Nudix hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX hydrolase 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HPN3_LEIBR

TriTrypDb:

LbrM.35.3890 , LBRM2903_350049100

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPN3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0047631	ADP-ribose diphosphatase activity	6	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.402
CLV_NRD_NRD_1	73	75	PF00675	0.397
CLV_PCSK_KEX2_1	73	75	PF00082	0.390
DEG_APCC_DBOX_1	6	14	PF00400	0.469
DEG_Nend_UBRbox_1	1	4	PF02207	0.540
DOC_ANK_TNKS_1	150	157	PF00023	0.397
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.343
DOC_MAPK_gen_1	73	83	PF00069	0.340
DOC_PP2B_LxvP_1	177	180	PF13499	0.457
DOC_WW_Pin1_4	104	109	PF00397	0.216
DOC_WW_Pin1_4	130	135	PF00397	0.397
DOC_WW_Pin1_4	54	59	PF00397	0.511
LIG_14-3-3_CanoR_1	20	25	PF00244	0.435
LIG_14-3-3_CanoR_1	73	81	PF00244	0.470
LIG_Actin_WH2_2	3	19	PF00022	0.535
LIG_BIR_III_2	32	36	PF00653	0.420
LIG_BRCT_BRCA1_1	75	79	PF00533	0.476
LIG_Clathr_ClatBox_1	149	153	PF01394	0.469
LIG_FHA_1	118	124	PF00498	0.350
LIG_FHA_1	125	131	PF00498	0.327
LIG_FHA_1	44	50	PF00498	0.397
LIG_FHA_2	211	217	PF00498	0.454
LIG_FHA_2	6	12	PF00498	0.538
LIG_LIR_Gen_1	76	86	PF02991	0.343
LIG_LIR_Nem_3	76	82	PF02991	0.343
LIG_SH2_CRK	86	90	PF00017	0.343
LIG_SH2_STAT5	198	201	PF00017	0.375
LIG_SH2_STAT5	212	215	PF00017	0.457
LIG_SH2_STAT5	26	29	PF00017	0.553
LIG_SH2_STAT5	5	8	PF00017	0.549
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.421
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.541
LIG_SUMO_SIM_par_1	125	133	PF11976	0.341
LIG_TRAF2_2	164	169	PF00917	0.474
LIG_UBA3_1	177	185	PF00899	0.482
LIG_WRC_WIRS_1	211	216	PF05994	0.449
MOD_CK2_1	210	216	PF00069	0.455
MOD_CK2_1	49	55	PF00069	0.465
MOD_CK2_1	5	11	PF00069	0.542
MOD_GlcNHglycan	192	195	PF01048	0.380
MOD_GlcNHglycan	51	54	PF01048	0.572
MOD_GSK3_1	124	131	PF00069	0.428
MOD_GSK3_1	16	23	PF00069	0.432
MOD_GSK3_1	179	186	PF00069	0.550
MOD_GSK3_1	45	52	PF00069	0.486
MOD_N-GLC_1	104	109	PF02516	0.286
MOD_NEK2_1	142	147	PF00069	0.324
MOD_NEK2_1	16	21	PF00069	0.550
MOD_NEK2_1	24	29	PF00069	0.553
MOD_PKA_1	73	79	PF00069	0.469
MOD_PKA_2	196	202	PF00069	0.321
MOD_PKA_2	43	49	PF00069	0.452
MOD_PKA_2	72	78	PF00069	0.470
MOD_Plk_4	210	216	PF00069	0.427
MOD_ProDKin_1	104	110	PF00069	0.216
MOD_ProDKin_1	130	136	PF00069	0.397
MOD_ProDKin_1	54	60	PF00069	0.508
MOD_SUMO_rev_2	182	187	PF00179	0.425
TRG_DiLeu_BaEn_2	117	123	PF01217	0.469
TRG_ENDOCYTIC_2	212	215	PF00928	0.403
TRG_ER_diArg_1	72	74	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P576	Leptomonas seymouri	63%	97%
A0A0S4JQK4	Bodo saltans	40%	91%
A0A1X0P4G7	Trypanosomatidae	44%	92%
A0A3S7XBB4	Leishmania donovani	85%	100%
A0A422N1K2	Trypanosoma rangeli	44%	92%
A4ID31	Leishmania infantum	85%	100%
D0A8I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	90%
E9ATE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	80%
O61902	Caenorhabditis elegans	45%	100%
Q01976	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	96%
Q4Q150	Leishmania major	85%	100%
Q5RCY2	Pongo abelii	34%	100%
Q6AY63	Rattus norvegicus	35%	100%
Q9JKX6	Mus musculus	33%	100%
Q9P791	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q9UKK9	Homo sapiens	36%	100%
V5B9P3	Trypanosoma cruzi	48%	92%