F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HPM8_LEIBR

TriTrypDb:

LbrM.35.3840 , LBRM2903_350048500

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.411
CLV_C14_Caspase3-7	428	432	PF00656	0.491
CLV_NRD_NRD_1	29	31	PF00675	0.617
CLV_NRD_NRD_1	349	351	PF00675	0.595
CLV_PCSK_KEX2_1	200	202	PF00082	0.660
CLV_PCSK_KEX2_1	349	351	PF00082	0.641
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.660
CLV_PCSK_PC7_1	196	202	PF00082	0.528
CLV_PCSK_SKI1_1	131	135	PF00082	0.546
CLV_PCSK_SKI1_1	177	181	PF00082	0.564
CLV_PCSK_SKI1_1	393	397	PF00082	0.645
DEG_Nend_UBRbox_2	1	3	PF02207	0.459
DEG_ODPH_VHL_1	58	69	PF01847	0.439
DOC_CKS1_1	320	325	PF01111	0.434
DOC_CYCLIN_RxL_1	488	498	PF00134	0.486
DOC_MAPK_FxFP_2	118	121	PF00069	0.377
DOC_MAPK_gen_1	136	144	PF00069	0.396
DOC_MAPK_gen_1	16	22	PF00069	0.444
DOC_MAPK_gen_1	349	357	PF00069	0.338
DOC_MAPK_gen_1	72	80	PF00069	0.431
DOC_MAPK_MEF2A_6	72	80	PF00069	0.431
DOC_PP1_RVXF_1	175	182	PF00149	0.383
DOC_PP1_RVXF_1	288	294	PF00149	0.274
DOC_PP2B_LxvP_1	493	496	PF13499	0.508
DOC_PP2B_LxvP_1	58	61	PF13499	0.445
DOC_PP4_FxxP_1	118	121	PF00568	0.384
DOC_USP7_MATH_1	119	123	PF00917	0.421
DOC_USP7_MATH_1	232	236	PF00917	0.489
DOC_USP7_MATH_1	331	335	PF00917	0.294
DOC_USP7_MATH_1	369	373	PF00917	0.345
DOC_USP7_MATH_1	459	463	PF00917	0.488
DOC_USP7_MATH_1	487	491	PF00917	0.558
DOC_WW_Pin1_4	162	167	PF00397	0.387
DOC_WW_Pin1_4	240	245	PF00397	0.539
DOC_WW_Pin1_4	319	324	PF00397	0.433
DOC_WW_Pin1_4	482	487	PF00397	0.382
LIG_14-3-3_CanoR_1	30	34	PF00244	0.367
LIG_14-3-3_CanoR_1	300	305	PF00244	0.441
LIG_14-3-3_CanoR_1	339	344	PF00244	0.406
LIG_14-3-3_CanoR_1	349	358	PF00244	0.352
LIG_14-3-3_CanoR_1	379	383	PF00244	0.453
LIG_14-3-3_CanoR_1	419	425	PF00244	0.520
LIG_AP2alpha_2	231	233	PF02296	0.464
LIG_AP2alpha_2	468	470	PF02296	0.496
LIG_BIR_III_2	483	487	PF00653	0.380
LIG_eIF4E_1	95	101	PF01652	0.418
LIG_EVH1_2	255	259	PF00568	0.379
LIG_FHA_1	249	255	PF00498	0.546
LIG_FHA_1	350	356	PF00498	0.418
LIG_FHA_1	379	385	PF00498	0.455
LIG_FHA_1	4	10	PF00498	0.426
LIG_FHA_1	402	408	PF00498	0.487
LIG_FHA_1	424	430	PF00498	0.466
LIG_FHA_1	475	481	PF00498	0.488
LIG_FHA_1	84	90	PF00498	0.405
LIG_FHA_1	96	102	PF00498	0.326
LIG_FHA_2	13	19	PF00498	0.390
LIG_FHA_2	149	155	PF00498	0.413
LIG_FHA_2	193	199	PF00498	0.430
LIG_FHA_2	244	250	PF00498	0.431
LIG_FHA_2	290	296	PF00498	0.291
LIG_FHA_2	320	326	PF00498	0.408
LIG_FHA_2	498	504	PF00498	0.474
LIG_LIR_Apic_2	160	166	PF02991	0.368
LIG_LIR_Apic_2	318	323	PF02991	0.436
LIG_LIR_Gen_1	328	338	PF02991	0.375
LIG_LIR_Gen_1	404	412	PF02991	0.449
LIG_LIR_Gen_1	506	515	PF02991	0.331
LIG_LIR_Nem_3	265	271	PF02991	0.346
LIG_LIR_Nem_3	36	40	PF02991	0.445
LIG_LIR_Nem_3	404	409	PF02991	0.466
LIG_LIR_Nem_3	435	440	PF02991	0.557
LIG_LIR_Nem_3	506	510	PF02991	0.347
LIG_NRBOX	532	538	PF00104	0.529
LIG_SH2_CRK	163	167	PF00017	0.273
LIG_SH2_CRK	320	324	PF00017	0.435
LIG_SH2_CRK	97	101	PF00017	0.427
LIG_SH2_NCK_1	163	167	PF00017	0.398
LIG_SH2_NCK_1	206	210	PF00017	0.486
LIG_SH2_SRC	382	385	PF00017	0.347
LIG_SH2_STAP1	97	101	PF00017	0.363
LIG_SH2_STAT5	13	16	PF00017	0.440
LIG_SH2_STAT5	132	135	PF00017	0.347
LIG_SH2_STAT5	260	263	PF00017	0.382
LIG_SH2_STAT5	382	385	PF00017	0.450
LIG_SH2_STAT5	415	418	PF00017	0.490
LIG_SH2_STAT5	45	48	PF00017	0.477
LIG_SH2_STAT5	452	455	PF00017	0.481
LIG_SH2_STAT5	95	98	PF00017	0.345
LIG_SH3_3	224	230	PF00018	0.336
LIG_SH3_3	250	256	PF00018	0.458
LIG_SUMO_SIM_anti_2	283	290	PF11976	0.368
LIG_SUMO_SIM_anti_2	305	315	PF11976	0.369
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.394
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.424
LIG_SUMO_SIM_par_1	18	24	PF11976	0.455
LIG_SUMO_SIM_par_1	356	361	PF11976	0.365
LIG_SUMO_SIM_par_1	392	400	PF11976	0.468
LIG_SUMO_SIM_par_1	76	82	PF11976	0.401
LIG_TRAF2_1	39	42	PF00917	0.438
LIG_TRFH_1	45	49	PF08558	0.356
LIG_UBA3_1	64	72	PF00899	0.421
LIG_WRC_WIRS_1	451	456	PF05994	0.474
MOD_CDK_SPxxK_3	240	247	PF00069	0.411
MOD_CK1_1	207	213	PF00069	0.458
MOD_CK1_1	23	29	PF00069	0.474
MOD_CK1_1	234	240	PF00069	0.444
MOD_CK1_1	243	249	PF00069	0.488
MOD_CK1_1	303	309	PF00069	0.402
MOD_CK1_1	36	42	PF00069	0.464
MOD_CK1_1	378	384	PF00069	0.417
MOD_CK1_1	399	405	PF00069	0.476
MOD_CK1_1	423	429	PF00069	0.488
MOD_CK1_1	485	491	PF00069	0.458
MOD_CK2_1	12	18	PF00069	0.461
MOD_CK2_1	148	154	PF00069	0.328
MOD_CK2_1	289	295	PF00069	0.282
MOD_CK2_1	319	325	PF00069	0.401
MOD_CK2_1	331	337	PF00069	0.318
MOD_CK2_1	348	354	PF00069	0.410
MOD_CK2_1	36	42	PF00069	0.385
MOD_CK2_1	497	503	PF00069	0.460
MOD_Cter_Amidation	347	350	PF01082	0.530
MOD_GlcNHglycan	240	243	PF01048	0.730
MOD_GlcNHglycan	264	267	PF01048	0.657
MOD_GlcNHglycan	276	279	PF01048	0.515
MOD_GlcNHglycan	513	516	PF01048	0.297
MOD_GlcNHglycan	521	524	PF01048	0.320
MOD_GlcNHglycan	81	84	PF01048	0.679
MOD_GSK3_1	213	220	PF00069	0.356
MOD_GSK3_1	231	238	PF00069	0.567
MOD_GSK3_1	29	36	PF00069	0.385
MOD_GSK3_1	299	306	PF00069	0.384
MOD_GSK3_1	365	372	PF00069	0.462
MOD_GSK3_1	395	402	PF00069	0.445
MOD_GSK3_1	460	467	PF00069	0.432
MOD_GSK3_1	513	520	PF00069	0.309
MOD_GSK3_1	79	86	PF00069	0.386
MOD_N-GLC_1	33	38	PF02516	0.506
MOD_N-GLC_2	104	106	PF02516	0.537
MOD_NEK2_1	148	153	PF00069	0.373
MOD_NEK2_1	180	185	PF00069	0.347
MOD_NEK2_1	217	222	PF00069	0.374
MOD_NEK2_1	261	266	PF00069	0.343
MOD_NEK2_1	273	278	PF00069	0.302
MOD_NEK2_1	289	294	PF00069	0.307
MOD_NEK2_1	304	309	PF00069	0.414
MOD_NEK2_1	311	316	PF00069	0.405
MOD_NEK2_1	401	406	PF00069	0.481
MOD_NEK2_1	517	522	PF00069	0.309
MOD_NEK2_1	79	84	PF00069	0.404
MOD_NEK2_2	331	336	PF00069	0.302
MOD_NEK2_2	369	374	PF00069	0.343
MOD_NEK2_2	433	438	PF00069	0.480
MOD_PIKK_1	23	29	PF00454	0.402
MOD_PIKK_1	59	65	PF00454	0.465
MOD_PIKK_1	95	101	PF00454	0.458
MOD_PK_1	405	411	PF00069	0.469
MOD_PK_1	475	481	PF00069	0.391
MOD_PKA_1	349	355	PF00069	0.371
MOD_PKA_2	29	35	PF00069	0.303
MOD_PKA_2	299	305	PF00069	0.413
MOD_PKA_2	348	354	PF00069	0.430
MOD_PKA_2	378	384	PF00069	0.443
MOD_PKA_2	410	416	PF00069	0.472
MOD_Plk_1	192	198	PF00069	0.432
MOD_Plk_1	23	29	PF00069	0.323
MOD_Plk_1	33	39	PF00069	0.288
MOD_Plk_1	399	405	PF00069	0.433
MOD_Plk_4	120	126	PF00069	0.419
MOD_Plk_4	148	154	PF00069	0.360
MOD_Plk_4	213	219	PF00069	0.352
MOD_Plk_4	284	290	PF00069	0.405
MOD_Plk_4	3	9	PF00069	0.426
MOD_Plk_4	33	39	PF00069	0.385
MOD_Plk_4	341	347	PF00069	0.402
MOD_Plk_4	378	384	PF00069	0.432
MOD_Plk_4	420	426	PF00069	0.492
MOD_Plk_4	475	481	PF00069	0.414
MOD_Plk_4	503	509	PF00069	0.270
MOD_Plk_4	513	519	PF00069	0.309
MOD_ProDKin_1	162	168	PF00069	0.385
MOD_ProDKin_1	240	246	PF00069	0.539
MOD_ProDKin_1	319	325	PF00069	0.439
MOD_ProDKin_1	482	488	PF00069	0.383
MOD_SUMO_for_1	51	54	PF00179	0.379
TRG_DiLeu_BaEn_1	42	47	PF01217	0.401
TRG_DiLeu_BaEn_1	73	78	PF01217	0.409
TRG_DiLeu_BaEn_4	53	59	PF01217	0.375
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.384
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.413
TRG_ENDOCYTIC_2	330	333	PF00928	0.364
TRG_ENDOCYTIC_2	97	100	PF00928	0.385
TRG_NES_CRM1_1	146	160	PF08389	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ9	Leptomonas seymouri	61%	98%
A0A1X0P3D8	Trypanosomatidae	29%	100%
A0A3S7XB84	Leishmania donovani	81%	100%
A4ID38	Leishmania infantum	81%	100%
E9ATE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q157	Leishmania major	83%	100%