Putative signal recognition particle receptor like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle receptor like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPM4_LEIBR

TriTrypDb:

LbrM.35.3800 , LBRM2903_350048100

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005785	signal recognition particle receptor complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0098796	membrane protein complex	2	10
GO:0140534	endoplasmic reticulum protein-containing complex	2	10
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0005789	endoplasmic reticulum membrane	4	3
GO:0016020	membrane	2	3
GO:0031090	organelle membrane	3	3
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HPM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPM4

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006612	protein targeting to membrane	5	12
GO:0006613	cotranslational protein targeting to membrane	6	12
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0045047	protein targeting to ER	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0051668	localization within membrane	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0070972	protein localization to endoplasmic reticulum	6	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	12
GO:0072657	protein localization to membrane	4	12
GO:0090150	establishment of protein localization to membrane	4	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005047	signal recognition particle binding	4	10
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043021	ribonucleoprotein complex binding	3	10
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0044877	protein-containing complex binding	2	10
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.369
CLV_C14_Caspase3-7	176	180	PF00656	0.369
CLV_NRD_NRD_1	199	201	PF00675	0.304
CLV_NRD_NRD_1	25	27	PF00675	0.459
CLV_NRD_NRD_1	370	372	PF00675	0.428
CLV_NRD_NRD_1	526	528	PF00675	0.295
CLV_PCSK_KEX2_1	199	201	PF00082	0.383
CLV_PCSK_KEX2_1	227	229	PF00082	0.382
CLV_PCSK_KEX2_1	25	27	PF00082	0.473
CLV_PCSK_KEX2_1	273	275	PF00082	0.564
CLV_PCSK_KEX2_1	349	351	PF00082	0.413
CLV_PCSK_KEX2_1	370	372	PF00082	0.414
CLV_PCSK_KEX2_1	376	378	PF00082	0.460
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.382
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.595
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.413
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.499
CLV_PCSK_SKI1_1	199	203	PF00082	0.368
CLV_PCSK_SKI1_1	295	299	PF00082	0.324
CLV_PCSK_SKI1_1	370	374	PF00082	0.413
CLV_PCSK_SKI1_1	55	59	PF00082	0.351
CLV_PCSK_SKI1_1	72	76	PF00082	0.278
DEG_Nend_Nbox_1	1	3	PF02207	0.381
DOC_ANK_TNKS_1	140	147	PF00023	0.342
DOC_CYCLIN_yCln2_LP_2	571	577	PF00134	0.292
DOC_MAPK_gen_1	542	551	PF00069	0.342
DOC_MAPK_gen_1	72	81	PF00069	0.413
DOC_MAPK_MEF2A_6	588	596	PF00069	0.308
DOC_MAPK_MEF2A_6	75	83	PF00069	0.387
DOC_PP1_RVXF_1	229	236	PF00149	0.186
DOC_PP2B_LxvP_1	448	451	PF13499	0.308
DOC_PP4_FxxP_1	73	76	PF00568	0.413
DOC_USP7_MATH_1	164	168	PF00917	0.424
DOC_USP7_MATH_1	221	225	PF00917	0.345
DOC_USP7_MATH_1	538	542	PF00917	0.413
DOC_USP7_UBL2_3	226	230	PF12436	0.340
DOC_USP7_UBL2_3	324	328	PF12436	0.287
DOC_USP7_UBL2_3	389	393	PF12436	0.533
DOC_USP7_UBL2_3	92	96	PF12436	0.383
DOC_WW_Pin1_4	177	182	PF00397	0.430
LIG_14-3-3_CanoR_1	268	272	PF00244	0.503
LIG_14-3-3_CanoR_1	295	300	PF00244	0.322
LIG_Actin_WH2_2	354	372	PF00022	0.327
LIG_Actin_WH2_2	573	590	PF00022	0.377
LIG_FHA_1	2	8	PF00498	0.354
LIG_FHA_1	304	310	PF00498	0.413
LIG_FHA_1	364	370	PF00498	0.296
LIG_FHA_1	475	481	PF00498	0.262
LIG_FHA_2	168	174	PF00498	0.373
LIG_FHA_2	17	23	PF00498	0.600
LIG_FHA_2	254	260	PF00498	0.548
LIG_FHA_2	358	364	PF00498	0.438
LIG_FHA_2	550	556	PF00498	0.292
LIG_FHA_2	581	587	PF00498	0.292
LIG_LIR_Gen_1	122	132	PF02991	0.379
LIG_LIR_Gen_1	353	361	PF02991	0.292
LIG_LIR_Gen_1	552	561	PF02991	0.292
LIG_LIR_Gen_1	583	592	PF02991	0.292
LIG_LIR_Nem_3	122	128	PF02991	0.379
LIG_LIR_Nem_3	353	357	PF02991	0.292
LIG_LIR_Nem_3	535	539	PF02991	0.292
LIG_LIR_Nem_3	552	557	PF02991	0.292
LIG_LIR_Nem_3	583	587	PF02991	0.292
LIG_LIR_Nem_3	61	67	PF02991	0.310
LIG_LYPXL_S_1	69	73	PF13949	0.327
LIG_PCNA_yPIPBox_3	25	37	PF02747	0.309
LIG_Pex14_1	299	303	PF04695	0.292
LIG_REV1ctd_RIR_1	71	75	PF16727	0.413
LIG_SH2_CRK	125	129	PF00017	0.413
LIG_SH2_CRK	395	399	PF00017	0.292
LIG_SH2_STAP1	125	129	PF00017	0.325
LIG_SH2_STAP1	395	399	PF00017	0.292
LIG_SH2_STAT3	416	419	PF00017	0.292
LIG_SH2_STAT3	94	97	PF00017	0.439
LIG_SH2_STAT5	271	274	PF00017	0.697
LIG_SH2_STAT5	303	306	PF00017	0.308
LIG_SH3_3	238	244	PF00018	0.380
LIG_SH3_3	586	592	PF00018	0.308
LIG_SUMO_SIM_anti_2	3	11	PF11976	0.375
LIG_SUMO_SIM_anti_2	477	484	PF11976	0.264
LIG_SUMO_SIM_par_1	3	11	PF11976	0.375
LIG_SUMO_SIM_par_1	477	484	PF11976	0.291
LIG_TRAF2_1	134	137	PF00917	0.379
LIG_UBA3_1	317	324	PF00899	0.413
LIG_WRC_WIRS_1	351	356	PF05994	0.292
MOD_CDC14_SPxK_1	184	187	PF00782	0.186
MOD_CDK_SPxK_1	181	187	PF00069	0.186
MOD_CK1_1	106	112	PF00069	0.326
MOD_CK1_1	135	141	PF00069	0.318
MOD_CK1_1	152	158	PF00069	0.393
MOD_CK1_1	167	173	PF00069	0.284
MOD_CK1_1	6	12	PF00069	0.391
MOD_CK2_1	16	22	PF00069	0.554
MOD_CK2_1	253	259	PF00069	0.577
MOD_Cter_Amidation	197	200	PF01082	0.323
MOD_Cter_Amidation	228	231	PF01082	0.439
MOD_Cter_Amidation	23	26	PF01082	0.510
MOD_Cter_Amidation	347	350	PF01082	0.349
MOD_GlcNHglycan	10	13	PF01048	0.507
MOD_GlcNHglycan	108	111	PF01048	0.325
MOD_GlcNHglycan	120	124	PF01048	0.323
MOD_GlcNHglycan	136	140	PF01048	0.349
MOD_GlcNHglycan	151	154	PF01048	0.397
MOD_GlcNHglycan	157	160	PF01048	0.395
MOD_GlcNHglycan	163	167	PF01048	0.283
MOD_GlcNHglycan	213	216	PF01048	0.428
MOD_GlcNHglycan	223	226	PF01048	0.282
MOD_GlcNHglycan	460	464	PF01048	0.262
MOD_GlcNHglycan	596	599	PF01048	0.320
MOD_GSK3_1	106	113	PF00069	0.408
MOD_GSK3_1	16	23	PF00069	0.478
MOD_GSK3_1	162	169	PF00069	0.376
MOD_GSK3_1	177	184	PF00069	0.419
MOD_GSK3_1	295	302	PF00069	0.380
MOD_GSK3_1	338	345	PF00069	0.292
MOD_GSK3_1	353	360	PF00069	0.292
MOD_GSK3_1	470	477	PF00069	0.215
MOD_GSK3_1	549	556	PF00069	0.304
MOD_N-GLC_1	110	115	PF02516	0.380
MOD_N-GLC_1	132	137	PF02516	0.380
MOD_N-GLC_1	149	154	PF02516	0.297
MOD_N-GLC_1	221	226	PF02516	0.262
MOD_N-GLC_2	530	532	PF02516	0.292
MOD_NEK2_1	1	6	PF00069	0.367
MOD_NEK2_1	103	108	PF00069	0.382
MOD_NEK2_1	365	370	PF00069	0.446
MOD_NEK2_2	429	434	PF00069	0.292
MOD_PIKK_1	103	109	PF00454	0.237
MOD_PIKK_1	167	173	PF00454	0.188
MOD_PK_1	393	399	PF00069	0.292
MOD_PKA_1	199	205	PF00069	0.434
MOD_PKA_2	17	23	PF00069	0.407
MOD_PKA_2	199	205	PF00069	0.438
MOD_PKA_2	267	273	PF00069	0.590
MOD_PKB_1	293	301	PF00069	0.322
MOD_Plk_1	110	116	PF00069	0.340
MOD_Plk_1	342	348	PF00069	0.292
MOD_Plk_1	421	427	PF00069	0.322
MOD_Plk_4	124	130	PF00069	0.335
MOD_Plk_4	213	219	PF00069	0.186
MOD_Plk_4	267	273	PF00069	0.623
MOD_Plk_4	295	301	PF00069	0.325
MOD_Plk_4	3	9	PF00069	0.373
MOD_Plk_4	353	359	PF00069	0.413
MOD_Plk_4	393	399	PF00069	0.292
MOD_Plk_4	421	427	PF00069	0.299
MOD_Plk_4	563	569	PF00069	0.292
MOD_ProDKin_1	177	183	PF00069	0.430
MOD_SUMO_for_1	375	378	PF00179	0.446
MOD_SUMO_rev_2	308	317	PF00179	0.439
MOD_SUMO_rev_2	555	561	PF00179	0.292
MOD_SUMO_rev_2	59	65	PF00179	0.276
TRG_ENDOCYTIC_2	125	128	PF00928	0.383
TRG_ENDOCYTIC_2	129	132	PF00928	0.370
TRG_ENDOCYTIC_2	358	361	PF00928	0.413
TRG_ENDOCYTIC_2	395	398	PF00928	0.292
TRG_ENDOCYTIC_2	584	587	PF00928	0.292
TRG_ENDOCYTIC_2	70	73	PF00928	0.303
TRG_ENDOCYTIC_2	78	81	PF00928	0.276
TRG_ER_diArg_1	199	201	PF00400	0.382
TRG_ER_diArg_1	292	295	PF00400	0.537
TRG_ER_diArg_1	369	371	PF00400	0.421
TRG_NES_CRM1_1	555	570	PF08389	0.292
TRG_NLS_MonoExtC_3	225	230	PF00514	0.314
TRG_NLS_MonoExtN_4	226	231	PF00514	0.339
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q5	Leptomonas seymouri	74%	99%
A0A0S4JKS8	Bodo saltans	57%	100%
A0A1X0P3D4	Trypanosomatidae	63%	100%
A0A3R7RBB0	Trypanosoma rangeli	61%	100%
A0A3S7XBC9	Leishmania donovani	86%	99%
A4ID41	Leishmania infantum	87%	99%
D0A8J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9ATD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
P06625	Canis lupus familiaris	36%	94%
P08240	Homo sapiens	37%	94%
Q3MHE8	Bos taurus	37%	94%
Q4Q161	Leishmania major	85%	100%
Q9DBG7	Mus musculus	38%	94%
Q9U5L1	Drosophila melanogaster	38%	98%
V5DNM6	Trypanosoma cruzi	61%	100%