LeishMANIAdb
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SKA2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
SKA2 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HPL8_LEIBR
TriTrypDb:
LbrM.35.3740 , LBRM2903_350047200
Length:
183

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPL8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.490
CLV_PCSK_KEX2_1 101 103 PF00082 0.603
CLV_PCSK_PC1ET2_1 101 103 PF00082 0.652
CLV_PCSK_PC7_1 98 104 PF00082 0.430
CLV_PCSK_SKI1_1 125 129 PF00082 0.365
DEG_Nend_Nbox_1 1 3 PF02207 0.584
DOC_CYCLIN_yCln2_LP_2 153 159 PF00134 0.454
DOC_MAPK_gen_1 125 134 PF00069 0.497
DOC_MAPK_MEF2A_6 26 35 PF00069 0.372
DOC_PIKK_1 61 69 PF02985 0.442
DOC_PP2B_LxvP_1 151 154 PF13499 0.510
DOC_PP2B_LxvP_1 157 160 PF13499 0.587
DOC_USP7_MATH_1 10 14 PF00917 0.588
DOC_USP7_MATH_1 110 114 PF00917 0.479
DOC_USP7_MATH_1 142 146 PF00917 0.544
DOC_USP7_UBL2_3 40 44 PF12436 0.472
LIG_14-3-3_CanoR_1 47 53 PF00244 0.441
LIG_14-3-3_CanoR_1 91 97 PF00244 0.517
LIG_FHA_1 13 19 PF00498 0.504
LIG_FHA_1 47 53 PF00498 0.510
LIG_FHA_1 85 91 PF00498 0.500
LIG_FHA_1 92 98 PF00498 0.554
LIG_LIR_Nem_3 113 119 PF02991 0.644
LIG_PCNA_yPIPBox_3 102 116 PF02747 0.649
LIG_SH2_STAT5 72 75 PF00017 0.485
LIG_SH3_3 146 152 PF00018 0.597
LIG_SH3_3 153 159 PF00018 0.714
LIG_SUMO_SIM_par_1 171 176 PF11976 0.440
MOD_CK1_1 3 9 PF00069 0.687
MOD_CK1_1 92 98 PF00069 0.431
MOD_GlcNHglycan 111 115 PF01048 0.558
MOD_GlcNHglycan 144 147 PF01048 0.571
MOD_GlcNHglycan 5 8 PF01048 0.549
MOD_GSK3_1 12 19 PF00069 0.540
MOD_GSK3_1 68 75 PF00069 0.397
MOD_GSK3_1 80 87 PF00069 0.405
MOD_NEK2_1 1 6 PF00069 0.582
MOD_NEK2_1 173 178 PF00069 0.441
MOD_NEK2_1 36 41 PF00069 0.455
MOD_NEK2_2 21 26 PF00069 0.438
MOD_PKA_2 46 52 PF00069 0.437
MOD_PKA_2 92 98 PF00069 0.554
MOD_Plk_1 110 116 PF00069 0.528
MOD_Plk_2-3 84 90 PF00069 0.488
MOD_Plk_4 68 74 PF00069 0.385
MOD_Plk_4 92 98 PF00069 0.525
MOD_SUMO_rev_2 75 83 PF00179 0.589
TRG_DiLeu_BaEn_4 61 67 PF01217 0.438
TRG_ER_diArg_1 90 93 PF00400 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBR8 Leptomonas seymouri 48% 100%
A0A1X0P3J1 Trypanosomatidae 32% 100%
A0A3S7XB75 Leishmania donovani 70% 96%
A4ID46 Leishmania infantum 70% 97%
D0A8J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 98%
E9ATD0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 71% 100%
Q4Q167 Leishmania major 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS