Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPJ7_LEIBR

TriTrypDb:

LbrM.35.3530 , LBRM2903_350044800

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HPJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.401
CLV_C14_Caspase3-7	416	420	PF00656	0.414
CLV_C14_Caspase3-7	492	496	PF00656	0.355
CLV_NRD_NRD_1	102	104	PF00675	0.589
CLV_NRD_NRD_1	278	280	PF00675	0.662
CLV_NRD_NRD_1	402	404	PF00675	0.455
CLV_NRD_NRD_1	438	440	PF00675	0.487
CLV_NRD_NRD_1	47	49	PF00675	0.663
CLV_NRD_NRD_1	470	472	PF00675	0.383
CLV_NRD_NRD_1	499	501	PF00675	0.560
CLV_NRD_NRD_1	513	515	PF00675	0.473
CLV_NRD_NRD_1	539	541	PF00675	0.421
CLV_NRD_NRD_1	576	578	PF00675	0.516
CLV_NRD_NRD_1	586	588	PF00675	0.462
CLV_NRD_NRD_1	678	680	PF00675	0.491
CLV_NRD_NRD_1	739	741	PF00675	0.448
CLV_NRD_NRD_1	775	777	PF00675	0.616
CLV_NRD_NRD_1	92	94	PF00675	0.516
CLV_NRD_NRD_1	98	100	PF00675	0.561
CLV_PCSK_FUR_1	537	541	PF00082	0.564
CLV_PCSK_FUR_1	584	588	PF00082	0.547
CLV_PCSK_KEX2_1	102	104	PF00082	0.526
CLV_PCSK_KEX2_1	278	280	PF00082	0.668
CLV_PCSK_KEX2_1	402	404	PF00082	0.439
CLV_PCSK_KEX2_1	438	440	PF00082	0.456
CLV_PCSK_KEX2_1	47	49	PF00082	0.663
CLV_PCSK_KEX2_1	470	472	PF00082	0.381
CLV_PCSK_KEX2_1	512	514	PF00082	0.522
CLV_PCSK_KEX2_1	539	541	PF00082	0.446
CLV_PCSK_KEX2_1	576	578	PF00082	0.516
CLV_PCSK_KEX2_1	586	588	PF00082	0.462
CLV_PCSK_KEX2_1	605	607	PF00082	0.390
CLV_PCSK_KEX2_1	677	679	PF00082	0.389
CLV_PCSK_KEX2_1	739	741	PF00082	0.462
CLV_PCSK_KEX2_1	775	777	PF00082	0.578
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.562
CLV_PCSK_PC1ET2_1	775	777	PF00082	0.578
CLV_PCSK_SKI1_1	266	270	PF00082	0.510
CLV_PCSK_SKI1_1	300	304	PF00082	0.414
CLV_PCSK_SKI1_1	357	361	PF00082	0.296
CLV_PCSK_SKI1_1	410	414	PF00082	0.590
CLV_PCSK_SKI1_1	470	474	PF00082	0.486
CLV_PCSK_SKI1_1	514	518	PF00082	0.507
CLV_PCSK_SKI1_1	545	549	PF00082	0.567
CLV_PCSK_SKI1_1	554	558	PF00082	0.550
DEG_APCC_DBOX_1	356	364	PF00400	0.302
DEG_COP1_1	68	76	PF00400	0.575
DEG_SPOP_SBC_1	54	58	PF00917	0.458
DOC_CKS1_1	117	122	PF01111	0.498
DOC_CKS1_1	176	181	PF01111	0.507
DOC_CKS1_1	274	279	PF01111	0.621
DOC_CYCLIN_RxL_1	297	304	PF00134	0.457
DOC_MAPK_gen_1	512	519	PF00069	0.360
DOC_MAPK_gen_1	726	736	PF00069	0.344
DOC_PP2B_LxvP_1	230	233	PF13499	0.497
DOC_PP2B_LxvP_1	303	306	PF13499	0.460
DOC_USP7_MATH_1	122	126	PF00917	0.638
DOC_USP7_MATH_1	146	150	PF00917	0.768
DOC_USP7_MATH_1	201	205	PF00917	0.679
DOC_USP7_MATH_1	4	8	PF00917	0.551
