NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF498/DUF598), putative

Species:

Leishmania braziliensis

UniProt:

A4HPP0_LEIBR

TriTrypDb:

LbrM.35.3960 , LBRM2903_350049800

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HPP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPP0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0010257	NADH dehydrogenase complex assembly	6	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0032981	mitochondrial respiratory chain complex I assembly	7	11
GO:0033108	mitochondrial respiratory chain complex assembly	6	11
GO:0043933	protein-containing complex organization	4	11
GO:0065003	protein-containing complex assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.531
CLV_C14_Caspase3-7	589	593	PF00656	0.592
CLV_NRD_NRD_1	144	146	PF00675	0.539
CLV_NRD_NRD_1	155	157	PF00675	0.537
CLV_NRD_NRD_1	176	178	PF00675	0.641
CLV_NRD_NRD_1	27	29	PF00675	0.460
CLV_NRD_NRD_1	361	363	PF00675	0.335
CLV_NRD_NRD_1	501	503	PF00675	0.622
CLV_NRD_NRD_1	570	572	PF00675	0.541
CLV_NRD_NRD_1	614	616	PF00675	0.660
CLV_NRD_NRD_1	78	80	PF00675	0.593
CLV_PCSK_FUR_1	18	22	PF00082	0.501
CLV_PCSK_FUR_1	562	566	PF00082	0.549
CLV_PCSK_KEX2_1	144	146	PF00082	0.539
CLV_PCSK_KEX2_1	163	165	PF00082	0.537
CLV_PCSK_KEX2_1	174	176	PF00082	0.656
CLV_PCSK_KEX2_1	20	22	PF00082	0.488
CLV_PCSK_KEX2_1	207	209	PF00082	0.561
CLV_PCSK_KEX2_1	336	338	PF00082	0.335
CLV_PCSK_KEX2_1	361	363	PF00082	0.335
CLV_PCSK_KEX2_1	499	501	PF00082	0.615
CLV_PCSK_KEX2_1	564	566	PF00082	0.500
CLV_PCSK_KEX2_1	570	572	PF00082	0.502
CLV_PCSK_KEX2_1	614	616	PF00082	0.660
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.537
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.642
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.610
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.561
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.335
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.676
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.555
CLV_PCSK_PC7_1	16	22	PF00082	0.619
CLV_PCSK_PC7_1	610	616	PF00082	0.649
CLV_PCSK_SKI1_1	235	239	PF00082	0.573
CLV_PCSK_SKI1_1	331	335	PF00082	0.324
CLV_PCSK_SKI1_1	362	366	PF00082	0.331
CLV_PCSK_SKI1_1	450	454	PF00082	0.478
CLV_PCSK_SKI1_1	486	490	PF00082	0.647
CLV_PCSK_SKI1_1	586	590	PF00082	0.542
CLV_PCSK_SKI1_1	604	608	PF00082	0.617
CLV_PCSK_SKI1_1	86	90	PF00082	0.624
DEG_APCC_DBOX_1	361	369	PF00400	0.355
DEG_Nend_UBRbox_1	1	4	PF02207	0.631
DOC_CKS1_1	126	131	PF01111	0.642
DOC_CKS1_1	249	254	PF01111	0.718
DOC_CYCLIN_RxL_1	318	329	PF00134	0.355
DOC_MAPK_gen_1	361	367	PF00069	0.342
DOC_MAPK_MEF2A_6	300	308	PF00069	0.355
DOC_PP1_RVXF_1	10	16	PF00149	0.642
DOC_PP1_RVXF_1	319	326	PF00149	0.344
DOC_PP1_RVXF_1	329	335	PF00149	0.319
DOC_PP1_RVXF_1	84	90	PF00149	0.654
DOC_USP7_MATH_1	162	166	PF00917	0.642
DOC_USP7_MATH_1	178	182	PF00917	0.472
DOC_USP7_MATH_1	196	200	PF00917	0.561
DOC_USP7_MATH_1	22	26	PF00917	0.395
DOC_USP7_MATH_1	43	47	PF00917	0.754
DOC_USP7_MATH_1	442	446	PF00917	0.602
