LeishMANIAdb
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Mitogen activated kinase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitogen activated kinase-like protein
Gene product:
mitogen activated kinase-like protein
Species:
Leishmania braziliensis
UniProt:
A4HPN6_LEIBR
TriTrypDb:
LbrM.35.3920 , LBRM2903_350049400 *
Length:
977

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4HPN6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPN6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 392 396 PF00656 0.617
CLV_C14_Caspase3-7 637 641 PF00656 0.688
CLV_C14_Caspase3-7 856 860 PF00656 0.467
CLV_C14_Caspase3-7 965 969 PF00656 0.738
CLV_NRD_NRD_1 26 28 PF00675 0.356
CLV_NRD_NRD_1 659 661 PF00675 0.422
CLV_NRD_NRD_1 683 685 PF00675 0.456
CLV_NRD_NRD_1 690 692 PF00675 0.440
CLV_PCSK_KEX2_1 26 28 PF00082 0.260
CLV_PCSK_KEX2_1 33 35 PF00082 0.278
CLV_PCSK_KEX2_1 483 485 PF00082 0.431
CLV_PCSK_KEX2_1 674 676 PF00082 0.431
CLV_PCSK_KEX2_1 682 684 PF00082 0.417
CLV_PCSK_KEX2_1 784 786 PF00082 0.333
CLV_PCSK_KEX2_1 883 885 PF00082 0.249
CLV_PCSK_PC1ET2_1 33 35 PF00082 0.289
CLV_PCSK_PC1ET2_1 483 485 PF00082 0.489
CLV_PCSK_PC1ET2_1 674 676 PF00082 0.434
CLV_PCSK_PC1ET2_1 682 684 PF00082 0.417
CLV_PCSK_PC1ET2_1 784 786 PF00082 0.282
CLV_PCSK_PC1ET2_1 883 885 PF00082 0.267
CLV_PCSK_PC7_1 479 485 PF00082 0.378
CLV_PCSK_SKI1_1 237 241 PF00082 0.347
CLV_PCSK_SKI1_1 330 334 PF00082 0.462
CLV_PCSK_SKI1_1 426 430 PF00082 0.428
CLV_PCSK_SKI1_1 530 534 PF00082 0.431
CLV_PCSK_SKI1_1 684 688 PF00082 0.361
CLV_PCSK_SKI1_1 799 803 PF00082 0.236
CLV_PCSK_SKI1_1 816 820 PF00082 0.236
DEG_APCC_DBOX_1 107 115 PF00400 0.685
DEG_APCC_DBOX_1 425 433 PF00400 0.607
DEG_APCC_DBOX_1 504 512 PF00400 0.616
DOC_CYCLIN_RxL_1 421 431 PF00134 0.661
DOC_CYCLIN_yCln2_LP_2 109 115 PF00134 0.560
DOC_CYCLIN_yCln2_LP_2 531 537 PF00134 0.562
DOC_MAPK_gen_1 227 236 PF00069 0.643
DOC_MAPK_gen_1 434 442 PF00069 0.612
DOC_MAPK_gen_1 816 825 PF00069 0.436
DOC_MAPK_HePTP_8 70 82 PF00069 0.458
DOC_MAPK_MEF2A_6 108 117 PF00069 0.413
DOC_MAPK_MEF2A_6 73 82 PF00069 0.464
DOC_MAPK_MEF2A_6 762 771 PF00069 0.436
DOC_PP1_RVXF_1 436 443 PF00149 0.548
DOC_PP2B_LxvP_1 109 112 PF13499 0.665
DOC_PP2B_LxvP_1 531 534 PF13499 0.557
