Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPJ9_LEIBR

TriTrypDb:

LbrM.35.3550 , LBRM2903_350045000

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HPJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.422
CLV_PCSK_KEX2_1	3	5	PF00082	0.408
CLV_PCSK_SKI1_1	111	115	PF00082	0.661
CLV_PCSK_SKI1_1	26	30	PF00082	0.333
CLV_PCSK_SKI1_1	8	12	PF00082	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DEG_SPOP_SBC_1	88	92	PF00917	0.325
DOC_MAPK_gen_1	52	61	PF00069	0.518
DOC_MAPK_MEF2A_6	54	62	PF00069	0.455
DOC_PP2B_LxvP_1	60	63	PF13499	0.276
DOC_PP4_FxxP_1	139	142	PF00568	0.444
DOC_USP7_MATH_1	113	117	PF00917	0.383
DOC_WW_Pin1_4	144	149	PF00397	0.439
DOC_WW_Pin1_4	15	20	PF00397	0.582
DOC_WW_Pin1_4	2	7	PF00397	0.643
LIG_14-3-3_CanoR_1	111	116	PF00244	0.387
LIG_14-3-3_CanoR_1	31	35	PF00244	0.676
LIG_14-3-3_CanoR_1	54	58	PF00244	0.467
LIG_BRCT_BRCA1_1	115	119	PF00533	0.418
LIG_FHA_1	53	59	PF00498	0.570
LIG_FHA_1	67	73	PF00498	0.270
LIG_FHA_1	88	94	PF00498	0.465
LIG_FHA_2	127	133	PF00498	0.457
LIG_LIR_Apic_2	137	142	PF02991	0.484
LIG_LIR_Apic_2	143	148	PF02991	0.499
LIG_LIR_Gen_1	55	63	PF02991	0.482
LIG_LIR_Gen_1	64	74	PF02991	0.266
LIG_LIR_Nem_3	55	60	PF02991	0.482
LIG_LIR_Nem_3	64	70	PF02991	0.266
LIG_Pex14_2	13	17	PF04695	0.612
LIG_SH2_CRK	145	149	PF00017	0.420
LIG_SH2_GRB2like	34	37	PF00017	0.641
LIG_SH2_STAP1	109	113	PF00017	0.429
LIG_SUMO_SIM_anti_2	55	62	PF11976	0.511
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.184
LIG_SUMO_SIM_par_1	58	64	PF11976	0.282
LIG_SUMO_SIM_par_1	69	75	PF11976	0.267
LIG_UBA3_1	118	123	PF00899	0.420
MOD_CDC14_SPxK_1	5	8	PF00782	0.534
MOD_CDK_SPxK_1	2	8	PF00069	0.549
MOD_CDK_SPxxK_3	15	22	PF00069	0.593
MOD_CK1_1	140	146	PF00069	0.410
MOD_CK2_1	126	132	PF00069	0.444
MOD_CK2_1	47	53	PF00069	0.565
MOD_GlcNHglycan	139	142	PF01048	0.632
MOD_GlcNHglycan	148	151	PF01048	0.607
MOD_GlcNHglycan	99	102	PF01048	0.657
MOD_GSK3_1	140	147	PF00069	0.415
MOD_GSK3_1	40	47	PF00069	0.665
MOD_N-GLC_1	111	116	PF02516	0.590
MOD_NEK2_1	89	94	PF00069	0.434
MOD_PIKK_1	113	119	PF00454	0.459
MOD_PIKK_1	131	137	PF00454	0.335
MOD_PKA_2	21	27	PF00069	0.671
MOD_PKA_2	30	36	PF00069	0.581
MOD_PKA_2	53	59	PF00069	0.554
MOD_Plk_1	111	117	PF00069	0.389
MOD_Plk_1	52	58	PF00069	0.573
MOD_Plk_4	30	36	PF00069	0.698
MOD_Plk_4	53	59	PF00069	0.551
MOD_Plk_4	66	72	PF00069	0.258
MOD_Plk_4	78	84	PF00069	0.404
MOD_ProDKin_1	144	150	PF00069	0.440
MOD_ProDKin_1	15	21	PF00069	0.581
MOD_ProDKin_1	2	8	PF00069	0.644
TRG_DiLeu_BaEn_2	52	58	PF01217	0.544
TRG_ER_diArg_1	2	4	PF00400	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX9	Leptomonas seymouri	59%	100%
A0A0S4IXN1	Bodo saltans	43%	100%
A0A1X0P3B6	Trypanosomatidae	54%	97%
A0A3Q8IL19	Leishmania donovani	80%	100%
A4ID65	Leishmania infantum	80%	100%
D0A8L5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	96%
E9ATB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q186	Leishmania major	81%	100%