NADH-ubiquinone_oxidoreductase_complex_I_subunit_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HPL9_LEIBR

TriTrypDb:

LbrM.35.3750 , LBRM2903_350047300

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HPL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPL9

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0003954	NADH dehydrogenase activity	4	1
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	5	1
GO:0005215	transporter activity	1	1
GO:0008137	NADH dehydrogenase (ubiquinone) activity	4	1
GO:0009055	electron transfer activity	3	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	1
GO:0016491	oxidoreductase activity	2	2
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0050136	NADH dehydrogenase (quinone) activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.620
CLV_C14_Caspase3-7	8	12	PF00656	0.517
CLV_NRD_NRD_1	239	241	PF00675	0.462
CLV_NRD_NRD_1	252	254	PF00675	0.457
CLV_NRD_NRD_1	87	89	PF00675	0.582
CLV_PCSK_KEX2_1	239	241	PF00082	0.460
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.460
DEG_SCF_FBW7_2	226	233	PF00400	0.592
DOC_MAPK_gen_1	64	73	PF00069	0.628
DOC_WW_Pin1_4	226	231	PF00397	0.545
DOC_WW_Pin1_4	99	104	PF00397	0.555
LIG_14-3-3_CanoR_1	105	110	PF00244	0.486
LIG_14-3-3_CanoR_1	19	29	PF00244	0.487
LIG_14-3-3_CanoR_1	88	94	PF00244	0.633
LIG_APCC_ABBAyCdc20_2	239	245	PF00400	0.461
LIG_deltaCOP1_diTrp_1	121	130	PF00928	0.538
LIG_FHA_1	131	137	PF00498	0.550
LIG_FHA_1	64	70	PF00498	0.662
LIG_FHA_2	106	112	PF00498	0.641
LIG_LIR_Apic_2	111	116	PF02991	0.510
LIG_LIR_Apic_2	127	131	PF02991	0.575
LIG_LIR_Gen_1	149	157	PF02991	0.482
LIG_LIR_Gen_1	26	37	PF02991	0.703
LIG_LIR_Gen_1	63	73	PF02991	0.560
LIG_LIR_Gen_1	87	98	PF02991	0.622
LIG_LIR_Nem_3	145	151	PF02991	0.532
LIG_LIR_Nem_3	26	32	PF02991	0.702
LIG_LIR_Nem_3	63	68	PF02991	0.558
LIG_LIR_Nem_3	87	93	PF02991	0.562
LIG_PDZ_Class_3	254	259	PF00595	0.550
LIG_SH2_CRK	113	117	PF00017	0.476
LIG_SH2_CRK	152	156	PF00017	0.471
LIG_SH2_CRK	90	94	PF00017	0.672
LIG_SH2_GRB2like	135	138	PF00017	0.527
LIG_SH2_NCK_1	113	117	PF00017	0.476
LIG_SH2_SRC	109	112	PF00017	0.571
LIG_SH2_SRC	135	138	PF00017	0.527
LIG_SH2_SRC	15	18	PF00017	0.523
LIG_SH2_STAP1	148	152	PF00017	0.619
LIG_SH2_STAP1	243	247	PF00017	0.454
LIG_SH2_STAT5	109	112	PF00017	0.544
LIG_SH2_STAT5	113	116	PF00017	0.525
LIG_SH2_STAT5	135	138	PF00017	0.527
LIG_SH2_STAT5	148	151	PF00017	0.506
LIG_SH2_STAT5	154	157	PF00017	0.455
LIG_SH2_STAT5	168	171	PF00017	0.246
LIG_SH2_STAT5	42	45	PF00017	0.664
LIG_SH2_STAT5	96	99	PF00017	0.530
LIG_SH3_3	100	106	PF00018	0.569
LIG_SH3_3	137	143	PF00018	0.495
LIG_SH3_3	22	28	PF00018	0.639
LIG_SH3_3	74	80	PF00018	0.594
LIG_SH3_4	53	60	PF00018	0.708
LIG_SH3_CIN85_PxpxPR_1	54	59	PF14604	0.568
MOD_CDK_SPxK_1	99	105	PF00069	0.608
MOD_CK1_1	23	29	PF00069	0.570
MOD_CK1_1	36	42	PF00069	0.582
MOD_CK1_1	9	15	PF00069	0.746
MOD_CK1_1	99	105	PF00069	0.553
MOD_CK2_1	203	209	PF00069	0.454
MOD_CK2_1	57	63	PF00069	0.626
MOD_CMANNOS	125	128	PF00535	0.585
MOD_GlcNHglycan	22	25	PF01048	0.477
MOD_GlcNHglycan	59	62	PF01048	0.666
MOD_GlcNHglycan	8	11	PF01048	0.648
MOD_GSK3_1	105	112	PF00069	0.663
MOD_NEK2_1	203	208	PF00069	0.446
MOD_NEK2_1	218	223	PF00069	0.394
MOD_NEK2_1	247	252	PF00069	0.479
MOD_NEK2_1	49	54	PF00069	0.466
MOD_NEK2_1	97	102	PF00069	0.639
MOD_PIKK_1	36	42	PF00454	0.570
MOD_PKA_2	63	69	PF00069	0.550
MOD_Plk_4	89	95	PF00069	0.599
MOD_ProDKin_1	226	232	PF00069	0.545
MOD_ProDKin_1	99	105	PF00069	0.558
TRG_ENDOCYTIC_2	152	155	PF00928	0.474
TRG_ENDOCYTIC_2	217	220	PF00928	0.423
TRG_ENDOCYTIC_2	29	32	PF00928	0.636
TRG_ENDOCYTIC_2	90	93	PF00928	0.637
TRG_ER_diArg_1	104	107	PF00400	0.575
TRG_ER_diArg_1	248	251	PF00400	0.492
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M7	Leptomonas seymouri	82%	98%
A0A0S4JE10	Bodo saltans	64%	91%
A0A1X0P3C8	Trypanosomatidae	75%	100%
A0A3Q8IGB6	Leishmania donovani	92%	100%
A4ID45	Leishmania infantum	92%	100%
D0A8J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9ATD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q166	Leishmania major	91%	100%
V5BS71	Trypanosoma cruzi	72%	100%