CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HPL0_LEIBR

TriTrypDb:

LbrM.35.3660 , LBRM2903_350046400

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.317
CLV_C14_Caspase3-7	321	325	PF00656	0.543
CLV_C14_Caspase3-7	97	101	PF00656	0.314
CLV_NRD_NRD_1	175	177	PF00675	0.349
CLV_NRD_NRD_1	219	221	PF00675	0.292
CLV_NRD_NRD_1	292	294	PF00675	0.445
CLV_NRD_NRD_1	41	43	PF00675	0.445
CLV_NRD_NRD_1	563	565	PF00675	0.421
CLV_NRD_NRD_1	690	692	PF00675	0.508
CLV_NRD_NRD_1	87	89	PF00675	0.376
CLV_NRD_NRD_1	93	95	PF00675	0.366
CLV_PCSK_KEX2_1	175	177	PF00082	0.349
CLV_PCSK_KEX2_1	219	221	PF00082	0.292
CLV_PCSK_KEX2_1	292	294	PF00082	0.445
CLV_PCSK_KEX2_1	364	366	PF00082	0.689
CLV_PCSK_KEX2_1	41	43	PF00082	0.445
CLV_PCSK_KEX2_1	563	565	PF00082	0.451
CLV_PCSK_KEX2_1	633	635	PF00082	0.753
CLV_PCSK_KEX2_1	651	653	PF00082	0.451
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.689
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.773
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.496
CLV_PCSK_SKI1_1	151	155	PF00082	0.351
CLV_PCSK_SKI1_1	219	223	PF00082	0.292
CLV_PCSK_SKI1_1	45	49	PF00082	0.353
CLV_PCSK_SKI1_1	52	56	PF00082	0.402
CLV_PCSK_SKI1_1	566	570	PF00082	0.366
CLV_PCSK_SKI1_1	717	721	PF00082	0.427
CLV_Separin_Fungi	165	171	PF03568	0.215
CLV_Separin_Metazoa	216	220	PF03568	0.292
DEG_APCC_DBOX_1	130	138	PF00400	0.215
DEG_APCC_DBOX_1	159	167	PF00400	0.357
DEG_APCC_DBOX_1	602	610	PF00400	0.473
DEG_SCF_FBW7_1	338	345	PF00400	0.522
DEG_SPOP_SBC_1	10	14	PF00917	0.504
DEG_SPOP_SBC_1	611	615	PF00917	0.365
DOC_ANK_TNKS_1	595	602	PF00023	0.505
DOC_CKS1_1	501	506	PF01111	0.326
DOC_CYCLIN_RxL_1	41	49	PF00134	0.346
DOC_CYCLIN_RxL_1	563	572	PF00134	0.314
DOC_CYCLIN_yCln2_LP_2	520	523	PF00134	0.484
DOC_MAPK_DCC_7	131	139	PF00069	0.351
DOC_MAPK_gen_1	175	187	PF00069	0.352
DOC_MAPK_gen_1	235	245	PF00069	0.351
DOC_MAPK_gen_1	364	370	PF00069	0.516
DOC_MAPK_gen_1	50	57	PF00069	0.429
DOC_MAPK_gen_1	563	571	PF00069	0.386
DOC_MAPK_gen_1	573	580	PF00069	0.447
DOC_MAPK_gen_1	603	610	PF00069	0.466
DOC_MAPK_MEF2A_6	131	139	PF00069	0.351
DOC_MAPK_MEF2A_6	235	243	PF00069	0.351
DOC_MAPK_MEF2A_6	603	610	PF00069	0.469
DOC_MIT_MIM_1	46	54	PF04212	0.291
DOC_PP1_RVXF_1	217	224	PF00149	0.293
DOC_PP1_RVXF_1	246	252	PF00149	0.351
DOC_PP2B_LxvP_1	520	523	PF13499	0.484
DOC_PP4_FxxP_1	501	504	PF00568	0.426
DOC_SPAK_OSR1_1	71	75	PF12202	0.316
DOC_USP7_MATH_1	11	15	PF00917	0.481
