Flagellar associated protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPK0_LEIBR

TriTrypDb:

LbrM.35.3560 , LBRM2903_350045100

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005819	spindle	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0072686	mitotic spindle	6	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HPK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPK0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.564
CLV_MEL_PAP_1	185	191	PF00089	0.421
CLV_NRD_NRD_1	120	122	PF00675	0.535
CLV_NRD_NRD_1	364	366	PF00675	0.528
CLV_NRD_NRD_1	64	66	PF00675	0.583
CLV_PCSK_KEX2_1	120	122	PF00082	0.556
CLV_PCSK_KEX2_1	246	248	PF00082	0.582
CLV_PCSK_KEX2_1	364	366	PF00082	0.528
CLV_PCSK_KEX2_1	64	66	PF00082	0.583
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.639
CLV_PCSK_SKI1_1	215	219	PF00082	0.511
DOC_CKS1_1	44	49	PF01111	0.628
DOC_PP4_FxxP_1	189	192	PF00568	0.651
DOC_PP4_FxxP_1	236	239	PF00568	0.636
DOC_USP7_MATH_1	196	200	PF00917	0.532
DOC_USP7_MATH_1	203	207	PF00917	0.534
DOC_USP7_MATH_1	311	315	PF00917	0.711
DOC_USP7_MATH_1	318	322	PF00917	0.698
DOC_USP7_UBL2_3	226	230	PF12436	0.642
DOC_WW_Pin1_4	192	197	PF00397	0.459
DOC_WW_Pin1_4	43	48	PF00397	0.519
LIG_14-3-3_CanoR_1	364	372	PF00244	0.353
LIG_14-3-3_CanoR_1	64	70	PF00244	0.389
LIG_APCC_ABBAyCdc20_2	96	102	PF00400	0.614
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BRCT_BRCA1_1	232	236	PF00533	0.481
LIG_BRCT_BRCA1_1	350	354	PF00533	0.455
LIG_FHA_1	103	109	PF00498	0.554
LIG_FHA_1	112	118	PF00498	0.565
LIG_FHA_1	149	155	PF00498	0.628
LIG_FHA_1	208	214	PF00498	0.621
LIG_FHA_1	30	36	PF00498	0.596
LIG_FHA_1	324	330	PF00498	0.733
LIG_FHA_2	267	273	PF00498	0.721
LIG_FHA_2	29	35	PF00498	0.567
LIG_FHA_2	299	305	PF00498	0.585
LIG_FHA_2	307	313	PF00498	0.517
LIG_FHA_2	326	332	PF00498	0.463
LIG_FHA_2	43	49	PF00498	0.562
LIG_LIR_Apic_2	233	239	PF02991	0.557
LIG_LIR_Gen_1	380	387	PF02991	0.441
LIG_LIR_Nem_3	380	386	PF02991	0.441
LIG_MLH1_MIPbox_1	350	354	PF16413	0.475
LIG_MYND_1	16	20	PF01753	0.666
LIG_SH2_GRB2like	4	7	PF00017	0.626
LIG_SH2_PTP2	344	347	PF00017	0.501
LIG_SH2_SRC	4	7	PF00017	0.689
LIG_SH2_STAP1	100	104	PF00017	0.606
LIG_SH2_STAT5	116	119	PF00017	0.497
LIG_SH2_STAT5	262	265	PF00017	0.696
LIG_SH2_STAT5	344	347	PF00017	0.459
LIG_SH2_STAT5	353	356	PF00017	0.460
LIG_SH3_3	127	133	PF00018	0.577
LIG_SH3_3	160	166	PF00018	0.594
LIG_SH3_3	41	47	PF00018	0.422
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.528
LIG_TRAF2_1	394	397	PF00917	0.540
LIG_WRC_WIRS_1	50	55	PF05994	0.622
MOD_CK1_1	150	156	PF00069	0.531
MOD_CK1_1	199	205	PF00069	0.682
MOD_CK1_1	375	381	PF00069	0.459
MOD_CK1_1	391	397	PF00069	0.589
MOD_CK1_1	85	91	PF00069	0.437
MOD_CK2_1	266	272	PF00069	0.726
MOD_CK2_1	28	34	PF00069	0.571
MOD_CK2_1	391	397	PF00069	0.512
MOD_GlcNHglycan	178	182	PF01048	0.632
MOD_GlcNHglycan	192	195	PF01048	0.653
MOD_GlcNHglycan	201	204	PF01048	0.519
MOD_GlcNHglycan	207	210	PF01048	0.629
MOD_GlcNHglycan	283	286	PF01048	0.730
MOD_GlcNHglycan	290	293	PF01048	0.699
MOD_GlcNHglycan	301	304	PF01048	0.689
MOD_GlcNHglycan	312	316	PF01048	0.718
MOD_GlcNHglycan	320	323	PF01048	0.600
MOD_GlcNHglycan	390	393	PF01048	0.347
MOD_GSK3_1	111	118	PF00069	0.624
MOD_GSK3_1	192	199	PF00069	0.634
MOD_GSK3_1	203	210	PF00069	0.537
MOD_GSK3_1	25	32	PF00069	0.596
MOD_GSK3_1	258	265	PF00069	0.719
MOD_GSK3_1	273	280	PF00069	0.707
MOD_N-GLC_1	196	201	PF02516	0.574
MOD_NEK2_1	228	233	PF00069	0.626
MOD_NEK2_1	253	258	PF00069	0.731
MOD_NEK2_1	273	278	PF00069	0.405
MOD_NEK2_1	325	330	PF00069	0.602
MOD_NEK2_1	35	40	PF00069	0.614
MOD_PIKK_1	111	117	PF00454	0.621
MOD_PIKK_1	148	154	PF00454	0.631
MOD_PIKK_1	207	213	PF00454	0.616
MOD_PIKK_1	4	10	PF00454	0.690
MOD_PK_1	71	77	PF00069	0.410
MOD_PKA_1	364	370	PF00069	0.470
MOD_PKA_2	111	117	PF00069	0.585
MOD_PKA_2	248	254	PF00069	0.670
MOD_PKA_2	364	370	PF00069	0.470
MOD_Plk_1	375	381	PF00069	0.378
MOD_Plk_1	71	77	PF00069	0.442
MOD_Plk_2-3	266	272	PF00069	0.726
MOD_Plk_4	150	156	PF00069	0.584
MOD_Plk_4	258	264	PF00069	0.709
MOD_ProDKin_1	192	198	PF00069	0.458
MOD_ProDKin_1	43	49	PF00069	0.519
MOD_SUMO_rev_2	346	354	PF00179	0.605
MOD_SUMO_rev_2	391	401	PF00179	0.557
TRG_ENDOCYTIC_2	158	161	PF00928	0.663
TRG_ENDOCYTIC_2	344	347	PF00928	0.459
TRG_ER_diArg_1	247	250	PF00400	0.501
TRG_ER_diArg_1	363	365	PF00400	0.512
TRG_NLS_MonoExtN_4	245	250	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N3	Leptomonas seymouri	64%	100%
A0A1X0P414	Trypanosomatidae	41%	97%
A0A3Q8IKI9	Leishmania donovani	86%	100%
A0A422NVL8	Trypanosoma rangeli	41%	98%
A4ID64	Leishmania infantum	86%	100%
D0A8L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	98%
E9ATB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q185	Leishmania major	86%	100%
V5B6X3	Trypanosoma cruzi	39%	96%