CLP1_P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPN9_LEIBR

TriTrypDb:

LbrM.35.3950 , LBRM2903_350049700

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPN9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	1
GO:0006397	mRNA processing	7	1
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0008380	RNA splicing	7	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043631	RNA polyadenylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0019205	nucleobase-containing compound kinase activity	5	12
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	422	424	PF00675	0.391
CLV_NRD_NRD_1	9	11	PF00675	0.412
CLV_NRD_NRD_1	95	97	PF00675	0.412
CLV_PCSK_KEX2_1	102	104	PF00082	0.379
CLV_PCSK_KEX2_1	422	424	PF00082	0.391
CLV_PCSK_KEX2_1	5	7	PF00082	0.625
CLV_PCSK_KEX2_1	9	11	PF00082	0.524
CLV_PCSK_KEX2_1	95	97	PF00082	0.435
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.435
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.531
CLV_PCSK_SKI1_1	135	139	PF00082	0.411
CLV_PCSK_SKI1_1	9	13	PF00082	0.400
CLV_PCSK_SKI1_1	96	100	PF00082	0.441
CLV_Separin_Metazoa	263	267	PF03568	0.271
CLV_Separin_Metazoa	317	321	PF03568	0.412
DEG_ODPH_VHL_1	390	402	PF01847	0.348
DOC_CYCLIN_RxL_1	335	348	PF00134	0.475
DOC_MAPK_gen_1	102	109	PF00069	0.349
DOC_MAPK_gen_1	134	142	PF00069	0.411
DOC_MAPK_gen_1	4	13	PF00069	0.570
DOC_PP1_RVXF_1	339	346	PF00149	0.430
DOC_PP2B_LxvP_1	149	152	PF13499	0.360
DOC_PP4_FxxP_1	302	305	PF00568	0.483
DOC_USP7_MATH_1	188	192	PF00917	0.411
DOC_USP7_MATH_1	339	343	PF00917	0.459
DOC_USP7_MATH_1	368	372	PF00917	0.404
DOC_USP7_MATH_2	309	315	PF00917	0.425
DOC_WW_Pin1_4	169	174	PF00397	0.284
DOC_WW_Pin1_4	323	328	PF00397	0.392
LIG_14-3-3_CanoR_1	113	119	PF00244	0.327
LIG_14-3-3_CanoR_1	282	287	PF00244	0.447
LIG_14-3-3_CanoR_1	312	319	PF00244	0.453
LIG_14-3-3_CanoR_1	47	52	PF00244	0.412
LIG_14-3-3_CanoR_1	57	63	PF00244	0.359
LIG_14-3-3_CanoR_1	9	14	PF00244	0.449
LIG_14-3-3_CanoR_1	96	106	PF00244	0.402
LIG_APCC_ABBA_1	51	56	PF00400	0.486
LIG_APCC_ABBAyCdc20_2	341	347	PF00400	0.361
LIG_BRCT_BRCA1_1	341	345	PF00533	0.487
LIG_Clathr_ClatBox_1	343	347	PF01394	0.350
LIG_Clathr_ClatBox_1	62	66	PF01394	0.467
LIG_deltaCOP1_diTrp_1	280	286	PF00928	0.301
LIG_FHA_1	102	108	PF00498	0.422
LIG_FHA_1	209	215	PF00498	0.211
LIG_FHA_1	301	307	PF00498	0.400
LIG_FHA_1	48	54	PF00498	0.407
LIG_FHA_2	443	449	PF00498	0.516
LIG_LIR_Apic_2	299	305	PF02991	0.397
LIG_LIR_Gen_1	17	27	PF02991	0.391
LIG_LIR_Gen_1	280	291	PF02991	0.300
LIG_LIR_Gen_1	369	379	PF02991	0.447
LIG_LIR_Nem_3	17	22	PF02991	0.383
LIG_LIR_Nem_3	280	286	PF02991	0.300
LIG_LIR_Nem_3	326	331	PF02991	0.510
LIG_LIR_Nem_3	369	375	PF02991	0.456
LIG_MYND_1	173	177	PF01753	0.281
LIG_NRBOX	122	128	PF00104	0.411
LIG_PCNA_yPIPBox_3	282	295	PF02747	0.331
LIG_PDZ_Class_2	447	452	PF00595	0.428
LIG_SH2_CRK	19	23	PF00017	0.381
LIG_SH2_CRK	200	204	PF00017	0.331
LIG_SH2_CRK	258	262	PF00017	0.479
LIG_SH2_NCK_1	19	23	PF00017	0.381
LIG_SH2_SRC	150	153	PF00017	0.215
LIG_SH2_STAP1	210	214	PF00017	0.189
LIG_SH2_STAP1	230	234	PF00017	0.145
LIG_SH2_STAP1	49	53	PF00017	0.442
LIG_SH2_STAT3	199	202	PF00017	0.411
LIG_SH2_STAT5	181	184	PF00017	0.380
LIG_SH2_STAT5	19	22	PF00017	0.462
LIG_SH2_STAT5	210	213	PF00017	0.388
LIG_SH2_STAT5	322	325	PF00017	0.322
LIG_SH2_STAT5	401	404	PF00017	0.477
