LeishMANIAdb
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Nascent polypeptide-associated complex subunit beta

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Nascent polypeptide-associated complex subunit beta
Gene product:
transcription factor BTF3, putative
Species:
Leishmania braziliensis
UniProt:
A4HPP5_LEIBR
TriTrypDb:
LbrM.35.4010 , LBRM2903_350050300
Length:
103

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HPP5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPP5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 96 100 PF00656 0.569
CLV_NRD_NRD_1 10 12 PF00675 0.554
CLV_NRD_NRD_1 24 26 PF00675 0.413
CLV_NRD_NRD_1 45 47 PF00675 0.377
CLV_PCSK_KEX2_1 24 26 PF00082 0.389
CLV_PCSK_KEX2_1 45 47 PF00082 0.295
CLV_PCSK_KEX2_1 9 11 PF00082 0.544
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.560
CLV_Separin_Metazoa 13 17 PF03568 0.671
DOC_MAPK_gen_1 38 44 PF00069 0.580
DOC_PP4_FxxP_1 70 73 PF00568 0.491
DOC_USP7_UBL2_3 28 32 PF12436 0.662
DOC_WW_Pin1_4 47 52 PF00397 0.503
LIG_APCC_ABBA_1 49 54 PF00400 0.503
LIG_FHA_2 32 38 PF00498 0.613
LIG_LIR_Gen_1 50 60 PF02991 0.503
LIG_LIR_Nem_3 50 55 PF02991 0.503
LIG_SH2_STAT5 69 72 PF00017 0.504
LIG_SH3_4 72 79 PF00018 0.503
LIG_TRAF2_1 94 97 PF00917 0.539
MOD_CK1_1 78 84 PF00069 0.491
MOD_CK2_1 91 97 PF00069 0.640
MOD_GlcNHglycan 64 68 PF01048 0.335
MOD_GlcNHglycan 86 89 PF01048 0.291
MOD_GlcNHglycan 93 96 PF01048 0.546
MOD_GSK3_1 19 26 PF00069 0.569
MOD_NEK2_1 14 19 PF00069 0.603
MOD_NEK2_1 23 28 PF00069 0.599
MOD_NEK2_2 19 24 PF00069 0.567
MOD_PIKK_1 1 7 PF00454 0.553
MOD_PIKK_1 78 84 PF00454 0.516
MOD_PKA_1 24 30 PF00069 0.724
MOD_PKA_2 23 29 PF00069 0.581
MOD_ProDKin_1 47 53 PF00069 0.503
MOD_SUMO_rev_2 33 40 PF00179 0.543
MOD_SUMO_rev_2 87 95 PF00179 0.489
TRG_ER_diArg_1 23 25 PF00400 0.659
TRG_ER_diArg_1 44 46 PF00400 0.577

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWY6 Leptomonas seymouri 96% 100%
A0A0S4JL81 Bodo saltans 68% 89%
A0A1X0P4U0 Trypanosomatidae 74% 100%
A0A3S7XBD2 Leishmania donovani 98% 100%
A0A422MZD2 Trypanosoma rangeli 73% 100%
A2R091 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 41% 66%
A4ID19 Leishmania infantum 98% 100%
D0A8G9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 100%
E9ATF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
Q1DI23 Coccidioides immitis (strain RS) 44% 66%
Q2H4X9 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 38% 69%
Q4I283 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 39% 67%
Q4Q138 Leishmania major 97% 100%
Q54TR8 Dictyostelium discoideum 51% 73%
Q7SDU4 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 39% 68%
Q92371 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 34% 68%
V5BE97 Trypanosoma cruzi 73% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS