Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPK2_LEIBR

TriTrypDb:

LbrM.35.3580 , LBRM2903_350045300

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPK2

PDB structure(s): 7aih_Aa , 7am2_Aa , 7ane_Aa

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.679
CLV_NRD_NRD_1	160	162	PF00675	0.476
CLV_NRD_NRD_1	177	179	PF00675	0.536
CLV_PCSK_KEX2_1	17	19	PF00082	0.671
CLV_PCSK_KEX2_1	177	179	PF00082	0.512
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.698
CLV_PCSK_SKI1_1	55	59	PF00082	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.602
DOC_CKS1_1	179	184	PF01111	0.615
DOC_CKS1_1	48	53	PF01111	0.459
DOC_MAPK_gen_1	52	62	PF00069	0.658
DOC_WW_Pin1_4	178	183	PF00397	0.541
DOC_WW_Pin1_4	47	52	PF00397	0.528
DOC_WW_Pin1_4	62	67	PF00397	0.515
DOC_WW_Pin1_4	89	94	PF00397	0.456
LIG_14-3-3_CanoR_1	132	136	PF00244	0.381
LIG_14-3-3_CanoR_1	189	193	PF00244	0.673
LIG_14-3-3_CanoR_1	3	11	PF00244	0.664
LIG_BRCT_BRCA1_1	91	95	PF00533	0.455
LIG_CaM_IQ_9	2	18	PF13499	0.702
LIG_FHA_1	3	9	PF00498	0.661
LIG_FHA_1	54	60	PF00498	0.583
LIG_FHA_1	86	92	PF00498	0.470
LIG_FHA_2	131	137	PF00498	0.489
LIG_FHA_2	68	74	PF00498	0.759
LIG_LIR_Nem_3	26	31	PF02991	0.553
LIG_LIR_Nem_3	92	98	PF02991	0.445
LIG_PTB_Apo_2	30	37	PF02174	0.538
LIG_SH2_CRK	28	32	PF00017	0.626
LIG_SH2_GRB2like	138	141	PF00017	0.458
LIG_SH2_SRC	138	141	PF00017	0.458
LIG_SH2_STAT5	138	141	PF00017	0.458
LIG_SH2_STAT5	49	52	PF00017	0.422
LIG_SH3_1	58	64	PF00018	0.618
LIG_SH3_3	104	110	PF00018	0.551
LIG_SH3_3	45	51	PF00018	0.532
LIG_SH3_3	58	64	PF00018	0.560
LIG_TYR_ITSM	24	31	PF00017	0.651
MOD_CDK_SPK_2	47	52	PF00069	0.532
MOD_CDK_SPxK_1	47	53	PF00069	0.531
MOD_CDK_SPxxK_3	89	96	PF00069	0.448
MOD_CK1_1	108	114	PF00069	0.496
MOD_CK1_1	47	53	PF00069	0.512
MOD_CK2_1	131	137	PF00069	0.385
MOD_CK2_1	67	73	PF00069	0.739
MOD_GSK3_1	127	134	PF00069	0.407
MOD_GSK3_1	148	155	PF00069	0.518
MOD_GSK3_1	183	190	PF00069	0.670
MOD_GSK3_1	62	69	PF00069	0.697
MOD_GSK3_1	85	92	PF00069	0.500
MOD_N-GLC_1	130	135	PF02516	0.608
MOD_N-GLC_1	153	158	PF02516	0.567
MOD_NEK2_1	2	7	PF00069	0.673
MOD_NEK2_1	44	49	PF00069	0.536
MOD_NEK2_1	84	89	PF00069	0.550
MOD_NEK2_2	188	193	PF00069	0.673
MOD_PIKK_1	155	161	PF00454	0.563
MOD_PIKK_1	2	8	PF00454	0.669
MOD_PKA_2	131	137	PF00069	0.532
MOD_PKA_2	188	194	PF00069	0.676
MOD_PKA_2	2	8	PF00069	0.664
MOD_Plk_1	130	136	PF00069	0.591
MOD_Plk_1	148	154	PF00069	0.329
MOD_Plk_1	53	59	PF00069	0.576
MOD_Plk_4	188	194	PF00069	0.676
MOD_Plk_4	44	50	PF00069	0.553
MOD_ProDKin_1	178	184	PF00069	0.546
MOD_ProDKin_1	47	53	PF00069	0.524
MOD_ProDKin_1	62	68	PF00069	0.514
MOD_ProDKin_1	89	95	PF00069	0.455
MOD_SUMO_rev_2	125	130	PF00179	0.522
TRG_ENDOCYTIC_2	28	31	PF00928	0.635
TRG_ER_diArg_1	177	179	PF00400	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXS2	Leptomonas seymouri	85%	100%
A0A0S4JKW3	Bodo saltans	49%	84%
A0A1X0P3E4	Trypanosomatidae	67%	100%
A0A3S5H832	Leishmania donovani	93%	100%
A0A422NVM1	Trypanosoma rangeli	70%	100%
A4ID62	Leishmania infantum	93%	100%
D0A8L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9ATB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q183	Leishmania major	92%	100%