Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2870), putative

Species:

Leishmania braziliensis

UniProt:

A4HPL6_LEIBR

TriTrypDb:

LbrM.35.3720 , LBRM2903_350047000

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPL6

Function

Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	20
GO:0032886	regulation of microtubule-based process	4	20
GO:0050789	regulation of biological process	2	20
GO:0050794	regulation of cellular process	3	20
GO:0060632	regulation of microtubule-based movement	5	20
GO:0065007	biological regulation	1	20

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.377
CLV_NRD_NRD_1	234	236	PF00675	0.242
CLV_NRD_NRD_1	261	263	PF00675	0.279
CLV_NRD_NRD_1	328	330	PF00675	0.691
CLV_NRD_NRD_1	86	88	PF00675	0.467
CLV_PCSK_KEX2_1	118	120	PF00082	0.536
CLV_PCSK_KEX2_1	261	263	PF00082	0.258
CLV_PCSK_KEX2_1	63	65	PF00082	0.468
CLV_PCSK_KEX2_1	86	88	PF00082	0.523
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.474
CLV_PCSK_SKI1_1	118	122	PF00082	0.429
CLV_PCSK_SKI1_1	185	189	PF00082	0.354
CLV_PCSK_SKI1_1	19	23	PF00082	0.405
CLV_PCSK_SKI1_1	286	290	PF00082	0.285
CLV_PCSK_SKI1_1	324	328	PF00082	0.541
CLV_PCSK_SKI1_1	68	72	PF00082	0.369
DEG_SPOP_SBC_1	24	28	PF00917	0.439
DOC_CYCLIN_RxL_1	182	191	PF00134	0.342
DOC_CYCLIN_RxL_1	282	292	PF00134	0.373
DOC_MAPK_gen_1	222	232	PF00069	0.459
DOC_MAPK_gen_1	279	289	PF00069	0.386
DOC_MAPK_gen_1	329	337	PF00069	0.542
DOC_MAPK_gen_1	63	71	PF00069	0.369
DOC_MAPK_MEF2A_6	225	232	PF00069	0.457
DOC_MAPK_MEF2A_6	63	71	PF00069	0.322
DOC_USP7_MATH_1	154	158	PF00917	0.558
DOC_USP7_MATH_1	238	242	PF00917	0.489
DOC_USP7_MATH_1	293	297	PF00917	0.629
DOC_USP7_UBL2_3	227	231	PF12436	0.461
DOC_WW_Pin1_4	122	127	PF00397	0.454
DOC_WW_Pin1_4	299	304	PF00397	0.717
DOC_WW_Pin1_4	37	42	PF00397	0.651
LIG_14-3-3_CanoR_1	140	150	PF00244	0.436
LIG_EH1_1	64	72	PF00400	0.480
LIG_eIF4E_1	182	188	PF01652	0.328
LIG_FHA_1	175	181	PF00498	0.441
LIG_FHA_1	20	26	PF00498	0.609
LIG_FHA_1	300	306	PF00498	0.735
LIG_FHA_1	318	324	PF00498	0.622
LIG_FHA_1	33	39	PF00498	0.556
LIG_LIR_LC3C_4	176	181	PF02991	0.455
LIG_LIR_Nem_3	144	150	PF02991	0.438
LIG_LIR_Nem_3	162	168	PF02991	0.352
LIG_LIR_Nem_3	263	268	PF02991	0.451
LIG_LYPXL_S_1	146	150	PF13949	0.394
LIG_LYPXL_yS_3	147	150	PF13949	0.281
LIG_PCNA_yPIPBox_3	97	106	PF02747	0.373
LIG_SH2_CRK	109	113	PF00017	0.415
LIG_SH2_NCK_1	168	172	PF00017	0.361
LIG_SH2_SRC	168	171	PF00017	0.358
LIG_SH2_STAT3	248	251	PF00017	0.449
LIG_SH2_STAT5	219	222	PF00017	0.543
LIG_SH3_3	300	306	PF00018	0.752
LIG_TRAF2_1	73	76	PF00917	0.502
LIG_UBA3_1	112	121	PF00899	0.289
LIG_WRC_WIRS_1	139	144	PF05994	0.247
MOD_CK1_1	149	155	PF00069	0.399
MOD_CK1_1	28	34	PF00069	0.696
MOD_CK1_1	296	302	PF00069	0.644
MOD_CK1_1	307	313	PF00069	0.738
MOD_CK1_1	40	46	PF00069	0.728
MOD_CK1_1	49	55	PF00069	0.390
MOD_CK2_1	125	131	PF00069	0.335
MOD_CK2_1	23	29	PF00069	0.450
MOD_CK2_1	325	331	PF00069	0.676
MOD_CK2_1	70	76	PF00069	0.338
MOD_GlcNHglycan	127	130	PF01048	0.458
MOD_GlcNHglycan	307	310	PF01048	0.770
MOD_GlcNHglycan	72	75	PF01048	0.362
MOD_GSK3_1	19	26	PF00069	0.466
MOD_GSK3_1	28	35	PF00069	0.627
MOD_GSK3_1	289	296	PF00069	0.693
MOD_GSK3_1	305	312	PF00069	0.733
MOD_GSK3_1	36	43	PF00069	0.582
MOD_GSK3_1	45	52	PF00069	0.592
MOD_N-GLC_1	154	159	PF02516	0.620
MOD_NEK2_1	120	125	PF00069	0.483
MOD_NEK2_1	212	217	PF00069	0.489
MOD_NEK2_1	289	294	PF00069	0.524
MOD_NEK2_1	70	75	PF00069	0.422
MOD_NEK2_1	88	93	PF00069	0.466
MOD_PKA_1	261	267	PF00069	0.392
MOD_PKA_2	261	267	PF00069	0.467
MOD_PKA_2	278	284	PF00069	0.402
MOD_PKA_2	32	38	PF00069	0.472
MOD_PKA_2	49	55	PF00069	0.450
MOD_Plk_1	13	19	PF00069	0.416
MOD_Plk_1	174	180	PF00069	0.538
MOD_Plk_1	212	218	PF00069	0.491
MOD_Plk_2-3	13	19	PF00069	0.451
MOD_Plk_4	49	55	PF00069	0.568
MOD_Plk_4	76	82	PF00069	0.391
MOD_ProDKin_1	122	128	PF00069	0.456
MOD_ProDKin_1	299	305	PF00069	0.718
MOD_ProDKin_1	37	43	PF00069	0.648
MOD_SUMO_for_1	166	169	PF00179	0.319
MOD_SUMO_rev_2	189	194	PF00179	0.494
TRG_DiLeu_BaEn_1	175	180	PF01217	0.412
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.416
TRG_ENDOCYTIC_2	109	112	PF00928	0.416
TRG_ENDOCYTIC_2	147	150	PF00928	0.519
TRG_ENDOCYTIC_2	255	258	PF00928	0.472
TRG_ENDOCYTIC_2	265	268	PF00928	0.424
TRG_ER_diArg_1	118	120	PF00400	0.282
TRG_ER_diArg_1	244	247	PF00400	0.501
TRG_ER_diArg_1	86	88	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K9	Leptomonas seymouri	60%	100%
A0A0S4JE13	Bodo saltans	37%	100%
A0A0S4JHQ4	Bodo saltans	37%	100%
A0A1X0P0N8	Trypanosomatidae	25%	100%
A0A1X0P4D1	Trypanosomatidae	43%	100%
A0A3Q8IRH9	Leishmania donovani	24%	100%
A0A3S7XB90	Leishmania donovani	77%	100%
A0A422MZF7	Trypanosoma rangeli	43%	100%
A4HPW7	Leishmania braziliensis	25%	100%
A4ID48	Leishmania infantum	77%	100%
A4IDM9	Leishmania infantum	24%	100%
D0A4B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A8J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ATC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9ATN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q0W4	Leishmania major	25%	100%
Q4Q169	Leishmania major	77%	100%
V5B6Z0	Trypanosoma cruzi	43%	100%