Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HPN0_LEIBR

TriTrypDb:

LbrM.35.3860 , LBRM2903_350048700

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HPN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPN0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.482
CLV_C14_Caspase3-7	218	222	PF00656	0.636
CLV_NRD_NRD_1	108	110	PF00675	0.388
CLV_NRD_NRD_1	112	114	PF00675	0.385
CLV_NRD_NRD_1	135	137	PF00675	0.407
CLV_NRD_NRD_1	225	227	PF00675	0.459
CLV_NRD_NRD_1	240	242	PF00675	0.522
CLV_PCSK_KEX2_1	112	114	PF00082	0.398
CLV_PCSK_KEX2_1	135	137	PF00082	0.407
CLV_PCSK_KEX2_1	225	227	PF00082	0.459
CLV_PCSK_KEX2_1	240	242	PF00082	0.522
CLV_PCSK_SKI1_1	241	245	PF00082	0.439
CLV_PCSK_SKI1_1	272	276	PF00082	0.439
DOC_MAPK_gen_1	135	142	PF00069	0.605
DOC_MAPK_HePTP_8	80	92	PF00069	0.332
DOC_MAPK_MEF2A_6	83	92	PF00069	0.332
DOC_PP2B_LxvP_1	183	186	PF13499	0.620
DOC_USP7_MATH_1	119	123	PF00917	0.521
DOC_USP7_MATH_1	67	71	PF00917	0.493
DOC_USP7_MATH_1	75	79	PF00917	0.450
DOC_USP7_MATH_1	81	85	PF00917	0.352
DOC_WW_Pin1_4	241	246	PF00397	0.643
DOC_WW_Pin1_4	273	278	PF00397	0.738
DOC_WW_Pin1_4	284	289	PF00397	0.646
DOC_WW_Pin1_4	63	68	PF00397	0.467
LIG_14-3-3_CanoR_1	225	234	PF00244	0.632
LIG_14-3-3_CanoR_1	63	67	PF00244	0.379
LIG_BRCT_BRCA1_1	285	289	PF00533	0.623
LIG_FHA_1	43	49	PF00498	0.435
LIG_FHA_1	83	89	PF00498	0.292
LIG_FHA_2	127	133	PF00498	0.558
LIG_FHA_2	15	21	PF00498	0.486
LIG_FHA_2	205	211	PF00498	0.724
LIG_FHA_2	263	269	PF00498	0.729
LIG_LIR_Apic_2	276	282	PF02991	0.641
LIG_LIR_Nem_3	268	274	PF02991	0.636
LIG_PCNA_yPIPBox_3	160	170	PF02747	0.643
LIG_PDZ_Class_1	284	289	PF00595	0.624
LIG_Pex14_2	5	9	PF04695	0.397
LIG_REV1ctd_RIR_1	2	12	PF16727	0.393
LIG_SH2_GRB2like	251	254	PF00017	0.656
LIG_SH2_STAT5	251	254	PF00017	0.679
LIG_SH2_STAT5	262	265	PF00017	0.699
LIG_SH2_STAT5	279	282	PF00017	0.611
LIG_SH2_STAT5	57	60	PF00017	0.406
LIG_SH3_3	230	236	PF00018	0.732
LIG_SH3_3	252	258	PF00018	0.637
LIG_SH3_3	271	277	PF00018	0.655
LIG_SUMO_SIM_anti_2	84	91	PF11976	0.332
LIG_SUMO_SIM_par_1	93	99	PF11976	0.243
LIG_TRAF2_1	227	230	PF00917	0.652
LIG_TRFH_1	232	236	PF08558	0.634
MOD_CK1_1	181	187	PF00069	0.674
MOD_CK1_1	228	234	PF00069	0.647
MOD_CK1_1	260	266	PF00069	0.717
MOD_CK1_1	62	68	PF00069	0.480
MOD_CK1_1	70	76	PF00069	0.453
MOD_CK2_1	126	132	PF00069	0.556
MOD_CK2_1	224	230	PF00069	0.695
MOD_CK2_1	262	268	PF00069	0.731
MOD_Cter_Amidation	110	113	PF01082	0.300
MOD_DYRK1A_RPxSP_1	63	67	PF00069	0.379
MOD_GlcNHglycan	121	124	PF01048	0.326
MOD_GlcNHglycan	72	75	PF01048	0.690
MOD_GSK3_1	12	19	PF00069	0.494
MOD_GSK3_1	171	178	PF00069	0.693
MOD_GSK3_1	181	188	PF00069	0.667
MOD_GSK3_1	224	231	PF00069	0.687
MOD_GSK3_1	257	264	PF00069	0.713
MOD_GSK3_1	280	287	PF00069	0.630
MOD_GSK3_1	29	36	PF00069	0.307
MOD_GSK3_1	59	66	PF00069	0.450
MOD_GSK3_1	69	76	PF00069	0.439
MOD_N-GLC_1	70	75	PF02516	0.707
MOD_NEK2_1	96	101	PF00069	0.243
MOD_PIKK_1	178	184	PF00454	0.718
MOD_PIKK_1	225	231	PF00454	0.715
MOD_PKA_1	225	231	PF00069	0.630
MOD_PKA_2	224	230	PF00069	0.633
MOD_PKA_2	62	68	PF00069	0.379
MOD_Plk_4	228	234	PF00069	0.647
MOD_Plk_4	257	263	PF00069	0.738
MOD_Plk_4	75	81	PF00069	0.486
MOD_Plk_4	82	88	PF00069	0.285
MOD_ProDKin_1	241	247	PF00069	0.645
MOD_ProDKin_1	273	279	PF00069	0.738
MOD_ProDKin_1	63	69	PF00069	0.469
MOD_SUMO_rev_2	15	23	PF00179	0.373
TRG_ER_diArg_1	112	114	PF00400	0.601
TRG_ER_diArg_1	191	194	PF00400	0.656
TRG_ER_diArg_1	239	241	PF00400	0.747
TRG_NLS_MonoExtC_3	108	113	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJD1	Leishmania donovani	61%	98%
A4ID36	Leishmania infantum	61%	98%
E9ATE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	97%
Q4Q155	Leishmania major	61%	99%