DOC_USP7_MATH_1	27	31	PF00917	0.384
DOC_USP7_MATH_1	480	484	PF00917	0.449
DOC_USP7_MATH_1	524	528	PF00917	0.514
DOC_USP7_MATH_1	533	537	PF00917	0.606
DOC_USP7_MATH_1	611	615	PF00917	0.365
DOC_USP7_MATH_1	657	661	PF00917	0.651
DOC_USP7_MATH_1	749	753	PF00917	0.564
DOC_WW_Pin1_4	113	118	PF00397	0.508
DOC_WW_Pin1_4	137	142	PF00397	0.343
DOC_WW_Pin1_4	338	343	PF00397	0.563
DOC_WW_Pin1_4	346	351	PF00397	0.601
DOC_WW_Pin1_4	413	418	PF00397	0.654
DOC_WW_Pin1_4	435	440	PF00397	0.637
DOC_WW_Pin1_4	500	505	PF00397	0.352
DOC_WW_Pin1_4	525	530	PF00397	0.605
DOC_WW_Pin1_4	682	687	PF00397	0.593
LIG_14-3-3_CanoR_1	180	184	PF00244	0.335
LIG_14-3-3_CanoR_1	516	521	PF00244	0.521
LIG_14-3-3_CanoR_1	673	679	PF00244	0.604
LIG_14-3-3_CanoR_1	94	102	PF00244	0.552
LIG_Actin_WH2_2	188	206	PF00022	0.351
LIG_APCC_ABBA_1	352	357	PF00400	0.533
LIG_APCC_ABBA_1	54	59	PF00400	0.411
LIG_BRCT_BRCA1_1	30	34	PF00533	0.400
LIG_BRCT_BRCA1_1	724	728	PF00533	0.293
LIG_CaM_NSCaTE_8	674	681	PF13499	0.633
LIG_Clathr_ClatBox_1	54	58	PF01394	0.306
LIG_FHA_1	180	186	PF00498	0.351
LIG_FHA_1	197	203	PF00498	0.351
LIG_FHA_1	275	281	PF00498	0.331
LIG_FHA_1	308	314	PF00498	0.532
LIG_FHA_1	375	381	PF00498	0.597
LIG_FHA_1	438	444	PF00498	0.563
LIG_FHA_1	471	477	PF00498	0.370
LIG_FHA_1	501	507	PF00498	0.343
LIG_FHA_1	630	636	PF00498	0.718
LIG_FHA_1	638	644	PF00498	0.612
LIG_FHA_1	700	706	PF00498	0.551
LIG_FHA_1	729	735	PF00498	0.509
LIG_FHA_2	11	17	PF00498	0.546
LIG_FHA_2	283	289	PF00498	0.369
LIG_FHA_2	503	509	PF00498	0.536
LIG_FHA_2	526	532	PF00498	0.493
LIG_Integrin_isoDGR_2	671	673	PF01839	0.567
LIG_IRF3_LxIS_1	469	475	PF10401	0.360
LIG_LIR_Gen_1	46	56	PF02991	0.310
LIG_LIR_Gen_1	579	589	PF02991	0.453
LIG_LIR_Gen_1	677	687	PF02991	0.618
LIG_LIR_Nem_3	231	237	PF02991	0.350
LIG_LIR_Nem_3	401	406	PF02991	0.575
LIG_LIR_Nem_3	46	51	PF02991	0.306
LIG_LIR_Nem_3	579	584	PF02991	0.434
LIG_LIR_Nem_3	67	73	PF02991	0.310
LIG_LIR_Nem_3	677	682	PF02991	0.626
LIG_LIR_Nem_3	712	718	PF02991	0.423
LIG_LYPXL_yS_3	214	217	PF13949	0.292
LIG_NRBOX	642	648	PF00104	0.474
LIG_PDZ_Class_2	760	765	PF00595	0.483
LIG_Pex14_1	17	21	PF04695	0.453
LIG_Pex14_1	402	406	PF04695	0.487
LIG_Pex14_1	492	496	PF04695	0.330
LIG_Pex14_2	224	228	PF04695	0.292
LIG_SH2_CRK	581	585	PF00017	0.439
LIG_SH2_CRK	70	74	PF00017	0.310
LIG_SH2_CRK	716	720	PF00017	0.435
LIG_SH2_NCK_1	581	585	PF00017	0.439
LIG_SH2_PTP2	171	174	PF00017	0.335
LIG_SH2_PTP2	90	93	PF00017	0.315
