EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair, putative

Species:

Leishmania braziliensis

UniProt:

A4HPM9_LEIBR

TriTrypDb:

LbrM.35.3850 , LBRM2903_350048600

Length:

103

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPM9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	77	79	PF00675	0.378
DEG_Nend_UBRbox_3	1	3	PF02207	0.644
DOC_MAPK_gen_1	55	61	PF00069	0.480
LIG_CtBP_PxDLS_1	65	71	PF00389	0.480
LIG_FHA_2	81	87	PF00498	0.402
LIG_LIR_Gen_1	36	43	PF02991	0.335
LIG_LIR_Gen_1	87	98	PF02991	0.326
LIG_LIR_Nem_3	36	41	PF02991	0.331
LIG_LIR_Nem_3	87	93	PF02991	0.328
LIG_Rb_pABgroove_1	32	40	PF01858	0.355
LIG_SH2_NCK_1	17	21	PF00017	0.682
LIG_SH2_PTP2	58	61	PF00017	0.227
LIG_SH2_SRC	17	20	PF00017	0.681
LIG_SH2_STAP1	90	94	PF00017	0.447
LIG_SH2_STAT5	58	61	PF00017	0.308
LIG_SxIP_EBH_1	3	12	PF03271	0.608
LIG_TRAF2_1	16	19	PF00917	0.493
LIG_TRAF2_1	89	92	PF00917	0.468
LIG_TYR_ITIM	15	20	PF00017	0.679
MOD_CK2_1	66	72	PF00069	0.335
MOD_CK2_1	86	92	PF00069	0.150
MOD_GlcNHglycan	45	48	PF01048	0.467
MOD_GSK3_1	80	87	PF00069	0.378
MOD_N-GLC_1	43	48	PF02516	0.454
MOD_N-GLC_1	66	71	PF02516	0.227
MOD_NEK2_1	1	6	PF00069	0.609
MOD_NEK2_1	96	101	PF00069	0.477
MOD_Plk_1	73	79	PF00069	0.424
MOD_Plk_1	84	90	PF00069	0.398
MOD_Plk_2-3	86	92	PF00069	0.448
TRG_DiLeu_BaEn_3	91	97	PF01217	0.480
TRG_ENDOCYTIC_2	17	20	PF00928	0.674
TRG_ENDOCYTIC_2	58	61	PF00928	0.384
TRG_ENDOCYTIC_2	90	93	PF00928	0.358
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM5	Leptomonas seymouri	69%	100%
A0A0S4J6C4	Bodo saltans	53%	100%
A0A1X0P443	Trypanosomatidae	60%	100%
A0A3Q8IRB5	Leishmania donovani	83%	100%
A0A3R7N819	Trypanosoma rangeli	59%	100%
A4ID37	Leishmania infantum	83%	100%
D0A8I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ATE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q156	Leishmania major	83%	100%