DOC_PP2B_LxvP_1 80 83 PF13499 0.485
DOC_USP7_MATH_1 186 190 PF00917 0.581
DOC_USP7_MATH_1 335 339 PF00917 0.657
DOC_USP7_MATH_1 552 556 PF00917 0.546
DOC_USP7_MATH_1 638 642 PF00917 0.622
DOC_USP7_MATH_1 95 99 PF00917 0.567
DOC_USP7_MATH_2 895 901 PF00917 0.531
DOC_USP7_UBL2_3 720 724 PF12436 0.436
DOC_USP7_UBL2_3 861 865 PF12436 0.531
DOC_WW_Pin1_4 522 527 PF00397 0.561
DOC_WW_Pin1_4 690 695 PF00397 0.553
LIG_14-3-3_CanoR_1 181 190 PF00244 0.643
LIG_14-3-3_CanoR_1 326 334 PF00244 0.554
LIG_14-3-3_CanoR_1 34 44 PF00244 0.664
LIG_14-3-3_CanoR_1 418 428 PF00244 0.714
LIG_14-3-3_CanoR_1 438 443 PF00244 0.693
LIG_14-3-3_CanoR_1 484 493 PF00244 0.573
LIG_14-3-3_CanoR_1 505 509 PF00244 0.712
LIG_14-3-3_CanoR_1 921 929 PF00244 0.492
LIG_14-3-3_CanoR_1 964 972 PF00244 0.675
LIG_APCC_ABBA_1 469 474 PF00400 0.704
LIG_APCC_ABBA_1 932 937 PF00400 0.603
LIG_BIR_II_1 1 5 PF00653 0.653
LIG_BRCT_BRCA1_1 728 732 PF00533 0.492
LIG_BRCT_BRCA1_1 972 976 PF00533 0.725
LIG_FHA_1 125 131 PF00498 0.372
LIG_FHA_1 265 271 PF00498 0.592
LIG_FHA_1 30 36 PF00498 0.631
LIG_FHA_1 339 345 PF00498 0.648
LIG_FHA_1 374 380 PF00498 0.636
LIG_FHA_1 456 462 PF00498 0.597
LIG_FHA_1 484 490 PF00498 0.582
LIG_FHA_1 526 532 PF00498 0.574
LIG_FHA_1 711 717 PF00498 0.492
LIG_FHA_1 73 79 PF00498 0.617
LIG_FHA_1 764 770 PF00498 0.444
LIG_FHA_1 837 843 PF00498 0.478
LIG_FHA_1 924 930 PF00498 0.477
LIG_FHA_2 183 189 PF00498 0.610
LIG_FHA_2 238 244 PF00498 0.615
LIG_FHA_2 270 276 PF00498 0.536
LIG_FHA_2 314 320 PF00498 0.671
LIG_FHA_2 776 782 PF00498 0.531
LIG_LIR_Apic_2 849 855 PF02991 0.436
LIG_LIR_Gen_1 161 171 PF02991 0.629
LIG_LIR_Gen_1 17 25 PF02991 0.662
LIG_LIR_Gen_1 185 195 PF02991 0.545
LIG_LIR_Gen_1 312 322 PF02991 0.629
LIG_LIR_Gen_1 468 476 PF02991 0.526
LIG_LIR_Gen_1 487 496 PF02991 0.682
LIG_LIR_Gen_1 66 74 PF02991 0.513
LIG_LIR_Nem_3 161 167 PF02991 0.652
LIG_LIR_Nem_3 17 22 PF02991 0.678
LIG_LIR_Nem_3 185 190 PF02991 0.612
LIG_LIR_Nem_3 395 401 PF02991 0.607
LIG_LIR_Nem_3 41 47 PF02991 0.701
LIG_LIR_Nem_3 412 416 PF02991 0.529
LIG_LIR_Nem_3 468 472 PF02991 0.612
LIG_LIR_Nem_3 487 493 PF02991 0.691
LIG_LIR_Nem_3 62 67 PF02991 0.615
LIG_LIR_Nem_3 685 690 PF02991 0.591
LIG_LIR_Nem_3 885 890 PF02991 0.373
LIG_NRBOX 155 161 PF00104 0.193
LIG_PCNA_PIPBox_1 377 386 PF02747 0.590
LIG_PCNA_yPIPBox_3 776 790 PF02747 0.492
LIG_PTB_Apo_2 463 470 PF02174 0.606
LIG_SH2_CRK 164 168 PF00017 0.568
LIG_SH2_CRK 44 48 PF00017 0.555
LIG_SH2_CRK 490 494 PF00017 0.582
LIG_SH2_NCK_1 187 191 PF00017 0.606
LIG_SH2_SRC 13 16 PF00017 0.573
LIG_SH2_STAP1 31 35 PF00017 0.551
LIG_SH2_STAP1 74 78 PF00017 0.546
LIG_SH2_STAT3 403 406 PF00017 0.515
LIG_SH2_STAT5 31 34 PF00017 0.652
LIG_SH2_STAT5 403 406 PF00017 0.611
LIG_SH2_STAT5 439 442 PF00017 0.737
LIG_SH2_STAT5 631 634 PF00017 0.589
LIG_SH2_STAT5 74 77 PF00017 0.531
LIG_SH2_STAT5 757 760 PF00017 0.436
LIG_SH2_STAT5 807 810 PF00017 0.445
LIG_SH3_3 541 547 PF00018 0.592
LIG_SUMO_SIM_anti_2 127 132 PF11976 0.435
LIG_SUMO_SIM_anti_2 149 155 PF11976 0.404
LIG_SUMO_SIM_anti_2 267 273 PF11976 0.578
LIG_SUMO_SIM_anti_2 559 565 PF11976 0.574
LIG_SUMO_SIM_anti_2 742 747 PF11976 0.377
LIG_SUMO_SIM_par_1 111 116 PF11976 0.427
LIG_SUMO_SIM_par_1 266 273 PF11976 0.519
LIG_SUMO_SIM_par_1 340 345 PF11976 0.667
LIG_SUMO_SIM_par_1 346 351 PF11976 0.623
LIG_SUMO_SIM_par_1 561 567 PF11976 0.532
LIG_SUMO_SIM_par_1 609 615 PF11976 0.639
LIG_SUMO_SIM_par_1 925 931 PF11976 0.527
LIG_TRAF2_1 211 214 PF00917 0.603
LIG_TRAF2_1 599 602 PF00917 0.522
LIG_TRAF2_1 676 679 PF00917 0.577
LIG_TRAF2_1 894 897 PF00917 0.482
LIG_TRAF2_1 952 955 PF00917 0.749
LIG_TYR_ITIM 162 167 PF00017 0.654
LIG_TYR_ITIM 42 47 PF00017 0.357
LIG_TYR_ITSM 183 190 PF00017 0.410
LIG_UBA3_1 159 168 PF00899 0.559
LIG_UBA3_1 532 538 PF00899 0.615
LIG_UBA3_1 561 568 PF00899 0.445
LIG_WRC_WIRS_1 380 385 PF05994 0.509
LIG_WRC_WIRS_1 439 444 PF05994 0.435
MOD_CK1_1 149 155 PF00069 0.373
MOD_CK1_1 325 331 PF00069 0.547
MOD_CK1_1 338 344 PF00069 0.598
MOD_CK1_1 351 357 PF00069 0.611
MOD_CK1_1 367 373 PF00069 0.438
MOD_CK1_1 389 395 PF00069 0.598
MOD_CK1_1 40 46 PF00069 0.579
MOD_CK1_1 414 420 PF00069 0.500
MOD_CK1_1 525 531 PF00069 0.523
MOD_CK1_1 615 621 PF00069 0.375
MOD_CK1_1 693 699 PF00069 0.314
MOD_CK1_1 714 720 PF00069 0.271
MOD_CK1_1 900 906 PF00069 0.404
MOD_CK1_1 962 968 PF00069 0.574
MOD_CK2_1 182 188 PF00069 0.524
MOD_CK2_1 237 243 PF00069 0.636
MOD_CK2_1 313 319 PF00069 0.604