LIG_SH2_SRC	598	601	PF00017	0.491
LIG_SH2_STAP1	21	25	PF00017	0.445
LIG_SH2_STAT3	487	490	PF00017	0.339
LIG_SH2_STAT5	171	174	PF00017	0.420
LIG_SH2_STAT5	183	186	PF00017	0.287
LIG_SH2_STAT5	264	267	PF00017	0.357
LIG_SH2_STAT5	487	490	PF00017	0.449
LIG_SH2_STAT5	502	505	PF00017	0.456
LIG_SH2_STAT5	567	570	PF00017	0.391
LIG_SH2_STAT5	598	601	PF00017	0.491
LIG_SH2_STAT5	90	93	PF00017	0.297
LIG_SH3_3	111	117	PF00018	0.449
LIG_SH3_3	209	215	PF00018	0.357
LIG_SH3_3	233	239	PF00018	0.292
LIG_SH3_3	300	306	PF00018	0.632
LIG_SH3_3	605	611	PF00018	0.479
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.335
LIG_SUMO_SIM_par_1	309	314	PF11976	0.510
LIG_SUMO_SIM_par_1	471	477	PF11976	0.453
LIG_SUMO_SIM_par_1	730	735	PF11976	0.315
LIG_TYR_ITIM	212	217	PF00017	0.351
LIG_TYR_ITIM	68	73	PF00017	0.309
LIG_TYR_ITSM	577	584	PF00017	0.401
MOD_CDK_SPK_2	525	530	PF00069	0.494
MOD_CK1_1	113	119	PF00069	0.521
MOD_CK1_1	318	324	PF00069	0.731
MOD_CK1_1	326	332	PF00069	0.559
MOD_CK1_1	337	343	PF00069	0.670
MOD_CK1_1	374	380	PF00069	0.598
MOD_CK1_1	401	407	PF00069	0.507
MOD_CK1_1	447	453	PF00069	0.542
MOD_CK1_1	614	620	PF00069	0.559
MOD_CK1_1	677	683	PF00069	0.583
MOD_CK1_1	752	758	PF00069	0.596
MOD_CK2_1	16	22	PF00069	0.421
MOD_CK2_1	34	40	PF00069	0.434
MOD_CK2_1	443	449	PF00069	0.657
MOD_GlcNHglycan	13	16	PF01048	0.578
MOD_GlcNHglycan	230	233	PF01048	0.351
MOD_GlcNHglycan	252	255	PF01048	0.292
MOD_GlcNHglycan	30	33	PF01048	0.401
MOD_GlcNHglycan	328	331	PF01048	0.481
MOD_GlcNHglycan	373	376	PF01048	0.575
MOD_GlcNHglycan	4	8	PF01048	0.631
MOD_GlcNHglycan	484	487	PF01048	0.403
MOD_GlcNHglycan	659	662	PF01048	0.623
MOD_GlcNHglycan	674	677	PF01048	0.601
MOD_GlcNHglycan	84	87	PF01048	0.270
MOD_GSK3_1	109	116	PF00069	0.362
MOD_GSK3_1	250	257	PF00069	0.292
MOD_GSK3_1	270	277	PF00069	0.171
MOD_GSK3_1	307	314	PF00069	0.662
MOD_GSK3_1	334	341	PF00069	0.531
MOD_GSK3_1	342	349	PF00069	0.570
MOD_GSK3_1	355	362	PF00069	0.640
MOD_GSK3_1	431	438	PF00069	0.682
MOD_GSK3_1	443	450	PF00069	0.627
MOD_GSK3_1	464	471	PF00069	0.516
MOD_GSK3_1	569	576	PF00069	0.373
MOD_GSK3_1	610	617	PF00069	0.461
MOD_GSK3_1	629	636	PF00069	0.494
MOD_GSK3_1	653	660	PF00069	0.733
MOD_GSK3_1	674	681	PF00069	0.560
MOD_GSK3_1	728	735	PF00069	0.386
MOD_GSK3_1	752	759	PF00069	0.480
MOD_N-GLC_1	350	355	PF02516	0.589
MOD_NEK2_1	202	207	PF00069	0.305
MOD_NEK2_1	226	231	PF00069	0.215
MOD_NEK2_1	274	279	PF00069	0.454
