Small acidic protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Small acidic protein family, putative

Species:

Leishmania braziliensis

UniProt:

A4HPL5_LEIBR

TriTrypDb:

LbrM.35.3710 , LBRM2903_350046900

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.370
CLV_NRD_NRD_1	75	77	PF00675	0.543
CLV_NRD_NRD_1	97	99	PF00675	0.664
CLV_PCSK_KEX2_1	148	150	PF00082	0.376
CLV_PCSK_KEX2_1	186	188	PF00082	0.376
CLV_PCSK_KEX2_1	56	58	PF00082	0.618
CLV_PCSK_KEX2_1	99	101	PF00082	0.643
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.376
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.426
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.699
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.676
CLV_PCSK_SKI1_1	12	16	PF00082	0.373
CLV_PCSK_SKI1_1	148	152	PF00082	0.430
CLV_PCSK_SKI1_1	76	80	PF00082	0.512
DEG_APCC_DBOX_1	75	83	PF00400	0.397
DEG_SPOP_SBC_1	109	113	PF00917	0.718
DOC_USP7_MATH_1	110	114	PF00917	0.713
DOC_USP7_MATH_1	179	183	PF00917	0.296
DOC_USP7_MATH_1	38	42	PF00917	0.352
DOC_USP7_MATH_1	78	82	PF00917	0.540
DOC_USP7_UBL2_3	73	77	PF12436	0.549
LIG_14-3-3_CanoR_1	100	109	PF00244	0.556
LIG_14-3-3_CanoR_1	11	21	PF00244	0.394
LIG_14-3-3_CanoR_1	174	179	PF00244	0.501
LIG_14-3-3_CanoR_1	187	193	PF00244	0.286
LIG_AP2alpha_1	3	7	PF02296	0.390
LIG_BIR_II_1	1	5	PF00653	0.410
LIG_BRCT_BRCA1_1	138	142	PF00533	0.501
LIG_FHA_1	126	132	PF00498	0.620
LIG_FHA_1	13	19	PF00498	0.562
LIG_FHA_1	175	181	PF00498	0.249
LIG_FHA_2	87	93	PF00498	0.527
LIG_LIR_Gen_1	5	14	PF02991	0.369
LIG_LIR_Nem_3	5	10	PF02991	0.371
LIG_PCNA_PIPBox_1	65	74	PF02747	0.399
LIG_PDZ_Class_2	205	210	PF00595	0.376
LIG_Pex14_2	3	7	PF04695	0.390
LIG_SUMO_SIM_anti_2	41	46	PF11976	0.472
LIG_TRAF2_1	34	37	PF00917	0.581
LIG_TRAF2_1	90	93	PF00917	0.542
MOD_CK1_1	113	119	PF00069	0.703
MOD_CK1_1	191	197	PF00069	0.380
MOD_CK1_1	83	89	PF00069	0.667
MOD_CK2_1	178	184	PF00069	0.421
MOD_CK2_1	191	197	PF00069	0.430
MOD_CK2_1	86	92	PF00069	0.591
MOD_Cter_Amidation	203	206	PF01082	0.376
MOD_GlcNHglycan	138	141	PF01048	0.470
MOD_GlcNHglycan	181	184	PF01048	0.404
MOD_GlcNHglycan	197	200	PF01048	0.392
MOD_GlcNHglycan	82	85	PF01048	0.664
MOD_GSK3_1	109	116	PF00069	0.733
MOD_GSK3_1	159	166	PF00069	0.319
MOD_GSK3_1	170	177	PF00069	0.359
MOD_GSK3_1	191	198	PF00069	0.498
MOD_LATS_1	172	178	PF00433	0.501
MOD_N-GLC_1	188	193	PF02516	0.249
MOD_NEK2_1	178	183	PF00069	0.501
MOD_PIKK_1	160	166	PF00454	0.249
MOD_PIKK_1	191	197	PF00454	0.501
MOD_PKA_2	116	122	PF00069	0.773
MOD_PKB_1	98	106	PF00069	0.552
MOD_Plk_1	188	194	PF00069	0.355
MOD_SUMO_rev_2	143	150	PF00179	0.433
MOD_SUMO_rev_2	181	188	PF00179	0.501
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.524
TRG_NES_CRM1_1	37	51	PF08389	0.529
TRG_NLS_Bipartite_1	56	77	PF00514	0.423
TRG_NLS_MonoExtC_3	72	77	PF00514	0.385
TRG_NLS_MonoExtC_3	98	104	PF00514	0.730
TRG_NLS_MonoExtN_4	98	103	PF00514	0.732
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDM8	Leptomonas seymouri	54%	100%
A0A3S7XB92	Leishmania donovani	74%	100%
A4ID49	Leishmania infantum	74%	100%
D0A8J9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ATC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q170	Leishmania major	75%	100%