Short chain dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HPK8_LEIBR

TriTrypDb:

LbrM.35.3640 , LBRM2903_350046200

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

A4HPK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPK8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016491	oxidoreductase activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.362
CLV_NRD_NRD_1	248	250	PF00675	0.559
CLV_NRD_NRD_1	296	298	PF00675	0.609
CLV_PCSK_FUR_1	24	28	PF00082	0.302
CLV_PCSK_KEX2_1	23	25	PF00082	0.363
CLV_PCSK_KEX2_1	248	250	PF00082	0.559
CLV_PCSK_KEX2_1	26	28	PF00082	0.335
CLV_PCSK_KEX2_1	296	298	PF00082	0.576
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.245
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.576
CLV_PCSK_PC7_1	19	25	PF00082	0.369
CLV_PCSK_SKI1_1	117	121	PF00082	0.515
CLV_PCSK_SKI1_1	23	27	PF00082	0.317
CLV_PCSK_SKI1_1	234	238	PF00082	0.617
CLV_PCSK_SKI1_1	284	288	PF00082	0.500
CLV_PCSK_SKI1_1	298	302	PF00082	0.513
CLV_PCSK_SKI1_1	3	7	PF00082	0.318
DEG_APCC_DBOX_1	116	124	PF00400	0.315
DEG_APCC_DBOX_1	2	10	PF00400	0.367
DEG_APCC_DBOX_1	283	291	PF00400	0.373
DEG_APCC_DBOX_1	296	304	PF00400	0.337
DOC_MAPK_MEF2A_6	212	221	PF00069	0.238
DOC_PP1_SILK_1	190	195	PF00149	0.300
DOC_WW_Pin1_4	172	177	PF00397	0.325
DOC_WW_Pin1_4	249	254	PF00397	0.411
LIG_14-3-3_CanoR_1	100	109	PF00244	0.325
LIG_14-3-3_CanoR_1	194	204	PF00244	0.226
LIG_14-3-3_CanoR_1	297	301	PF00244	0.373
LIG_Actin_WH2_1	178	196	PF00022	0.293
LIG_Actin_WH2_2	181	196	PF00022	0.269
LIG_Actin_WH2_2	56	73	PF00022	0.252
LIG_BIR_II_1	1	5	PF00653	0.269
LIG_CtBP_PxDLS_1	46	51	PF00389	0.406
LIG_FHA_1	11	17	PF00498	0.356
LIG_FHA_1	114	120	PF00498	0.305
LIG_FHA_1	214	220	PF00498	0.164
LIG_FHA_1	286	292	PF00498	0.334
LIG_FHA_1	96	102	PF00498	0.249
LIG_GBD_Chelix_1	275	283	PF00786	0.424
LIG_LIR_Gen_1	103	109	PF02991	0.328
LIG_LIR_Gen_1	138	149	PF02991	0.296
LIG_LIR_Nem_3	103	108	PF02991	0.323
LIG_LIR_Nem_3	138	144	PF02991	0.248
LIG_MAD2	234	242	PF02301	0.361
LIG_NRBOX	5	11	PF00104	0.356
LIG_PTB_Apo_2	147	154	PF02174	0.340
LIG_PTB_Phospho_1	147	153	PF10480	0.289
LIG_SH2_STAP1	105	109	PF00017	0.325
LIG_SH2_STAT5	122	125	PF00017	0.262
LIG_SH2_STAT5	153	156	PF00017	0.232
LIG_SH2_STAT5	197	200	PF00017	0.226
LIG_SH2_STAT5	226	229	PF00017	0.226
LIG_SH2_STAT5	87	90	PF00017	0.293
LIG_SUMO_SIM_anti_2	11	16	PF11976	0.317
LIG_SUMO_SIM_anti_2	177	184	PF11976	0.238
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.270
LIG_SUMO_SIM_par_1	8	13	PF11976	0.181
LIG_TRAF2_1	140	143	PF00917	0.164
LIG_TRFH_1	281	285	PF08558	0.287
LIG_TYR_ITIM	120	125	PF00017	0.293
LIG_UBA3_1	272	278	PF00899	0.276
MOD_CDC14_SPxK_1	175	178	PF00782	0.325
MOD_CDK_SPxK_1	172	178	PF00069	0.325
MOD_CK1_1	172	178	PF00069	0.297
MOD_CK1_1	195	201	PF00069	0.226
MOD_CK1_1	299	305	PF00069	0.330
MOD_CK2_1	90	96	PF00069	0.325
MOD_GlcNHglycan	194	197	PF01048	0.438
MOD_GlcNHglycan	42	45	PF01048	0.290
MOD_GlcNHglycan	53	56	PF01048	0.464
MOD_GSK3_1	108	115	PF00069	0.279
MOD_GSK3_1	165	172	PF00069	0.256
MOD_GSK3_1	188	195	PF00069	0.226
MOD_GSK3_1	213	220	PF00069	0.260
MOD_GSK3_1	226	233	PF00069	0.263
MOD_GSK3_1	36	43	PF00069	0.283
MOD_GSK3_1	65	72	PF00069	0.242
MOD_LATS_1	232	238	PF00433	0.380
MOD_N-GLC_1	169	174	PF02516	0.533
MOD_N-GLC_1	65	70	PF02516	0.489
MOD_NEK2_1	10	15	PF00069	0.275
MOD_NEK2_2	213	218	PF00069	0.164
MOD_PIKK_1	165	171	PF00454	0.300
MOD_PKA_1	296	302	PF00069	0.329
MOD_PKA_2	296	302	PF00069	0.370
MOD_Plk_1	213	219	PF00069	0.164
MOD_Plk_1	65	71	PF00069	0.289
MOD_Plk_4	10	16	PF00069	0.379
MOD_Plk_4	188	194	PF00069	0.269
MOD_ProDKin_1	172	178	PF00069	0.325
MOD_ProDKin_1	249	255	PF00069	0.405
MOD_SUMO_rev_2	233	243	PF00179	0.437
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.164
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.226
TRG_ENDOCYTIC_2	105	108	PF00928	0.325
TRG_ENDOCYTIC_2	122	125	PF00928	0.123
TRG_ER_diArg_1	23	25	PF00400	0.561
TRG_ER_diArg_1	27	30	PF00400	0.527
TRG_NLS_MonoExtN_4	23	30	PF00514	0.451
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0B4FP77	Metarhizium brunneum (strain ARSEF 3297)	30%	100%
A0A0B4GT47	Metarhizium anisopliae (strain ARSEF 549)	31%	100%
A0A0B4GU97	Metarhizium guizhouense (strain ARSEF 977)	30%	100%
A0A0B4HVU2	Metarhizium majus (strain ARSEF 297)	30%	100%
A0A0N1I1P8	Leptomonas seymouri	29%	89%
A0A0N1I7L3	Leptomonas seymouri	75%	100%
A0A0S4IWL0	Bodo saltans	27%	96%
A0A0S4JL82	Bodo saltans	43%	100%
A0A0S4JMY7	Bodo saltans	29%	89%
A0A0S4JXD8	Bodo saltans	26%	100%
A0A140FAN3	Pinus massoniana	30%	86%
A0A1L5BU05	Sphingobium indicum (strain DSM 16412 / CCM 7286 / MTCC 6364 / B90A)	29%	100%
A0A1X0P3I1	Trypanosomatidae	58%	100%
A0A2U8U2K8	Sarocladium schorii	25%	100%
A0A3Q8IHN8	Leishmania donovani	31%	91%
A0A3Q8IIU6	Leishmania donovani	25%	100%
A0A3R7KI53	Trypanosoma rangeli	27%	100%
A0A3S5IS03	Trypanosoma rangeli	55%	100%
A0A3S7XB64	Leishmania donovani	86%	100%
A0A411PQN6	Paecilomyces divaricatus	29%	100%
A0A422NCL5	Trypanosoma rangeli	28%	100%
A0A422NNE9	Trypanosoma rangeli	32%	90%
A1L1W4	Danio rerio	25%	90%
A4HM71	Leishmania braziliensis	30%	100%
A4IAT4	Leishmania infantum	31%	91%
A4IB16	Leishmania infantum	25%	100%
A4ID56	Leishmania infantum	86%	100%
A5DND6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	90%
A5JYX5	Caenorhabditis elegans	26%	99%
A5PJJ7	Bos taurus	27%	97%
A6NNS2	Homo sapiens	26%	98%
A6SG70	Botryotinia fuckeliana (strain B05.10)	30%	92%
A7DY56	Cochlearia officinalis	26%	100%
A7F8T1	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	29%	92%
A7LB59	Arachis hypogaea	25%	87%
A7LB60	Arachis hypogaea	29%	88%
A9UM79	Xenopus tropicalis	26%	98%
D0A8K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
D3U1D9	Klebsiella oxytoca	30%	100%
D3ZGP9	Rattus norvegicus	26%	98%
D4Z260	Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S)	29%	100%
E3VWI6	Streptomyces arenae	26%	100%
E9AEL0	Leishmania major	31%	100%
E9AEU5	Leishmania major	24%	100%
E9ATC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	81%
E9B5S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	91%
E9EHG1	Metarhizium acridum (strain CQMa 102)	31%	100%
E9ET40	Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)	30%	100%
F4JZN6	Arabidopsis thaliana	25%	92%
M2ZIX7	Pseudocercospora fijiensis (strain CIRAD86)	28%	99%
O05730	Helicobacter pylori (strain ATCC 700392 / 26695)	26%	100%
O32291	Bacillus subtilis (strain 168)	28%	86%
O42866	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O86034	Rhizobium meliloti (strain 1021)	24%	100%
P00335	Klebsiella aerogenes	29%	100%
P0DKC5	Arabidopsis thaliana	29%	88%
P0DKC6	Arabidopsis thaliana	29%	88%
P0DKC7	Arabidopsis thaliana	26%	100%
P14061	Homo sapiens	30%	93%
P16232	Rattus norvegicus	30%	100%
P16542	Streptomyces violaceoruber	29%	100%
P16544	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	31%	100%
P28845	Homo sapiens	30%	100%
P31808	Escherichia coli (strain K12)	27%	100%
P38004	Chlamydia trachomatis (strain D/UW-3/Cx)	27%	100%
P39577	Bacillus subtilis (strain 168)	28%	100%
P40580	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P41177	Streptomyces virginiae	29%	100%
P42317	Bacillus subtilis (strain 168)	26%	100%
P50172	Mus musculus	30%	100%
P51656	Mus musculus	27%	89%
P51657	Rattus norvegicus	29%	89%
P51975	Ovis aries	30%	100%
P51976	Oryctolagus cuniculus	31%	75%
P54554	Bacillus subtilis (strain 168)	28%	100%
P55434	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	26%	100%
P80365	Homo sapiens	30%	76%
P9WGP8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WGP9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
P9WGR4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WGR5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
Q01198	Sphingobium sp. (strain NBRC 103272 / SYK-6)	27%	100%
Q05016	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q05528	Dickeya dadantii (strain 3937)	27%	100%
Q05A13	Mus musculus	27%	97%
Q06136	Homo sapiens	31%	92%
Q09851	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q0IH28	Xenopus laevis	33%	95%
Q0VFE7	Xenopus tropicalis	32%	99%
Q1RMJ5	Bos taurus	28%	98%
Q1WNP0	Pan troglodytes	30%	93%
Q29608	Saimiri sciureus	29%	100%
Q2KIJ5	Bos taurus	29%	92%
Q3T0R4	Bos taurus	32%	94%
Q4A054	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	26%	100%
Q4JK73	Macaca fascicularis	27%	100%
Q4Q177	Leishmania major	87%	100%
Q566S6	Danio rerio	29%	99%
Q5BL28	Danio rerio	26%	96%
Q5HLD8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	28%	100%
Q5M875	Rattus norvegicus	25%	100%
Q5R6U1	Pongo abelii	31%	94%
Q5RCF8	Pongo abelii	26%	100%
Q5RJY4	Rattus norvegicus	30%	94%
Q5XGF7	Xenopus tropicalis	28%	90%
Q62730	Rattus norvegicus	27%	80%
Q6AYS8	Rattus norvegicus	27%	100%
Q6CE86	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	82%
Q6CHP1	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	79%
Q6CVS4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	88%
Q6DCT3	Xenopus laevis	26%	90%
Q6GDV6	Staphylococcus aureus (strain MRSA252)	22%	100%
Q6IAN0	Homo sapiens	31%	94%
Q6NRV4	Xenopus laevis	26%	90%
Q6P7J1	Xenopus laevis	28%	100%
Q6PUF3	Danio rerio	31%	100%
Q6PUF4	Gallus gallus	37%	100%
Q6QLL4	Cavia porcellus	28%	100%
Q6R0J2	Mesocricetus auratus	29%	100%
Q7M3I4	Oryctolagus cuniculus	31%	100%
Q7Q732	Anopheles gambiae	28%	97%
Q7RZR2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	85%
Q7SYS6	Xenopus laevis	26%	100%
Q7TQA3	Mus musculus	32%	99%
Q7Z5P4	Homo sapiens	24%	100%
Q8CHS7	Mus musculus	27%	98%
Q8CN40	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	28%	100%
Q8HZJ8	Bos taurus	31%	100%
Q8LKV5	Sesamum indicum	27%	85%
Q8N3Y7	Homo sapiens	31%	99%
Q8NBQ5	Homo sapiens	27%	100%
Q8SPU8	Bos taurus	27%	100%
Q8T197	Dictyostelium discoideum	28%	97%
Q8VCR2	Mus musculus	28%	100%
Q8VID1	Rattus norvegicus	25%	100%
Q8WNV7	Sus scrofa	25%	100%
Q93W57	Sesamum indicum	31%	88%
Q99J47	Mus musculus	31%	95%
Q9BTZ2	Homo sapiens	26%	100%
Q9CXR1	Mus musculus	27%	91%
Q9EQ06	Mus musculus	29%	100%
Q9LBV3	Streptomyces virginiae	25%	100%
Q9LUE4	Arabidopsis thaliana	29%	89%
Q9LUF2	Arabidopsis thaliana	26%	100%
Q9N126	Bos taurus	30%	98%
Q9NYR8	Homo sapiens	29%	98%
Q9PKF7	Chlamydia muridarum (strain MoPn / Nigg)	27%	100%
Q9RPT1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%
Q9STY8	Arabidopsis thaliana	27%	99%
Q9T0G0	Arabidopsis thaliana	27%	79%
Q9Y140	Drosophila melanogaster	27%	94%
Q9Y394	Homo sapiens	24%	90%
Q9ZKW1	Helicobacter pylori (strain J99 / ATCC 700824)	27%	100%
Q9ZW03	Arabidopsis thaliana	28%	100%
Q9ZW04	Arabidopsis thaliana	29%	100%
Q9ZW13	Arabidopsis thaliana	29%	100%
V5BS47	Trypanosoma cruzi	54%	100%