MOD_NEK2_1	380	385	PF00069	0.684
MOD_NEK2_1	393	398	PF00069	0.535
MOD_NEK2_1	472	477	PF00069	0.304
MOD_NEK2_1	569	574	PF00069	0.361
MOD_NEK2_1	728	733	PF00069	0.302
MOD_NEK2_2	431	436	PF00069	0.495
MOD_NEK2_2	674	679	PF00069	0.638
MOD_PIKK_1	16	22	PF00454	0.322
MOD_PIKK_1	323	329	PF00454	0.490
MOD_PIKK_1	510	516	PF00454	0.525
MOD_PIKK_1	699	705	PF00454	0.516
MOD_PIKK_1	732	738	PF00454	0.398
MOD_PKA_1	633	639	PF00069	0.641
MOD_PKA_2	179	185	PF00069	0.335
MOD_PKA_2	315	321	PF00069	0.734
MOD_PKA_2	515	521	PF00069	0.519
MOD_PKA_2	569	575	PF00069	0.480
MOD_PKA_2	576	582	PF00069	0.518
MOD_PKA_2	633	639	PF00069	0.640
MOD_PKA_2	672	678	PF00069	0.620
MOD_PKA_2	93	99	PF00069	0.560
MOD_Plk_1	323	329	PF00069	0.511
MOD_Plk_1	393	399	PF00069	0.560
MOD_Plk_1	720	726	PF00069	0.309
MOD_Plk_4	110	116	PF00069	0.416
MOD_Plk_4	179	185	PF00069	0.356
MOD_Plk_4	202	208	PF00069	0.215
MOD_Plk_4	282	288	PF00069	0.341
MOD_Plk_4	315	321	PF00069	0.790
MOD_Plk_4	331	337	PF00069	0.588
MOD_Plk_4	398	404	PF00069	0.507
MOD_Plk_4	516	522	PF00069	0.635
MOD_Plk_4	576	582	PF00069	0.584
MOD_Plk_4	674	680	PF00069	0.629
MOD_Plk_4	752	758	PF00069	0.481
MOD_Plk_4	98	104	PF00069	0.327
MOD_ProDKin_1	113	119	PF00069	0.521
MOD_ProDKin_1	137	143	PF00069	0.343
MOD_ProDKin_1	338	344	PF00069	0.563
MOD_ProDKin_1	346	352	PF00069	0.604
MOD_ProDKin_1	413	419	PF00069	0.652
MOD_ProDKin_1	435	441	PF00069	0.640
MOD_ProDKin_1	500	506	PF00069	0.369
MOD_ProDKin_1	525	531	PF00069	0.606
MOD_ProDKin_1	682	688	PF00069	0.593
MOD_SUMO_for_1	249	252	PF00179	0.351
MOD_SUMO_for_1	81	84	PF00179	0.276
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.351
TRG_ENDOCYTIC_2	171	174	PF00928	0.335
TRG_ENDOCYTIC_2	214	217	PF00928	0.340
TRG_ENDOCYTIC_2	581	584	PF00928	0.444
TRG_ENDOCYTIC_2	70	73	PF00928	0.309
TRG_ENDOCYTIC_2	716	719	PF00928	0.380
TRG_ENDOCYTIC_2	90	93	PF00928	0.245
TRG_ER_diArg_1	174	176	PF00400	0.342
TRG_ER_diArg_1	218	220	PF00400	0.292
TRG_ER_diArg_1	291	293	PF00400	0.446
TRG_ER_diArg_1	294	297	PF00400	0.460
TRG_ER_diArg_1	563	566	PF00400	0.427
TRG_ER_diArg_1	574	577	PF00400	0.420
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	717	721	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P689	Leptomonas seymouri	47%	94%
A0A1X0P424	Trypanosomatidae	34%	100%
A0A3S7XBD6	Leishmania donovani	67%	97%
A4ID54	Leishmania infantum	67%	97%
E9ATC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	96%
Q4Q175	Leishmania major	66%	100%