MOD_CK2_1 35 41 PF00069 0.516
MOD_CK2_1 860 866 PF00069 0.404
MOD_GlcNHglycan 221 224 PF01048 0.450
MOD_GlcNHglycan 291 294 PF01048 0.534
MOD_GlcNHglycan 344 347 PF01048 0.589
MOD_GlcNHglycan 412 416 PF01048 0.547
MOD_GlcNHglycan 421 424 PF01048 0.531
MOD_GlcNHglycan 486 489 PF01048 0.596
MOD_GlcNHglycan 513 516 PF01048 0.413
MOD_GlcNHglycan 576 579 PF01048 0.528
MOD_GlcNHglycan 728 731 PF01048 0.376
MOD_GlcNHglycan 862 865 PF01048 0.335
MOD_GlcNHglycan 884 887 PF01048 0.418
MOD_GlcNHglycan 901 905 PF01048 0.393
MOD_GlcNHglycan 961 964 PF01048 0.519
MOD_GSK3_1 182 189 PF00069 0.590
MOD_GSK3_1 194 201 PF00069 0.629
MOD_GSK3_1 338 345 PF00069 0.549
MOD_GSK3_1 36 43 PF00069 0.569
MOD_GSK3_1 360 367 PF00069 0.519
MOD_GSK3_1 379 386 PF00069 0.328
MOD_GSK3_1 389 396 PF00069 0.556
MOD_GSK3_1 455 462 PF00069 0.617
MOD_GSK3_1 710 717 PF00069 0.289
MOD_GSK3_1 72 79 PF00069 0.297
MOD_GSK3_1 830 837 PF00069 0.274
MOD_GSK3_1 860 867 PF00069 0.418
MOD_GSK3_1 916 923 PF00069 0.311
MOD_GSK3_1 959 966 PF00069 0.614
MOD_N-GLC_1 465 470 PF02516 0.510
MOD_N-GLC_1 574 579 PF02516 0.439
MOD_N-GLC_2 194 196 PF02516 0.438
MOD_N-GLC_2 668 670 PF02516 0.382
MOD_NEK2_1 1 6 PF00069 0.431
MOD_NEK2_1 146 151 PF00069 0.358
MOD_NEK2_1 20 25 PF00069 0.515
MOD_NEK2_1 219 224 PF00069 0.437
MOD_NEK2_1 289 294 PF00069 0.543
MOD_NEK2_1 313 318 PF00069 0.566
MOD_NEK2_1 322 327 PF00069 0.531
MOD_NEK2_1 35 40 PF00069 0.579
MOD_NEK2_1 364 369 PF00069 0.468
MOD_NEK2_1 373 378 PF00069 0.486
MOD_NEK2_1 455 460 PF00069 0.539
MOD_NEK2_1 589 594 PF00069 0.355
MOD_NEK2_1 823 828 PF00069 0.307
MOD_NEK2_2 284 289 PF00069 0.475
MOD_NEK2_2 583 588 PF00069 0.551
MOD_PIKK_1 371 377 PF00454 0.483
MOD_PIKK_1 386 392 PF00454 0.414
MOD_PIKK_1 393 399 PF00454 0.574
MOD_PIKK_1 693 699 PF00454 0.335
MOD_PIKK_1 823 829 PF00454 0.404
MOD_PIKK_1 95 101 PF00454 0.466
MOD_PKA_1 237 243 PF00069 0.426
MOD_PKA_1 483 489 PF00069 0.478
MOD_PKA_2 325 331 PF00069 0.522
MOD_PKA_2 36 42 PF00069 0.381
MOD_PKA_2 483 489 PF00069 0.482
MOD_PKA_2 504 510 PF00069 0.653
MOD_PKA_2 726 732 PF00069 0.349
MOD_PKA_2 920 926 PF00069 0.289
MOD_PKA_2 963 969 PF00069 0.609
MOD_PKB_1 436 444 PF00069 0.603
MOD_Plk_1 307 313 PF00069 0.495
MOD_Plk_1 386 392 PF00069 0.556
