MORN repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle pole body protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4HPP6_LEIBR

TriTrypDb:

LbrM.35.4020 , LBRM2903_350050400

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005815	microtubule organizing center	2	1
GO:0005816	spindle pole body	3	1
GO:0036064	ciliary basal body	3	1
GO:0044732	mitotic spindle pole body	4	1

Expansion

Sequence features

A4HPP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPP6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.303
CLV_NRD_NRD_1	295	297	PF00675	0.311
DEG_Nend_UBRbox_2	1	3	PF02207	0.578
DOC_MAPK_FxFP_2	164	167	PF00069	0.440
DOC_MAPK_gen_1	224	233	PF00069	0.313
DOC_MAPK_MEF2A_6	227	235	PF00069	0.335
DOC_MAPK_MEF2A_6	46	54	PF00069	0.366
DOC_PP4_FxxP_1	164	167	PF00568	0.420
DOC_PP4_FxxP_1	235	238	PF00568	0.364
LIG_14-3-3_CanoR_1	27	33	PF00244	0.241
LIG_APCC_ABBA_1	245	250	PF00400	0.408
LIG_APCC_ABBA_1	52	57	PF00400	0.366
LIG_FHA_2	279	285	PF00498	0.445
LIG_Integrin_isoDGR_2	254	256	PF01839	0.369
LIG_LIR_Apic_2	163	167	PF02991	0.425
LIG_LIR_Nem_3	205	210	PF02991	0.323
LIG_LIR_Nem_3	241	247	PF02991	0.389
LIG_REV1ctd_RIR_1	76	85	PF16727	0.288
LIG_SH2_NCK_1	309	313	PF00017	0.529
LIG_SH2_PTP2	244	247	PF00017	0.408
LIG_SH2_SRC	210	213	PF00017	0.379
LIG_SH2_SRC	309	312	PF00017	0.475
LIG_SH2_STAT3	172	175	PF00017	0.291
LIG_SH2_STAT3	195	198	PF00017	0.361
LIG_SH2_STAT5	172	175	PF00017	0.261
LIG_SH2_STAT5	176	179	PF00017	0.260
LIG_SH2_STAT5	210	213	PF00017	0.363
LIG_SH2_STAT5	219	222	PF00017	0.285
LIG_SH2_STAT5	234	237	PF00017	0.243
LIG_SH2_STAT5	244	247	PF00017	0.272
LIG_SH2_STAT5	53	56	PF00017	0.257
LIG_SH2_STAT5	62	65	PF00017	0.275
LIG_SH2_STAT5	7	10	PF00017	0.411
LIG_SH2_STAT5	77	80	PF00017	0.252
LIG_SH2_STAT5	87	90	PF00017	0.207
LIG_SH2_STAT5	91	94	PF00017	0.168
LIG_SH3_3	301	307	PF00018	0.425
LIG_TRAF2_1	286	289	PF00917	0.295
LIG_TRFH_1	186	190	PF08558	0.408
LIG_WRC_WIRS_1	161	166	PF05994	0.446
MOD_CK1_1	168	174	PF00069	0.363
MOD_CK1_1	264	270	PF00069	0.433
MOD_CK2_1	284	290	PF00069	0.391
MOD_Cter_Amidation	215	218	PF01082	0.342
MOD_Cter_Amidation	58	61	PF01082	0.411
MOD_GlcNHglycan	10	13	PF01048	0.420
MOD_GlcNHglycan	167	170	PF01048	0.369
MOD_GlcNHglycan	204	207	PF01048	0.356
MOD_GlcNHglycan	214	217	PF01048	0.354
MOD_GlcNHglycan	24	27	PF01048	0.313
MOD_GlcNHglycan	263	266	PF01048	0.430
MOD_GSK3_1	103	110	PF00069	0.415
MOD_GSK3_1	156	163	PF00069	0.506
MOD_N-GLC_1	89	94	PF02516	0.408
MOD_NEK2_1	103	108	PF00069	0.241
MOD_NEK2_1	261	266	PF00069	0.459
MOD_NEK2_1	55	60	PF00069	0.379
MOD_Plk_2-3	191	197	PF00069	0.423
MOD_Plk_2-3	284	290	PF00069	0.512
MOD_Plk_4	115	121	PF00069	0.385
MOD_Plk_4	264	270	PF00069	0.344
TRG_ENDOCYTIC_2	244	247	PF00928	0.408
TRG_ENDOCYTIC_2	309	312	PF00928	0.389
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIK8	Leptomonas seymouri	25%	88%
A0A0N1PBP4	Leptomonas seymouri	82%	100%
A0A0S4JF26	Bodo saltans	59%	99%
A0A0S4KIY0	Bodo saltans	27%	88%
A0A1X0NTG8	Trypanosomatidae	26%	72%
A0A1X0P1A5	Trypanosomatidae	29%	88%
A0A1X0P3N0	Trypanosomatidae	65%	94%
A0A3R7M394	Trypanosoma rangeli	65%	95%
A0A3R7NAK8	Trypanosoma rangeli	24%	77%
A0A3S7X3U7	Leishmania donovani	28%	88%
A0A3S7XBA2	Leishmania donovani	90%	100%
A0A422P0W0	Trypanosoma rangeli	30%	88%
A4HCH7	Leishmania braziliensis	24%	76%
A4HIR9	Leishmania braziliensis	28%	100%
A4HRY3	Leishmania infantum	23%	97%
A4I615	Leishmania infantum	28%	88%
A4ID18	Leishmania infantum	89%	100%
C9ZRE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	88%
C9ZSQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	72%
D0A8G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	97%
E9ACP2	Leishmania major	23%	100%
E9AJY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9ATG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B1A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	88%
Q4Q137	Leishmania major	91%	100%
Q4Q6V8	Leishmania major	28%	100%
Q4QBK7	Leishmania major	23%	76%
Q4R842	Macaca fascicularis	25%	100%
V5B1N1	Trypanosoma cruzi	27%	90%
V5BX28	Trypanosoma cruzi	27%	100%