Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPL7_LEIBR

TriTrypDb:

LbrM.35.3730 , LBRM2903_350047100

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPL7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	488	492	PF00656	0.579
CLV_C14_Caspase3-7	524	528	PF00656	0.503
CLV_C14_Caspase3-7	59	63	PF00656	0.492
CLV_C14_Caspase3-7	751	755	PF00656	0.575
CLV_NRD_NRD_1	514	516	PF00675	0.471
CLV_PCSK_KEX2_1	238	240	PF00082	0.580
CLV_PCSK_KEX2_1	307	309	PF00082	0.627
CLV_PCSK_KEX2_1	514	516	PF00082	0.471
CLV_PCSK_KEX2_1	655	657	PF00082	0.311
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.580
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.627
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.311
CLV_PCSK_SKI1_1	235	239	PF00082	0.676
CLV_PCSK_SKI1_1	244	248	PF00082	0.608
CLV_PCSK_SKI1_1	289	293	PF00082	0.535
CLV_PCSK_SKI1_1	403	407	PF00082	0.411
CLV_PCSK_SKI1_1	502	506	PF00082	0.294
CLV_PCSK_SKI1_1	656	660	PF00082	0.309
CLV_PCSK_SKI1_1	776	780	PF00082	0.452
CLV_PCSK_SKI1_1	792	796	PF00082	0.472
DEG_SCF_FBW7_1	39	46	PF00400	0.652
DEG_SPOP_SBC_1	227	231	PF00917	0.688
DEG_SPOP_SBC_1	358	362	PF00917	0.643
DOC_CDC14_PxL_1	721	729	PF14671	0.447
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.616
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.486
DOC_MAPK_gen_1	307	317	PF00069	0.674
DOC_MAPK_gen_1	32	39	PF00069	0.598
DOC_MAPK_gen_1	655	663	PF00069	0.332
DOC_MAPK_MEF2A_6	420	428	PF00069	0.391
DOC_MAPK_NFAT4_5	425	433	PF00069	0.466
DOC_MIT_MIM_1	637	647	PF04212	0.343
DOC_PP2B_LxvP_1	335	338	PF13499	0.641
DOC_PP2B_LxvP_1	444	447	PF13499	0.578
DOC_PP2B_LxvP_1	661	664	PF13499	0.516
DOC_USP7_MATH_1	226	230	PF00917	0.647
DOC_USP7_MATH_1	257	261	PF00917	0.669
DOC_USP7_MATH_1	320	324	PF00917	0.607
DOC_USP7_MATH_1	326	330	PF00917	0.755
DOC_USP7_MATH_1	344	348	PF00917	0.569
DOC_USP7_MATH_1	358	362	PF00917	0.614
DOC_USP7_MATH_1	372	376	PF00917	0.491
DOC_USP7_MATH_1	41	45	PF00917	0.656
DOC_USP7_MATH_1	485	489	PF00917	0.608
DOC_USP7_MATH_1	582	586	PF00917	0.392
DOC_USP7_MATH_2	357	363	PF00917	0.532
DOC_USP7_UBL2_3	75	79	PF12436	0.671
DOC_USP7_UBL2_3	94	98	PF12436	0.491
DOC_WW_Pin1_4	201	206	PF00397	0.627
DOC_WW_Pin1_4	212	217	PF00397	0.616
DOC_WW_Pin1_4	279	284	PF00397	0.672
DOC_WW_Pin1_4	367	372	PF00397	0.725
DOC_WW_Pin1_4	375	380	PF00397	0.647
DOC_WW_Pin1_4	39	44	PF00397	0.649
DOC_WW_Pin1_4	578	583	PF00397	0.375
DOC_WW_Pin1_4	600	605	PF00397	0.539
DOC_WW_Pin1_4	708	713	PF00397	0.469
LIG_14-3-3_CanoR_1	18	26	PF00244	0.633
LIG_14-3-3_CanoR_1	310	318	PF00244	0.756
LIG_14-3-3_CanoR_1	325	335	PF00244	0.515
LIG_14-3-3_CanoR_1	34	40	PF00244	0.458
LIG_14-3-3_CanoR_1	397	405	PF00244	0.443
LIG_14-3-3_CanoR_1	425	431	PF00244	0.386
LIG_14-3-3_CanoR_1	514	523	PF00244	0.464
LIG_14-3-3_CanoR_1	54	58	PF00244	0.629
LIG_14-3-3_CanoR_1	656	661	PF00244	0.307
LIG_14-3-3_CanoR_1	714	722	PF00244	0.413
LIG_14-3-3_CanoR_1	726	734	PF00244	0.364
LIG_14-3-3_CanoR_1	765	772	PF00244	0.450
LIG_14-3-3_CanoR_1	804	813	PF00244	0.365
LIG_AP2alpha_2	3	5	PF02296	0.592
LIG_APCC_ABBA_1	165	170	PF00400	0.445
LIG_APCC_ABBAyCdc20_2	118	124	PF00400	0.387
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BIR_III_1	1	5	PF00653	0.648
LIG_BIR_III_3	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	328	332	PF00533	0.589
LIG_BRCT_BRCA1_1	497	501	PF00533	0.413
LIG_BRCT_BRCA1_1	784	788	PF00533	0.405
LIG_Clathr_ClatBox_1	736	740	PF01394	0.455
LIG_FHA_1	105	111	PF00498	0.567
LIG_FHA_1	220	226	PF00498	0.545
LIG_FHA_1	240	246	PF00498	0.546
LIG_FHA_1	358	364	PF00498	0.537
LIG_FHA_1	529	535	PF00498	0.507
LIG_FHA_1	670	676	PF00498	0.377
LIG_FHA_1	731	737	PF00498	0.279
LIG_FHA_1	751	757	PF00498	0.371
LIG_FHA_2	245	251	PF00498	0.606
LIG_FHA_2	261	267	PF00498	0.679
LIG_FHA_2	273	279	PF00498	0.579
LIG_FHA_2	657	663	PF00498	0.424
LIG_FHA_2	714	720	PF00498	0.426
LIG_FHA_2	749	755	PF00498	0.584
LIG_FHA_2	87	93	PF00498	0.612
LIG_LIR_Apic_2	553	559	PF02991	0.453
LIG_LIR_Gen_1	126	136	PF02991	0.616
LIG_LIR_Gen_1	157	168	PF02991	0.558
LIG_LIR_Gen_1	329	340	PF02991	0.510
LIG_LIR_Gen_1	390	396	PF02991	0.525
LIG_LIR_Gen_1	629	638	PF02991	0.333
LIG_LIR_Gen_1	674	684	PF02991	0.353
LIG_LIR_Gen_1	719	727	PF02991	0.467
LIG_LIR_LC3C_4	641	646	PF02991	0.401
LIG_LIR_Nem_3	126	131	PF02991	0.619
LIG_LIR_Nem_3	157	163	PF02991	0.563
LIG_LIR_Nem_3	329	335	PF02991	0.521
LIG_LIR_Nem_3	390	395	PF02991	0.462
LIG_LIR_Nem_3	402	408	PF02991	0.499
LIG_LIR_Nem_3	498	504	PF02991	0.410
LIG_LIR_Nem_3	629	633	PF02991	0.361
LIG_LIR_Nem_3	674	679	PF02991	0.349
LIG_LIR_Nem_3	719	724	PF02991	0.467
LIG_NRBOX	390	396	PF00104	0.525
LIG_NRBOX	430	436	PF00104	0.434
LIG_NRBOX	726	732	PF00104	0.432
LIG_PDZ_Class_2	810	815	PF00595	0.425
LIG_Pex14_2	405	409	PF04695	0.465
LIG_Pex14_2	501	505	PF04695	0.442
LIG_Pex14_2	574	578	PF04695	0.356
LIG_SH2_CRK	128	132	PF00017	0.390
LIG_SH2_CRK	164	168	PF00017	0.445
LIG_SH2_GRB2like	549	552	PF00017	0.535
LIG_SH2_NCK_1	160	164	PF00017	0.483
LIG_SH2_STAP1	160	164	PF00017	0.497
LIG_SH2_STAP1	568	572	PF00017	0.434
LIG_SH2_STAP1	676	680	PF00017	0.348
LIG_SH2_STAT3	537	540	PF00017	0.453
LIG_SH2_STAT3	568	571	PF00017	0.435
LIG_SH2_STAT5	549	552	PF00017	0.535
LIG_SH2_STAT5	568	571	PF00017	0.370
LIG_SH2_STAT5	706	709	PF00017	0.377
LIG_SH3_2	216	221	PF14604	0.663
LIG_SH3_3	213	219	PF00018	0.620
LIG_SH3_3	312	318	PF00018	0.553
LIG_SH3_3	335	341	PF00018	0.574
LIG_SH3_3	719	725	PF00018	0.397
LIG_SUMO_SIM_anti_2	459	466	PF11976	0.440
LIG_SUMO_SIM_anti_2	681	686	PF11976	0.431
LIG_SUMO_SIM_anti_2	733	738	PF11976	0.290
LIG_SUMO_SIM_par_1	10	15	PF11976	0.602
LIG_TRAF2_1	760	763	PF00917	0.395
LIG_TYR_ITIM	162	167	PF00017	0.435
LIG_WRC_WIRS_1	627	632	PF05994	0.444
MOD_CDC14_SPxK_1	711	714	PF00782	0.488
MOD_CDK_SPxK_1	201	207	PF00069	0.489
MOD_CDK_SPxK_1	708	714	PF00069	0.474
MOD_CDK_SPxxK_3	279	286	PF00069	0.671
MOD_CK1_1	229	235	PF00069	0.722
MOD_CK1_1	252	258	PF00069	0.542
MOD_CK1_1	260	266	PF00069	0.653
MOD_CK1_1	301	307	PF00069	0.712
MOD_CK1_1	313	319	PF00069	0.573
MOD_CK1_1	347	353	PF00069	0.584
MOD_CK1_1	362	368	PF00069	0.697
MOD_CK1_1	375	381	PF00069	0.565
MOD_CK1_1	449	455	PF00069	0.454
MOD_CK1_1	56	62	PF00069	0.499
MOD_CK1_1	580	586	PF00069	0.519
MOD_CK1_1	603	609	PF00069	0.528
MOD_CK1_1	741	747	PF00069	0.592
MOD_CK1_1	764	770	PF00069	0.333
MOD_CK1_1	85	91	PF00069	0.664
MOD_CK2_1	134	140	PF00069	0.570
MOD_CK2_1	272	278	PF00069	0.611
MOD_CK2_1	358	364	PF00069	0.537
MOD_CK2_1	581	587	PF00069	0.532
MOD_CK2_1	656	662	PF00069	0.394
MOD_CK2_1	713	719	PF00069	0.431
MOD_CK2_1	86	92	PF00069	0.557
MOD_GlcNHglycan	231	234	PF01048	0.676
MOD_GlcNHglycan	312	315	PF01048	0.674
MOD_GlcNHglycan	318	321	PF01048	0.610
MOD_GlcNHglycan	328	331	PF01048	0.542
MOD_GlcNHglycan	351	354	PF01048	0.624
MOD_GlcNHglycan	374	377	PF01048	0.596
MOD_GlcNHglycan	43	46	PF01048	0.595
MOD_GlcNHglycan	452	455	PF01048	0.522
MOD_GlcNHglycan	584	587	PF01048	0.475
MOD_GlcNHglycan	716	719	PF01048	0.432
MOD_GSK3_1	203	210	PF00069	0.666
MOD_GSK3_1	316	323	PF00069	0.613
MOD_GSK3_1	326	333	PF00069	0.569
MOD_GSK3_1	35	42	PF00069	0.558
MOD_GSK3_1	358	365	PF00069	0.640
MOD_GSK3_1	446	453	PF00069	0.450
MOD_GSK3_1	45	52	PF00069	0.602
MOD_GSK3_1	459	466	PF00069	0.503
MOD_GSK3_1	496	503	PF00069	0.322
MOD_GSK3_1	576	583	PF00069	0.455
MOD_GSK3_1	596	603	PF00069	0.477
MOD_GSK3_1	738	745	PF00069	0.479
MOD_GSK3_1	748	755	PF00069	0.549
MOD_GSK3_1	804	811	PF00069	0.446
MOD_GSK3_1	82	89	PF00069	0.710
MOD_N-GLC_1	252	257	PF02516	0.541
MOD_N-GLC_1	550	555	PF02516	0.537
MOD_NEK2_1	14	19	PF00069	0.606
MOD_NEK2_1	148	153	PF00069	0.495
MOD_NEK2_1	195	200	PF00069	0.642
MOD_NEK2_1	211	216	PF00069	0.507
MOD_NEK2_1	450	455	PF00069	0.630
MOD_NEK2_1	5	10	PF00069	0.558
MOD_NEK2_1	500	505	PF00069	0.385
MOD_NEK2_1	596	601	PF00069	0.372
MOD_NEK2_1	730	735	PF00069	0.273
MOD_NEK2_1	796	801	PF00069	0.529
MOD_NEK2_1	84	89	PF00069	0.553
MOD_NEK2_2	509	514	PF00069	0.417
MOD_NEK2_2	638	643	PF00069	0.345
MOD_NEK2_2	809	814	PF00069	0.684
MOD_PIKK_1	134	140	PF00454	0.518
MOD_PIKK_1	17	23	PF00454	0.569
MOD_PIKK_1	260	266	PF00454	0.685
MOD_PIKK_1	301	307	PF00454	0.545
MOD_PIKK_1	330	336	PF00454	0.517
MOD_PIKK_1	93	99	PF00454	0.526
MOD_PKA_2	17	23	PF00069	0.678
MOD_PKA_2	321	327	PF00069	0.588
MOD_PKA_2	35	41	PF00069	0.449
MOD_PKA_2	396	402	PF00069	0.672
MOD_PKA_2	53	59	PF00069	0.631
MOD_PKA_2	713	719	PF00069	0.431
MOD_PKA_2	725	731	PF00069	0.370
MOD_PKA_2	748	754	PF00069	0.596
MOD_PKA_2	764	770	PF00069	0.486
MOD_PKA_2	796	802	PF00069	0.500
MOD_PKB_1	308	316	PF00069	0.692
MOD_Plk_1	14	20	PF00069	0.579
MOD_Plk_1	358	364	PF00069	0.580
MOD_Plk_1	550	556	PF00069	0.601
MOD_Plk_2-3	359	365	PF00069	0.535
MOD_Plk_4	496	502	PF00069	0.405
MOD_Plk_4	656	662	PF00069	0.315
MOD_Plk_4	752	758	PF00069	0.441
MOD_Plk_4	796	802	PF00069	0.478
MOD_ProDKin_1	201	207	PF00069	0.631
MOD_ProDKin_1	212	218	PF00069	0.613
MOD_ProDKin_1	279	285	PF00069	0.670
MOD_ProDKin_1	367	373	PF00069	0.725
MOD_ProDKin_1	375	381	PF00069	0.646
MOD_ProDKin_1	39	45	PF00069	0.650
MOD_ProDKin_1	578	584	PF00069	0.381
MOD_ProDKin_1	600	606	PF00069	0.538
MOD_ProDKin_1	708	714	PF00069	0.474
MOD_SUMO_for_1	117	120	PF00179	0.472
MOD_SUMO_for_1	220	223	PF00179	0.543
MOD_SUMO_rev_2	273	282	PF00179	0.571
MOD_SUMO_rev_2	87	96	PF00179	0.545
TRG_DiLeu_BaEn_1	173	178	PF01217	0.370
TRG_DiLeu_BaEn_1	752	757	PF01217	0.407
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.410
TRG_DiLeu_BaLyEn_6	698	703	PF01217	0.380
TRG_DiLeu_BaLyEn_6	801	806	PF01217	0.480
TRG_ENDOCYTIC_2	128	131	PF00928	0.404
TRG_ENDOCYTIC_2	160	163	PF00928	0.490
TRG_ENDOCYTIC_2	164	167	PF00928	0.464
TRG_ENDOCYTIC_2	648	651	PF00928	0.356
TRG_ENDOCYTIC_2	676	679	PF00928	0.349
TRG_ER_diArg_1	33	36	PF00400	0.639
TRG_ER_diArg_1	513	515	PF00400	0.458
TRG_ER_diArg_1	558	561	PF00400	0.491
TRG_ER_diArg_1	622	625	PF00400	0.484
TRG_NES_CRM1_1	674	686	PF08389	0.357
TRG_NLS_MonoCore_2	306	311	PF00514	0.690
TRG_NLS_MonoExtN_4	235	242	PF00514	0.680
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	469	474	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	701	705	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	770	775	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	804	808	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P691	Leptomonas seymouri	48%	92%
A0A3S7XB99	Leishmania donovani	81%	99%
A4ID47	Leishmania infantum	81%	99%
E9ATC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4Q168	Leishmania major	82%	100%