	7	PF02799	0.530
MOD_OFUCOSY	125	130	PF10250	0.328
MOD_OFUCOSY	289	296	PF10250	0.271
MOD_PIKK_1	269	275	PF00454	0.205
MOD_PK_1	24	30	PF00069	0.612
MOD_PKA_1	23	29	PF00069	0.618
MOD_PKA_1	291	297	PF00069	0.404
MOD_PKA_2	11	17	PF00069	0.517
MOD_PKA_2	23	29	PF00069	0.606
MOD_PKA_2	291	297	PF00069	0.290
MOD_PKA_2	303	309	PF00069	0.369
MOD_Plk_2-3	29	35	PF00069	0.598
MOD_Plk_4	171	177	PF00069	0.464
MOD_Plk_4	303	309	PF00069	0.316
MOD_ProDKin_1	152	158	PF00069	0.544
MOD_ProDKin_1	229	235	PF00069	0.671
MOD_ProDKin_1	236	242	PF00069	0.647
TRG_ENDOCYTIC_2	120	123	PF00928	0.289
TRG_ENDOCYTIC_2	271	274	PF00928	0.404
TRG_ER_diArg_1	185	188	PF00400	0.539
TRG_ER_diArg_1	190	192	PF00400	0.548
TRG_ER_diArg_1	23	25	PF00400	0.644
TRG_ER_diArg_1	291	293	PF00400	0.193
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK3	Leptomonas seymouri	53%	97%
A0A0S4JLL7	Bodo saltans	31%	100%
A0A1X0P3L1	Trypanosomatidae	40%	100%
A0A3Q8IJF1	Leishmania donovani	78%	100%
A4ID13	Leishmania infantum	78%	100%
D0A8G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ATG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q132	Leishmania major	77%	100%
V5BIP2	Trypanosoma cruzi	35%	100%