Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPM7_LEIBR

TriTrypDb:

LbrM.35.3830 , LBRM2903_350048400

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.303
CLV_C14_Caspase3-7	72	76	PF00656	0.614
CLV_C14_Caspase3-7	79	83	PF00656	0.481
CLV_NRD_NRD_1	19	21	PF00675	0.527
CLV_NRD_NRD_1	339	341	PF00675	0.803
CLV_NRD_NRD_1	436	438	PF00675	0.417
CLV_NRD_NRD_1	461	463	PF00675	0.384
CLV_NRD_NRD_1	60	62	PF00675	0.653
CLV_PCSK_KEX2_1	19	21	PF00082	0.492
CLV_PCSK_KEX2_1	339	341	PF00082	0.754
CLV_PCSK_KEX2_1	461	463	PF00082	0.539
CLV_PCSK_KEX2_1	60	62	PF00082	0.758
CLV_PCSK_KEX2_1	65	67	PF00082	0.723
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.729
CLV_PCSK_PC7_1	61	67	PF00082	0.657
CLV_PCSK_SKI1_1	289	293	PF00082	0.481
CLV_PCSK_SKI1_1	352	356	PF00082	0.635
CLV_PCSK_SKI1_1	462	466	PF00082	0.462
CLV_PCSK_SKI1_1	65	69	PF00082	0.775
DEG_APCC_DBOX_1	152	160	PF00400	0.445
DEG_SCF_FBW7_1	137	143	PF00400	0.311
DEG_SPOP_SBC_1	233	237	PF00917	0.546
DOC_CKS1_1	137	142	PF01111	0.421
DOC_CKS1_1	321	326	PF01111	0.472
DOC_CKS1_1	433	438	PF01111	0.442
DOC_CYCLIN_yCln2_LP_2	24	27	PF00134	0.364
DOC_MAPK_gen_1	19	25	PF00069	0.530
DOC_MAPK_gen_1	437	443	PF00069	0.476
DOC_PP2B_LxvP_1	23	26	PF13499	0.496
DOC_PP2B_LxvP_1	278	281	PF13499	0.492
DOC_PP4_FxxP_1	113	116	PF00568	0.557
DOC_PP4_MxPP_1	365	368	PF00568	0.508
DOC_USP7_MATH_1	116	120	PF00917	0.642
DOC_USP7_MATH_1	251	255	PF00917	0.342
DOC_USP7_MATH_1	27	31	PF00917	0.544
DOC_USP7_MATH_1	281	285	PF00917	0.617
DOC_USP7_MATH_1	388	392	PF00917	0.474
DOC_USP7_MATH_1	51	55	PF00917	0.781
DOC_USP7_MATH_1	73	77	PF00917	0.581
DOC_USP7_UBL2_3	373	377	PF12436	0.518
DOC_USP7_UBL2_3	65	69	PF12436	0.545
DOC_USP7_UBL2_3	96	100	PF12436	0.454
DOC_WW_Pin1_4	136	141	PF00397	0.412
DOC_WW_Pin1_4	192	197	PF00397	0.485
DOC_WW_Pin1_4	320	325	PF00397	0.741
DOC_WW_Pin1_4	432	437	PF00397	0.447
DOC_WW_Pin1_4	53	58	PF00397	0.599
LIG_14-3-3_CanoR_1	134	138	PF00244	0.373
LIG_14-3-3_CanoR_1	229	234	PF00244	0.453
LIG_14-3-3_CanoR_1	31	36	PF00244	0.356
LIG_Actin_WH2_2	206	224	PF00022	0.487
LIG_APCC_ABBA_1	268	273	PF00400	0.463
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BRCT_BRCA1_1	29	33	PF00533	0.566
LIG_CSL_BTD_1	137	140	PF09270	0.466
LIG_CtBP_PxDLS_1	240	244	PF00389	0.370
LIG_FHA_1	193	199	PF00498	0.329
LIG_FHA_1	216	222	PF00498	0.575
LIG_FHA_1	321	327	PF00498	0.715
LIG_FHA_1	411	417	PF00498	0.438
LIG_FHA_1	467	473	PF00498	0.547
LIG_FHA_2	137	143	PF00498	0.553
LIG_FHA_2	156	162	PF00498	0.509
LIG_FHA_2	206	212	PF00498	0.376
LIG_FHA_2	242	248	PF00498	0.351
LIG_FHA_2	261	267	PF00498	0.396
LIG_FHA_2	77	83	PF00498	0.520
LIG_GBD_Chelix_1	80	88	PF00786	0.611
LIG_Integrin_RGD_1	422	424	PF01839	0.314
LIG_LIR_Apic_2	111	116	PF02991	0.578
LIG_LIR_Apic_2	395	400	PF02991	0.419
LIG_LIR_Apic_2	431	436	PF02991	0.332
LIG_LIR_Gen_1	34	44	PF02991	0.449
LIG_LIR_Gen_1	4	15	PF02991	0.464
LIG_LIR_Gen_1	455	464	PF02991	0.460
LIG_LIR_Nem_3	183	187	PF02991	0.417
LIG_LIR_Nem_3	30	36	PF02991	0.492
LIG_LIR_Nem_3	4	10	PF02991	0.490
LIG_NRBOX	177	183	PF00104	0.354
