Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HPI8_LEIBR

TriTrypDb:

LbrM.35.3440 , LBRM2903_350043800

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HPI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HPI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.573
CLV_MEL_PAP_1	212	218	PF00089	0.398
CLV_NRD_NRD_1	121	123	PF00675	0.379
CLV_NRD_NRD_1	200	202	PF00675	0.439
CLV_NRD_NRD_1	239	241	PF00675	0.532
CLV_NRD_NRD_1	317	319	PF00675	0.512
CLV_NRD_NRD_1	40	42	PF00675	0.544
CLV_NRD_NRD_1	457	459	PF00675	0.557
CLV_NRD_NRD_1	478	480	PF00675	0.555
CLV_NRD_NRD_1	56	58	PF00675	0.522
CLV_NRD_NRD_1	95	97	PF00675	0.407
CLV_PCSK_FUR_1	476	480	PF00082	0.575
CLV_PCSK_KEX2_1	121	123	PF00082	0.551
CLV_PCSK_KEX2_1	200	202	PF00082	0.439
CLV_PCSK_KEX2_1	238	240	PF00082	0.534
CLV_PCSK_KEX2_1	317	319	PF00082	0.454
CLV_PCSK_KEX2_1	457	459	PF00082	0.531
CLV_PCSK_KEX2_1	478	480	PF00082	0.577
CLV_PCSK_PC7_1	196	202	PF00082	0.447
CLV_PCSK_SKI1_1	137	141	PF00082	0.496
CLV_PCSK_SKI1_1	145	149	PF00082	0.576
CLV_PCSK_SKI1_1	239	243	PF00082	0.524
CLV_PCSK_SKI1_1	33	37	PF00082	0.441
CLV_PCSK_SKI1_1	458	462	PF00082	0.526
CLV_PCSK_SKI1_1	480	484	PF00082	0.515
CLV_PCSK_SKI1_1	58	62	PF00082	0.489
DEG_APCC_DBOX_1	237	245	PF00400	0.489
DEG_APCC_DBOX_1	393	401	PF00400	0.495
DEG_APCC_DBOX_1	56	64	PF00400	0.467
DOC_CYCLIN_RxL_1	172	182	PF00134	0.560
DOC_CYCLIN_RxL_1	52	62	PF00134	0.412
DOC_MAPK_gen_1	57	63	PF00069	0.645
DOC_MAPK_MEF2A_6	24	32	PF00069	0.516
DOC_MIT_MIM_1	540	549	PF04212	0.573
DOC_PP1_RVXF_1	327	333	PF00149	0.533
DOC_USP7_MATH_1	514	518	PF00917	0.555
DOC_USP7_UBL2_3	461	465	PF12436	0.499
LIG_14-3-3_CanoR_1	159	165	PF00244	0.483
LIG_14-3-3_CanoR_1	184	189	PF00244	0.405
LIG_14-3-3_CanoR_1	215	222	PF00244	0.514
LIG_14-3-3_CanoR_1	269	274	PF00244	0.453
LIG_14-3-3_CanoR_1	306	311	PF00244	0.573
LIG_14-3-3_CanoR_1	383	387	PF00244	0.329
LIG_14-3-3_CanoR_1	526	532	PF00244	0.596
LIG_14-3-3_CanoR_1	533	542	PF00244	0.544
LIG_14-3-3_CanoR_1	96	103	PF00244	0.439
LIG_APCC_ABBAyCdc20_2	402	408	PF00400	0.362
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_FHA_1	272	278	PF00498	0.468
LIG_FHA_1	409	415	PF00498	0.588
LIG_FHA_1	416	422	PF00498	0.655
LIG_FHA_1	481	487	PF00498	0.517
LIG_FHA_1	542	548	PF00498	0.645
LIG_FHA_2	123	129	PF00498	0.573
LIG_FHA_2	70	76	PF00498	0.493
LIG_FHA_2	8	14	PF00498	0.472
LIG_FHA_2	99	105	PF00498	0.367
LIG_LIR_Gen_1	16	25	PF02991	0.384
LIG_LIR_Gen_1	2	12	PF02991	0.434
LIG_LIR_Nem_3	16	21	PF02991	0.385
LIG_LIR_Nem_3	2	7	PF02991	0.446
LIG_LIR_Nem_3	22	28	PF02991	0.301
LIG_LIR_Nem_3	522	528	PF02991	0.696
LIG_LYPXL_SIV_4	524	532	PF13949	0.603
LIG_Pex14_2	14	18	PF04695	0.407
LIG_SH2_CRK	25	29	PF00017	0.418
LIG_SH2_CRK	525	529	PF00017	0.494
LIG_SH2_STAP1	4	8	PF00017	0.435
LIG_SH2_STAT3	463	466	PF00017	0.622
LIG_SUMO_SIM_par_1	268	274	PF11976	0.334
LIG_SUMO_SIM_par_1	80	85	PF11976	0.396
LIG_TRAF2_1	297	300	PF00917	0.544
LIG_TRAF2_1	373	376	PF00917	0.544
LIG_TRAF2_1	424	427	PF00917	0.587
LIG_TRAF2_1	51	54	PF00917	0.543
LIG_UBA3_1	481	488	PF00899	0.569
LIG_UBA3_1	60	65	PF00899	0.489
MOD_CK1_1	19	25	PF00069	0.516
MOD_CK1_1	496	502	PF00069	0.583
MOD_CK1_1	99	105	PF00069	0.367
MOD_CK2_1	294	300	PF00069	0.467
MOD_CK2_1	306	312	PF00069	0.394
MOD_CK2_1	69	75	PF00069	0.491
MOD_CK2_1	7	13	PF00069	0.513
MOD_CK2_1	98	104	PF00069	0.439
MOD_GlcNHglycan	18	21	PF01048	0.594
MOD_GlcNHglycan	296	299	PF01048	0.487
MOD_GlcNHglycan	312	316	PF01048	0.358
MOD_GlcNHglycan	446	451	PF01048	0.537
MOD_GlcNHglycan	516	519	PF01048	0.714
MOD_GlcNHglycan	522	525	PF01048	0.663
MOD_GSK3_1	214	221	PF00069	0.481
MOD_GSK3_1	271	278	PF00069	0.413
MOD_GSK3_1	364	371	PF00069	0.478
MOD_GSK3_1	509	516	PF00069	0.575
MOD_N-GLC_1	16	21	PF02516	0.519
MOD_N-GLC_1	184	189	PF02516	0.399
MOD_N-GLC_1	306	311	PF02516	0.476
MOD_N-GLC_1	422	427	PF02516	0.551
MOD_N-GLC_1	533	538	PF02516	0.596
MOD_NEK2_1	132	137	PF00069	0.462
MOD_NEK2_1	362	367	PF00069	0.566
MOD_NEK2_1	437	442	PF00069	0.549
MOD_NEK2_1	7	12	PF00069	0.515
MOD_PIKK_1	132	138	PF00454	0.424
MOD_PIKK_1	158	164	PF00454	0.514
MOD_PIKK_1	239	245	PF00454	0.372
MOD_PIKK_1	362	368	PF00454	0.472
MOD_PIKK_1	437	443	PF00454	0.547
MOD_PIKK_1	533	539	PF00454	0.654
MOD_PIKK_1	86	92	PF00454	0.621
MOD_PK_1	306	312	PF00069	0.476
MOD_PKA_1	200	206	PF00069	0.490
MOD_PKA_1	239	245	PF00069	0.352
MOD_PKA_1	96	102	PF00069	0.370
MOD_PKA_2	132	138	PF00069	0.538
MOD_PKA_2	158	164	PF00069	0.514
MOD_PKA_2	199	205	PF00069	0.434
MOD_PKA_2	214	220	PF00069	0.417
MOD_PKA_2	239	245	PF00069	0.386
MOD_PKA_2	382	388	PF00069	0.375
MOD_PKA_2	466	472	PF00069	0.424
MOD_PKA_2	493	499	PF00069	0.639
MOD_Plk_1	16	22	PF00069	0.518
MOD_Plk_1	184	190	PF00069	0.444
MOD_Plk_1	306	312	PF00069	0.368
MOD_Plk_1	325	331	PF00069	0.374
MOD_Plk_1	408	414	PF00069	0.462
MOD_Plk_1	446	452	PF00069	0.538
MOD_Plk_1	99	105	PF00069	0.665
MOD_Plk_2-3	382	388	PF00069	0.462
MOD_Plk_2-3	69	75	PF00069	0.329
MOD_Plk_4	306	312	PF00069	0.517
MOD_SUMO_for_1	323	326	PF00179	0.532
MOD_SUMO_for_1	63	66	PF00179	0.422
MOD_SUMO_rev_2	29	35	PF00179	0.614
MOD_SUMO_rev_2	455	462	PF00179	0.606
TRG_DiLeu_BaEn_4	325	331	PF01217	0.531
TRG_DiLeu_BaEn_4	446	452	PF01217	0.560
TRG_ENDOCYTIC_2	25	28	PF00928	0.424
TRG_ENDOCYTIC_2	4	7	PF00928	0.437
TRG_ENDOCYTIC_2	525	528	PF00928	0.630
TRG_ER_diArg_1	120	122	PF00400	0.368
TRG_ER_diArg_1	199	201	PF00400	0.445
TRG_ER_diArg_1	237	240	PF00400	0.484
TRG_ER_diArg_1	316	318	PF00400	0.504
TRG_ER_diArg_1	456	458	PF00400	0.560
TRG_ER_diArg_1	476	479	PF00400	0.585
TRG_NLS_MonoExtN_4	461	468	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	177	182	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	288	293	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Z1	Leptomonas seymouri	66%	99%
A0A0S4JEL3	Bodo saltans	34%	99%
A0A3Q8IHG3	Leishmania donovani	83%	100%
A4IDB0	Leishmania infantum	83%	100%
D0A8F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ATA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q197	Leishmania major	84%	100%
V5AU66	Trypanosoma cruzi	41%	100%