Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HPJ1_LEIBR

TriTrypDb:

LbrM.35.3470 , LBRM2903_350044100

Length:

884

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HPJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	31	33	PF00675	0.661
CLV_NRD_NRD_1	593	595	PF00675	0.604
CLV_NRD_NRD_1	662	664	PF00675	0.547
CLV_NRD_NRD_1	752	754	PF00675	0.579
CLV_PCSK_FUR_1	29	33	PF00082	0.675
CLV_PCSK_KEX2_1	29	31	PF00082	0.691
CLV_PCSK_KEX2_1	593	595	PF00082	0.604
CLV_PCSK_KEX2_1	752	754	PF00082	0.579
CLV_PCSK_SKI1_1	288	292	PF00082	0.469
DEG_Nend_UBRbox_2	1	3	PF02207	0.510
DEG_SCF_FBW7_1	835	841	PF00400	0.463
DEG_SCF_FBW7_2	323	330	PF00400	0.350
DEG_SCF_FBW7_2	775	781	PF00400	0.390
DOC_ANK_TNKS_1	148	155	PF00023	0.362
DOC_CKS1_1	478	483	PF01111	0.273
DOC_CKS1_1	775	780	PF01111	0.389
DOC_CKS1_1	835	840	PF01111	0.461
DOC_CYCLIN_yCln2_LP_2	478	484	PF00134	0.277
DOC_MAPK_DCC_7	288	298	PF00069	0.345
DOC_MAPK_gen_1	77	86	PF00069	0.350
DOC_MAPK_JIP1_4	80	86	PF00069	0.349
DOC_MAPK_MEF2A_6	322	331	PF00069	0.329
DOC_MAPK_MEF2A_6	77	86	PF00069	0.350
DOC_PP2B_LxvP_1	364	367	PF13499	0.382
DOC_USP7_MATH_1	125	129	PF00917	0.391
DOC_USP7_MATH_1	239	243	PF00917	0.376
DOC_USP7_MATH_1	439	443	PF00917	0.395
DOC_USP7_MATH_1	508	512	PF00917	0.451
DOC_USP7_MATH_1	553	557	PF00917	0.507
DOC_USP7_MATH_1	570	574	PF00917	0.430
DOC_WW_Pin1_4	323	328	PF00397	0.406
DOC_WW_Pin1_4	4	9	PF00397	0.437
DOC_WW_Pin1_4	411	416	PF00397	0.381
DOC_WW_Pin1_4	477	482	PF00397	0.268
DOC_WW_Pin1_4	546	551	PF00397	0.454
DOC_WW_Pin1_4	774	779	PF00397	0.381
DOC_WW_Pin1_4	834	839	PF00397	0.458
LIG_14-3-3_CanoR_1	149	153	PF00244	0.313
LIG_14-3-3_CanoR_1	226	232	PF00244	0.386
LIG_14-3-3_CanoR_1	274	282	PF00244	0.336
LIG_14-3-3_CanoR_1	288	293	PF00244	0.315
LIG_14-3-3_CanoR_1	322	329	PF00244	0.336
LIG_14-3-3_CanoR_1	337	347	PF00244	0.273
LIG_14-3-3_CanoR_1	663	673	PF00244	0.354
LIG_14-3-3_CanoR_1	721	725	PF00244	0.278
LIG_14-3-3_CanoR_1	799	804	PF00244	0.410
LIG_APCC_ABBA_1	849	854	PF00400	0.368
LIG_APCC_ABBAyCdc20_2	41	47	PF00400	0.447
LIG_BRCT_BRCA1_1	192	196	PF00533	0.416
LIG_BRCT_BRCA1_1	213	217	PF00533	0.400
LIG_Clathr_ClatBox_1	331	335	PF01394	0.362
LIG_eIF4E_1	861	867	PF01652	0.355
LIG_FHA_1	128	134	PF00498	0.353
LIG_FHA_1	175	181	PF00498	0.366
LIG_FHA_1	18	24	PF00498	0.431
LIG_FHA_1	276	282	PF00498	0.418
LIG_FHA_1	289	295	PF00498	0.253
LIG_FHA_1	324	330	PF00498	0.470
LIG_FHA_1	383	389	PF00498	0.396