LIG_PDZ_Class_2	469	474	PF00595	0.552
LIG_SH2_GRB2like	168	171	PF00017	0.358
LIG_SH2_NCK_1	397	401	PF00017	0.390
LIG_SH2_SRC	397	400	PF00017	0.449
LIG_SH2_STAT3	107	110	PF00017	0.450
LIG_SH2_STAT5	410	413	PF00017	0.368
LIG_SH3_3	266	272	PF00018	0.500
LIG_SH3_3	347	353	PF00018	0.699
LIG_SH3_3	45	51	PF00018	0.461
LIG_SUMO_SIM_par_1	204	211	PF11976	0.358
LIG_SUMO_SIM_par_1	239	244	PF11976	0.502
LIG_TRAF2_1	108	111	PF00917	0.582
LIG_TRAF2_1	158	161	PF00917	0.438
LIG_TRAF2_1	300	303	PF00917	0.534
LIG_WRC_WIRS_1	7	12	PF05994	0.520
MOD_CDK_SPK_2	432	437	PF00069	0.447
MOD_CDK_SPxK_1	432	438	PF00069	0.444
MOD_CDK_SPxxK_3	53	60	PF00069	0.509
MOD_CK1_1	215	221	PF00069	0.535
MOD_CK1_1	231	237	PF00069	0.429
MOD_CK1_1	284	290	PF00069	0.628
MOD_CK1_1	29	35	PF00069	0.529
MOD_CK1_1	384	390	PF00069	0.411
MOD_CK1_1	55	61	PF00069	0.684
MOD_CK1_1	76	82	PF00069	0.484
MOD_CK2_1	155	161	PF00069	0.501
MOD_CK2_1	465	471	PF00069	0.604
MOD_CMANNOS	430	433	PF00535	0.552
MOD_GlcNHglycan	118	121	PF01048	0.522
MOD_GlcNHglycan	13	16	PF01048	0.567
MOD_GlcNHglycan	236	239	PF01048	0.604
MOD_GlcNHglycan	253	256	PF01048	0.234
MOD_GlcNHglycan	383	386	PF01048	0.457
MOD_GlcNHglycan	70	74	PF01048	0.808
MOD_GlcNHglycan	75	78	PF01048	0.721
MOD_GSK3_1	136	143	PF00069	0.328
MOD_GSK3_1	228	235	PF00069	0.511
MOD_GSK3_1	241	248	PF00069	0.439
MOD_GSK3_1	27	34	PF00069	0.595
MOD_GSK3_1	280	287	PF00069	0.475
MOD_GSK3_1	377	384	PF00069	0.520
MOD_GSK3_1	388	395	PF00069	0.339
MOD_GSK3_1	428	435	PF00069	0.448
MOD_GSK3_1	51	58	PF00069	0.623
MOD_GSK3_1	69	76	PF00069	0.685
MOD_NEK2_1	148	153	PF00069	0.498
MOD_NEK2_1	228	233	PF00069	0.596
MOD_NEK2_1	52	57	PF00069	0.550
MOD_NEK2_2	410	415	PF00069	0.437
MOD_OFUCOSY	408	414	PF10250	0.450
MOD_PIKK_1	295	301	PF00454	0.766
MOD_PIKK_1	388	394	PF00454	0.449
MOD_PIKK_1	46	52	PF00454	0.583
MOD_PIKK_1	55	61	PF00454	0.700
MOD_PKA_2	133	139	PF00069	0.451
MOD_PKA_2	228	234	PF00069	0.575
MOD_Plk_1	241	247	PF00069	0.469
MOD_Plk_1	3	9	PF00069	0.462
MOD_Plk_4	133	139	PF00069	0.464
MOD_Plk_4	245	251	PF00069	0.541
MOD_Plk_4	287	293	PF00069	0.595
MOD_Plk_4	322	328	PF00069	0.591
MOD_ProDKin_1	136	142	PF00069	0.415
MOD_ProDKin_1	192	198	PF00069	0.485
MOD_ProDKin_1	320	326	PF00069	0.743
MOD_ProDKin_1	432	438	PF00069	0.444
MOD_ProDKin_1	53	59	PF00069	0.601
MOD_SUMO_for_1	67	70	PF00179	0.666
TRG_DiLeu_BaEn_1	273	278	PF01217	0.458
TRG_ENDOCYTIC_2	169	172	PF00928	0.526
TRG_ENDOCYTIC_2	36	39	PF00928	0.508
TRG_ER_diArg_1	339	341	PF00400	0.746
TRG_ER_diArg_1	460	462	PF00400	0.358
TRG_ER_diArg_1	60	62	PF00400	0.678
TRG_NES_CRM1_1	192	204	PF08389	0.529
TRG_NLS_MonoExtC_3	64	69	PF00514	0.724
TRG_NLS_MonoExtN_4	62	69	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I528	Leptomonas seymouri	48%	98%
A0A1X0P3J4	Trypanosomatidae	26%	100%
A0A3R7M2K8	Trypanosoma rangeli	27%	100%
A0A3S7XBB1	Leishmania donovani	75%	100%
E9AHX7	Leishmania infantum	75%	100%
E9ATD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q158	Leishmania major	73%	100%
V5BML3	Trypanosoma cruzi	27%	100%