DOC_USP7_MATH_1	522	526	PF00917	0.623
DOC_USP7_MATH_1	66	70	PF00917	0.570
DOC_USP7_UBL2_3	414	418	PF12436	0.559
DOC_USP7_UBL2_3	499	503	PF12436	0.715
DOC_WW_Pin1_4	125	130	PF00397	0.612
DOC_WW_Pin1_4	188	193	PF00397	0.608
DOC_WW_Pin1_4	248	253	PF00397	0.664
DOC_WW_Pin1_4	261	266	PF00397	0.249
DOC_WW_Pin1_4	397	402	PF00397	0.693
DOC_WW_Pin1_4	403	408	PF00397	0.701
LIG_14-3-3_CanoR_1	2	6	PF00244	0.640
LIG_14-3-3_CanoR_1	253	259	PF00244	0.536
LIG_14-3-3_CanoR_1	300	305	PF00244	0.349
LIG_14-3-3_CanoR_1	361	368	PF00244	0.447
LIG_14-3-3_CanoR_1	420	427	PF00244	0.720
LIG_14-3-3_CanoR_1	441	447	PF00244	0.745
LIG_14-3-3_CanoR_1	614	624	PF00244	0.649
LIG_AP2alpha_2	186	188	PF02296	0.565
LIG_EH_1	242	246	PF12763	0.593
LIG_FHA_1	138	144	PF00498	0.581
LIG_FHA_1	255	261	PF00498	0.593
LIG_FHA_1	299	305	PF00498	0.320
LIG_FHA_1	525	531	PF00498	0.714
LIG_FHA_1	547	553	PF00498	0.545
LIG_FHA_1	620	626	PF00498	0.654
LIG_FHA_1	8	14	PF00498	0.713
LIG_FHA_2	482	488	PF00498	0.573
LIG_FHA_2	587	593	PF00498	0.559
LIG_FHA_2	98	104	PF00498	0.529
LIG_LIR_Gen_1	114	122	PF02991	0.563
LIG_LIR_Gen_1	293	302	PF02991	0.324
LIG_LIR_Gen_1	444	453	PF02991	0.630
LIG_LIR_Gen_1	458	468	PF02991	0.528
LIG_LIR_Nem_3	114	119	PF02991	0.559
LIG_LIR_Nem_3	152	158	PF02991	0.515
LIG_LIR_Nem_3	182	188	PF02991	0.578
LIG_LIR_Nem_3	293	297	PF02991	0.324
LIG_LIR_Nem_3	379	384	PF02991	0.547
LIG_LIR_Nem_3	444	449	PF02991	0.644
LIG_LIR_Nem_3	458	464	PF02991	0.527
LIG_LIR_Nem_3	466	471	PF02991	0.547
LIG_LIR_Nem_3	483	488	PF02991	0.574
LIG_LYPXL_L_2	308	317	PF13949	0.335
LIG_MYND_1	451	455	PF01753	0.602
LIG_MYND_1	518	522	PF01753	0.655
LIG_NRBOX	301	307	PF00104	0.378
LIG_Pex14_2	607	611	PF04695	0.631
LIG_PTB_Apo_2	384	391	PF02174	0.556
LIG_RPA_C_Fungi	356	368	PF08784	0.408
LIG_SH2_CRK	431	435	PF00017	0.616
LIG_SH2_CRK	446	450	PF00017	0.494
LIG_SH2_CRK	603	607	PF00017	0.609
LIG_SH2_STAT3	194	197	PF00017	0.570
LIG_SH2_STAT5	30	33	PF00017	0.573
LIG_SH2_STAT5	446	449	PF00017	0.497
LIG_SH2_STAT5	479	482	PF00017	0.559
LIG_SH2_STAT5	587	590	PF00017	0.651
LIG_SH3_1	177	183	PF00018	0.522
LIG_SH3_3	123	129	PF00018	0.570
LIG_SH3_3	177	183	PF00018	0.602
LIG_SH3_3	28	34	PF00018	0.577
LIG_SH3_3	541	547	PF00018	0.530
LIG_SUMO_SIM_anti_2	301	306	PF11976	0.355
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.447
LIG_TRAF2_1	168	171	PF00917	0.628
LIG_TRAF2_1	293	296	PF00917	0.335
LIG_TRAF2_1	472	475	PF00917	0.675
LIG_TRFH_1	188	192	PF08558	0.733
LIG_WRC_WIRS_1	291	296	PF05994	0.331
MOD_CDC14_SPxK_1	400	403	PF00782	0.701
MOD_CDK_SPK_2	248	253	PF00069	0.727
MOD_CDK_SPxK_1	397	403	PF00069	0.697
MOD_CDK_SPxxK_3	125	132	PF00069	0.711
MOD_CDK_SPxxK_3	188	195	PF00069	0.602
MOD_CK1_1	181	187	PF00069	0.579
MOD_CK1_1	212	218	PF00069	0.589
MOD_CK1_1	220	226	PF00069	0.565
MOD_CK1_1	264	270	PF00069	0.344
MOD_CK1_1	360	366	PF00069	0.442
MOD_CK1_1	45	51	PF00069	0.548
MOD_CK1_1	506	512	PF00069	0.624
MOD_CK2_1	290	296	PF00069	0.340
MOD_CK2_1	481	487	PF00069	0.567
MOD_GlcNHglycan	120	123	PF01048	0.688
MOD_GlcNHglycan	211	214	PF01048	0.571
MOD_GlcNHglycan	216	219	PF01048	0.599
MOD_GlcNHglycan	362	365	PF01048	0.419
MOD_GlcNHglycan	505	508	PF01048	0.615
MOD_GlcNHglycan	524	527	PF01048	0.618
MOD_GSK3_1	254	261	PF00069	0.575
MOD_GSK3_1	275	282	PF00069	0.328
MOD_GSK3_1	388	395	PF00069	0.566
MOD_GSK3_1	43	50	PF00069	0.680
MOD_GSK3_1	524	531	PF00069	0.623
MOD_GSK3_1	615	622	PF00069	0.663
MOD_N-GLC_1	481	486	PF02516	0.565
MOD_NEK2_1	1	6	PF00069	0.644
MOD_NEK2_1	258	263	PF00069	0.355
MOD_NEK2_1	316	321	PF00069	0.334
MOD_NEK2_1	344	349	PF00069	0.227
MOD_NEK2_1	357	362	PF00069	0.337
MOD_NEK2_1	392	397	PF00069	0.574
MOD_NEK2_1	596	601	PF00069	0.523
MOD_PIKK_1	169	175	PF00454	0.531
MOD_PIKK_1	235	241	PF00454	0.582
MOD_PIKK_1	344	350	PF00454	0.227
MOD_PIKK_1	392	398	PF00454	0.577
MOD_PIKK_1	419	425	PF00454	0.711
MOD_PK_1	300	306	PF00069	0.227
MOD_PKA_1	336	342	PF00069	0.335
MOD_PKA_2	1	7	PF00069	0.641
MOD_PKA_2	209	215	PF00069	0.567
MOD_PKA_2	336	342	PF00069	0.335
MOD_PKA_2	360	366	PF00069	0.447
MOD_PKA_2	419	425	PF00069	0.711
MOD_PKA_2	490	496	PF00069	0.682
MOD_PKA_2	556	562	PF00069	0.495
MOD_Plk_1	137	143	PF00069	0.614
MOD_Plk_1	197	203	PF00069	0.702
MOD_Plk_1	298	304	PF00069	0.395
MOD_Plk_1	480	486	PF00069	0.555
MOD_Plk_2-3	388	394	PF00069	0.565
MOD_Plk_2-3	481	487	PF00069	0.567
MOD_Plk_2-3	556	562	PF00069	0.495
MOD_Plk_4	137	143	PF00069	0.591
MOD_Plk_4	22	28	PF00069	0.409
MOD_Plk_4	264	270	PF00069	0.324
MOD_Plk_4	300	306	PF00069	0.327
MOD_Plk_4	336	342	PF00069	0.335
MOD_Plk_4	405	411	PF00069	0.634
MOD_Plk_4	463	469	PF00069	0.541
MOD_ProDKin_1	125	131	PF00069	0.612
MOD_ProDKin_1	188	194	PF00069	0.605
MOD_ProDKin_1	248	254	PF00069	0.659
MOD_ProDKin_1	261	267	PF00069	0.249
MOD_ProDKin_1	397	403	PF00069	0.697
MOD_SUMO_for_1	472	475	PF00179	0.688
MOD_SUMO_rev_2	228	237	PF00179	0.570
MOD_SUMO_rev_2	540	549	PF00179	0.526
MOD_SUMO_rev_2	72	82	PF00179	0.520
TRG_DiLeu_BaEn_1	138	143	PF01217	0.538
TRG_DiLeu_BaEn_2	153	159	PF01217	0.543
TRG_DiLeu_BaEn_4	138	144	PF01217	0.613
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.650
TRG_ENDOCYTIC_2	116	119	PF00928	0.528
TRG_ENDOCYTIC_2	155	158	PF00928	0.534
TRG_ENDOCYTIC_2	185	188	PF00928	0.560
TRG_ENDOCYTIC_2	431	434	PF00928	0.623
TRG_ENDOCYTIC_2	446	449	PF00928	0.497
TRG_ENDOCYTIC_2	603	606	PF00928	0.608
TRG_ER_diArg_1	143	145	PF00400	0.528
TRG_ER_diArg_1	15	18	PF00400	0.533
TRG_ER_diArg_1	175	177	PF00400	0.653
TRG_ER_diArg_1	5	8	PF00400	0.692
TRG_ER_diArg_1	613	615	PF00400	0.637
TRG_NLS_Bipartite_1	156	178	PF00514	0.566
TRG_NLS_MonoCore_2	173	178	PF00514	0.579
TRG_NLS_MonoExtC_3	173	178	PF00514	0.645
TRG_Pf-PMV_PEXEL_1	145	150	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ3	Leptomonas seymouri	86%	100%
A0A0S4JNA4	Bodo saltans	71%	100%
A0A1X0P3D3	Trypanosomatidae	77%	100%
A0A3S7XBD0	Leishmania donovani	95%	100%
A4ID24	Leishmania infantum	95%	100%
D0A8H4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9ATF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q143	Leishmania major	94%	100%
V5B9N8	Trypanosoma cruzi	77%	100%