LIG_SH2_STAT5	49	52	PF00017	0.400
LIG_SH3_3	161	167	PF00018	0.447
LIG_SH3_3	240	246	PF00018	0.354
LIG_SH3_3	261	267	PF00018	0.387
LIG_SH3_3	303	309	PF00018	0.496
LIG_SH3_3	333	339	PF00018	0.406
LIG_SH3_3	362	368	PF00018	0.499
LIG_SH3_3	386	392	PF00018	0.352
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.312
LIG_SUMO_SIM_anti_2	268	275	PF11976	0.360
LIG_SUMO_SIM_par_1	176	182	PF11976	0.276
LIG_SUMO_SIM_par_1	268	275	PF11976	0.282
LIG_TRAF2_1	15	18	PF00917	0.367
LIG_TRAF2_1	415	418	PF00917	0.584
LIG_TRAF2_1	445	448	PF00917	0.432
LIG_TYR_ITIM	256	261	PF00017	0.421
MOD_CDK_SPK_2	169	174	PF00069	0.331
MOD_CK1_1	114	120	PF00069	0.300
MOD_CK1_1	179	185	PF00069	0.332
MOD_CK1_1	223	229	PF00069	0.320
MOD_CK1_1	350	356	PF00069	0.556
MOD_CK2_1	230	236	PF00069	0.465
MOD_CK2_1	271	277	PF00069	0.415
MOD_CK2_1	311	317	PF00069	0.414
MOD_CK2_1	377	383	PF00069	0.334
MOD_CK2_1	442	448	PF00069	0.454
MOD_GlcNHglycan	113	116	PF01048	0.283
MOD_GlcNHglycan	188	191	PF01048	0.322
MOD_GlcNHglycan	213	217	PF01048	0.347
MOD_GlcNHglycan	225	228	PF01048	0.301
MOD_GlcNHglycan	32	35	PF01048	0.508
MOD_GlcNHglycan	351	355	PF01048	0.643
MOD_GSK3_1	188	195	PF00069	0.411
MOD_GSK3_1	208	215	PF00069	0.145
MOD_GSK3_1	225	232	PF00069	0.441
MOD_GSK3_1	323	330	PF00069	0.560
MOD_GSK3_1	432	439	PF00069	0.388
MOD_GSK3_1	5	12	PF00069	0.512
MOD_GSK3_1	97	104	PF00069	0.470
MOD_N-GLC_1	203	208	PF02516	0.309
MOD_N-GLC_1	220	225	PF02516	0.271
MOD_N-GLC_1	234	239	PF02516	0.357
MOD_NEK2_1	203	208	PF00069	0.383
MOD_NEK2_1	229	234	PF00069	0.295
MOD_NEK2_1	331	336	PF00069	0.486
MOD_NEK2_1	42	47	PF00069	0.366
MOD_NEK2_1	436	441	PF00069	0.443
MOD_NEK2_2	432	437	PF00069	0.497
MOD_PIKK_1	208	214	PF00454	0.189
MOD_PIKK_1	220	226	PF00454	0.169
MOD_PKA_1	4	10	PF00069	0.487
MOD_PKA_2	186	192	PF00069	0.411
MOD_PKA_2	265	271	PF00069	0.258
MOD_PKA_2	281	287	PF00069	0.298
MOD_PKA_2	311	317	PF00069	0.509
MOD_PKA_2	432	438	PF00069	0.482
MOD_PKA_2	5	11	PF00069	0.495
MOD_PKA_2	94	100	PF00069	0.393
MOD_Plk_1	17	23	PF00069	0.333
MOD_Plk_1	203	209	PF00069	0.395
MOD_Plk_1	368	374	PF00069	0.496
MOD_Plk_4	133	139	PF00069	0.360
MOD_Plk_4	17	23	PF00069	0.382
MOD_Plk_4	176	182	PF00069	0.292
MOD_Plk_4	192	198	PF00069	0.227
MOD_Plk_4	203	209	PF00069	0.278
MOD_Plk_4	225	231	PF00069	0.437
MOD_Plk_4	282	288	PF00069	0.307
MOD_Plk_4	339	345	PF00069	0.503
MOD_Plk_4	395	401	PF00069	0.500
MOD_Plk_4	47	53	PF00069	0.398
MOD_Plk_4	58	64	PF00069	0.287
MOD_ProDKin_1	169	175	PF00069	0.284
MOD_ProDKin_1	323	329	PF00069	0.396
MOD_SUMO_rev_2	73	78	PF00179	0.384
TRG_DiLeu_BaEn_1	17	22	PF01217	0.383
TRG_DiLeu_BaEn_1	408	413	PF01217	0.348
TRG_DiLeu_BaLyEn_6	416	421	PF01217	0.490
TRG_ENDOCYTIC_2	19	22	PF00928	0.381
TRG_ENDOCYTIC_2	200	203	PF00928	0.411
TRG_ENDOCYTIC_2	258	261	PF00928	0.421
TRG_ER_diArg_1	421	423	PF00400	0.437
TRG_ER_diArg_1	9	11	PF00400	0.539
TRG_NLS_MonoExtN_4	2	8	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ5	Leptomonas seymouri	75%	100%
A0A0S4JES6	Bodo saltans	30%	100%
A0A1X0P3J8	Trypanosomatidae	45%	100%
A0A3Q8IL58	Leishmania donovani	94%	100%
A0A422N1N1	Trypanosoma rangeli	45%	100%
A4ID25	Leishmania infantum	94%	100%
D0A8H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ATF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q144	Leishmania major	92%	100%
V5AU86	Trypanosoma cruzi	47%	100%