LIG_FHA_1	478	484	PF00498	0.331
LIG_FHA_1	582	588	PF00498	0.514
LIG_FHA_1	60	66	PF00498	0.360
LIG_FHA_1	660	666	PF00498	0.351
LIG_FHA_1	699	705	PF00498	0.306
LIG_FHA_1	733	739	PF00498	0.352
LIG_FHA_1	742	748	PF00498	0.371
LIG_FHA_1	835	841	PF00498	0.463
LIG_FHA_1	842	848	PF00498	0.421
LIG_FHA_1	85	91	PF00498	0.415
LIG_FHA_1	853	859	PF00498	0.325
LIG_FHA_2	157	163	PF00498	0.324
LIG_FHA_2	578	584	PF00498	0.505
LIG_FHA_2	643	649	PF00498	0.311
LIG_FHA_2	721	727	PF00498	0.317
LIG_LIR_Apic_2	289	295	PF02991	0.434
LIG_LIR_Apic_2	706	710	PF02991	0.349
LIG_LIR_Gen_1	142	153	PF02991	0.380
LIG_LIR_Gen_1	163	172	PF02991	0.388
LIG_LIR_Gen_1	406	416	PF02991	0.373
LIG_LIR_Gen_1	779	790	PF02991	0.337
LIG_LIR_LC3C_4	330	333	PF02991	0.313
LIG_LIR_Nem_3	162	168	PF02991	0.398
LIG_LIR_Nem_3	182	186	PF02991	0.230
LIG_LIR_Nem_3	198	204	PF02991	0.282
LIG_LIR_Nem_3	358	364	PF02991	0.386
LIG_LIR_Nem_3	406	411	PF02991	0.360
LIG_LIR_Nem_3	462	467	PF02991	0.389
LIG_LIR_Nem_3	477	482	PF02991	0.272
LIG_LIR_Nem_3	62	67	PF02991	0.408
LIG_LIR_Nem_3	706	712	PF02991	0.281
LIG_LIR_Nem_3	779	785	PF02991	0.341
LIG_LIR_Nem_3	816	822	PF02991	0.362
LIG_LYPXL_S_1	36	40	PF13949	0.653
LIG_LYPXL_S_1	708	712	PF13949	0.485
LIG_LYPXL_yS_3	37	40	PF13949	0.455
LIG_LYPXL_yS_3	709	712	PF13949	0.290
LIG_MYND_1	114	118	PF01753	0.451
LIG_PCNA_PIPBox_1	509	518	PF02747	0.438
LIG_PCNA_yPIPBox_3	504	516	PF02747	0.443
LIG_Pex14_1	357	361	PF04695	0.455
LIG_Pex14_1	688	692	PF04695	0.369
LIG_Pex14_2	172	176	PF04695	0.389
LIG_PTAP_UEV_1	549	554	PF05743	0.451
LIG_PTB_Apo_2	39	46	PF02174	0.450
LIG_PTB_Apo_2	66	73	PF02174	0.356
LIG_PTB_Phospho_1	39	45	PF10480	0.456
LIG_REV1ctd_RIR_1	92	100	PF16727	0.429
LIG_SH2_CRK	186	190	PF00017	0.378
LIG_SH2_CRK	361	365	PF00017	0.290
LIG_SH2_CRK	399	403	PF00017	0.359
LIG_SH2_CRK	772	776	PF00017	0.379
LIG_SH2_GRB2like	393	396	PF00017	0.368
LIG_SH2_GRB2like	67	70	PF00017	0.356
LIG_SH2_NCK_1	790	794	PF00017	0.391
LIG_SH2_PTP2	707	710	PF00017	0.350
LIG_SH2_SRC	245	248	PF00017	0.308
LIG_SH2_SRC	393	396	PF00017	0.368
LIG_SH2_SRC	67	70	PF00017	0.356
LIG_SH2_SRC	677	680	PF00017	0.361
LIG_SH2_SRC	707	710	PF00017	0.350
LIG_SH2_STAP1	303	307	PF00017	0.349
LIG_SH2_STAP1	97	101	PF00017	0.429
LIG_SH2_STAT3	97	100	PF00017	0.430
LIG_SH2_STAT5	183	186	PF00017	0.336
LIG_SH2_STAT5	218	221	PF00017	0.368
LIG_SH2_STAT5	245	248	PF00017	0.382
LIG_SH2_STAT5	292	295	PF00017	0.390