DOC_USP7_MATH_1	582	586	PF00917	0.365
DOC_USP7_MATH_1	89	93	PF00917	0.470
DOC_USP7_UBL2_3	605	609	PF12436	0.496
DOC_USP7_UBL2_3	746	750	PF12436	0.316
DOC_WW_Pin1_4	116	121	PF00397	0.708
DOC_WW_Pin1_4	124	129	PF00397	0.623
DOC_WW_Pin1_4	142	147	PF00397	0.751
DOC_WW_Pin1_4	154	159	PF00397	0.615
DOC_WW_Pin1_4	175	180	PF00397	0.669
DOC_WW_Pin1_4	273	278	PF00397	0.600
DOC_WW_Pin1_4	345	350	PF00397	0.578
DOC_WW_Pin1_4	352	357	PF00397	0.267
DOC_WW_Pin1_4	365	370	PF00397	0.369
DOC_WW_Pin1_4	384	389	PF00397	0.411
LIG_14-3-3_CanoR_1	150	158	PF00244	0.583
LIG_14-3-3_CanoR_1	223	228	PF00244	0.774
LIG_14-3-3_CanoR_1	334	342	PF00244	0.442
LIG_14-3-3_CanoR_1	357	363	PF00244	0.310
LIG_14-3-3_CanoR_1	568	574	PF00244	0.388
LIG_14-3-3_CanoR_1	810	815	PF00244	0.551
LIG_Actin_WH2_2	310	328	PF00022	0.437
LIG_APCC_ABBAyCdc20_2	786	792	PF00400	0.335
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_CaM_IQ_9	516	531	PF13499	0.353
LIG_EH1_1	766	774	PF00400	0.496
LIG_FHA_1	112	118	PF00498	0.488
LIG_FHA_1	293	299	PF00498	0.534
LIG_FHA_1	458	464	PF00498	0.632
LIG_FHA_1	55	61	PF00498	0.537
LIG_FHA_2	167	173	PF00498	0.688
LIG_FHA_2	176	182	PF00498	0.739
LIG_FHA_2	334	340	PF00498	0.312
LIG_FHA_2	359	365	PF00498	0.330
LIG_FHA_2	381	387	PF00498	0.556
LIG_FHA_2	414	420	PF00498	0.505
LIG_FHA_2	689	695	PF00498	0.475
LIG_FHA_2	711	717	PF00498	0.609
LIG_FHA_2	766	772	PF00498	0.441
LIG_FHA_2	78	84	PF00498	0.511
LIG_LIR_Gen_1	419	429	PF02991	0.379
LIG_LIR_Gen_1	762	770	PF02991	0.341
LIG_LIR_Nem_3	318	322	PF02991	0.389
LIG_LIR_Nem_3	37	42	PF02991	0.476
LIG_LIR_Nem_3	419	424	PF02991	0.387
LIG_LIR_Nem_3	436	440	PF02991	0.367
LIG_LIR_Nem_3	541	547	PF02991	0.502
LIG_LIR_Nem_3	762	766	PF02991	0.330
LIG_MYND_1	228	232	PF01753	0.628
LIG_NRBOX	298	304	PF00104	0.386
LIG_Pex14_2	320	324	PF04695	0.447
LIG_RPA_C_Fungi	581	593	PF08784	0.363
LIG_SH2_CRK	421	425	PF00017	0.456
LIG_SH2_CRK	437	441	PF00017	0.482
LIG_SH2_CRK	544	548	PF00017	0.501
LIG_SH2_CRK	752	756	PF00017	0.474
LIG_SH2_SRC	790	793	PF00017	0.342
LIG_SH2_STAP1	309	313	PF00017	0.467
LIG_SH2_STAP1	790	794	PF00017	0.340
LIG_SH2_STAT5	341	344	PF00017	0.333
LIG_SH2_STAT5	35	38	PF00017	0.622
LIG_SH2_STAT5	405	408	PF00017	0.507
LIG_SH2_STAT5	640	643	PF00017	0.537
LIG_SH3_1	209	215	PF00018	0.686
LIG_SH3_2	274	279	PF14604	0.689
LIG_SH3_3	114	120	PF00018	0.684
LIG_SH3_3	125	131	PF00018	0.519
LIG_SH3_3	17	23	PF00018	0.521
LIG_SH3_3	209	215	PF00018	0.627
