Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPJ0_LEIBR

TriTrypDb:

LbrM.35.3460 , LBRM2903_350044000

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HPJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.519
CLV_NRD_NRD_1	249	251	PF00675	0.366
CLV_PCSK_KEX2_1	134	136	PF00082	0.529
CLV_PCSK_KEX2_1	226	228	PF00082	0.419
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.542
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.360
CLV_PCSK_SKI1_1	180	184	PF00082	0.333
CLV_PCSK_SKI1_1	226	230	PF00082	0.476
CLV_PCSK_SKI1_1	91	95	PF00082	0.333
DEG_APCC_DBOX_1	253	261	PF00400	0.470
DEG_Nend_UBRbox_2	1	3	PF02207	0.537
DOC_ANK_TNKS_1	139	146	PF00023	0.420
DOC_PP1_RVXF_1	132	139	PF00149	0.444
DOC_PP4_MxPP_1	217	220	PF00568	0.624
DOC_USP7_MATH_1	119	123	PF00917	0.403
DOC_USP7_MATH_1	143	147	PF00917	0.413
DOC_USP7_MATH_1	175	179	PF00917	0.559
DOC_USP7_MATH_1	253	257	PF00917	0.619
DOC_USP7_MATH_1	54	58	PF00917	0.531
DOC_USP7_UBL2_3	226	230	PF12436	0.504
LIG_APCC_ABBA_1	19	24	PF00400	0.534
LIG_BRCT_BRCA1_1	2	6	PF00533	0.630
LIG_FHA_1	111	117	PF00498	0.238
LIG_FHA_1	154	160	PF00498	0.334
LIG_FHA_1	195	201	PF00498	0.615
LIG_FHA_1	33	39	PF00498	0.591
LIG_FHA_1	61	67	PF00498	0.557
LIG_FHA_1	94	100	PF00498	0.565
LIG_FHA_2	239	245	PF00498	0.627
LIG_FHA_2	293	299	PF00498	0.731
LIG_LIR_Apic_2	49	54	PF02991	0.525
LIG_LIR_Gen_1	110	119	PF02991	0.342
LIG_LIR_Nem_3	27	33	PF02991	0.510
LIG_LIR_Nem_3	49	53	PF02991	0.547
LIG_LIR_Nem_3	85	90	PF02991	0.522
LIG_MLH1_MIPbox_1	2	6	PF16413	0.630
LIG_Pex14_1	107	111	PF04695	0.574
LIG_SH2_CRK	87	91	PF00017	0.499
LIG_SH2_CRK	92	96	PF00017	0.487
LIG_SH2_GRB2like	50	53	PF00017	0.513
LIG_SH2_PTP2	72	75	PF00017	0.526
LIG_SH2_SRC	72	75	PF00017	0.426
LIG_SH2_STAT5	198	201	PF00017	0.525
LIG_SH2_STAT5	224	227	PF00017	0.696
LIG_SH2_STAT5	5	8	PF00017	0.567
LIG_SH2_STAT5	59	62	PF00017	0.575
LIG_SH2_STAT5	72	75	PF00017	0.484
LIG_SH3_3	209	215	PF00018	0.604
LIG_TRAF2_1	220	223	PF00917	0.626
LIG_TYR_ITIM	90	95	PF00017	0.493
LIG_WRC_WIRS_1	128	133	PF05994	0.532
LIG_WRC_WIRS_1	148	153	PF05994	0.449
MOD_Cter_Amidation	131	134	PF01082	0.507
MOD_GlcNHglycan	121	124	PF01048	0.251
MOD_GlcNHglycan	24	29	PF01048	0.404
MOD_GlcNHglycan	303	306	PF01048	0.491
MOD_GlcNHglycan	56	59	PF01048	0.349
MOD_GlcNHglycan	96	99	PF01048	0.333
MOD_GSK3_1	110	117	PF00069	0.361
MOD_GSK3_1	143	150	PF00069	0.413
MOD_N-GLC_1	114	119	PF02516	0.363
MOD_NEK2_1	114	119	PF00069	0.145
MOD_NEK2_1	155	160	PF00069	0.372
MOD_NEK2_1	60	65	PF00069	0.533
MOD_NEK2_1	83	88	PF00069	0.534
MOD_NEK2_1	94	99	PF00069	0.512
MOD_PKA_2	253	259	PF00069	0.615
MOD_PKA_2	301	307	PF00069	0.613
MOD_Plk_1	114	120	PF00069	0.348
MOD_Plk_4	143	149	PF00069	0.342
MOD_Plk_4	155	161	PF00069	0.449
MOD_SUMO_rev_2	204	208	PF00179	0.636
MOD_SUMO_rev_2	76	81	PF00179	0.595
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.551
TRG_ENDOCYTIC_2	109	112	PF00928	0.476
TRG_ENDOCYTIC_2	30	33	PF00928	0.517
TRG_ENDOCYTIC_2	50	53	PF00928	0.517
TRG_ENDOCYTIC_2	72	75	PF00928	0.522
TRG_ENDOCYTIC_2	87	90	PF00928	0.453
TRG_ENDOCYTIC_2	92	95	PF00928	0.360
TRG_ER_diArg_1	133	136	PF00400	0.360
TRG_NLS_MonoExtC_3	225	230	PF00514	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P459	Leptomonas seymouri	83%	100%
A0A0S4JIL7	Bodo saltans	50%	100%
A0A1X0P3F8	Trypanosomatidae	61%	100%
A0A3R7NG42	Trypanosoma rangeli	63%	100%
A0A3S5H831	Leishmania donovani	88%	100%
A4ID73	Leishmania infantum	90%	100%
D0A8F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ATA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q195	Leishmania major	90%	100%
V5BIN2	Trypanosoma cruzi	59%	100%