LIG_SH2_STAT5	479	482	PF00017	0.445
LIG_SH2_STAT5	637	640	PF00017	0.333
LIG_SH2_STAT5	67	70	PF00017	0.430
LIG_SH2_STAT5	677	680	PF00017	0.365
LIG_SH2_STAT5	692	695	PF00017	0.300
LIG_SH2_STAT5	707	710	PF00017	0.267
LIG_SH2_STAT5	718	721	PF00017	0.308
LIG_SH2_STAT5	74	77	PF00017	0.391
LIG_SH2_STAT5	748	751	PF00017	0.299
LIG_SH2_STAT5	772	775	PF00017	0.320
LIG_SH2_STAT5	834	837	PF00017	0.455
LIG_SH2_STAT5	861	864	PF00017	0.355
LIG_SH3_3	547	553	PF00018	0.452
LIG_SH3_3	582	588	PF00018	0.496
LIG_SH3_3	73	79	PF00018	0.370
LIG_SUMO_SIM_anti_2	330	335	PF11976	0.365
LIG_SUMO_SIM_anti_2	51	57	PF11976	0.454
LIG_SUMO_SIM_anti_2	864	869	PF11976	0.251
LIG_SUMO_SIM_anti_2	87	94	PF11976	0.419
LIG_SUMO_SIM_par_1	252	259	PF11976	0.371
LIG_SUMO_SIM_par_1	330	335	PF11976	0.365
LIG_SUMO_SIM_par_1	413	419	PF11976	0.394
LIG_SUMO_SIM_par_1	51	57	PF11976	0.454
LIG_TRAF2_1	46	49	PF00917	0.439
LIG_TRAF2_1	580	583	PF00917	0.466
LIG_TRAF2_1	851	854	PF00917	0.370
LIG_TYR_ITIM	397	402	PF00017	0.377
LIG_TYR_ITIM	810	815	PF00017	0.358
LIG_UBA3_1	90	96	PF00899	0.425
LIG_WRC_WIRS_1	126	131	PF05994	0.399
LIG_WRC_WIRS_1	169	174	PF05994	0.306
LIG_WRC_WIRS_1	348	353	PF05994	0.395
LIG_WRC_WIRS_1	461	466	PF05994	0.328
LIG_WRC_WIRS_1	643	648	PF05994	0.306
MOD_CDK_SPxxK_3	4	11	PF00069	0.438
MOD_CK1_1	160	166	PF00069	0.323
MOD_CK1_1	167	173	PF00069	0.297
MOD_CK1_1	174	180	PF00069	0.296
MOD_CK1_1	255	261	PF00069	0.375
MOD_CK1_1	280	286	PF00069	0.339
MOD_CK1_1	406	412	PF00069	0.360
MOD_CK1_1	477	483	PF00069	0.346
MOD_CK1_1	491	497	PF00069	0.442
MOD_CK1_1	499	505	PF00069	0.429
MOD_CK1_1	511	517	PF00069	0.447
MOD_CK1_1	537	543	PF00069	0.451
MOD_CK1_1	544	550	PF00069	0.466
MOD_CK1_1	573	579	PF00069	0.465
MOD_CK1_1	608	614	PF00069	0.486
MOD_CK1_1	628	634	PF00069	0.357
MOD_CK1_1	650	656	PF00069	0.411
MOD_CK1_1	742	748	PF00069	0.314
MOD_CK2_1	125	131	PF00069	0.396
MOD_CK2_1	336	342	PF00069	0.345
MOD_CK2_1	347	353	PF00069	0.345
MOD_CK2_1	4	10	PF00069	0.433
MOD_CK2_1	416	422	PF00069	0.387
MOD_CK2_1	43	49	PF00069	0.446
MOD_CK2_1	529	535	PF00069	0.439
MOD_CK2_1	577	583	PF00069	0.479
MOD_CK2_1	642	648	PF00069	0.321
MOD_Cter_Amidation	591	594	PF01082	0.603
MOD_GlcNHglycan	123	126	PF01048	0.600
MOD_GlcNHglycan	159	162	PF01048	0.583
MOD_GlcNHglycan	197	200	PF01048	0.531
MOD_GlcNHglycan	241	244	PF01048	0.593
MOD_GlcNHglycan	268	271	PF01048	0.570
MOD_GlcNHglycan	338	341	PF01048	0.629
MOD_GlcNHglycan	427	430	PF01048	0.518
MOD_GlcNHglycan	441	444	PF01048	0.569
MOD_GlcNHglycan	517	520	PF01048	0.624
MOD_GlcNHglycan	539	542	PF01048	0.682
MOD_GlcNHglycan	550	553	PF01048	0.698
MOD_GlcNHglycan	560	563	PF01048	0.660
MOD_GlcNHglycan	575	579	PF01048	0.647
MOD_GlcNHglycan	605	608	PF01048	0.688
MOD_GlcNHglycan	610	613	PF01048	0.676
MOD_GlcNHglycan	654	657	PF01048	0.676
MOD_GlcNHglycan	741	744	PF01048	0.535
MOD_GlcNHglycan	786	789	PF01048	0.570
MOD_GSK3_1	121	128	PF00069	0.403
MOD_GSK3_1	13	20	PF00069	0.429
MOD_GSK3_1	156	163	PF00069	0.396
MOD_GSK3_1	164	171	PF00069	0.343
MOD_GSK3_1	190	197	PF00069	0.431
MOD_GSK3_1	205	212	PF00069	0.325
MOD_GSK3_1	252	259	PF00069	0.363
MOD_GSK3_1	262	269	PF00069	0.357
MOD_GSK3_1	273	280	PF00069	0.331
MOD_GSK3_1	317	324	PF00069	0.322
MOD_GSK3_1	347	354	PF00069	0.498
MOD_GSK3_1	406	413	PF00069	0.427
MOD_GSK3_1	488	495	PF00069	0.434
MOD_GSK3_1	499	506	PF00069	0.455
MOD_GSK3_1	511	518	PF00069	0.413
MOD_GSK3_1	535	542	PF00069	0.471
MOD_GSK3_1	544	551	PF00069	0.480
MOD_GSK3_1	553	560	PF00069	0.473
MOD_GSK3_1	570	577	PF00069	0.440
MOD_GSK3_1	623	630	PF00069	0.361
MOD_GSK3_1	631	638	PF00069	0.355
MOD_GSK3_1	659	666	PF00069	0.407
MOD_GSK3_1	694	701	PF00069	0.350
MOD_GSK3_1	708	715	PF00069	0.296
MOD_GSK3_1	720	727	PF00069	0.278
MOD_GSK3_1	754	761	PF00069	0.365
MOD_GSK3_1	770	777	PF00069	0.287
MOD_GSK3_1	784	791	PF00069	0.335
MOD_GSK3_1	793	800	PF00069	0.352
MOD_GSK3_1	834	841	PF00069	0.460
MOD_N-GLC_1	157	162	PF02516	0.525
MOD_N-GLC_1	210	215	PF02516	0.631
MOD_N-GLC_1	23	28	PF02516	0.653
MOD_N-GLC_1	232	237	PF02516	0.636
MOD_N-GLC_1	351	356	PF02516	0.668
MOD_N-GLC_1	388	393	PF02516	0.603
MOD_N-GLC_1	499	504	PF02516	0.658
MOD_N-GLC_1	529	534	PF02516	0.637
MOD_N-GLC_1	699	704	PF02516	0.586
MOD_NEK2_1	148	153	PF00069	0.332
MOD_NEK2_1	168	173	PF00069	0.311
MOD_NEK2_1	266	271	PF00069	0.387
MOD_NEK2_1	277	282	PF00069	0.335
MOD_NEK2_1	317	322	PF00069	0.357
MOD_NEK2_1	351	356	PF00069	0.420
MOD_NEK2_1	40	45	PF00069	0.454
MOD_NEK2_1	410	415	PF00069	0.387
MOD_NEK2_1	416	421	PF00069	0.409
MOD_NEK2_1	515	520	PF00069	0.429
MOD_NEK2_1	581	586	PF00069	0.469
MOD_NEK2_1	647	652	PF00069	0.379
MOD_NEK2_1	665	670	PF00069	0.293
MOD_NEK2_1	725	730	PF00069	0.333
MOD_NEK2_1	732	737	PF00069	0.351
MOD_NEK2_1	758	763	PF00069	0.360
MOD_NEK2_1	805	810	PF00069	0.331
MOD_NEK2_1	84	89	PF00069	0.418
MOD_NEK2_1	876	881	PF00069	0.532
MOD_NEK2_1	95	100	PF00069	0.370
MOD_NEK2_2	118	123	PF00069	0.413
MOD_NEK2_2	161	166	PF00069	0.328
MOD_NEK2_2	508	513	PF00069	0.445
MOD_PIKK_1	280	286	PF00454	0.339
MOD_PIKK_1	628	634	PF00454	0.350
MOD_PIKK_1	95	101	PF00454	0.356
MOD_PKA_1	663	669	PF00069	0.329
MOD_PKA_2	148	154	PF00069	0.382
MOD_PKA_2	273	279	PF00069	0.305
MOD_PKA_2	321	327	PF00069	0.330
MOD_PKA_2	336	342	PF00069	0.289
MOD_PKA_2	720	726	PF00069	0.298
MOD_Plk_1	161	167	PF00069	0.330
MOD_Plk_1	210	216	PF00069	0.426
MOD_Plk_1	310	316	PF00069	0.362
MOD_Plk_1	351	357	PF00069	0.520
MOD_Plk_1	529	535	PF00069	0.439
MOD_Plk_1	581	587	PF00069	0.468
MOD_Plk_1	699	705	PF00069	0.380
MOD_Plk_1	797	803	PF00069	0.401
MOD_Plk_1	852	858	PF00069	0.346
MOD_Plk_4	148	154	PF00069	0.321
MOD_Plk_4	161	167	PF00069	0.366
MOD_Plk_4	179	185	PF00069	0.266
MOD_Plk_4	277	283	PF00069	0.335
MOD_Plk_4	351	357	PF00069	0.412
MOD_Plk_4	388	394	PF00069	0.351
MOD_Plk_4	40	46	PF00069	0.447
MOD_Plk_4	400	406	PF00069	0.332
MOD_Plk_4	474	480	PF00069	0.353
MOD_Plk_4	511	517	PF00069	0.438
MOD_Plk_4	553	559	PF00069	0.464
MOD_Plk_4	59	65	PF00069	0.321
MOD_Plk_4	642	648	PF00069	0.362
MOD_Plk_4	699	705	PF00069	0.376
MOD_Plk_4	708	714	PF00069	0.316
MOD_Plk_4	720	726	PF00069	0.260
MOD_Plk_4	754	760	PF00069	0.367
MOD_Plk_4	805	811	PF00069	0.382
MOD_Plk_4	861	867	PF00069	0.355
MOD_ProDKin_1	323	329	PF00069	0.410
MOD_ProDKin_1	4	10	PF00069	0.438
MOD_ProDKin_1	411	417	PF00069	0.386
MOD_ProDKin_1	477	483	PF00069	0.272
MOD_ProDKin_1	546	552	PF00069	0.454
MOD_ProDKin_1	774	780	PF00069	0.385
MOD_ProDKin_1	834	840	PF00069	0.458
MOD_SUMO_rev_2	428	437	PF00179	0.307
TRG_DiLeu_BaEn_2	341	347	PF01217	0.295
TRG_DiLeu_BaEn_4	131	137	PF01217	0.385
TRG_DiLeu_BaEn_4	582	588	PF01217	0.466
TRG_DiLeu_BaLyEn_6	845	850	PF01217	0.451
TRG_ENDOCYTIC_2	361	364	PF00928	0.312
TRG_ENDOCYTIC_2	37	40	PF00928	0.455
TRG_ENDOCYTIC_2	399	402	PF00928	0.357
TRG_ENDOCYTIC_2	709	712	PF00928	0.290
TRG_ENDOCYTIC_2	772	775	PF00928	0.376
TRG_ENDOCYTIC_2	812	815	PF00928	0.361
TRG_ER_diArg_1	28	31	PF00400	0.493
TRG_ER_diArg_1	593	595	PF00400	0.402
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	372	376	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	799	804	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	848	853	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XB55	Leishmania donovani	68%	100%
A4ID72	Leishmania infantum	68%	100%
E9ATA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%