LIG_SH3_3	271	277	PF00018	0.573
LIG_SUMO_SIM_anti_2	768	774	PF11976	0.436
LIG_SUMO_SIM_par_1	768	774	PF11976	0.436
LIG_TRAF2_1	170	173	PF00917	0.657
LIG_TRAF2_1	450	453	PF00917	0.486
LIG_TRAF2_1	600	603	PF00917	0.540
LIG_TRAF2_1	705	708	PF00917	0.523
LIG_TRAF2_1	713	716	PF00917	0.548
LIG_UBA3_1	59	63	PF00899	0.456
LIG_WRC_WIRS_1	359	364	PF05994	0.264
MOD_CDK_SPK_2	273	278	PF00069	0.624
MOD_CDK_SPK_2	352	357	PF00069	0.347
MOD_CDK_SPK_2	365	370	PF00069	0.369
MOD_CDK_SPxK_1	273	279	PF00069	0.745
MOD_CDK_SPxxK_3	345	352	PF00069	0.587
MOD_CK1_1	149	155	PF00069	0.637
MOD_CK1_1	244	250	PF00069	0.507
MOD_CK1_1	340	346	PF00069	0.364
MOD_CK1_1	355	361	PF00069	0.363
MOD_CK1_1	380	386	PF00069	0.547
MOD_CK1_1	457	463	PF00069	0.533
MOD_CK2_1	166	172	PF00069	0.651
MOD_CK2_1	175	181	PF00069	0.724
MOD_CK2_1	287	293	PF00069	0.393
MOD_CK2_1	333	339	PF00069	0.320
MOD_CK2_1	34	40	PF00069	0.659
MOD_CK2_1	358	364	PF00069	0.353
MOD_CK2_1	380	386	PF00069	0.490
MOD_CK2_1	688	694	PF00069	0.411
MOD_CK2_1	710	716	PF00069	0.377
MOD_CK2_1	77	83	PF00069	0.532
MOD_Cter_Amidation	100	103	PF01082	0.535
MOD_GlcNHglycan	105	108	PF01048	0.658
MOD_GlcNHglycan	134	137	PF01048	0.586
MOD_GlcNHglycan	146	149	PF01048	0.627
MOD_GlcNHglycan	152	155	PF01048	0.677
MOD_GlcNHglycan	204	207	PF01048	0.699
MOD_GlcNHglycan	249	252	PF01048	0.745
MOD_GlcNHglycan	379	382	PF01048	0.685
MOD_GlcNHglycan	447	450	PF01048	0.637
MOD_GlcNHglycan	495	498	PF01048	0.343
MOD_GSK3_1	103	110	PF00069	0.511
MOD_GSK3_1	112	119	PF00069	0.503
MOD_GSK3_1	142	149	PF00069	0.717
MOD_GSK3_1	150	157	PF00069	0.606
MOD_GSK3_1	182	189	PF00069	0.618
MOD_GSK3_1	242	249	PF00069	0.705
MOD_GSK3_1	269	276	PF00069	0.648
MOD_GSK3_1	287	294	PF00069	0.598
MOD_GSK3_1	333	340	PF00069	0.327
MOD_GSK3_1	373	380	PF00069	0.618
MOD_GSK3_1	413	420	PF00069	0.546
MOD_N-GLC_1	242	247	PF02516	0.511
MOD_N-GLC_1	315	320	PF02516	0.542
MOD_NEK2_1	315	320	PF00069	0.414
MOD_NEK2_1	413	418	PF00069	0.415
MOD_NEK2_1	433	438	PF00069	0.371
MOD_NEK2_1	445	450	PF00069	0.375
MOD_NEK2_1	473	478	PF00069	0.379
MOD_NEK2_1	69	74	PF00069	0.668
MOD_NEK2_2	309	314	PF00069	0.434
MOD_NEK2_2	790	795	PF00069	0.347
MOD_PIKK_1	107	113	PF00454	0.666
MOD_PIKK_1	217	223	PF00454	0.674
MOD_PIKK_1	5	11	PF00454	0.615
MOD_PIKK_1	698	704	PF00454	0.467
MOD_PKA_2	149	155	PF00069	0.581
MOD_PKA_2	333	339	PF00069	0.375
MOD_PKA_2	4	10	PF00069	0.553
MOD_PKA_2	569	575	PF00069	0.529
MOD_PKA_2	616	622	PF00069	0.445
MOD_PKA_2	725	731	PF00069	0.544
MOD_PKA_2	809	815	PF00069	0.547
MOD_PKB_1	3	11	PF00069	0.620
MOD_Plk_1	315	321	PF00069	0.489
MOD_Plk_1	454	460	PF00069	0.405
MOD_Plk_1	54	60	PF00069	0.497
MOD_Plk_1	609	615	PF00069	0.428
MOD_Plk_1	69	75	PF00069	0.557
MOD_Plk_1	790	796	PF00069	0.340
MOD_Plk_4	315	321	PF00069	0.397
MOD_Plk_4	337	343	PF00069	0.381
MOD_Plk_4	358	364	PF00069	0.263
MOD_Plk_4	419	425	PF00069	0.480
MOD_Plk_4	55	61	PF00069	0.479
MOD_Plk_4	72	78	PF00069	0.556
MOD_Plk_4	765	771	PF00069	0.429
MOD_Plk_4	778	784	PF00069	0.478
MOD_ProDKin_1	116	122	PF00069	0.710
MOD_ProDKin_1	124	130	PF00069	0.617
MOD_ProDKin_1	142	148	PF00069	0.751
MOD_ProDKin_1	154	160	PF00069	0.616
MOD_ProDKin_1	175	181	PF00069	0.671
MOD_ProDKin_1	273	279	PF00069	0.598
MOD_ProDKin_1	345	351	PF00069	0.569
MOD_ProDKin_1	352	358	PF00069	0.264
MOD_ProDKin_1	365	371	PF00069	0.373
MOD_ProDKin_1	384	390	PF00069	0.409
MOD_SUMO_for_1	705	708	PF00179	0.481
MOD_SUMO_rev_2	743	751	PF00179	0.400
TRG_DiLeu_BaEn_1	627	632	PF01217	0.524
TRG_DiLeu_BaEn_4	172	178	PF01217	0.652
TRG_DiLeu_BaEn_4	453	459	PF01217	0.539
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.293
TRG_ENDOCYTIC_2	14	17	PF00928	0.718
TRG_ENDOCYTIC_2	421	424	PF00928	0.382
TRG_ENDOCYTIC_2	437	440	PF00928	0.562
TRG_ENDOCYTIC_2	544	547	PF00928	0.504
TRG_ENDOCYTIC_2	752	755	PF00928	0.481
TRG_ER_diArg_1	222	225	PF00400	0.764
TRG_ER_diArg_1	277	279	PF00400	0.713
TRG_ER_diArg_1	437	439	PF00400	0.470
TRG_ER_diArg_1	46	48	PF00400	0.615
TRG_ER_diArg_1	470	472	PF00400	0.391
TRG_ER_diArg_1	477	480	PF00400	0.381
TRG_ER_diArg_1	512	514	PF00400	0.525
TRG_ER_diArg_1	522	525	PF00400	0.499
TRG_ER_diArg_1	537	540	PF00400	0.359
TRG_ER_diArg_1	584	587	PF00400	0.534
TRG_ER_diArg_1	677	679	PF00400	0.402
TRG_ER_diArg_1	738	740	PF00400	0.459
TRG_ER_diArg_1	783	786	PF00400	0.475
TRG_ER_diArg_1	794	797	PF00400	0.376
TRG_NLS_MonoExtC_3	98	103	PF00514	0.573
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	663	668	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	786	791	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCJ0	Leptomonas seymouri	47%	100%
A0A1X0P4M8	Trypanosomatidae	34%	98%
A0A3Q8IW63	Leishmania donovani	73%	100%
A0A3R7KTP5	Trypanosoma rangeli	31%	100%
D0A8L7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
E9AHX5	Leishmania infantum	73%	100%
E9ATA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q188	Leishmania major	71%	100%
V5BS35	Trypanosoma cruzi	30%	100%