Macro domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPJ6_LEIBR

TriTrypDb:

LbrM.35.3520 , LBRM2903_350044600

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.325
CLV_NRD_NRD_1	13	15	PF00675	0.402
CLV_NRD_NRD_1	26	28	PF00675	0.480
CLV_NRD_NRD_1	51	53	PF00675	0.593
CLV_NRD_NRD_1	63	65	PF00675	0.491
CLV_PCSK_KEX2_1	15	17	PF00082	0.404
CLV_PCSK_KEX2_1	51	53	PF00082	0.664
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.434
CLV_PCSK_PC7_1	11	17	PF00082	0.431
CLV_PCSK_SKI1_1	188	192	PF00082	0.481
CLV_PCSK_SKI1_1	19	23	PF00082	0.435
CLV_PCSK_SKI1_1	64	68	PF00082	0.620
DOC_CYCLIN_RxL_1	14	24	PF00134	0.697
DOC_MAPK_gen_1	27	35	PF00069	0.531
DOC_MAPK_MEF2A_6	245	254	PF00069	0.270
DOC_MAPK_MEF2A_6	27	35	PF00069	0.439
DOC_PP2B_PxIxI_1	30	36	PF00149	0.289
DOC_USP7_MATH_1	151	155	PF00917	0.357
DOC_WW_Pin1_4	54	59	PF00397	0.319
LIG_14-3-3_CanoR_1	51	56	PF00244	0.429
LIG_Clathr_ClatBox_1	229	233	PF01394	0.361
LIG_deltaCOP1_diTrp_1	259	267	PF00928	0.281
LIG_FHA_1	92	98	PF00498	0.371
LIG_FHA_2	106	112	PF00498	0.284
LIG_LIR_Apic_2	24	29	PF02991	0.621
LIG_LIR_Apic_2	54	58	PF02991	0.365
LIG_LIR_Gen_1	259	267	PF02991	0.286
LIG_LIR_Nem_3	184	190	PF02991	0.332
LIG_LIR_Nem_3	259	263	PF02991	0.277
LIG_Pex14_2	263	267	PF04695	0.375
LIG_PTB_Apo_2	261	268	PF02174	0.385
LIG_SH2_CRK	187	191	PF00017	0.291
LIG_SH2_CRK	217	221	PF00017	0.284
LIG_SH2_CRK	26	30	PF00017	0.660
LIG_SH2_PTP2	55	58	PF00017	0.332
LIG_SH2_SRC	4	7	PF00017	0.708
LIG_SH2_STAT5	242	245	PF00017	0.268
LIG_SH2_STAT5	4	7	PF00017	0.708
LIG_SH2_STAT5	55	58	PF00017	0.359
LIG_SH3_3	161	167	PF00018	0.309
MOD_CDK_SPK_2	54	59	PF00069	0.315
MOD_CK1_1	54	60	PF00069	0.350
MOD_CK2_1	172	178	PF00069	0.322
MOD_Cter_Amidation	12	15	PF01082	0.398
MOD_GlcNHglycan	116	119	PF01048	0.473
MOD_GlcNHglycan	164	167	PF01048	0.581
MOD_GlcNHglycan	207	210	PF01048	0.455
MOD_GlcNHglycan	225	228	PF01048	0.481
MOD_GSK3_1	194	201	PF00069	0.342
MOD_GSK3_1	269	276	PF00069	0.343
MOD_GSK3_1	76	83	PF00069	0.411
MOD_GSK3_1	91	98	PF00069	0.382
MOD_NEK2_1	136	141	PF00069	0.424
MOD_NEK2_1	21	26	PF00069	0.639
MOD_NEK2_1	80	85	PF00069	0.419
MOD_PIKK_1	73	79	PF00454	0.335
MOD_PKA_1	51	57	PF00069	0.373
MOD_PKA_2	51	57	PF00069	0.373
MOD_Plk_1	91	97	PF00069	0.322
MOD_Plk_4	51	57	PF00069	0.385
MOD_Plk_4	92	98	PF00069	0.345
MOD_ProDKin_1	54	60	PF00069	0.317
TRG_DiLeu_BaEn_2	250	256	PF01217	0.259
TRG_ENDOCYTIC_2	121	124	PF00928	0.320
TRG_ENDOCYTIC_2	187	190	PF00928	0.303
TRG_ENDOCYTIC_2	217	220	PF00928	0.290
TRG_ENDOCYTIC_2	50	53	PF00928	0.406
TRG_ENDOCYTIC_2	71	74	PF00928	0.276
TRG_ER_diArg_1	50	52	PF00400	0.389
TRG_NLS_Bipartite_1	51	68	PF00514	0.347
TRG_NLS_MonoExtC_3	13	18	PF00514	0.631
TRG_NLS_MonoExtN_4	11	18	PF00514	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7L9	Leptomonas seymouri	81%	100%
A0A1X0P3L3	Trypanosomatidae	61%	100%
A0A3Q8IP45	Leishmania donovani	91%	100%
A0A3R7NPI9	Trypanosoma rangeli	58%	100%
A4ID67	Leishmania infantum	91%	100%
D0A8L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ATA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q189	Leishmania major	91%	100%
V5B6W8	Trypanosoma cruzi	60%	100%