Intu_longin_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPJ2_LEIBR

TriTrypDb:

LbrM.35.3480 , LBRM2903_350044200

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HPJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPJ2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0016192	vesicle-mediated transport	4	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.648
CLV_MEL_PAP_1	61	67	PF00089	0.296
CLV_NRD_NRD_1	75	77	PF00675	0.390
CLV_PCSK_SKI1_1	168	172	PF00082	0.451
CLV_PCSK_SKI1_1	177	181	PF00082	0.374
CLV_PCSK_SKI1_1	247	251	PF00082	0.602
CLV_PCSK_SKI1_1	372	376	PF00082	0.612
CLV_PCSK_SKI1_1	510	514	PF00082	0.502
CLV_Separin_Metazoa	244	248	PF03568	0.587
DEG_SPOP_SBC_1	2	6	PF00917	0.606
DOC_ANK_TNKS_1	435	442	PF00023	0.597
DOC_CDC14_PxL_1	278	286	PF14671	0.435
DOC_CYCLIN_RxL_1	369	378	PF00134	0.525
DOC_MAPK_FxFP_2	37	40	PF00069	0.421
DOC_MAPK_gen_1	27	37	PF00069	0.239
DOC_MAPK_gen_1	76	84	PF00069	0.329
DOC_MAPK_MEF2A_6	471	479	PF00069	0.418
DOC_PP1_RVXF_1	245	252	PF00149	0.500
DOC_PP2B_LxvP_1	130	133	PF13499	0.565
DOC_PP2B_LxvP_1	307	310	PF13499	0.474
DOC_PP2B_LxvP_1	455	458	PF13499	0.620
DOC_PP2B_LxvP_1	513	516	PF13499	0.734
DOC_PP4_FxxP_1	222	225	PF00568	0.648
DOC_PP4_FxxP_1	279	282	PF00568	0.526
DOC_PP4_FxxP_1	37	40	PF00568	0.421
DOC_SPAK_OSR1_1	64	68	PF12202	0.296
DOC_USP7_MATH_1	160	164	PF00917	0.631
DOC_USP7_MATH_1	170	174	PF00917	0.404
DOC_USP7_MATH_1	205	209	PF00917	0.551
DOC_USP7_MATH_1	218	222	PF00917	0.539
DOC_USP7_MATH_1	355	359	PF00917	0.446
DOC_USP7_MATH_1	414	418	PF00917	0.668
DOC_USP7_MATH_1	57	61	PF00917	0.324
DOC_USP7_UBL2_3	406	410	PF12436	0.671
DOC_WW_Pin1_4	140	145	PF00397	0.587
DOC_WW_Pin1_4	262	267	PF00397	0.528
DOC_WW_Pin1_4	3	8	PF00397	0.489
DOC_WW_Pin1_4	430	435	PF00397	0.625
DOC_WW_Pin1_4	83	88	PF00397	0.324
LIG_14-3-3_CanoR_1	177	182	PF00244	0.492
LIG_14-3-3_CanoR_1	354	361	PF00244	0.584
LIG_14-3-3_CanoR_1	471	476	PF00244	0.549
LIG_14-3-3_CanoR_1	480	489	PF00244	0.563
LIG_14-3-3_CanoR_1	76	85	PF00244	0.364
LIG_Actin_WH2_2	422	438	PF00022	0.438
LIG_deltaCOP1_diTrp_1	467	476	PF00928	0.519
LIG_EH1_1	505	513	PF00400	0.502
LIG_eIF4E_1	506	512	PF01652	0.602
LIG_FHA_1	105	111	PF00498	0.334
LIG_FHA_1	124	130	PF00498	0.321
LIG_FHA_1	393	399	PF00498	0.559
LIG_FHA_1	461	467	PF00498	0.574
LIG_FHA_1	483	489	PF00498	0.525
LIG_FHA_2	3	9	PF00498	0.664
LIG_FHA_2	381	387	PF00498	0.527
LIG_GBD_Chelix_1	297	305	PF00786	0.553
LIG_LIR_Apic_2	219	225	PF02991	0.707
LIG_LIR_Gen_1	470	479	PF02991	0.512
LIG_LIR_Nem_3	211	215	PF02991	0.400
LIG_LIR_Nem_3	314	319	PF02991	0.423
LIG_LIR_Nem_3	470	475	PF02991	0.522
LIG_NRBOX	116	122	PF00104	0.324
LIG_REV1ctd_RIR_1	172	181	PF16727	0.404
LIG_SH2_CRK	19	23	PF00017	0.421
LIG_SH2_NCK_1	257	261	PF00017	0.488
LIG_SH2_PTP2	319	322	PF00017	0.418
LIG_SH2_STAT3	506	509	PF00017	0.590
LIG_SH2_STAT5	19	22	PF00017	0.421
LIG_SH2_STAT5	215	218	PF00017	0.428
LIG_SH2_STAT5	276	279	PF00017	0.435
LIG_SH2_STAT5	304	307	PF00017	0.446
LIG_SH2_STAT5	319	322	PF00017	0.503
LIG_SH2_STAT5	38	41	PF00017	0.475
LIG_SH2_STAT5	445	448	PF00017	0.646
LIG_SH2_STAT5	478	481	PF00017	0.495
LIG_SH3_3	15	21	PF00018	0.230
LIG_SH3_3	6	12	PF00018	0.594
LIG_SUMO_SIM_anti_2	484	490	PF11976	0.463
LIG_SUMO_SIM_par_1	128	134	PF11976	0.389
LIG_SUMO_SIM_par_1	336	343	PF11976	0.439
LIG_TYR_ITIM	301	306	PF00017	0.546
LIG_WRC_WIRS_1	171	176	PF05994	0.404
MOD_CDK_SPxK_1	430	436	PF00069	0.622
MOD_CK1_1	123	129	PF00069	0.615
MOD_CK1_1	147	153	PF00069	0.640
MOD_CK1_1	173	179	PF00069	0.371
MOD_CK1_1	184	190	PF00069	0.465
MOD_CK1_1	267	273	PF00069	0.521
MOD_CK1_1	394	400	PF00069	0.533
MOD_CK1_1	460	466	PF00069	0.543
MOD_CK1_1	484	490	PF00069	0.471
MOD_CK1_1	497	503	PF00069	0.393
MOD_CK2_1	227	233	PF00069	0.630
MOD_CK2_1	380	386	PF00069	0.531
MOD_CK2_1	461	467	PF00069	0.621
MOD_CK2_1	83	89	PF00069	0.421
MOD_CMANNOS	469	472	PF00535	0.540
MOD_GlcNHglycan	122	125	PF01048	0.572
MOD_GlcNHglycan	146	149	PF01048	0.586
MOD_GlcNHglycan	186	189	PF01048	0.423
MOD_GlcNHglycan	202	205	PF01048	0.683
MOD_GlcNHglycan	207	210	PF01048	0.585
MOD_GlcNHglycan	216	219	PF01048	0.410
MOD_GlcNHglycan	345	350	PF01048	0.473
MOD_GlcNHglycan	357	360	PF01048	0.499
MOD_GlcNHglycan	377	380	PF01048	0.552
MOD_GlcNHglycan	416	419	PF01048	0.676
MOD_GlcNHglycan	93	96	PF01048	0.324
MOD_GSK3_1	131	138	PF00069	0.586
MOD_GSK3_1	140	147	PF00069	0.621
MOD_GSK3_1	173	180	PF00069	0.463
MOD_GSK3_1	194	201	PF00069	0.532
MOD_GSK3_1	214	221	PF00069	0.579
MOD_GSK3_1	392	399	PF00069	0.544
MOD_GSK3_1	40	47	PF00069	0.239
MOD_GSK3_1	405	412	PF00069	0.473
MOD_GSK3_1	456	463	PF00069	0.610
MOD_GSK3_1	467	474	PF00069	0.536
MOD_GSK3_1	67	74	PF00069	0.342
MOD_N-GLC_1	482	487	PF02516	0.457
MOD_NEK2_1	1	6	PF00069	0.696
MOD_NEK2_1	111	116	PF00069	0.183
MOD_NEK2_1	146	151	PF00069	0.574
MOD_NEK2_1	181	186	PF00069	0.520
MOD_NEK2_1	375	380	PF00069	0.471
MOD_NEK2_1	481	486	PF00069	0.445
MOD_NEK2_1	91	96	PF00069	0.338
MOD_NEK2_2	170	175	PF00069	0.502
MOD_NEK2_2	405	410	PF00069	0.607
MOD_PIKK_1	288	294	PF00454	0.429
MOD_PIKK_1	44	50	PF00454	0.239
MOD_PKA_2	78	84	PF00069	0.371
MOD_Plk_1	218	224	PF00069	0.493
MOD_Plk_1	232	238	PF00069	0.502
MOD_Plk_1	482	488	PF00069	0.489
MOD_Plk_4	177	183	PF00069	0.490
MOD_Plk_4	264	270	PF00069	0.496
MOD_Plk_4	362	368	PF00069	0.508
MOD_Plk_4	445	451	PF00069	0.446
MOD_Plk_4	461	467	PF00069	0.649
MOD_Plk_4	471	477	PF00069	0.536
MOD_Plk_4	484	490	PF00069	0.600
MOD_ProDKin_1	140	146	PF00069	0.589
MOD_ProDKin_1	262	268	PF00069	0.527
MOD_ProDKin_1	3	9	PF00069	0.482
MOD_ProDKin_1	430	436	PF00069	0.627
MOD_ProDKin_1	83	89	PF00069	0.324
TRG_DiLeu_BaEn_1	507	512	PF01217	0.595
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.290
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.526
TRG_DiLeu_LyEn_5	507	512	PF01217	0.525
TRG_ENDOCYTIC_2	19	22	PF00928	0.471
TRG_ENDOCYTIC_2	276	279	PF00928	0.519
TRG_ENDOCYTIC_2	303	306	PF00928	0.443
TRG_ENDOCYTIC_2	404	407	PF00928	0.665
TRG_ENDOCYTIC_2	478	481	PF00928	0.514
TRG_Pf-PMV_PEXEL_1	502	507	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW11	Leptomonas seymouri	45%	100%
A0A3Q8IR86	Leishmania donovani	77%	100%
A4ID71	Leishmania infantum	77%	100%
E9ATA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q193	Leishmania major	76%	100%