MOD_Plk_1 40 46 PF00069 0.369
MOD_Plk_1 411 417 PF00069 0.507
MOD_Plk_1 465 471 PF00069 0.598
MOD_Plk_1 763 769 PF00069 0.272
MOD_Plk_1 967 973 PF00069 0.659
MOD_Plk_2-3 775 781 PF00069 0.314
MOD_Plk_4 113 119 PF00069 0.351
MOD_Plk_4 124 130 PF00069 0.235
MOD_Plk_4 149 155 PF00069 0.331
MOD_Plk_4 158 164 PF00069 0.287
MOD_Plk_4 20 26 PF00069 0.605
MOD_Plk_4 253 259 PF00069 0.641
MOD_Plk_4 264 270 PF00069 0.430
MOD_Plk_4 300 306 PF00069 0.385
MOD_Plk_4 344 350 PF00069 0.442
MOD_Plk_4 379 385 PF00069 0.495
MOD_Plk_4 504 510 PF00069 0.663
MOD_Plk_4 576 582 PF00069 0.538
MOD_Plk_4 793 799 PF00069 0.333
MOD_Plk_4 923 929 PF00069 0.284
MOD_Plk_4 967 973 PF00069 0.616
MOD_ProDKin_1 522 528 PF00069 0.441
MOD_ProDKin_1 690 696 PF00069 0.430
MOD_SUMO_for_1 537 540 PF00179 0.601
MOD_SUMO_rev_2 441 449 PF00179 0.680
MOD_SUMO_rev_2 477 485 PF00179 0.402
MOD_SUMO_rev_2 612 618 PF00179 0.580
MOD_SUMO_rev_2 671 676 PF00179 0.533
MOD_SUMO_rev_2 856 863 PF00179 0.404
MOD_SUMO_rev_2 954 960 PF00179 0.593
TRG_AP2beta_CARGO_1 17 26 PF09066 0.460
TRG_DiLeu_BaEn_1 66 71 PF01217 0.418
TRG_DiLeu_BaEn_3 213 219 PF01217 0.443
TRG_DiLeu_BaEn_4 601 607 PF01217 0.375
TRG_DiLeu_BaLyEn_6 557 562 PF01217 0.589
TRG_DiLeu_BaLyEn_6 696 701 PF01217 0.335
TRG_DiLeu_LyEn_5 66 71 PF01217 0.383
TRG_ENDOCYTIC_2 164 167 PF00928 0.679
TRG_ENDOCYTIC_2 187 190 PF00928 0.597
TRG_ENDOCYTIC_2 314 317 PF00928 0.480
TRG_ENDOCYTIC_2 439 442 PF00928 0.571
TRG_ENDOCYTIC_2 44 47 PF00928 0.619
TRG_ENDOCYTIC_2 48 51 PF00928 0.553
TRG_ENDOCYTIC_2 490 493 PF00928 0.622
TRG_ENDOCYTIC_2 64 67 PF00928 0.274
TRG_ER_diArg_1 25 27 PF00400 0.306
TRG_ER_diArg_1 436 439 PF00400 0.655
TRG_ER_diArg_1 787 790 PF00400 0.193
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.589
TRG_Pf-PMV_PEXEL_1 426 431 PF00026 0.515

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7Q2 Leptomonas seymouri 29% 95%
A0A0N1HX31 Leptomonas seymouri 62% 100%
A0A0S4JAS0 Bodo saltans 46% 97%
A0A0S4JMC0 Bodo saltans 46% 100%
A0A1X0P3F4 Trypanosomatidae 48% 98%
A0A3Q8IGC6 Leishmania donovani 82% 100%
A4ID28 Leishmania infantum 82% 100%
E9ATF0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q147 Leishmania major 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS