NIPSNAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NIPSNAP, putative

Species:

Leishmania braziliensis

UniProt:

A4HPL3_LEIBR

TriTrypDb:

LbrM.35.3690 , LBRM2903_350046700

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPL3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	7	9	PF00675	0.483
CLV_NRD_NRD_1	80	82	PF00675	0.334
CLV_PCSK_KEX2_1	7	9	PF00082	0.415
CLV_PCSK_PC7_1	3	9	PF00082	0.459
DEG_Nend_Nbox_1	1	3	PF02207	0.501
DEG_ODPH_VHL_1	26	39	PF01847	0.393
DOC_CKS1_1	174	179	PF01111	0.497
DOC_WW_Pin1_4	128	133	PF00397	0.390
DOC_WW_Pin1_4	173	178	PF00397	0.490
LIG_14-3-3_CanoR_1	190	196	PF00244	0.368
LIG_APCC_ABBA_1	130	135	PF00400	0.460
LIG_DCNL_PONY_1	1	4	PF03556	0.591
LIG_FHA_1	146	152	PF00498	0.410
LIG_FHA_1	174	180	PF00498	0.562
LIG_FHA_1	21	27	PF00498	0.502
LIG_FHA_1	54	60	PF00498	0.530
LIG_LIR_Apic_2	93	97	PF02991	0.516
LIG_LIR_Gen_1	148	153	PF02991	0.407
LIG_LIR_Gen_1	157	164	PF02991	0.250
LIG_LIR_Gen_1	29	39	PF02991	0.473
LIG_LIR_Gen_1	99	108	PF02991	0.393
LIG_LIR_Nem_3	121	127	PF02991	0.417
LIG_LIR_Nem_3	148	152	PF02991	0.356
LIG_LIR_Nem_3	157	163	PF02991	0.271
LIG_LIR_Nem_3	29	34	PF02991	0.473
LIG_LIR_Nem_3	89	94	PF02991	0.393
LIG_LIR_Nem_3	99	103	PF02991	0.378
LIG_Pex14_1	90	94	PF04695	0.448
LIG_RPA_C_Insects	100	115	PF08784	0.206
LIG_SH2_CRK	100	104	PF00017	0.236
LIG_SH2_CRK	124	128	PF00017	0.381
LIG_SH2_GRB2like	71	74	PF00017	0.377
LIG_SH2_PTP2	160	163	PF00017	0.413
LIG_SH2_PTP2	65	68	PF00017	0.348
LIG_SH2_PTP2	94	97	PF00017	0.348
LIG_SH2_STAT3	126	129	PF00017	0.426
LIG_SH2_STAT3	41	44	PF00017	0.348
LIG_SH2_STAT5	126	129	PF00017	0.370
LIG_SH2_STAT5	160	163	PF00017	0.400
LIG_SH2_STAT5	24	27	PF00017	0.377
LIG_SH2_STAT5	65	68	PF00017	0.348
LIG_SH2_STAT5	94	97	PF00017	0.377
LIG_SH3_1	40	46	PF00018	0.377
LIG_SH3_3	171	177	PF00018	0.536
LIG_SH3_3	22	28	PF00018	0.491
LIG_SH3_3	40	46	PF00018	0.210
LIG_TRFH_1	24	28	PF08558	0.206
LIG_WRC_WIRS_1	31	36	PF05994	0.377
MOD_CDC14_SPxK_1	131	134	PF00782	0.458
MOD_CDK_SPxK_1	128	134	PF00069	0.386
MOD_CK1_1	120	126	PF00069	0.510
MOD_CK1_1	139	145	PF00069	0.471
MOD_GlcNHglycan	13	16	PF01048	0.548
MOD_GlcNHglycan	137	141	PF01048	0.532
MOD_GSK3_1	175	182	PF00069	0.478
MOD_N-GLC_1	117	122	PF02516	0.496
MOD_NEK2_1	101	106	PF00069	0.348
MOD_NEK2_1	145	150	PF00069	0.332
MOD_NEK2_1	179	184	PF00069	0.444
MOD_PIKK_1	118	124	PF00454	0.582
MOD_PKA_2	189	195	PF00069	0.366
MOD_PKB_1	45	53	PF00069	0.206
MOD_ProDKin_1	128	134	PF00069	0.396
MOD_ProDKin_1	173	179	PF00069	0.491
MOD_SUMO_rev_2	155	161	PF00179	0.387
TRG_ENDOCYTIC_2	100	103	PF00928	0.206
TRG_ENDOCYTIC_2	124	127	PF00928	0.384
TRG_ENDOCYTIC_2	160	163	PF00928	0.351
TRG_ENDOCYTIC_2	31	34	PF00928	0.305
TRG_ENDOCYTIC_2	65	68	PF00928	0.351
TRG_ENDOCYTIC_2	71	74	PF00928	0.411
TRG_ER_diArg_1	45	48	PF00400	0.293
TRG_ER_diArg_1	7	9	PF00400	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX6	Leptomonas seymouri	72%	100%
A0A1X0P390	Trypanosomatidae	53%	100%
A0A3S7XB71	Leishmania donovani	93%	100%
A0A422NA85	Trypanosoma rangeli	49%	100%
A4ID51	Leishmania infantum	94%	100%
E9ATC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q172	Leishmania major	93%	100%